scholarly journals A High-Throughput Comparative Proteomics of Milk Fat Globule Membrane Reveals Breed and Lactation Stages Specific Variation in Protein Abundance and Functional Differences Between Milk of Saanen Dairy Goat and Holstein Bovine

2021 ◽  
Vol 8 ◽  
Author(s):  
Wei Jia ◽  
Rong Zhang ◽  
Zhenbao Zhu ◽  
Lin Shi
Keyword(s):  
Lipid Metabolism ◽  
Milk Fat ◽  
Goat Milk ◽  
Differentially Expressed ◽  
Dairy Goat ◽  
Differentially Expressed Proteins ◽  
Mature Milk ◽  
Milk Fat Globule Membrane ◽  
Milk Fat Globule ◽  
Fat Globule

Large variations in the bioactivities and composition of milk fat globule membrane (MFGM) proteins were observed between Saanen dairy goat and Holstein bovine at various lactation periods. In the present study, 331, 250, 182, and 248 MFGM proteins were characterized in colostrum and mature milk for the two species by Q-Orbitrap HRMS-based proteomics techniques. KEGG pathway analyses displayed that differentially expressed proteins in colostrum involved in galactose metabolism and an adipogenesis pathway, and the differentially expressed proteins in mature milk associated with lipid metabolism and a PPAR signaling pathway. These results indicated that the types and functions of MFGM proteins in goat and bovine milk were different, and goat milk had a better function of fatty acid metabolism and glucose homeostasis, which can enhance our understanding of MFGM proteins in these two species across different lactation periods, and they provide significant information for the study of lipid metabolism and glycometabolism of goat milk.

scholarly journals Major proteins of the goat milk fat globule membrane

2010 ◽  
Vol 93 (3) ◽  
pp. 868-876 ◽  
Author(s):  
C. Cebo ◽  
H. Caillat ◽  
F. Bouvier ◽  
P. Martin
Keyword(s):  
Milk Fat ◽  
Goat Milk ◽  
Milk Fat Globule Membrane ◽  
Milk Fat Globule ◽  
Fat Globule

Dietary milk fat globule membrane improves endurance capacity in mice

2014 ◽  
Vol 307 (8) ◽  
pp. R1009-R1017 ◽  
Author(s):  
Satoshi Haramizu ◽  
Noriyasu Ota ◽  
Atsuko Otsuka ◽  
Kohjiro Hashizume ◽  
Satoshi Sugita ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Mrna Expression ◽  
Soleus Muscle ◽  
Milk Fat ◽  
Endurance Capacity ◽  
Dependent Manner ◽  
Milk Fat Globule Membrane ◽  
Milk Fat Globule ◽  
Fat Globule ◽  
Dose Dependent

Milk fat globule membrane (MFGM) comprises carbohydrates, membrane-specific proteins, glycoproteins, phospholipids, and sphingolipids. We evaluated the effects of MFGM consumption over a 12-wk period on endurance capacity and energy metabolism in BALB/c mice. Long-term MFGM intake combined with regular exercise improved endurance capacity, as evidenced by swimming time until fatigue, in a dose-dependent manner. The effect of dietary MFGM plus exercise was accompanied by higher oxygen consumption and lower respiratory quotient, as determined by indirect calorimetry. MFGM intake combined with exercise increased plasma levels of free fatty acids after swimming. After chronic intake of MFGM combined with exercise, the triglyceride content in the gastrocnemius muscle increased significantly. Mice given MFGM combined with exercise had higher mRNA levels of peroxisome proliferator-activated receptor-γ coactivator 1α (Pgc1α) and CPT-1b in the soleus muscle at rest, suggesting that increased lipid metabolism in skeletal muscle contributes, in part, to improved endurance capacity. MFGM treatment with cyclic equibiaxial stretch consisting of 10% elongation at 0.5 Hz with 1 h on and 5 h off increased the Pgc1α mRNA expression of differentiating C2C12 myoblasts in a dose-dependent manner. Supplementation with sphingomyelin increased endurance capacity in mice and Pgc1α mRNA expression in the soleus muscle in vivo and in differentiating myoblasts in vitro. These results indicate that dietary MFGM combined with exercise improves endurance performance via increased lipid metabolism and that sphingomyelin may be one of the components responsible for the beneficial effects of dietary MFGM.

Quantitative proteomic analysis of milk fat globule membrane (MFGM) proteins in human and bovine colostrum and mature milk samples through iTRAQ labeling

2016 ◽  
Vol 7 (5) ◽  
pp. 2438-2450 ◽  
Author(s):  
Mei Yang ◽  
Min Cong ◽  
Xiuming Peng ◽  
Junrui Wu ◽  
Rina Wu ◽  
...  
Keyword(s):  
Proteomic Analysis ◽  
Milk Fat ◽  
Bovine Colostrum ◽  
Mature Milk ◽  
Milk Fat Globule Membrane ◽  
Quantitative Proteomic Analysis ◽  
Itraq Labeling ◽  
Milk Samples ◽  
Milk Fat Globule ◽  
Fat Globule

Milk fat globule membrane (MFGM) proteins have many functions.

Comparative proteomics of milk fat globule membrane in goat colostrum and mature milk

2016 ◽  
Vol 209 ◽  
pp. 10-16 ◽  
Author(s):  
Jing Lu ◽  
Lu Liu ◽  
Xiaoyang Pang ◽  
Shuwen Zhang ◽  
Zhenhu Jia ◽  
...  
Keyword(s):  
Milk Fat ◽  
Comparative Proteomics ◽  
Mature Milk ◽  
Milk Fat Globule Membrane ◽  
Milk Fat Globule ◽  
Fat Globule

scholarly journals Characterization of the milk fat globule membrane proteome in colostrum and mature milk of Xinong Saanen goats

2020 ◽  
Vol 103 (4) ◽  
pp. 3017-3024 ◽  
Author(s):  
Yuxue Sun ◽  
Cuina Wang ◽  
Xiaomeng Sun ◽  
Shilong Jiang ◽  
Mingruo Guo
Keyword(s):  
Milk Fat ◽  
Membrane Proteome ◽  
Mature Milk ◽  
Milk Fat Globule Membrane ◽  
Milk Fat Globule ◽  
Fat Globule

Quantitative proteomic analysis of milk fat globule membrane (MFGM) proteins from donkey colostrum and mature milk

2019 ◽  
Vol 10 (7) ◽  
pp. 4256-4268 ◽  
Author(s):  
Weixuan Li ◽  
Mohan Li ◽  
Xueyan Cao ◽  
Mei Yang ◽  
Hongjiao Han ◽  
...  
Keyword(s):  
Proteomic Analysis ◽  
Milk Fat ◽  
Nutritional Quality ◽  
Mature Milk ◽  
Milk Fat Globule Membrane ◽  
Quantitative Proteomic Analysis ◽  
Milk Fat Globule ◽  
Fat Globule ◽  
Quality Of Milk

The composition and functions of milk fat globule membrane (MFGM) proteins are important indicators of the nutritional quality of milk.

scholarly journals Whole Goat Milk as a Source of Fat and Milk Fat Globule Membrane in Infant Formula

Nutrients ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3486
Author(s):  
Sophie Gallier ◽  
Louise Tolenaars ◽  
Colin Prosser
Keyword(s):  
Infant Formula ◽  
Milk Fat ◽  
Infant Nutrition ◽  
Goat Milk ◽  
Cow Milk ◽  
Suitable Alternative ◽  
Milk Fat Globule Membrane ◽  
Wide Range ◽  
Milk Fat Globule ◽  
Fat Globule

Cow milk is the most common dairy milk and has been extensively researched for its functional, technological and nutritional properties for a wide range of products. One such product category is infant formula, which is the most suitable alternative to feed infants, when breastfeeding is not possible. Most infant formulas are based on cow milk protein ingredients. For several reasons, consumers now seek alternatives such as goat milk, which has increasingly been used to manufacture infant, follow-on and young child formulas over the last 30 years. While similar in many aspects, compositional and functional differences exist between cow and goat milk. This offers the opportunity to explore different formulations or manufacturing options for formulas based on goat milk. The use of whole goat milk as the only source of proteins in formulas allows levels of milk fat, short and medium chain fatty acids, sn-2 palmitic acid, and milk fat globule membrane (MFGM) to be maximised. These features improve the composition and microstructure of whole goat milk-based infant formula, providing similarities to the complex human milk fat globules, and have been shown to benefit digestion, and cognitive and immune development. Recent research indicates a role for milk fat and MFGM on digestive health, the gut–brain axis and the gut–skin axis. This review highlights the lipid composition of whole goat milk-based infant formula and its potential for infant nutrition to support healthy digestion, brain development and immunity. Further work is warranted on the role of these components in allergy development and the advantages of goat milk fat and MFGM for infant nutrition and health.

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