scholarly journals Neural Mechanisms of Hearing Recovery for Cochlear-Implanted Patients: An Electroencephalogram Follow-Up Study

2021 ◽  
Vol 14 ◽  
Author(s):  
Songjian Wang ◽  
Meng Lin ◽  
Liwei Sun ◽  
Xueqing Chen ◽  
Xinxing Fu ◽  
...  
Keyword(s):  
Speech Perception ◽  
Functional Connectivity ◽  
Cochlear Implantation ◽  
Event Related Potentials ◽  
Oddball Paradigm ◽  
Phase Lag ◽  
Auditory Function ◽  
Implantation Time ◽  
Related Potentials ◽  
The Difference

BackgroundPatients with severe profound hearing loss could benefit from cochlear implantation (CI). However, the neural mechanism of such benefit is still unclear. Therefore, we analyzed the electroencephalogram (EEG) and behavioral indicators of auditory function remodeling in patients with CI. Both indicators were sampled at multiple time points after implantation (1, 90, and 180 days).MethodsFirst, the speech perception ability was evaluated with the recording of a list of Chinese words and sentences in 15 healthy controls (HC group) and 10 patients with CI (CI group). EEG data were collected using an oddball paradigm. Then, the characteristics of event-related potentials (ERPs) and mismatch negative (MMN) were compared between the CI group and the HC group. In addition, we analyzed the phase lag indices (PLI) in the CI group and the HC group and calculated the difference in functional connectivity between the two groups at different stages after implantation.ResultsThe behavioral indicator, speech recognition ability, in CI patients improved as the implantation time increased. The MMN analysis showed that CI patients could recognize the difference between standard and deviation stimuli just like the HCs 90 days after cochlear implantation. Comparing the latencies of N1/P2/MMN between the CI group and the HC group, we found that the latency of N1/P2 in CI patients was longer, while the latency of MMN in CI users was shorter. In addition, PLI-based whole-brain functional connectivity (PLI-FC) showed that the difference between the CI group and the HC group mainly exists in electrode pairs between the bilateral auditory area and the frontal area. Furthermore, all those differences gradually decreased with the increase in implantation time.ConclusionThe N1 amplitude, N1/P2/MMN latency, and PLI-FC in the alpha band may reflect the process of auditory function remodeling and could be an objective index for the assessment of speech perception ability and the effect of cochlear implantation.

scholarly journals Effect of Anodal-tDCS on Event-Related Potentials: A Controlled Study

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Ahmed Izzidien ◽  
Sriharasha Ramaraju ◽  
Mohammed Ali Roula ◽  
Peter W. McCarthy
Keyword(s):  
Parietal Lobe ◽  
Event Related Potentials ◽  
Controlled Study ◽  
Oddball Paradigm ◽  
Anodal Tdcs ◽  
Neurologically Impaired ◽  
Double Blind ◽  
Significant Difference ◽  
Related Potentials ◽  
The Difference

We aim to measure the postintervention effects of A-tDCS (anodal-tDCS) on brain potentials commonly used in BCI applications, namely, Event-Related Desynchronization (ERD), Event-Related Synchronization (ERS), and P300. Ten subjects were given sham and 1.5 mA A-tDCS for 15 minutes on two separate experiments in a double-blind, randomized order. Postintervention EEG was recorded while subjects were asked to perform a spelling task based on the “oddball paradigm” while P300 power was measured. Additionally, ERD and ERS were measured while subjects performed mental motor imagery tasks. ANOVA results showed that the absolute P300 power exhibited a statistically significant difference between sham and A-tDCS when measured over channel Pz (p=0.0002). However, the difference in ERD and ERS power was found to be statistically insignificant, in controversion of the the mainstay of the litrature on the subject. The outcomes confirm the possible postintervention effect of tDCS on the P300 response. Heightening P300 response using A-tDCS may help improve the accuracy of P300 spellers for neurologically impaired subjects. Additionally, it may help the development of neurorehabilitation methods targeting the parietal lobe.

scholarly journals Classification of Schizophrenia by Combination of Brain Effective and Functional Connectivity

2021 ◽  
Vol 15 ◽  
Author(s):  
Zongya Zhao ◽  
Jun Li ◽  
Yanxiang Niu ◽  
Chang Wang ◽  
Junqiang Zhao ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Right Hemisphere ◽  
Brain Connectivity ◽  
Effective Connectivity ◽  
Event Related Potentials ◽  
Single Type ◽  
Support Vector ◽  
Phase Lag ◽  
Related Potentials

At present, lots of studies have tried to apply machine learning to different electroencephalography (EEG) measures for diagnosing schizophrenia (SZ) patients. However, most EEG measures previously used are either a univariate measure or a single type of brain connectivity, which may not fully capture the abnormal brain changes of SZ patients. In this paper, event-related potentials were collected from 45 SZ patients and 30 healthy controls (HCs) during a learning task, and then a combination of partial directed coherence (PDC) effective and phase lag index (PLI) functional connectivity were used as features to train a support vector machine classifier with leave-one-out cross-validation for classification of SZ from HCs. Our results indicated that an excellent classification performance (accuracy = 95.16%, specificity = 94.44%, and sensitivity = 96.15%) was obtained when the combination of functional and effective connectivity features was used, and the corresponding optimal feature number was 15, which included 12 PDC and three PLI connectivity features. The selected effective connectivity features were mainly located between the frontal/temporal/central and visual/parietal lobes, and the selected functional connectivity features were mainly located between the frontal/temporal and visual cortexes of the right hemisphere. In addition, most of the selected effective connectivity abnormally enhanced in SZ patients compared with HCs, whereas all the selected functional connectivity features decreased in SZ patients. The above results showed that our proposed method has great potential to become a tool for the auxiliary diagnosis of SZ.

EEG Measurement of Emotion Processing in Children with Daytime Urinary Incontinence

2018 ◽  
Vol 46 (4) ◽  
pp. 336-341
Author(s):  
Justine Niemczyk ◽  
Monika Equit ◽  
Katja Rieck ◽  
Mathias Rubly ◽  
Catharina Wagner ◽  
...  
Keyword(s):  
Urinary Incontinence ◽  
Patient Group ◽  
Imaging Techniques ◽  
Emotion Processing ◽  
Event Related Potentials ◽  
Oddball Paradigm ◽  
Control Group ◽  
Central Processing ◽  
Daytime Urinary Incontinence ◽  
Related Potentials

Abstract. Objective: Daytime urinary incontinence (DUI) is common in childhood. The aim of the study was to neurophysiologically analyse the central emotion processing in children with DUI. Method: In 20 children with DUI (mean age 8.1 years, 55 % male) and 20 controls (mean age 9.1 years, 75 % male) visual event-related potentials (ERPs) were recorded after presenting emotionally valent (80 neutral, 40 positive, and 40 negative) pictures from the International Affective Picture System (IAPS) as an oddball-paradigm. All children received a full organic and psychiatric assessment. Results: Children with DUI did not differ significantly from controls regarding responses to emotional pictures in the frontal, central, and parietal regions and in the time intervals 250–450 ms, 450–650 ms, and 650–850 ms after stimulus onset. The patient group had more psychological symptoms and psychiatric comorbidities than the control group. Conclusions: EEG responses to emotional stimuli are not altered in children with DUI. Central emotion processing does not play a major role in DUI. Further research, including a larger sample size, a more homogeneous patient group (regarding subtype of DUI) or brain imaging techniques, could reveal more about the central processing in DUI.

Age does not necessarily influence latency of event-related potentials

2014 ◽  
Vol 33 (10) ◽  
pp. 723-727
Author(s):  
M. Westermann ◽  
I. W. Husstedt ◽  
A. Okegwo ◽  
S. Evers
Keyword(s):  
Normal Values ◽  
Rank Correlation ◽  
Event Related Potentials ◽  
Intrinsic Property ◽  
Total Sample ◽  
Oddball Paradigm ◽  
Age Dependent ◽  
Related Potentials ◽  
The Mean ◽  
P3 Component

SummaryEvent-related potentials (ERP) are regarded as age dependent. However, it is not known whether this is an intrinsic property of ERP or an extrinsic factor. We designed a setting in which ERP were evoked using a modified oddball paradigm with highly differentiable and detectable target and non-target stimuli. A total of 98 probands were enrolled in this study. We evaluated the latency and amplitude of the P3 component of visually evoked ERP. The mean P3 latency was 294 ± 28 ms and was not related to age (r = –0.089; p = 0.382; Spearman-rank-correlation). The P3 amplitude was related to age in the total sample (r = –0.323; p = 0.001; Spearmanrank-correlation) but not in the probands under the age of 60 years. There were no significant differences regarding sex. Our findings suggest that ERP are not age dependent if highly differentiable and detectable stimuli are used. This should be considered when normal values of ERP are created for clinical use.

scholarly journals Logatome Discrimination in Cochlear Implant Users: Subjective Tests Compared to the Mismatch Negativity

2010 ◽  
Vol 10 ◽  
pp. 329-339 ◽  
Author(s):  
Torsten Rahne ◽  
Michael Ziese ◽  
Dorothea Rostalski ◽  
Roland Mühler
Keyword(s):  
Speech Perception ◽  
Cochlear Implant ◽  
Mismatch Negativity ◽  
Speech Intelligibility ◽  
Event Related Potentials ◽  
Normal Hearing ◽  
Discrimination Test ◽  
Speech Database ◽  
Automated Speech Recognition ◽  
Related Potentials

This paper describes a logatome discrimination test for the assessment of speech perception in cochlear implant users (CI users), based on a multilingual speech database, the Oldenburg Logatome Corpus, which was originally recorded for the comparison of human and automated speech recognition. The logatome discrimination task is based on the presentation of 100 logatome pairs (i.e., nonsense syllables) with balanced representations of alternating “vowel-replacement” and “consonant-replacement” paradigms in order to assess phoneme confusions. Thirteen adult normal hearing listeners and eight adult CI users, including both good and poor performers, were included in the study and completed the test after their speech intelligibility abilities were evaluated with an established sentence test in noise. Furthermore, the discrimination abilities were measured electrophysiologically by recording the mismatch negativity (MMN) as a component of auditory event-related potentials. The results show a clear MMN response only for normal hearing listeners and CI users with good performance, correlating with their logatome discrimination abilities. Higher discrimination scores for vowel-replacement paradigms than for the consonant-replacement paradigms were found. We conclude that the logatome discrimination test is well suited to monitor the speech perception skills of CI users. Due to the large number of available spoken logatome items, the Oldenburg Logatome Corpus appears to provide a useful and powerful basis for further development of speech perception tests for CI users.

scholarly journals P300 and Decision Making under Risk and Ambiguity

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Lei Wang ◽  
Jiehui Zheng ◽  
Shenwei Huang ◽  
Haoye Sun
Keyword(s):  
Decision Making ◽  
Early Stage ◽  
Event Related Potentials ◽  
Underlying Mechanism ◽  
P300 Amplitude ◽  
Early Assessment ◽  
Decision Making Under Risk ◽  
Related Potentials ◽  
The Difference ◽  
Ambiguous Condition

Our study aims to contrast the neural temporal features of early stage of decision making in the context of risk and ambiguity. In monetary gambles under ambiguous or risky conditions, 12 participants were asked to make a decision to bet or not, with the event-related potentials (ERPs) recorded meantime. The proportion of choosing to bet in ambiguous condition was significantly lower than that in risky condition. An ERP component identified as P300 was found. The P300 amplitude elicited in risky condition was significantly larger than that in ambiguous condition. The lower bet rate in ambiguous condition and the smaller P300 amplitude elicited by ambiguous stimuli revealed that people showed much more aversion in the ambiguous condition than in the risky condition. The ERP results may suggest that decision making under ambiguity occupies higher working memory and recalls more past experience while decision making under risk mainly mobilizes attentional resources to calculate current information. These findings extended the current understanding of underlying mechanism for early assessment stage of decision making and explored the difference between the decision making under risk and ambiguity.

Implicit need for affiliation and processing of emotional images: Event-related potential correlates

2018 ◽  
Vol 46 (2) ◽  
pp. 273-280
Author(s):  
Jianfeng Wang ◽  
Yan Wu ◽  
Lushi Jing
Keyword(s):  
Cognitive Processes ◽  
Event Related Potentials ◽  
Event Related Potential ◽  
Oddball Paradigm ◽  
Emotional Information ◽  
Need For Affiliation ◽  
Additional Information ◽  
Negative Images ◽  
Related Potentials ◽  
Emotional Information Processing

Implicit motives play an important role in the regulation of many basic cognitive processes, particularly in the stage of attention. We conducted a study with a sample of 58 college students to examine selective attention to emotional stimuli as a function of individual differences in the implicit need for affiliation (nAff). In an affective oddball paradigm, event-related potentials were recorded while participants viewed positive, neutral, and negative images of people. Results showed that individuals high in nAff elicited larger late positive potential amplitudes to negative images than those low in nAff did. These findings replicate and extend the results of a previous study focused on these relationships and provide additional information on the neural correlates of affiliation-related emotional information processing.

Saliency of Vowel Features in Neural Responses of Cochlear Implant Users

2018 ◽  
Vol 49 (6) ◽  
pp. 388-397
Author(s):  
François Prévost ◽  
Alexandre Lehmann
Keyword(s):  
Speech Recognition ◽  
Cochlear Implant ◽  
Fundamental Frequency ◽  
Mismatch Negativity ◽  
Free Field ◽  
Event Related Potentials ◽  
Oddball Paradigm ◽  
Aural Rehabilitation ◽  
Spectral Components ◽  
Related Potentials

Cochlear implants restore hearing in deaf individuals, but speech perception remains challenging. Poor discrimination of spectral components is thought to account for limitations of speech recognition in cochlear implant users. We investigated how combined variations of spectral components along two orthogonal dimensions can maximize neural discrimination between two vowels, as measured by mismatch negativity. Adult cochlear implant users and matched normal-hearing listeners underwent electroencephalographic event-related potentials recordings in an optimum-1 oddball paradigm. A standard /a/ vowel was delivered in an acoustic free field along with stimuli having a deviant fundamental frequency (+3 and +6 semitones), a deviant first formant making it a /i/ vowel or combined deviant fundamental frequency and first formant (+3 and +6 semitones /i/ vowels). Speech recognition was assessed with a word repetition task. An analysis of variance between both amplitude and latency of mismatch negativity elicited by each deviant vowel was performed. The strength of correlations between these parameters of mismatch negativity and speech recognition as well as participants’ age was assessed. Amplitude of mismatch negativity was weaker in cochlear implant users but was maximized by variations of vowels’ first formant. Latency of mismatch negativity was later in cochlear implant users and was particularly extended by variations of the fundamental frequency. Speech recognition correlated with parameters of mismatch negativity elicited by the specific variation of the first formant. This nonlinear effect of acoustic parameters on neural discrimination of vowels has implications for implant processor programming and aural rehabilitation.

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