scholarly journals Comparison of Clinicopathological Characteristics Between the Anterior and Posterior Type of Squamous Cell Carcinoma of the Floor of the Mouth: The Anterior Type Is a Risk Factor for Multiple Primary Cancer

2021 ◽  
Vol 11 ◽  
Author(s):  
Yu Oikawa ◽  
Kae Tanaka ◽  
Toshimitsu Ohsako ◽  
Takuma Kugimoto ◽  
Takeshi Kuroshima ◽  
...  
Keyword(s):  
Overall Survival ◽  
Squamous Cell Carcinoma ◽  
Risk Factor ◽  
Survival Rates ◽  
Clinicopathological Characteristics ◽  
Multiple Primary Cancers ◽  
Multiple Primary Cancer ◽  
Primary Cancer ◽  
Floor Of The Mouth ◽  
Multiple Primary

BackgroundFloor of the mouth (FOM) squamous cell carcinoma (SCC) accounts for approximately 10% of all oral SCCs. FOM SCC can be classified into the anterior and posterior types according to their site of origin, but few studies have compared these types. This study sought to clarify differences in clinicopathological characteristics between these two types.MethodsA total of 1,220 patients with oral SCC were treated at our department from January 2001 to December 2015. Among these patients, 62 had FOM SCC. The FOM SCCs were classified into two groups: the anterior type and the posterior type. The anterior and posterior types were defined by the boundary connecting the spaces between the canine and the first premolar bilaterally. We retrospectively compared the sex, age, smoking and drinking history, clinical stage, treatment, histopathological diagnosis, multiple primary cancers, and outcomes of the two groups.ResultsAmong the 62 patients, 32 had the anterior type, while 30 had the posterior type. The anterior type was found more significantly in men (p = 0.01) and individuals with a smoking history than the posterior type (p = 0.04). pN2–3 cervical lymph node metastasis was significantly more common in the anterior type than in the posterior type (p = 0.01). The median depth of invasion in the anterior type was 4 mm. Multivariate analysis showed that the anterior type was an independent risk factor for multiple primary cancer development in FOM SCC (p = 0.02). The cumulative 10-year disease-specific survival rates of the anterior and posterior types were 92.8 and 95.0%, respectively, while the overall survival rates were 65.4 and 95.0%, respectively. In the anterior type FOM SCC, a lower overall survival rate was associated with multiple primary cancers and smoking-related diseases.ConclusionSmoking cessation and adequate systemic screening for multiple primary cancers are needed to improve the prognosis of FOM SCC, particularly the anterior type.

scholarly journals Multiple primary cancer risk in patients with squamous cell carcinoma of the oral cavity

Cancer ◽  
1987 ◽  
Vol 60 (12) ◽  
pp. 3083-3086 ◽  
Author(s):  
Hitoshi Shibuya ◽  
Shigemasa Hisamitsu ◽  
Shigeaki Shioiri ◽  
Junichi Horiuchi ◽  
Soji Suzuki
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cancer Risk ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Multiple Primary Cancer ◽  
Primary Cancer ◽  
Multiple Primary

scholarly journals Clinical Characteristics of Multiple Primary Cancer in Breast Cancer Patients

2007 ◽  
Vol 10 (4) ◽  
pp. 263 ◽  
Author(s):  
Sang Hee Jung ◽  
Seung Soo Kwak ◽  
Seong Chul Kim ◽  
Moon Ki Park ◽  
Gun Seok Lee ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Clinical Characteristics ◽  
Multiple Primary Cancer ◽  
Primary Cancer ◽  
Breast Cancer Patients ◽  
Multiple Primary

scholarly journals A Case of Multiple Primary Cancer on Bilateral Maxillary Gingiva

1985 ◽  
Vol 39 (3) ◽  
pp. 385-391
Author(s):  
Hideo Kurokawa ◽  
Minoru Kajiyama ◽  
Nobuto Nomura ◽  
Takahiro Kodama ◽  
Isao Akama ◽  
...  
Keyword(s):  
Multiple Primary Cancer ◽  
Primary Cancer ◽  
Multiple Primary

Clinical Characteristics and Abnormal p53 Expression of Lung Cancer Associated with Multiple Primary Cancer

1999 ◽  
Vol 47 (3) ◽  
pp. 331
Author(s):  
Chang Jin Shin ◽  
Hye Jung Park ◽  
Kyeong Cheol Shin ◽  
Young Ran Shim ◽  
Jin Hong Chung ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Clinical Characteristics ◽  
Multiple Primary Cancer ◽  
Primary Cancer ◽  
P53 Expression ◽  
Multiple Primary

Four cases of simultaneous triple primary cancers of the hypopharynx, esophagus, and stomach

2005 ◽  
Vol 132 (5) ◽  
pp. 788-793 ◽  
Author(s):  
Yoichi Ikeda ◽  
Mamoru Tsukuda ◽  
Junichi Ishitoya ◽  
Yasuhiro Arai ◽  
Hideki Matsuda ◽  
...  
Keyword(s):  
Treatment Modality ◽  
Argon Plasma Coagulation ◽  
Argon Plasma ◽  
Hypopharyngeal Cancer ◽  
Multiple Primary Cancers ◽  
Multiple Primary Cancer ◽  
Retrospective Case ◽  
Gastric Carcinomas ◽  
Multiple Primary ◽  
Retrospective Case Study

OBJECTIVE: To study the efficacy of intensive chemotherapy for simultaneous triple primary cancers of the hypopharynx, esophagus, and stomach. STUDY DESIGN: Retrospective case study. METHODS: From April 2000 to March 2002, we treated 4 patients who had simultaneous triple primary cancers, including hypopharyngeal, esophageal, and gastric carcinomas. These 4 patients were designated as the objects for analysis, and the treatment modality for simultaneous multiple primary cancer cases was examined. RESULTS: In 3 of 4 patients, all 3 primary cancers could be controlled by intensive induction chemotherapy and concurrent chemoradiotherapy for hypopharyngeal cancer and by endoscopic mucosal resection or argon plasma coagulation for esophageal and gastric carcinomas. CONCLUSIONS: In the treatment modality for simultaneous multiple primary cancers, including head and neck cancer, it is important to select intensive systemic chemotherapy and decide the order for treating each primary lesion in consideration of each patient's curability and prognosis. (Otolaryngol Head Neck Surg 2005;132:788-93.)

scholarly journals A clinical and genetic analysis of multiple primary cancer referrals to genetics services

2014 ◽  
Vol 23 (5) ◽  
pp. 581-587 ◽  
Author(s):  
James Whitworth ◽  
Jon Hoffman ◽  
Cyril Chapman ◽  
Kai Ren Ong ◽  
Fiona Lalloo ◽  
...  
Keyword(s):  
Genetic Analysis ◽  
Multiple Primary Cancer ◽  
Primary Cancer ◽  
Genetics Services ◽  
Multiple Primary

scholarly journals Downregulation of miR-29c-3p is associated with a poor prognosis in patients with laryngeal squamous cell carcinoma

2019 ◽  
Vol 14 (1) ◽  
Author(s):  
Ruihua Fang ◽  
Yongjin Huang ◽  
Jinghua Xie ◽  
Jianzhong Zhang ◽  
Xiaobin Ji
Keyword(s):  
Overall Survival ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Laryngeal Cancer ◽  
Squamous Cell ◽  
Poor Prognosis ◽  
Laryngeal Squamous Cell Carcinoma ◽  
Hazard Analysis ◽  
Clinicopathological Characteristics ◽  
Rank Test

Abstract Background Laryngeal squamous cell carcinoma (LSCC) is considered to be a common malignancy of the head and neck with poor prognosis for its late diagnosis, metastasis and recurrence. Growing evidence demonstrates that the dysregulation of miR-29c-3p (microRNA-29c-3p) plays an important role in various tumor processes. Our study investigates the expression of miR-29c-3p in LSCC and analyzes the correlation of its dysregulation with clinicopathologic parameters and prognosis. Methods The expression of hsa-miR-29c-3p in LSCC tissues and the adjacent normal laryngeal tissues was detected in 96 LSCC formalin-fixed paraffin-embedded tissues by quantitative real-time PCR (qRT-PCR). The SPSS statistical software package (17.0) was used to analyze the associations between miR-29c-3p expressions and various clinicopathological characteristics. The overall survival (OS) was analyzed by the Kaplan-Meier method and log-rank test, and we analyzed the independent factor of prognosis by Cox proportional hazard analysis. Results A downregulation of miR-29c-3p expression in LSCC was significantly correlated with smoking index, tumor size, tumor site, differentiation, T classification, TNM stage, and lymph node metastasis (P < 0.05), but there was no correlation with age and alcohol consumption (P > 0.05). In the multivariate survival analysis, low miR-29c-3p expression was associated with shorter overall survival (P < 0.05). Furthermore, miR-29c expression was an independent prognostic factor for laryngeal cancer patients. Conclusions MiR-29c-3p has different expression levels at different stages of tumor progression, suggesting that miR-29c-3p may be a promising biomarker for evaluating the progression of LSCC and the prognosis of patients with LSCC. MiR-29c-3p can also be a novel molecular target for anti-laryngeal cancer therapy.

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