Association Study of Apolipoprotein E Gene Polymorphism With Incidence and Delayed Resolution of Hemifacial Spasm

Objective: This study investigates the correlation between Apolipoprotein E gene (APOE) polymorphism and the incidence and delayed resolution of hemifacial spasms.Methods: The APOE genotypes of 151 patients with hemifacial spasm and 73 control cases were determined by cleaved amplification polymorphism sequence-tagged sites. The distribution of three APOE alleles (ε2, ε3, and ε4) in two groups and the delayed resolution rate in 6 genotypes were calculated and statistically analyzed.Results: The proportion of patients with APOE ε3/ε4 genotype in the hemifacial spasm group (25.17%) was significantly higher than that in the control group (12.33%) (P = 0.027). In terms of allele frequency, the proportion of the APOE ε4 allele in the hemifacial spasm group (15.56%) was significantly higher than that in the control group (6.85%) (P = 0.009). Meanwhile, the proportion of APOE ε4 allele carriers in the hemifacial spasm group (29.80%) was significantly higher than that in the control group (13.7%) (P = 0.009). Logistic regression analysis showed that the ε4 allele significantly increased the incidence of hemifacial spasm (OR 2.675, 95%CI 1.260-5.678, P = 0.010). Among the 32 patients with a delayed resolution, the ε3/ε3 and ε3/ε4 had the highest proportion in 6 genotypes. The delayed resolution rate of APOE ε3/ε4 (34.21%) was significantly higher than APOE ε3/ε3 (17.78%) (P < 0.05). The delayed resolution rate of APOE ε4 carriers was the highest (33.33%) in the 3 allele carriers, but there was no significant difference among the 3 allele carriers (P = 0.065).Conclusion: The polymorphism of APOE is relevant to the incidence rate of hemifacial spasms. APOE ε4 allele increases the incidence of hemifacial spasm. The APOE ε4 allele may promote the occurrence of delayed resolution.

Download Full-text

Apolipoprotein E gene polymorphism and the risk of cardiovascular disease and type 2 diabetes

BMC Cardiovascular Disorders ◽

10.1186/s12872-019-1194-0 ◽

2019 ◽

Vol 19 (1) ◽

Cited By ~ 4

Author(s):

Sudong Liu ◽

Jing Liu ◽

Ruiqiang Weng ◽

Xiaodong Gu ◽

Zhixiong Zhong

Keyword(s):

Type 2 Diabetes ◽

Cardiovascular Disease ◽

Apolipoprotein E ◽

Cross Sectional Study ◽

Cross Sectional ◽

E Gene ◽

Apolipoprotein E Gene ◽

Increased Risk ◽

Ε4 Allele

Abstract Background The role of apolipoprotein E gene (APOE) in lipid metabolism has been well established, and APOE is associated with the risk of cardiovascular disease (CVD) and diabetes mellitus (DM). However, the relationship between APOE polymorphisms and type 2 diabetes (T2DM) with or without CVD remains unclear. Methods In this cross-sectional study, a total of 924 participants including 211 controls (CVD-T2DM-), 247 T2DM patients with CVD (CVD-T2DM+), 232 CVD patients without T2DM (CVD + T2DM-) and 234 T2DM patients with CVD (CVD + T2DM+), were genotyped using chip platform. The association between APOE polymorphisms and T2DM patients with or without CVD was analyzed by univariable and multivariable logistic analysis. Results The present study showed that the frequency of E3/E4 increased in T2DM patients with CVD (p < 0.01). The ε4 allele was higher in CVD patients without T2DM (p < 0.01) and T2DM patients with CVD (p < 0.01) as compared with the controls. Conclusions The subjects carrying ε4 allele have increased risk of CVD and T2DM, and exhibit higher level of lipid profiles.

Download Full-text

Neurotoxicity from innate immune response is greatest with targeted replacement of ε4 allele of apolipoprotein E gene and is mediated by microglial p38MAPK

The FASEB Journal ◽

10.1096/fj.05-5423fje ◽

2006 ◽

Vol 20 (6) ◽

pp. 797-799 ◽

Cited By ~ 65

Author(s):

Izumi Maezawa ◽

Mary Nivison ◽

Kathleen S. Montine ◽

Nobuyo Maeda ◽

Thomas J. Montine

Keyword(s):

Immune Response ◽

Apolipoprotein E ◽

Innate Immune Response ◽

Innate Immune ◽

E Gene ◽

Apolipoprotein E Gene ◽

Ε4 Allele

Download Full-text

The influence of the ε4 allele of the apolipoprotein E gene on childhood IQ, nonverbal reasoning in old age, and lifetime cognitive change

Intelligence ◽

10.1016/s0160-2896(02)00114-9 ◽

2003 ◽

Vol 31 (1) ◽

pp. 85-92 ◽

Cited By ~ 18

Author(s):

Ian J Deary ◽

Lawrence J Whalley ◽

David St. Clair ◽

Gerome Breen ◽

Steve Leaper ◽

...

Keyword(s):

Apolipoprotein E ◽

Old Age ◽

Cognitive Change ◽

E Gene ◽

Apolipoprotein E Gene ◽

Ε4 Allele ◽

Nonverbal Reasoning

Download Full-text

The relationship between apolipoprotein E gene polymorphism and essential hypertension and the analysis of the efficacy of nanotechnology

Materials Express ◽

10.1166/mex.2021.2070 ◽

2021 ◽

Vol 11 (10) ◽

pp. 1645-1652

Author(s):

Guannan Qin ◽

Xingyu Xie ◽

Ying Liu ◽

Chuanyang Dai

Keyword(s):

Risk Factors ◽

Essential Hypertension ◽

Magnetic Nanoparticles ◽

Apolipoprotein E ◽

Control Group ◽

E Gene ◽

Apolipoprotein E Gene ◽

Apo E ◽

The Relationship ◽

Experimental Group

The study aimed to detect the genetic polymorphism of apolipoprotein E (Apo E) in residents of Guizhou, China, explore its relationship with essential hypertension, and discuss the efficacy of nanotechnology in the treatment of hypertension. A total of 200 people in Guizhou, China were detected with Apo E polymorphisms and were divided into groups, The experimental group consists of people with essential hypertension and the control group of normal people. The SPSS 26.0 software was used to determine the correlation between Apo E gene polymorphisms and the essential hypertension risk. Logistic regression analysis was adopted to determine the risk factors of the Apo E gene for essential hypertension. Magnetic nanoparticles are used to help extract DNA, improve efficiency, and analyze the distribution of alleles in the population. The distribution frequencies of the six genotypes of E2/2, E2/3, E3/3, E3/4, E2/4, and E4/4 were 1.0%, 15.5%, 64.0%, 17.0%, 1.5%, and 1.0%, respectively, and the distribution frequencies of the three alleles of ε2, ε3, and ε4 were 9.5%, 80.3%, and 10.3%, respectively. There are more Apo E gene ε4 carriers in the experimental group than the control group, and the difference was statistically significant (P <0.05). The Apo E ε4 allele carriers had higher low-density lipoprotein and Apo B levels than the Apo E ε3 and Apo E ε2 gene carriers. Family history of hypertension and Apo E ε4 were both the main risk factors for essential hypertension. This study investigated the relationship between apolipoprotein E gene polymorphism and essential hypertension, and extracted DNA by magnetic nanoparticles to help analyze the distribution of alleles in hypertension population, which could provide theoretical basis for the diagnosis and treatment of essential hypertension in Guizhou Province, China.

Download Full-text

Genetic influence of Apolipoprotein E gene ε2/ε3/ε4 isoforms on odds of mesial temporal lobe epilepsy

African Health Sciences ◽

10.4314/ahs.v21i2.48 ◽

2021 ◽

Vol 21 (2) ◽

pp. 866-874

Author(s):

Tao Xu ◽

Hui Zhang ◽

Xueliang Qiu ◽

Yuping Meng

Keyword(s):

Temporal Lobe Epilepsy ◽

Apolipoprotein E ◽

Temporal Lobe ◽

Mesial Temporal Lobe Epilepsy ◽

Case Control Studies ◽

E Gene ◽

Apoe Isoforms ◽

Apolipoprotein E Gene ◽

Significant Difference ◽

Mesial Temporal Lobe

Objective: The potential correlation between the ε2/ε3/ε4 variants of the ApoE (Apolipoprotein E) gene and the odds of mesial temporal lobe epilepsy was investigated. Methods: The database searching for eligible studies was performed in October 2020. A series of pooling analyses were conducted. Results: We enrolled a total of twelve case-control studies for pooling. Within the pooling analysis of ε4, there was an in- creased risk of mesial temporal lobe epilepsy in cases under the models of carrier ε4 vs. ε3, ε3ε4 vs. ε3ε3, and ε3ε4+ε4ε4 vs. ε3ε3 [P < 0.05, odds ratio (OR) > 1], compared with controls. Moreover, we observed similar positive results in the subgroup analyses of “China” and “Population-based control” under the genetic models of ε4 (P < 0.05, OR > 1). Nevertheless, we did not detect the significant difference between the mesial temporal lobe epilepsy cases and controls in the pooling analyses of ε2 (all P > 0.05). Conclusion: The ε3ε4 genotype of ApoE seems to be linked to the risk of mesial temporal lobe epilepsy for patients in China. More sample sizes are required to confirm the potential role of ApoE isoforms in the susceptibility to diverse types of epilepsy from different origins. Keywords: Epilepsy; ApoE; isoforms; susceptibility.

Download Full-text