scholarly journals Massive Calcified Epithelioid Hemangioendothelioma With Multifocal Involvement: An Imaging Diagnosis Dilemma and a Rare Case Report

2021 ◽  
Vol 11 ◽  
Author(s):  
Feng Che ◽  
Cai wei Yang ◽  
Xue Hu ◽  
Qian Li ◽  
Yi Wei ◽  
...  
Keyword(s):  
Vascular Tumor ◽  
Lymph Node Involvement ◽  
Epithelioid Hemangioendothelioma ◽  
Diagnostic Process ◽  
Hepatic Veins ◽  
Vascular Endothelial ◽  
Hilar Lymph Node ◽  
Multiple Organs ◽  
Rare Case Report ◽  
Node Involvement

Epithelioid hemangioendothelioma (EHE) is a rare malignant vascular tumor that develops from vascular endothelial or pre-endothelial cells. More than 60% patients have single-organ involvement, and involvement of multiple organs including the liver, lungs, and bones is extremely rare. The typical radiographic features of EHE include multiple small nodules in both lungs, which are usually located near small- and medium-sized blood vessels and the bronchi, and solitary, multiple, or diffuse lesions located at the hepatic periphery, spreading within the branches of the portal and hepatic veins. Radiologic calcification has been rarely reported in the literature. Here, we firstly described a case of a 53-year-old woman with EHE who presented with lungs, liver, bone, and right hilar lymph node involvement, manifesting as massive calcification on computed tomography. This case reminds physicians that EHE may present with unusual imaging manifestations, like massive calcification, and should be considered during the diagnostic process.

scholarly journals Colorectal Cancer Presenting as Single Pulmonary Hilar Lymph Node Metastasis

2018 ◽  
Vol 2018 ◽  
pp. 1-3
Author(s):  
Ahmed M. Habib ◽  
Xenophon Kassianides ◽  
Samuel Chan ◽  
Mahmoud Loubani ◽  
Syed Qadri
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Mediastinal Lymph Node ◽  
Lymph Node Involvement ◽  
Pulmonary Metastasectomy ◽  
Hilar Lymph Node ◽  
Node Metastasis ◽  
Mediastinal Metastasis ◽  
Node Involvement ◽  
Hilar Lymph Node Metastasis

Colorectal carcinoma is the second biggest cancer responsible for mortality. Lung metastasis is the commonest, following the liver. It is not uncommon to perform pulmonary metastasectomy and identify mediastinal metastasis. Previous studies have identified incidental lymph node involvement following routine mediastinal lymph node clearance in 20–50% of cases. However, solitary intrathoracic lymph node metastasis is exceedingly rare. Even when present, it is usually metachronous. In our case, we present an exceedingly rare case whereby the intrathoracic lymph node metastasis is solitary, not accompanying pulmonary disease and with no liver metastasis. We also review the evidence for mediastinal lymphadenectomy in the literature.

scholarly journals Bilateral ovarian serous cystadenocarcinoma metastasizing to cervix: a rare case report

2018 ◽  
Vol 7 (11) ◽  
pp. 4789
Author(s):  
Arati Mallick ◽  
Saubhagya K. Jena ◽  
Debasis Kuanar
Keyword(s):  
Ovarian Cancer ◽  
Poor Prognosis ◽  
Malignant Ascites ◽  
Lymph Node Involvement ◽  
Serous Cystadenocarcinoma ◽  
Gynaecologic Cancer ◽  
Rare Case Report ◽  
Node Involvement ◽  
Gynaecologic Malignancy ◽  
Metastatic Involvement

Ovarian carcinoma is the second most common gynaecologic cancer and the leading cause of death from gynaecologic malignancy. Two-third of all malignant epithelial ovarian tumors are constituted by serous ovarian cystadenocarcinomas. It is generally observed that ovarian cancer tends to remain intraabdominal even in advanced cases and that dissemination is usually by invasion of adjacent viscera, diffuse intraperitoneal implantation, and metastatic involvement of aortic and pelvic lymph nodes. Metastasizes to the uterine cervix, vagina, or vulva in ovarian cancer is rare. The reverse i.e. ovarian metastasis from cervical tumor is rather more common. Published literature suggest that, patients with cervical metastases had associated malignant ascites, retroperitoneal lymph node involvement, and significant peritoneal carcinomatosis. Cervical metastasis in ovarian malignancies always indicates the advanced stage of tumor and multi-organ involvement, indirectly stating poor prognosis. The median survival in cases of ovarian cancer metastasizing to cervix is 4.4 months. Authors report a case of bilateral ovarian serous cystadenocarcinoma metastasising to posterior lip of cervix resulted in poor prognosis and proved fatal for the patient with review of published literature.

scholarly journals Metastatic cutaneous epithelioid hemangioendothelioma involving right atrium - a case report

2016 ◽  
Vol 3 (3) ◽  
pp. 47
Author(s):  
Sandy Mpho Mosenye ◽  
Rahul Daimari ◽  
Neha Sharma ◽  
Princess Lelani Chikanda ◽  
Feng Zhou ◽  
...  
Keyword(s):  
Right Atrium ◽  
Cardiac Involvement ◽  
Soft Tissues ◽  
Vascular Tumor ◽  
Epithelioid Hemangioendothelioma ◽  
Malignant Potential ◽  
Vascular Endothelial ◽  
Rare Occurrence ◽  
Scalp Lesion ◽  
The Common

Epithelioid hemangioendothelioma (EHE) is a rare vascular endothelial tumour with unpredictable malignant potential. The common sites involved are the lung, liver and soft tissues; with cardiac involvement being a very rare occurrence. The diagnosis of this rare vascular tumor is made by typical histopathological findings and confirmed by specific immunohistochemistry. We present a case of a patient with a long standing painless scalp lesion who presented with pulmonary symptoms and ultimately diagnosed to have metastatic cutaneous EHE involving the lungs, pericardium and right atrium.

scholarly journals The role of hilar lymphadenectomy in patients subjected to hepatectomy due to colorectal metastasis

2011 ◽  
Vol 48 (3) ◽  
pp. 217-219 ◽  
Author(s):  
Eduardo Freitas Viana ◽  
Paulo Herman ◽  
Fabrício Ferreira Coelho ◽  
Thomas Augusto Taka ◽  
Luiz A. Carneiro D'Albuquerque ◽  
...  
Keyword(s):  
Lymph Node ◽  
Liver Resection ◽  
Survival Rates ◽  
Lymph Node Involvement ◽  
Hilar Lymph Node ◽  
Disease Staging ◽  
Impact On Survival ◽  
Node Involvement ◽  
Long Term Prognosis ◽  
Improvement In Survival

CONTEXT: Hepatectomy is the treatment of choice for colorectal liver metastases, and several studies have shown good results, with 5-year survival rates ranging from 40% to 57%. Several clinical and pathological predictive factors for survival after liver resection have been studied. Involvement of the hepatic hilum lymph nodes, the incidence of which varies from 2% to 10%, indicates a poor long-term prognosis. RESULTS: Despite variable results, some authors have reported a not-insignificant improvement in survival rate in liver-metastasis patients with hilar lymph node involvement who undergo combined liver resection and lymphadenectomy. Due to the low rates of morbidity and mortality for liver-resection surgery, several specialized centers perform liver resections combined with lymphadenectomies in selected cases. It should be noted that the therapeutic value of systemic lymphadenectomy is not yet entirely understood, and only controlled studies comparing groups with and without lymphadenectomy can fully resolve the issue. CONCLUSION: In any case, hilar lymph node dissection has been shown to be a useful tool for improving the accuracy of extra hepatic disease staging, regardless of its impact on survival.

scholarly journals Pazopanib in Pulmonary Epithelioid Hemangioendothelioma: Report of a Case

2020 ◽  
Vol 5 (02) ◽  
Author(s):  
Ibtihal Ahalli ◽  
Karima Oualla ◽  
Loubna Hejjane ◽  
Raihana Boujarnija ◽  
Kaouthar Messoudi ◽  
...  
Keyword(s):  
Lung Tumor ◽  
Vascular Tumor ◽  
Epithelioid Hemangioendothelioma ◽  
Low Grade ◽  
Vegf Receptor ◽  
Vascular Endothelial ◽  
Pulmonary Epithelioid Hemangioendothelioma ◽  
Grade Malignancy ◽  
Rare Malignancy ◽  
Endothelial Growth Factor

Pulmonary epithelioid hemangioendothelioma (PEH) is a rare vascular tumor of borderline or low-grade malignancy, Vascular endothelial growth factor (VEGF) and the VEGF receptor were found on PEH tumor cells, suggesting that target therapies that block VEGFR have a logical base in this rare malignancy. We report a 25 years old woman with a pulmonary hemangioendothelioma, treated with pazopanib, the only anti angiogenic registered agent for sarcoma, with clinical improvement of symptoms and durable stabilization for more than two years of lung tumor.

scholarly journals Hepatic Epithelioid Hemangioendothelioma

2018 ◽  
Vol 142 (2) ◽  
pp. 263-267 ◽  
Author(s):  
Lynette L. Studer ◽  
Dale M. Selby
Keyword(s):  
Vascular Endothelial Cells ◽  
Incidental Finding ◽  
Treatment Protocol ◽  
Vascular Tumor ◽  
Metastatic Carcinoma ◽  
Epithelioid Hemangioendothelioma ◽  
The Body ◽  
Fusion Product ◽  
Vascular Endothelial ◽  
Abdominal Symptoms

Epithelioid hemangioendothelioma is a rare vascular tumor, composed of epithelioid and histiocytoid vascular endothelial cells in myxoid or fibrotic stroma, which can arise in multiple locations throughout the body. In the liver, this neoplasm usually presents on imaging as an incidental finding of multifocal, heterogeneously enhancing nodules in both lobes or presents clinically with nonspecific abdominal symptoms. Histologically, the tumor has been mistaken for metastatic carcinoma, angiosarcoma, hepatocellular carcinoma, and cholangiocarcinoma. The neoplasm usually stains positive for vascular markers, such as factor VIII–related antigen, CD31, and CD34, and negative for cytokeratins. The translocation t(1;3)(p36.3;q25), resulting in the CAMTA1-WWTR1 fusion product, is the most commonly identified genetic abnormality with this tumor. Although hepatic epithelioid hemangioendothelioma can have a varied clinical course, it is generally considered less aggressive than angiosarcoma. There is no consensus treatment protocol and techniques including liver transplantation, liver resection, chemotherapy and/or radiation therapy, and surveillance have all been used with varying outcomes.

Prognostic Variability in Completely Resected pN1 Non-Small-Cell Lung Cancer

2008 ◽  
Vol 16 (5) ◽  
pp. 375-380 ◽  
Author(s):  
Alessandro Gonfiotti ◽  
Emanuele Crocetti ◽  
Andrea Lopes Pegna ◽  
Eugenio Paci ◽  
Alberto Janni
Keyword(s):  
Lung Cancer ◽  
Lymph Node ◽  
Prognostic Factor ◽  
Small Cell Lung Cancer ◽  
Survival Rates ◽  
Lymph Node Involvement ◽  
Small Cell ◽  
Small Cell Lung ◽  
Hilar Lymph Node ◽  
Node Involvement

We used the Tuscan Cancer Registry archives to retrieve records of 2,896 patients with a histological diagnosis of lung tumor from January 1996 to December 2000. Of 2,410 patients with non-small-cell lung cancer, 767 (31.8%) underwent complete resection. The following variables were analyzed for their influence on survival in the 157 patients with pathologic N1 status: sex, age, cell type, pathologic tumor status, number and level of involved lymph nodes, tumor grade, and type of surgery. Overall 5-year survival rates were 43.9% for 417 patients with pN0 disease, 10.8% for 176 with pN2 disease, and 31.6% for those with pN1 disease. In pN1 disease, the overall 5-year survival rates for patients with hilar and non-hilar lymph node involvement were 27.4% and 39.6%, respectively. Univariate analysis demonstrated that pathological T status and level of N1 involvement weresignificant prognostic factors. Cox proportional hazards analysis indicated that hilar lymph node involvement was an independent prognostic factor. N1 lymph node status was identified as an independent prognostic factor in a combination of subgroups with different prognoses.

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