scholarly journals Drosophila parabss Flies as a Screening Model for Traditional Medicine: Anticonvulsant Effects of Annona senegalensis

2021 ◽  
Vol 11 ◽  
Author(s):  
Samuel S. Dare ◽  
Emiliano Merlo ◽  
Jesus Rodriguez Curt ◽  
Peter E. Ekanem ◽  
Nan Hu ◽  
...  
Keyword(s):  
Developing Countries ◽  
Traditional Medicine ◽  
Intractable Epilepsy ◽  
Stem Bark ◽  
Bark Extract ◽  
Treatment Of Epilepsy ◽  
Custard Apple ◽  
Stem Bark Extract ◽  
New Treatments ◽  
And Control

Epilepsy is among the most common serious neurological disorders and affects around 50 million people worldwide, 80% of which live in developing countries. Despite the introduction of several new Anti-Epileptic Drugs (AEDs) in the last two decades, one third of treated patients have seizures refractory to pharmacotherapy. This highlights the need to develop new treatments with drugs targeting alternative seizure-induction mechanisms. Traditional medicine (TM) is used for the treatment of epilepsy in many developing countries and could constitute an affordable and accessible alternative to AEDs, but a lack of pre-clinical and clinical testing has so far prevented its wider acceptance worldwide. In this study we used Drosophila melanogaster paralyticbangsensitive(parabss) mutants as a model for epileptic seizure screening and tested, for the first time, the anti-seizure effect of a non-commercial AED. We evaluated the effect of the African custard-apple, Annona senegalensis, which is commonly used as a TM for the treatment of epilepsy in rural Africa, and compared it with the classical AED phenytoin. Our results showed that a stem bark extract from A. senegalensis was significantly more effective than a leaf extract and similar to phenytoin in the prevention and control of seizure-like behavior. These results support that Drosophila constitutes a robust animal model for the screening of TM with potential value for the treatment of intractable epilepsy.

scholarly journals Antimicrobial activity and phytochemistry of methanolic stem bark extract of Melia azedarach (Linn.)

2020 ◽  
Vol 12 (1) ◽  
pp. 407-411
Author(s):  
M. Ahmed ◽  
A.H. Bukar ◽  
M.Y. Amuda ◽  
A. Babagana
Keyword(s):  
Antimicrobial Activity ◽  
Developing Countries ◽  
Traditional Medicine ◽  
Stem Bark ◽  
Bark Extract ◽  
Melia Azedarach ◽  
Human Pathogens ◽  
Zone Of Inhibition ◽  
Medicinal Uses ◽  
Stem Bark Extract

The use of traditional medicine is increasing and gaining popularity throughout the developed and developing countries. About 80 % of the people in developing countries rely on traditional medicine for primary health care. The present study was carried out to evaluate the phytochemical constituents and antimicrobial activity of the stem bark of Melia azedarach extracted using methanol as solvent. Phytochemical screening revealed that methanolic stem bark extract contain alkaloid, cardiac glycoside, flavonoids, saponins, steroid, tannin and terpenoid. Antimicrobial efficiency were tested against four human pathogens: Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Streptococcus spp. The diameter of zone of inhibition (ZOI) was measured and it was found that the extract showed a maximum zone of inhibition against Gram negative and Gram positive pathogens and the zone of inhibition was found to be concentration dependent. The result obtained in this study may be indication that alcoholic extracts of this plant could be a possible source of obtaining new and effective herbal medicine to treat infections which justify the ethno    medicinal uses of Melia azedarach against infectious diseases agents.  Key words: Melia azedarach, antimicrobial, activity, traditional medicine, extract

scholarly journals Spathodea companulata (African tulip tree) stem and root barks extracts ameliorated N-nitroso diethylamine induced hepatic impairment in male rats

2021 ◽  
Vol 01 (01) ◽  
pp. 57-65
Author(s):  
Bala Muhammed ◽  
Keyword(s):  
Weight Loss ◽  
Body Weight ◽  
Traditional Medicine ◽  
Cardiac Glycoside ◽  
Hepatic Impairment ◽  
Stem Bark ◽  
Male Rats ◽  
Bark Extract ◽  
Root Bark ◽  
Stem Bark Extract

Spathodea campanulata Beauv. is an important plant widely used in traditional medicine for the treatment of hepatic disease. In the present study, we evaluate the phytochemical composition and hepatoprotective potential effect of the stem and root bark extracts of Spathodea companulata on dimethylnitrosamine (DEN) induced hepatic impairment in albino rats. Phytochemical compositions were analyzed using standard protocols. Forty-five male rats were grouped into 9 (A-I) of 5 rats each. Groups A-F were treated with stem bark extract, root bark extract, quercetin, DEN + stem bark extract, DEN + root bark extract, DEN + quercetin respectively while groups G-1 serve as control groups and were treated with corn oil only (Vehicle control), DEN only (Toxicant control), and distilled water (normal control) respectively. DEN was given at 25 mg/kg b.w., i.p on a weekly basis while all treatments were administered at 100 mg/kg BW orally for 60 days. Serum transaminase activities, body weight, and liver body weight ratio were evaluated. Results revealed the presence of alkaloids, cardiac glycoside, saponins, anthraquinone, steroids, and flavonoids in stem bark extract of Spathodea companulata, while the root bark contains cardiac glycoside, saponins, anthraquinonoid, steroids, and flavonoid. The DEN non-treated rat exhibited significant (p<0.05) weight loss and increase serum alanine transaminase (ALT) and aspartate transaminase (AST) activities when compared with the normal control. Treatment with stem and root bark extracts of Spathodea companulata significantly ameliorated the toxicant induce alterations in the transaminase activity and body weight loss when compared with the DEN nontreated rats. In conclusion, this study provides scientific validation of the use of this plant in traditional medicine for the management of hepatic disorders

AKTIVITAS ANTIBAKTERI METABOLIT SEKUNDER PADA KULIT BATANG GELUMPANG (Sterculia foetida L.)

2010 ◽  
Vol 5 (1) ◽  
Author(s):  
Maria Ulfa ◽  
Dewa Ayu Citra Rasmi
Keyword(s):  
Antibacterial Activity ◽  
Traditional Medicine ◽  
Secondary Compounds ◽  
Stem Bark ◽  
Bark Extract ◽  
Stomach Upset ◽  
Secondary Compound ◽  
Stem Bark Extract

ABSTRAK: Telah dilakukan ekstraksi dan identifikasi metabolit sekunder kulit batang Gelumpang (Sterculia foetida L.) dengan metode maserasi dan penapisan fitokimia menggunakan metode Ciulei. Kulit batang Gelumpang dimaserasi menggunakan pelarut n-heksan, DCM, metanol dan air. Gelumpang banyak digunakan sebagai obat sembelit dan encok. Untuk mendukung pemakaian secara empirik maka pada penelitian ini dilakukan uji penapisan metabolit sekunder dan uji aktivitas antibakteri terutama pada Staphyococcus aureus secara in vitro. Hasil  penapisan menunjukkan  kandungan kimia dari  ekstrak kulit batang Gelumpang adalah tanin, minyak atsiri, sterol, triterpen, kumarin dan flavonoid. Hal ini diperkuat dengan data KLT (eluen n-heksan:DCM = 8:12). Ekstrak kulit batang Gelumpang mempunyai daya antibakteri terhadap S.aureus dengan diameter daerah hambat (DDH) 2,4 mm    (n-heksan); 4,6 mm (DCM);  7,4 mm (metanol) dan 1,7 mm (air). Kata kunci; Gelumpang, Penapisan fitokimia, KLT, S. aureusABSTRACT: Extraction and identification of secondary compound Gelumpang (Sterculia    foetida L.) stem bark by maseration and screening phytochemical (Ciulei method) were carried out. Maseration using n-hexane, dichloromethane (DCM), methanol and aquadest were employed. Gelumpang are often used as traditional medicine for stomach upset or colic and  rheumatic. To support this utilization, this experiment was done to analyse the secondary compounds and to test antibacterial activity of Staphyococcus aureus. The results show that secondary compounds in Gelumpang extract were tannin, essencial oil, sterol, triterphenoid, cumarin and flavonoid. This is supported by TLC data (eluen n-hexane:DCM = 8:12). Gelumpang stem bark extract has antibacterial activity on S. aureus. This was shown by 2,4 mm (n-hexane); 4,6 mm (DCM); 7,4 mm (methanol) and 1,7 mm (aquadest) of the diameter of inhibition area.Key Words; Gelumpang, screening phytochemical, TLC, S. aureus

Sequestered uptake of chromium(VI) by Irvingia gabonensis stem bark extract anchored silica gel

2021 ◽  
Author(s):  
James F. Amaku ◽  
Segun A. Ogundare ◽  
Kovo G. Akpomie ◽  
Comfort M. Ngwu ◽  
Jeanet Conradie
Keyword(s):  
Silica Gel ◽  
Stem Bark ◽  
Bark Extract ◽  
Chromium Vi ◽  
Irvingia Gabonensis ◽  
Stem Bark Extract

scholarly journals Carbohydrate digestive enzymes are inhibited by Poincianella pluviosa stem bark extract: relevance on type 2 diabetes treatment

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Camila Gabriel Kato-Schwartz ◽  
Anacharis Babeto de Sá-Nakanishi ◽  
Ana Carolina Guidi ◽  
Geferson de Almeida Gonçalves ◽  
Fernanda Giacomini Bueno ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Digestive Enzymes ◽  
Stem Bark ◽  
Bark Extract ◽  
Diabetes Treatment ◽  
Type 2 Diabetes Treatment ◽  
Stem Bark Extract

scholarly journals Effect of Carica papaya L. Stem Bark Extracts on Cholesterol Concentration in Rats Induced with Streptosozin

2020 ◽  
Vol 151 ◽  
pp. 01011
Author(s):  
Safrida Safrida ◽  
Mustafa Sabri
Keyword(s):  
Body Weight ◽  
Carica Papaya ◽  
Stem Bark ◽  
Negative Control ◽  
Diabetic Rats ◽  
Cholesterol Concentration ◽  
Bark Extract ◽  
Treatment Groups ◽  
Randomized Design ◽  
Stem Bark Extract

This study was designed to determine the effect of Carica papaya L. stem bark extracts on cholesterol concentration in rats induced with glibenclamide. A completely randomized design was used for the experiment which consisted of 6 treatment groups, each group consisted of four rats, as follows:1) KN (negative control, non-diabetic rats); KP, diabetic rats given glibenclamide 10 mg/kg body weight; EP 1, diabetic rats given 0 mg/kg body weight/day extract; EP2, diabetic rats given 100 mg/kg body weight/day extract; and EP3, diabetic rats given 200 mg/kg body weight/day extract, EP4, diabetic rats given 300 mg/kg body weight/day extract for 28 day. The results showed that C. papaya L. stem bark extract decreased (P<0.05) cholesterol levels in diabetic rats. It was concluded that C. papaya L. stem bark extract had potential as anti-hypercholesterolemic in diabetic rats.

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