scholarly journals Sanhuang Decoction Controls Tumor Microenvironment by Ameliorating Chronic Stress in Breast Cancer: A Report of Ninety Cases

2021 ◽  
Vol 11 ◽  
Author(s):  
Ming Feng ◽  
Huanhuan Wang ◽  
Zhiyuan Zhu ◽  
Bowen Yao ◽  
Yongfei Li ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Clinical Trial ◽  
Treatment Group ◽  
Chronic Stress ◽  
The Body ◽  
The Self ◽  
Inflammatory Factors ◽  
Endocrine Treatment ◽  
Control Group

Long-term endocrine treatment which results in estrogen deprivation causes chronic stress associated with a series of uncomfortable symptoms leading not only to a decrease in quality of life but also to cancer recurrence, which may be mediated primarily through the enhanced expression of angiogenic factors, as well as a series of inflammatory microenvironmental changes that favor tumor progression. In this study, we designed a clinical trial and aimed to explore the effects of Sanhuang Decoction (SHD) treatment on chronic stress, inflammatory factors, and breast cancer recovery. A total of 90 patients with breast cancer who met the inclusion/exclusion criteria were randomly allocated to a treatment or control group. The treatment group received the standard endocrine treatment and the traditional Chinese medicine decoction known as SHD. The control group received the standard endocrine treatment only. The treatment period was 6 months. The modified Kupperman Menopausal Index, the self-rating anxiety scale, and the self-rating depression scale were evaluated once per month. The body microenvironment plasma indices related to chronic stress, such as oxidative and antioxidative stress markers, inflammatory factors, hemorheology, coagulation, lipid and D-dimer, immunologic functions, tumor biomarkers, and angiogenic factors of the vascular endothelial growth factor (VEGF) were measured before and after 6 months of treatment. After treatment for 5 months, the scores in the treatment group decreased to nearly normal levels and the control group showed no significant improvement. After treatment for 6 months, all indices related to the body microenvironment, as well as the tumor biomarkers and carcinoembryonic antigen, carbohydrate antigen 153, and angiogenic factor VEGF levels improved significantly to normal levels in the treatment group. Our primary research showed that treatment with SHD effectively improved the quality of life of breast cancer patients by facilitating a change in the body microenvironment that controlled tumor growth and prevented drug resistance.Clinical Trial RegistrationChinese Clinical Trial Registry, identifier ChiCTR-IIR-2000041413. Date of registration: 2017-06-07 (retrospective registration).

scholarly journals Reducing postsurgical exudate in breast cancer patients by using San Huang decoction to ameliorate inflammatory status: a prospective clinical trial

2018 ◽  
Vol 25 (6) ◽  
Author(s):  
Z. Y. Zhu ◽  
J. X. Xue ◽  
L. X. Yu ◽  
W. H. Bian ◽  
Y. F. Zhang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Clinical Trial ◽  
Treatment Group ◽  
Cancer Patients ◽  
Symptom Score ◽  
Inflammatory Factors ◽  
Control Group ◽  
Breast Cancer Patients ◽  
Drainage Fluid ◽  
Tnf Α

Background Reducing inflammatory factors in wound exudate is a promising treatment approach for healing wounds in postsurgical breast cancer patients. Traditional Chinese Medicine (tcm) treatments have been shown to be beneficial and safe for optimal regulation of oxidative stress during the postoperative period. In the present clinical trial, we evaluated the effectiveness of a promising Chinese herbal formula, San Huang decoction [shd (Radix astragali, Radix et rhizoma rhei, and Rhizoma curcuma longa, 3:1:1; supplemental Table 1)], on wound inflammatory response after mastectomy.Methods The study randomized 30 patients with breast cancer who fulfilled the inclusion and exclusion criteria to either a treatment (n = 15) or a control group (n = 15). Patients in the treatment group received liquid shd, taken twice daily with or without food. Treatment was given for 1 day before surgery and for 7 days postoperatively. Participants in the control group received a placebo on the same schedule as the treatment group. Outcomes measured in every subject included clinical tcm and wound inflammation symptom scores, daily and total amounts of drainage fluid, and levels of inflammatory factors in the exudate [tumour necrosis factor α (tnf-α), interleukins 6 (il-6), 8 (il-8), and 2R (il-2R), human C-reactive protein (crp)] at 2 hours and on days 1, 3, and 7 postoperatively.Results The total amount of drainage fluid over 7 days was significantly lower in the treatment group (572.20 } 93.95 mL) than in the control group (700.40 } 107.38 mL). The tcm symptom score was also lower in treatment group (day 7: 1.87 } 0.83 vs. 4.80 } 3.61, p = 0.049), as was the inflammatory symptom score (day 7: 0.67 } 0.72 vs. 3.67 } 2.50, p = 0.001). Levels of tnf-α, il-6, il-8, il-2R, and crp in drainage fluid were significantly lower with shd treatment.Conclusions Perioperative treatment with shd effectively lessened postoperative exudate and ameliorated inflammatory symptoms in patients who underwent surgery for breast cancer..

scholarly journals Effect of Baduanjin exercise intervention on cognitive function and quality of life in women with breast cancer receiving chemotherapy: study protocol of a randomized controlled trial

Trials ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Xiao-Lin Wei ◽  
Ru-Zhen Yuan ◽  
Yong-Mei Jin ◽  
Shu Li ◽  
Ming-Yue Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Clinical Trial ◽  
Cognitive Function ◽  
Exercise Intervention ◽  
Early Stage ◽  
Early Stage Breast Cancer ◽  
Pharmacological Intervention ◽  
Control Group

Abstract Background More than 50% cognitive impairment was reported by cancer patients before and after medical treatment. However, there are no effective interventions to manage the cognitive problem in women with breast cancer. This pilot study was designed to evaluate the protective effect of Baduanjin exercise on cognitive function and cancer-related symptoms in women with early-stage breast cancer undergoing chemotherapy. Method A single-blinded, randomized control trial was designed. The trial will recruit 70 patients with early-stage breast cancer scheduled to receive chemotherapy from Shanghai in China. All participants will be randomly assigned to (1:1) the supervised Baduanjin group (5 times/week, 30 min each time) or the wait-list control group for 3 months. The effect of Baduanjin exercise intervention will be evaluated by outcome measures including subjective and objective cognitive function, symptoms (fatigue, depression, and anxiety), and health-related quality of life at pre-intervention (T0), 8 weeks (T1), and 12 weeks (T2). The PCI score in the FACT-Cog as the primary cognitive outcome will be reported descriptively, while effect sizes and 95% confidence intervals (CIs) will be calculated. The collected data will be analyzed by using an intention-to-treat principle and linear mixed-effects modeling. Discussion This is the first randomized clinical trial to investigate whether Baduanjin exercise will have a positive role in improving cognitive function in women with breast cancer receiving chemotherapy. If possible, Baduanjin exercise will be a potential non-pharmacological intervention to manage cognitive dysfunction and promote survivorship care among breast cancer survivors. Trial registration Chinese Clinical Trial Registry (ChiCTR) ChiCTR2000033152. Registered on 22 May 2020

scholarly journals PENGARUH PEMBERIAN INHALASI KOMBINASI SALMETEROL/FLUTIKASON PROPIONAT TERHADAP KUALITAS HIDUP PENDERITA PENYAKIT PARU OBSTRUKTIF KNONIK STABIL

2019 ◽  
Vol 1 (2) ◽  
pp. 28-33
Author(s):  
Refi Sulistiasari
Keyword(s):  
Quality Of Life ◽  
Clinical Trial ◽  
Treatment Group ◽  
Control Group ◽  
Copd Assessment Test ◽  
Copd Patients ◽  
Significant Difference ◽  
Inhaled Therapy ◽  
St George's Respiratory Questionnaire

It is known that inflammation is the underlying cause of COPD, and this affects to quality of life of the patient. Provision of inhaled therapy combination of LABA and corticosteroids is one of therapy in pharmacology of stable PPOK patients. The aim of this study was to know the benefits of inhalation of 50 g / fluticasone propionate 500 g inhibition in stable COPD patients. The research design is clinical trial. The study was conducted for 3 months and was performed on 26 stable COPD patients divided into two groups: 15 patients for the treatment group and 15 patients for the control group. After the measurements were obtained, there was a significant difference in the quality of life as measured by St. George's Respiratory Questionnaire (SGRQ) (p = 0.001) and COPD Assessment Test (CAT) (0.001) measurements were made twice on the first and thirtieth days.

scholarly journals A Multicentre Randomized Clinical Trial on Efficacy and Safety of Huxin Formula in Patients Undergoing Percutaneous Coronary Intervention

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Huan-Lin Wu ◽  
Yun-Fei Wang ◽  
Jun-Zhe Li ◽  
Min-Zhou Zhang ◽  
Xiao-Gang Sheng ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Clinical Trial ◽  
Percutaneous Coronary Intervention ◽  
Treatment Group ◽  
Coronary Intervention ◽  
Control Group ◽  
Percutaneous Coronary ◽  
Quality Of Life Scale ◽  
Life Scale

Percutaneous coronary intervention (PCI) is widely used in clinical treatment of coronary artery disease. However, the effects of PCI on preventing restenosis after revascularization and improving the quality of life were not satisfying. Huxin Formula is formulated by modifying an experienced Chinese medicine formula and has been widely used in clinical practice due to its marked effects on coronary heart disease. A multicentre double-blind randomized controlled clinical trial was designed to evaluate the effects and safety of Huxin Formula in patients undergoing PCI. Our results showed that there was no significant difference between the two groups in main outcomes. For patients with ejection fraction (EF)>50%, score of the quality of life scale was higher in treatment group compared with control group. For patients with unstable angina, score of the quality of life scale in 360 days was significantly higher in treatment group compared with control group (P<0.05). No obvious adverse reaction was found in the use of Huxin Formula. In conclusion, Huxin Formula, believed to be a safe treatment for patients after PCI, has benefits in improving the quality of life in patients with unstable angina though it failed to show superiority in primary and secondary outcomes.

scholarly journals Efficacy of Hydroxychloroquine in Patients with COVID-19 (Chen et al., 2020): Moderate Evidence for a Treatment Effect on Pneumonia

2020 ◽  
Author(s):  
Eric-Jan Wagenmakers ◽  
Quentin Frederik Gronau
Keyword(s):  
Clinical Trial ◽  
Treatment Group ◽  
Body Temperature ◽  
Randomized Clinical Trial ◽  
Treatment Effect ◽  
Recovery Time ◽  
The Body ◽  
Control Group ◽  
Moderate Evidence ◽  
Temperature Recovery

A recent randomized clinical trial assessed the efficacy of hydroxychloroquine (HCQ) in the treatment of patients with common coronavirus disease-19 (COVID-19). 1 The results showed that “the body temperature recovery time and the cough remission time were significantly shortened in the HCQ treatment group. Besides, a larger proportion of patients with improved pneumonia in the HCQ treatment group (80.6%, 25 of 31) compared with the control group (54.8%, 17 of 31).” A Bayesian reanalysis of the pneumonia data provides support for the hypothesis that HCQ improves pneumonia in patients with COVID-19. However, the degree of this support is moderate. In line with the authors’ conclusion, more data are needed to draw definite conclusions.

scholarly journals PENGARUH PEMBERIAN INHALASI KOMBINASI SALMETEROL/FLUTIKASON PROPIONAT TERHADAP KUALITAS HIDUP PENDERITA PENYAKIT PARU OBSTRUKTIF KNONIK STABIL

2019 ◽  
Vol 1 (2) ◽  
pp. 28-33
Author(s):  
Refi Sulistiasari
Keyword(s):  
Quality Of Life ◽  
Clinical Trial ◽  
Treatment Group ◽  
Control Group ◽  
Copd Assessment Test ◽  
Copd Patients ◽  
Significant Difference ◽  
Inhaled Therapy ◽  
St George's Respiratory Questionnaire

It is known that inflammation is the underlying cause of COPD, and this affects to quality of life of the patient. Provision of inhaled therapy combination of LABA and corticosteroids is one of therapy in pharmacology of stable PPOK patients. The aim of this study was to know the benefits of inhalation of 50 mg / fluticasone propionate 500 mg inhibition in stable COPD patients. The research design is clinical trial. The study was conducted for 3 months and was performed on 26 stable COPD patients divided into two groups: 15 patients for the treatment group and 15 patients for the control group. After the measurements were obtained, there was a significant difference in the quality of life as measured by St. George's Respiratory Questionnaire (SGRQ) (p = 0.001) and COPD Assessment Test (CAT) (0.001) measurements were made twice on the first and thirtieth days.

scholarly journals Spore Powder ofGanoderma lucidumImproves Cancer-Related Fatigue in Breast Cancer Patients Undergoing Endocrine Therapy: A Pilot Clinical Trial

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Hong Zhao ◽  
Qingyuan Zhang ◽  
Ling Zhao ◽  
Xu Huang ◽  
Jincai Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Cancer Patients ◽  
Endocrine Therapy ◽  
Ganoderma Lucidum ◽  
Endocrine Treatment ◽  
Control Group ◽  
Breast Cancer Patients ◽  
Cancer Related Fatigue

The fatigue prevalence in breast cancer survivors is high during the endocrine treatment. However, there are few evidence-based interventions to manage this symptom. The aim of this study was to investigate the effectiveness of spore powder ofGanoderma lucidumfor cancer-related fatigue in breast cancer patients undergoing endocrine therapy. Spore powder ofGanoderma lucidumis a kind of Basidiomycete which is a widely used traditional medicine in China. 48 breast cancer patients with cancer-related fatigue undergoing endocrine therapy were randomized into the experimental or control group. FACT-F, HADS, and EORTC QLQ-C30 questionnaires data were collected at baseline and 4 weeks after treatment. The concentrations of TNF-α, IL-6, and liver-kidney functions were measured before and after intervention. The experimental group showed statistically significant improvements in the domains of physical well-being and fatigue subscale after intervention. These patients also reported less anxiety and depression and better quality of life. Immune markers of CRF were significantly lower and no serious adverse effects occurred during the study. This pilot study suggests that spore powder ofGanoderma lucidummay have beneficial effects on cancer-related fatigue and quality of life in breast cancer patients undergoing endocrine therapy without any significant adverse effect.

scholarly journals Study Protocol for Multi-Center, Open-Label, Randomized Controlled Trial for Assessing the Efficacy and Safety of Electroacupuncture for Cold Hypersensitivity in Hands and Feet

2021 ◽  
Author(s):  
Kyou-Young Lee ◽  
In-Sik Han ◽  
Dong-Nyung Lee ◽  
Dong-Il Kim ◽  
Junsang Yu ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Clinical Trial ◽  
Treatment Group ◽  
Acupuncture Treatment ◽  
Control Group ◽  
Efficacy And Safety ◽  
Untreated Control Group ◽  
Hands And Feet ◽  
Cold Hypersensitivity

Abstract Background: Cold hypersensitivity in the hands and feet (CHHF) is defined as the symptom of a sensation of coldness in the extremities under conditions that are not considered cold by an unaffected person. CHHF is common in East Asian women. CHHF can affect the quality of life by placing restrictions on one's daily activities. Although electroacupuncture (EA) and acupuncture have been widely used for treating CHHF, randomized clinical trial (RCT) has not yet been conducted for evaluating the safety and efficacy of EA or acupuncture for the treatment of CHHF. This study aims to evaluate the effects of EA in CHHF patients. Methods: This study is a randomized, multicenter, and parallel design clinical trial. Overall, 72 participants will be randomly assigned to the EA treatment group, acupuncture treatment group, and untreated control group in 1:1:1 ratio via a web-based randomization system. The EA treatment group and acupuncture treatment group will receive EA or acupuncture treatment by visiting ten times at intervals of twice a week for five weeks. Follow-up visits will be made four weeks after the end of treatment. For the untreated control group, three visits will be made. The primary outcome measures will be the CHHF visual analogue scale score. Secondary outcome measures will be the body temperature of hands and feet, total scores of the Korean version of the World Health Organization Quality of Life Scale abbreviated version, the results of the questionnaire of health-related quality of life, questionnaire of demonstration, and questionnaire of cold hypersensitivity.Discussion: This study will be the first clinical trial to evaluate the efficacy and safety of EA for the treatment of CHHF. We expect this study to provide basic evidence for the treatment of CHHF with EA, future large-scale RCT, and the development of general clinical guidelines for CHHF in the Korean medical field.Trial registration: CRIS, KCT0004306. Registered on October 14, 2019. https://cris.nih.go.kr/cris/search/search_result_st01.jsp?seq=14865

scholarly journals Community mental health nursing training package on body image quality among mental disorders patients

2020 ◽  
Vol 9 (4) ◽  
pp. 387
Author(s):  
Ibrahim Rahmat ◽  
Mohammad Hakimi ◽  
Soewadi Soewadi
Keyword(s):  
Mental Health ◽  
Body Image ◽  
Treatment Group ◽  
Image Quality ◽  
Mental Disorders ◽  
Community Health ◽  
The Body ◽  
Control Group ◽  
Mental Health Nursing

Mental health disorder could affect the physical, mental, social, and spiritual problems, leading to psychosocial issues such as body-image problem. Body-image is a basic need of human being to fulfill and therefore, the multidisciplinary team; physicians, nurses, and family should have adequate knowledge on the body-image. Increasing knowledge by training the nurses and community health volunteers can be performed to address body-image issues in patients with mental disorders among the community. This study held to identify the effects of community mental health nursing (CMHN) and Self-Concept Assessment Guidelines training on nurse and community health volunteer in increasing the body-image quality of patients with mental disorders. This study used pre and post quasi experimental test with nonequivalent control group design. By comparing the pre-test and post-test scores, nurse’s and community health volunteer’s knowledge were increasing after being given training. Data of body image was collected from 129 patients with mental disorder (treatment group of 69 and control group of 60) as volunteers. After the intervention, treatment group (p= 0.033) and control group (p= 0.075) show that significant increase in the quality of body-image only applies to the treatment group. Providing training on CMHN was effective to improve body-image quality of patients with mental disorders.

scholarly journals Influence of Body Image in Women Undergoing Treatment for Breast Cancer

2017 ◽  
Vol 39 (04) ◽  
pp. 175-183 ◽  
Author(s):  
Ana Prates ◽  
Ruffo Freitas-Junior ◽  
Mariana Prates ◽  
Márcia Veloso ◽  
Norami Barros
Keyword(s):  
Breast Cancer ◽  
Body Image ◽  
Body Satisfaction ◽  
Self Esteem ◽  
Breast Conserving Therapy ◽  
The Body ◽  
The Self ◽  
Control Group ◽  
Case Group ◽  
Satisfaction Scale

Objective The objective of this study was to investigate the self-esteem of women with and without breast cancer regarding their body image. Methods A quantitative, case-control study in which 90 women with breast cancer were evaluated in the case group, and 77 women without breast cancer in the control group. For data collection, the body satisfaction scale (BSS), a scale adapted and validated in Brazil, and the Rosenberg self-esteem questionnaire were used. For the statistical analysis of the data, the Statistical Package for the Social Sciences software (IBM-SPSS, Chicago, Il, US), version 16.0 was used. Results Compared with the women without breast cancer, those with breast cancer were more dissatisfied with body image related to appearance. Women undergoing neoadjuvant chemotherapy were more dissatisfied with their appearance compared with those with cancer who were not undergoing this treatment. Mastectomy also accounted for more dissatisfaction concerning appearance among women who underwent the procedure compared with the women who were submitted to breast-conserving therapy. Conclusion Women with breast cancer were more dissatisfied with their body image compared with those without breast cancer, particularly following mastectomy or during chemotherapy. The self-esteem was found to be negatively affected in patients who were dissatisfied with their body image.

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