scholarly journals Comparison of Central Corneal Thickness and Endothelial Cell Density in Patients with Various Types of Glaucoma and Patients without Glaucoma: A Case-control Study

2021 ◽  
Author(s):  
Khushboo Chawla ◽  
Shailesh Gadaginamath ◽  
Ashish Kumar Shah
Keyword(s):  
Endothelial Cell ◽  
Case Control Study ◽  
Corneal Thickness ◽  
Normal Tension Glaucoma ◽  
Case Control ◽  
P Value ◽  
Specular Microscopy ◽  
Significant Difference ◽  
Control Study

Introduction: Corneal affection in glaucoma patients is very high due to various risk factors that may lead to unforeseen and unplanned deleterious effects on the cornea leading to vision loss. Accurate intraocular pressure determination requires corneal thickness measurement and uncontrolled intraocular pressures, use of long term medication, intra ocular surgeries including cataract and glaucoma shunt surgeries may cause significant endothelial loss. Therefore, adequate planning and management and follow-up in these patients is required weighing all the long term consequences and emphasis the need for implementing adequate precautions. Aim: To evaluate and compare the Central Corneal Thickness (CCT) and corneal Endothelial Cell Density (ECD) in patients with glaucoma and without glaucoma by specular microscopy. Materials and Methods: A case-control study conducted in a Shekar Eye Hospital, Bengaluru, Karnataka, India, was conducted from August 2016 till April 2018 on a total 182 eyes from 182 patients were evaluated comprising of 91 cases and 91 controls. All participants underwent a detailed ophthalmological examination including slit lamp biomicroscopy, Intraocular Pressure (IOP) measurement, and CCT and ECD measurement by Tomey EM 3000 noncontact specular microscopy. The Statistical analysis was completes using Statistical Package For the Social Sciences (SPSS) 18.0 and R environment version 3.2.2 software’s. Results: The CCT of the glaucoma patients and the controls showed no significant difference (p-value=0.172). The CCT was comparatively thicker in Ocular Hypertension (OHTN) patients and thinner in Normal Tension Glaucoma (NTG) however statistical significance was not established. The mean ECD of controls was 2509.05±298.48 (cells/mm3) and that of cases was 2465.68±392.91 (cells/mm3) (p-value=0.404). The difference in the ECD amongst the glaucoma subgroups was not statistically significant (p-value=0.588). However, a lower ECD were seen in Pseudoexfoliation Glaucoma (PXG) and Primary Angle Closure Glaucoma (PACG) subgroups. Conclusion: No significant difference was found in CCT and endothelial cell in cornea of patients with and without glaucoma. Normal Tension Glaucoma (NTG) patients have comparatively thinner corneas and OHTN patients had thicker corneas. There was no significant correlation established between ECD of Normal corneal vs. Glaucoma and its subgroups.

scholarly journals Determinants of Developing Symptomatic Disease in Ethiopian COVID-19 Patients: A Case-Control Study

2020 ◽  
Author(s):  
Tigist Workneh Leulseged ◽  
Degu G. Alemahu ◽  
Ishmael S. Hassen ◽  
Endalkachew H. Maru ◽  
Wuletaw C. Zewde ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Case Control Study ◽  
Management Practice ◽  
Care Center ◽  
Binary Logistic Regression ◽  
Case Control ◽  
P Value ◽  
Symptomatic Disease ◽  
Significant Difference ◽  
Control Study

Abstract Background: Studies show that having some symptoms seems to be associated with more severe disease and poor prognosis. Therefore, knowing who is more susceptible to symptomatic COVID-19 disease is important to provide targeted preventive and management practice. The aim of the study was to assess the determinants of having symptomatic disease among COVID-19 patients admitted to Millennium COVID-19 Care Center in Ethiopia.Methods: A case-control study was conducted from August to September 2020 among a randomly selected 765 COVID-19 patients (372 Asymptomatic and 393 Symptomatic patients). Chi-square test and independent t-test were used to detect the presence of a statistically significant difference in the characteristics of the cases (symptomatic) and controls (asymptomatic), where p-value of <0.05 considered as having a statistically significant difference. Multivariable binary logistic regression was used to assess a statistically significant association between the independent variables and developing symptomatic COVID-19 where Adjusted Odds ratio (AOR), 95% CIs for AOR, and P-values were used for testing significance and interpretation of results. Results: The result of the multivariable binary logistic regression shows that age group (AOR= 1.818, 95% CI= 1.210, 2.731, p-value=0.004 for 30-39 years; AOR= 1.611, 95% CI= 1.016, 2.554, p-value=0.043 for 40-49 years and AOR= 4.076, 95% CI= 2.582, 6.435, p-value=0.0001 for years and above), sex (AOR= 1.672, 95% CI= 1.216, 2.299, p-value=0.002) and history of diabetes mellitus (AOR= 2.406, 95% CI= 1.384, 4.181, p-value=0.002) were found to be significant factors that determine the development of symptomatic disease in COVID-19 patients.Conclusions: Developing a symptomatic COVID-19 disease was found to be determined by exposures of old age, male sex, and being diabetic. Therefore, patients with the above factors should be given enough attention in the prevention and management process, including inpatient management, to pick symptoms earlier and to manage accordingly so that these patients can have a favorable treatment outcome.

scholarly journals Predictors of Death in Severe COVID-19 Patients at Millennium COVID-19 Care Center in Ethiopia: A Case-Control Study

2020 ◽  
Author(s):  
Endalkachew H. Maru ◽  
Tigist W. Leulseged ◽  
Ishmael S. Hassen ◽  
Wuletaw C. Zewde ◽  
Nigat W. Chamesew ◽  
...  
Keyword(s):  
Case Control Study ◽  
Care Center ◽  
Binary Logistic Regression ◽  
Case Control ◽  
P Value ◽  
Chi Square ◽  
P Values ◽  
Significant Difference ◽  
Chi Square Test ◽  
Control Study

ABSTRACTBackgroundAs the number of new cases and death due to COVID-19 is increasing, understanding the characteristics of severe COVID-19 patients and identifying characteristics that lead to death is a key to make an informed decision. In Ethiopia, as of September 27, 2020, a total of 72,700 cases and 1165 deaths were reported.ObjectiveThe study aimed to assess the determinants of death in Severe COVID-19 patients admitted to Millennium COVID-19 Care Center in Ethiopia.MethodsA case-control study of 147 Severe COVID-19 patients (49 deaths and 98 discharged alive cases) was conducted from August to September 2020. A comparison of underlying characteristics between cases (death) and controls (alive) was assessed using a chi-square test and an independent t-test with a p-value of <0.05 considered as having a statistically significant difference. Multivariable binary logistic regression was used to assess a statistically significant association between the predictor variables and outcome of Severe COVID-19 (Alive Vs Death) where Adjusted Odds ratio (AOR), 95% CIs for AOR, and P-values were used for testing significance and interpretation of results.ResultsHaving diabetes mellitus (AOR= 3.257, 95% CI= 1.348, 7.867, p-value=0.00), fever (AOR=0.328, 95% CI: 0.123, 0.878, p-value= 0.027) and Shortness of breath (AOR= 4.034, 95% CI= 1.481, 10.988, p-value=0.006) were found to be significant predictors of death in Severe COVID-19 patients.ConclusionsThe outcome of death in Severe COVID-19 patients is found to be associated with exposures to being diabetic and having SOB at admission. On the other hand, having a fever at admission was associated with a favorable outcome of being discharged alive.

Quality of Life in Children with Migraine: A Case–Control Study

2020 ◽  
Author(s):  
Saeid Sadeghian ◽  
Aliakbar Momen ◽  
Gholamreza Jelodar ◽  
Shahram Nasiri ◽  
Azin Khalafinia ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Case Control Study ◽  
Negative Impact ◽  
Case Control ◽  
Control Group ◽  
P Value ◽  
Quality Of Life Inventory ◽  
Significant Difference ◽  
Control Study

AbstractWe conducted a case–control study to determine the effects of migraine on quality of life (QOL) in children. Participants, aged between 6 and 18 years, were assigned to migraine (n = 70) and control (n = 70) groups. We used a translated version of Pediatric Quality of Life Inventory 4.0 questionnaire. From the children's perspective, the overall QOL scores in all domains were lower in children with migraine. Children in the migraine group had significant lower scores in the social, emotional, and physical functioning (p-value < 0.05) than control group. Interestingly, a significant difference in the educational performance was not seen (p-value = 0.101). Relative to the parents' responses and children, the overall scores in all domains were lower in children with migraine. Statistically significant lower scores were found only in emotional and physical domains (p-value < 0.05). The results of this study indicate that migraine imposes a substantial negative impact on the different aspects of QOL in children.

scholarly journals Association Between Serum Cadmium and Arsenic Levels with Bladder Cancer: A Case-control Study

2021 ◽  
Vol 14 (7) ◽  
Author(s):  
Vahid Moazed ◽  
Elham Jafari ◽  
Mohammad Reza Ebadzadeh ◽  
Amin Pourzare ◽  
Hamid Reza Gharehchahi ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Regression Models ◽  
Case Control Study ◽  
Case Control ◽  
P Value ◽  
Control Groups ◽  
Significant Difference ◽  
The Mean ◽  
And Control ◽  
Control Study

Background: Bladder cancer is the second most common cancer of the genitourinary system and the eighth cause of cancer death. In addition to known risk factors such as smoking and urinary stones, trace elements are also effective in causing bladder cancer and other cancers. Objectives: This study was conducted to determine the association between bladder cancer and the carcinogens cadmium and arsenic. Methods: This case-control study was conducted on 40 patients with bladder cancer admitted to Shahid Bahonar Hospital and a control group of 40 healthy individuals in Kerman, Iran, in 2018. The serum levels of arsenic and cadmium were measured by atomic absorptiometry. The paired t-test and chi-square tests were employed to assess the difference between cases and controls groups. An unadjusted and 2 multivariable conditional regression models were separately adjusted on sex, family cancer history, residence, occupation, and smoking and were used to estimate odds ratios (OR) and 95% confidence intervals (95% CI) to assess the association between arsenic and cadmium levels and bladder cancer. The statistical software SPSS version 26 and R software version 3.6.3 were used to perform the statistical analyses. Results: The mean cadmium level was 2.99 ± 1.45 and 2.59 ± 0.46 in the case and control groups, respectively, with no statistically significant difference between the groups (P = 0.100). The mean arsenic level was 2.12 ± 1.04 and 1.43 ± 0.73 in the case and control groups, respectively, demonstrating a statistically significant difference between the groups (P = 0.001). Unadjusted and adjusted conditional logistic regression models indicated significant association between arsenic levels and bladder cancer (unadjusted: odds ratio (OR) (95% CI): 0.66 (0.46 - 0.94), P-value = 0.022; adjusted: OR (95% CI): 0.64 (0.44 - 0.92), P-value = 0.018). Conclusions: Overall, cadmium and arsenic levels are higher in patients with bladder cancer, with a statistically significant difference for arsenic. However, these elements are not interrelated and are not related to other factors.

scholarly journals The relation between active smoking and colposcopical and cytological findings in the cervix uteri

2020 ◽  
Vol 9 (8) ◽  
pp. 3179
Author(s):  
Muhad A. Ali ◽  
Safa K. Salman ◽  
Rana M. Issa
Keyword(s):  
Case Control Study ◽  
Case Control ◽  
Study Data ◽  
Cervix Uteri ◽  
P Value ◽  
Cervical Carcinogenesis ◽  
Papanicolaou Smear ◽  
Cytological Abnormalities ◽  
Control Study

Background: All types of smoking have been associated with cervical neoplasia, and the long-term of use tobacco products and intensity of smoking could influence cervical carcinogenesis. The aim of this study is to identify the association between smoking and the presence of colposcopical and cytological abnormalities in cervix uteri.Methods: An observational case-control study was applied on 100 patients to investigate this relationship. The patients were divided into two groups, smokers’ group (70) cases and nonsmokers’ group (30) cases. All of the patients have been submitted to colposcopy and Papanicolaou smear. Comparison of colposcopic and cellular findings between both groups was done.Results: Authors found that there was a significance difference in the rate of abnormal colposcopical findings between two groups. This rate in smokers’ sample was 45.7% and in the second was 26.7% with p-value=0.04. Additionally, there was no significance difference in the rate of abnormal cytological findings. This rate in smokers’ group was 32.9% whereas in the second was 23.4% with p-value=0.6.Conclusions: This study data suggests that smoking increases abnormalities in papanicolaou smear and colposcopy.

scholarly journals COBALAMIN DEFICIENCY

2016 ◽  
Vol 23 (02) ◽  
pp. 176-181
Author(s):  
Shumaila Shaikh ◽  
Azhar Memon ◽  
Muhammad Atif Ata ◽  
Haji Khan Khoharo
Keyword(s):  
Helicobacter Pylori ◽  
Case Control Study ◽  
Case Control ◽  
University Hospital ◽  
Cobalamin Deficiency ◽  
P Value ◽  
Significant Difference ◽  
Design Case ◽  
H Pylori ◽  
Control Study

Objectives: The present study aims to evaluate the serum cobalamin inHelicobacter pylori (H. pylori) infected patients. Study Design: Case control study. Place andDuration: Department of Medicine, Isra University Hospital Hyderabad from March 2013- April2014. Methodology: A sample of 109 subjects including Helicobacter pylori positive subjectsand controls were selected according to study criteria. Centrifugation of blood was performedat 4000 rpm for 10 minutes and sera were stored at -20oC. Blood sera were used for H. pyloriserological testing. Blood counting was performed on hematoanalyzer. Cobas e411 analyzerwas used for detection of cobalamin. 64 kD H. pylori antigens was detected by ELISA. Thedata was entered into SPSS version 21.0. (IBM, Incorporation, USA) A 2-tailed p-value of ≤0.05was considered significant for statistical analysis. Results: Of total 109, 54.1% (n=59) wereH. pylori seropositive cases and others were controls i.e. 45.9% (n=50). Cases and controlsshowed cobalamin levels of 290±49.3 vs. 351±32.9 pg/ml respectively (p=0.0001). Red bloodcell indices were found to show statistically significant difference between cases and controls(p=0.001). Conclusion: Serum cobalamin deficiency was noted in both Helicobacter pyloripositive and controls, however deficiency was more pronounced in Helicobacter pylori positivesubjects.

Association between iron deficiency and provoked febrile seizure in a middle income country: A case control study in Tehran, Iran

2020 ◽  
Author(s):  
Fahimeh Ehsanipour ◽  
Samileh Noorbakhsh ◽  
Azita Tavasooli ◽  
Leila Tahernia
Keyword(s):  
Iron Deficiency ◽  
Likelihood Ratio ◽  
Case Control Study ◽  
Positive Likelihood Ratio ◽  
Negative Likelihood Ratio ◽  
Febrile Convulsion ◽  
Case Control ◽  
P Value ◽  
Significant Difference ◽  
Control Study

Abstract Objective: Febrile convulsion (FC) is the most common form of seizures disorder (3-4%) in childhood with good prognosis. Some evidences indicate that iron deficiency (ID) might play a role in initiation of FC. The aim of this case‐control study was to evaluate, the role for ID in pathogenesis of FC (febrile convulsion). We studied 35 FC children and 35 controls (febrile diseases without convulsion) Results The mean age of cases were 2.191 ± 0946 vs 1.93 ± 1.433 years in controls .Mean Hemoglobin level (11.6 ± 079 vs 11.86± 071; p value= 0.2); MCV (75.8 ± 4.3 vs 77.62± 4.1,p value= 0.08) ;serum ferritin levels (54.57 ± 24 vs 58.31± 23, p value= 0.64) had not significant difference between 2 groups. The ferritin level 36ng/ml; had 74.3% sensitivity, 20% specifity, 56% PPV, 52% NPV, Positive likelihood Ratio: 1.3; Negative likelihood Ratio: 0.93 to discriminate 2 groups. In our opinion, ID could not lead to FC in all children, but in some cases with genetic basis; ID raises the threshold for seizures. Due to high prevalence of ID (26%) especially in your Iranian population, adding the Iron to diet might be helpful in decreasing FC in susceptible cases.

scholarly journals Neutrophil–lymphocyte ratio for the prediction of histological chorioamnionitis in cases of preterm premature rupture of membranes: a case-control study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Greta Balciuniene ◽  
Greta Kvederaite-Budre ◽  
Violeta Gulbiniene ◽  
Irena Dumalakiene ◽  
Rita Viliene ◽  
...  
Keyword(s):  
Case Control Study ◽  
Case Control ◽  
P Value ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Preterm Premature Rupture ◽  
Significant Difference ◽  
Control Study

Abstract Background The neutrophil-lymphocyte ratio (NLR) is easily calculated blood test parameter, which can be used as marker to predict many inflammatory disorders. The aim of this study was to assess and compare the NLR in maternal blood with the white blood cell (WBC) count and C-reactive protein (CRP) concentration for the prediction of histological chorioamnionitis. Methods This was a case-control study of 137 woman with preterm premature rupture of membranes (PPROM) at a gestational age between 22+ 0 and 34+ 6 weeks. Blood samples, collected less than 48 h before delivery and at least 48 h after the administration of corticosteroids, were selected for the analysis. The NLR was calculated by dividing the number of neutrophils by the number of lymphocytes. Chorioamnionitis was diagnosed by the histopathological evaluation of placental membranes and chorionic plate. Results Patients with diagnosed histological chorioamnionitis (HCA) had significantly higher levels of WBC, CRP and NLR (p-value < 0.001). Levels of WBC, CRP and NLR predicted HCA with an area under the curve (AUC) of 0.81, 0.81 and 0.89, respectively. NLR had statistically significantly higher AUC than WBC, but no significant difference was found between AUCs of NLR and CRP. The cut-off level of NLR was found to be 5,97, which had a sensitivity of 77 % and a specificity of 95 %. Conclusion NLR has a good predictive value for HCA and could be used as an additional diagnostic marker for predicting histological chorioamnionitis in cases with preterm premature rupture of membranes before 34 weeks of gestation.

scholarly journals Evaluation of outcome following paracervical infiltration with or without saline and adrenaline during vaginal hysterectomy

2017 ◽  
Vol 6 (5) ◽  
pp. 1942
Author(s):  
Jayaraman Nambiar M. ◽  
Bhaygarekha Yettinamani ◽  
Muralidhar V. Pai
Keyword(s):  
Vaginal Hysterectomy ◽  
Postoperative Infection ◽  
Case Control Study ◽  
Operating Time ◽  
Case Control ◽  
P Value ◽  
Laparoscopic Assisted Vaginal Hysterectomy ◽  
Significant Difference ◽  
Laparoscopic Assisted ◽  
Control Study

Background: Paracervical infiltration is used in vaginal hysterectomy to facilitate dissection. Use of paracervical infiltration however can be associated with local ischemia and infection. We did a study to find out its benefits during vaginal hysterectomy.Methods: It was a prospective case control study. Patients were divided into two groups. In the first group, no paracervical infiltration was given. In the second group paracervical infiltration was given before hysterectomy. The operating time, blood loss and postoperative infection were noted in each group.Results: The operating time was slightly higher in vaginal hysterectomy group without infiltration (p=0.025) The operating time in laparoscopic assisted vaginal hysterectomy group was not significant (p=0.0296). There was significant difference in Hemoglobin after surgery in both groups (p value 0.614 for vaginal hysterectomy and 0.173 for laparoscopic assisted vaginal hysterectomy). There was no case of infection in both groups.Conclusions: From our study, we concluded that paracervical infiltration offers no distinctive advantage during vaginal hysterectomy or laparoscopic assisted vaginal hysterectomy. 

scholarly journals Dermatoglyphics in infants with isolated, non-familial cleft lip palate- a case control study from Southern India

2017 ◽  
Vol 4 (4) ◽  
pp. 1389
Author(s):  
Lia Sarah Anish ◽  
Sowmya S. G. ◽  
Rathika Shenoy ◽  
Vikram Shetty
Keyword(s):  
Cleft Lip ◽  
Genetic Factors ◽  
Case Control Study ◽  
Case Control ◽  
P Value ◽  
Study Group ◽  
Right Hand ◽  
Significant Difference ◽  
Control Study

Background: The role of genetic factors may be established by study of dermatoglyphics, therefore, any genetic abnormality during the formation of cleft lip and/or palate (CL/P) in the early trimester maybe reflected by altered dermatoglyphics. Aim: This study aims to assess altered dermatoglyphics in children with isolated, non-familial CL/P to understand the role of genetic factors in clefting.Methods: Case control study in a cranio-facial centre comprising of 40 infants (6-9 months) with CL/P and age and gender matched controls. Finger printing was done using black duplicating ink. A p-value of 0.05 was considered significant.Results: Majority (57.5%) had left sided clefting. Ulnar loops were the predominant digital pattern in the study group but there was no statistical difference with the controls, when all the finger patterns were considered together. There was significant difference in digital patterns in between the left thumb (p=0.033), ring (p=0.048) and little fingers (p=0.029) in the two groups. Comparison between the right and left hands within the study group showed significant difference in digital patterns in the thumb (p=0.047) and little finger (p<0.001). The study group also had a wider atd angle with significance (right hand p=0.038, left p=0.003) and a lower a-b ridge count with significance (right hand p= 0.045, left p=0.012).Conclusions: There was a definite dermatoglyphic difference specifically in the left hand, which was also the major side of clefting, within subjects as well as between subjects and controls.

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