scholarly journals Sex Differences in Migraine: A Twin Study

2021 ◽  
Vol 2 ◽  
Author(s):  
Morgan C. Fitzgerald ◽  
Ursula G. Saelzler ◽  
Matthew S. Panizzon
Keyword(s):  
Logistic Regression ◽  
Sex Differences ◽  
Sex Difference ◽  
Genetic Differences ◽  
Men And Women ◽  
Sex Limitation ◽  
Opposite Sex ◽  
Genetic And Environmental Factors ◽  
Multilevel Logistic Regression Model ◽  
Swedish Twin Registry

Migraine is a neurological disorder with a prominent sex difference such that two thirds of sufferers are female. The mechanisms behind the preponderance of migraine in women have yet to be elucidated. With data on 51,872 participants from the Swedish Twin Registry, we report results from two distinct analyses intended to clarify the degree to which genetic and environmental factors contribute to sex differences in migraine. First, we fit a sex-limitation model to determine if quantitative genetic differences (i.e., is migraine equally heritable across men and women) and/or qualitative genetic differences (i.e., are different genes involved in migraine across men and women) were present. Next, we used a multilevel logistic regression model to compare the prevalence of migraine in individuals from opposite-sex and same-sex twin pairs to determine whether differences in the prenatal hormone environment contribute to migraine risk. In the final analytic sample, women were found to have a significantly higher rate of migraine without aura relative to men (17.6% vs. 5.5%). The results from an ADE sex-limitation model indicate that migraine is equally heritable in men and women, with a broad sense heritability of 0.45, (95% CI = 0.40–0.50), while results from a reduced AE sex-limitation model provide subtle evidence for differences in the genes underlying migraine across men and women. The logistic regression analysis revealed a significant increase in migraine risk for females with a male co-twin relative to females with a female co-twin (OR = 1.51, 95% CI = 1.26–1.81). These results suggest that the prominent sex difference in migraine prevalence is not entirely accounted for by genetic factors, while demonstrating that masculinization of the prenatal environment may increase migraine risk for females. This effect points to a potential prenatal neuroendocrine factor in the development of migraine.

scholarly journals Sex differences in migraine: A twin study

2021 ◽  
Author(s):  
Morgan C Fitzgerald ◽  
Ursula G Saelzler ◽  
Matthew S Panizzon
Keyword(s):  
Logistic Regression ◽  
Sex Differences ◽  
Sex Difference ◽  
Genetic Differences ◽  
Men And Women ◽  
Sex Limitation ◽  
Opposite Sex ◽  
Genetic And Environmental Factors ◽  
Multilevel Logistic Regression Model ◽  
Swedish Twin Registry

Migraine is a neurological disorder with a prominent sex difference such that two thirds of sufferers are female. The mechanisms behind the preponderance of migraine in women have yet to be elucidated. With data on 51,872 participants from the Swedish Twin Registry, we report results from two distinct analyses intended to clarify the degree to which genetic and environmental factors contribute to sex differences in migraine. First, we fit a sex-limitation model to determine if quantitative genetic differences (i.e., is migraine equally heritable across men and women) and/or qualitative genetic differences (i.e., are different genes involved in migraine across men and women) were present. Next, we used a multilevel logistic regression model to compare the prevalence of migraine in individuals from opposite-sex and same-sex twin pairs to determine whether differences in the prenatal hormone environment contribute to migraine risk. In the final analytic sample, women were found to have a significantly higher rate of migraine without aura relative to men (17.6% vs 5.5%). The results from an ADE sex-limitation model indicate that migraine is equally heritable in men and women, with a broad sense heritability of .45, (95% CI = .40 - .50), while results from a reduced AE sex-limitation model provide subtle evidence for differences in the genes underlying migraine across men and women. The logistic regression analysis revealed a significant increase in migraine risk for females with a male co-twin relative to females with a female co-twin (OR = 1.51, 95% CI = 1.26 - 1.81). These results suggest that the prominent sex difference in migraine prevalence is not entirely accounted for by genetic factors while demonstrating that masculinization of the prenatal environment may increase migraine risk for females. This effect points to a potential prenatal neuroendocrine factor in the development of migraine.

scholarly journals Sex Differences in Genetic and Environmental Factors Contributing to Body-Height

Twin Research ◽  
2001 ◽  
Vol 4 (1) ◽  
pp. 25-29 ◽  
Author(s):  
Karri Silventoinen ◽  
Jaakko Kaprio ◽  
Eero Lahelma ◽  
Richard J. Viken ◽  
Richard J. Rose
Keyword(s):  
Sex Differences ◽  
Environmental Factors ◽  
Environmental Stress ◽  
Genetic Factors ◽  
Body Height ◽  
Men And Women ◽  
Cohort Difference ◽  
Sex Limitation ◽  
Heritability Estimates ◽  
Genetic And Environmental Factors

AbstractSex differences in the heritability of self-reported body-height in two Finnish twin cohorts were studied by using sex-limitation models. The first cohort was born in 1938–1949 (N = 4873 twin pairs) and the second in 1975–1979 (N = 2374 twin pairs). Body-height was greater in the younger cohort (difference of 3.1 cm for men and 2.9 cm for women). The heritability estimates were higher among men (h2 = 0.87 in the older cohort and h2 = 0.82 in the younger cohort) than women (h2 = 0.78 and h2 = 0.67, respectively). Sex-specific genetic factors were not statistically significant in either cohort, suggesting that the same genes contribute to variation in body height for both men and women. The stronger contribution of environmental factors to body-height among women questions the hypothesis that women are better buffered against environmental stress, at least for this phenotype.

The Relationship of Compliance with Coping Strategies and Self-Esteem

2003 ◽  
Vol 19 (2) ◽  
pp. 117-123 ◽  
Author(s):  
Gisli H. Gudjonsson ◽  
Jon Fridrik Sigurdsson
Keyword(s):  
Sex Differences ◽  
Coping Strategies ◽  
Multiple Regression ◽  
Sex Difference ◽  
Test Scores ◽  
Self Esteem ◽  
Stressful Situation ◽  
Men And Women ◽  
Relationship Of ◽  
The Relationship

Summary: The Gudjonsson Compliance Scale (GCS), the COPE Scale, and the Rosenberg Self-Esteem Scale were administered to 212 men and 212 women. Multiple regression of the test scores showed that low self-esteem and denial coping were the best predictors of compliance in both men and women. Significant sex differences emerged on all three scales, with women having lower self-esteem than men, being more compliant, and using different coping strategies when confronted with a stressful situation. The sex difference in compliance was mediated by differences in self-esteem between men and women.

Sex Differences in Time Production Revisited

2012 ◽  
Vol 33 (1) ◽  
pp. 35-42 ◽  
Author(s):  
Joseph Glicksohn ◽  
Yamit Hadad
Keyword(s):  
Sex Differences ◽  
Individual Differences ◽  
Sex Difference ◽  
Absolute Error ◽  
Internal Clock ◽  
Target Duration ◽  
Log P ◽  
Men And Women ◽  
Time Production ◽  
T Score

Individual differences in time production should indicate differences in the rate of functioning of an internal clock, assuming the existence of such a clock. And sex differences in time production should reflect a difference in the rate of functioning of that clock between men and women. One way of approaching the data is to compute individual regressions of produced duration (P) on target duration (T), after log transformation, and to derive estimates for the intercept and the slope. One could investigate a sex difference by comparing these estimates for men and women; one could also contrast them by looking at mean log(P). Using such indices, we found a sex difference in time production, female participants having a relatively faster internal clock, making shorter time productions, and having a smaller exponent. The question is whether a sex difference in time production would be found using other methods for analyzing the data: (1) the P/T ratio; (2) an absolute discrepancy (|P-T|) score; and (3) an absolute error (|P-T|/T) score. For the P/T ratio, female participants have a lower mean ratio in comparison to the male participants. In contrast, the |P-T| and |P-T|/T indices seem to be seriously compromised by wide individual differences.

Sex Differences in Participation, Performance, and Age of Ultramarathon Runners

2016 ◽  
Vol 11 (5) ◽  
pp. 635-642 ◽  
Author(s):  
Jonathon Senefeld ◽  
Carolyn Smith ◽  
Sandra K. Hunter
Keyword(s):  
Sex Differences ◽  
Sex Difference ◽  
Track And Field ◽  
Marathon Running ◽  
Participation Rates ◽  
Running Speed ◽  
Men And Women ◽  
Participation Of Women ◽  
The Us ◽  
Ultra Running

The sex difference in marathon running is increased with lower participation of women than men, but whether this occurs for ultramarathon running is not known. The study purpose was to determine whether the sex difference in performance widens among lower-placed runners and the association between the sex difference in running speed and participation rates. The top-10 ultramarathon running times, age at performance date, and the number of men and women finishers were analyzed from 20 races (45–160 km) in the US Track and Field Ultra Running Grand Prix. Men were faster than women for all events (18.7% ± 5.8%, P < .001). The sex difference in speed was the least for 100 km (14.9% ± 4.2%) and greatest for 45–50 km (19.3% ± 5.8%). The top-10 men were younger than the top-10 women (37.7 ± 3.2 and 39.0 ± 3.1 y, respectively, P < .001). The sex difference in speed increased with finishing place (1st place 15.6% ± 6.6% vs 10th 20.8% ± 5.6%, P < .001). Association analysis showed that the sex difference in speed was largest when there were fewer women than men finishers in a race; the strength of the association was greatest for the 80-km distance and least for the 160-km. Lower participation rates of women than men in the lower-distance ultramarathons and less depth among lower-placed women runners inflate the sex difference in ultramarathon performance.

Cultural and Sex Differences in Rating the Self and an Hypothetical Well-Adjusted Person on Jack's Divided Self and Care as Self-Sacrifice Subscales

1999 ◽  
Vol 84 (1) ◽  
pp. 67-83 ◽  
Author(s):  
J. Koutrelakos ◽  
A. J. Baranchik ◽  
N. Damato
Keyword(s):  
Factor Analysis ◽  
Sex Differences ◽  
Sex Difference ◽  
The Self ◽  
Same Sex ◽  
Men And Women ◽  
Divided Self ◽  
The Usa

Ratings of the self and of an hypothetical well-adjusted man and woman on the Divided Self and Care as Self-sacrifice subscales of the Silencing the Self Scale were obtained for samples of men and women in the USA and Greece. Factor analysis confirmed the items' assignment to subscales for each of the three sets of ratings. Generally, Greeks scored higher than Americans on both subscales. While men usually scored higher than women on the Care subscale in both countries, they only did so in Greece for the Divided Self. Women had greater discrepancies than men between their self and well-adjusted same-sex rating on both subscales in each country, with this sex difference being greater in Greece than the USA and greater on the Care subscale in both countries.

scholarly journals Sex Differences in Drug Disposition

2011 ◽  
Vol 2011 ◽  
pp. 1-14 ◽  
Author(s):  
Offie P. Soldin ◽  
Sarah H. Chung ◽  
Donald R. Mattison
Keyword(s):  
Clinical Pharmacology ◽  
Sex Differences ◽  
Drug Disposition ◽  
Genetic Differences ◽  
Men And Women ◽  
Males And Females ◽  
Effective Treatments

Physiological, hormonal, and genetic differences between males and females affect the prevalence, incidence, and severity of diseases and responses to therapy. Understanding these differences is important for designing safe and effective treatments. This paper summarizes sex differences that impact drug disposition and includes a general comparison of clinical pharmacology as it applies to men and women.

Sex Differences in Preferences for Coffee Sweetness among Japanese Students

2007 ◽  
Vol 105 (2) ◽  
pp. 403-404 ◽  
Author(s):  
Kazuko Yamazawa ◽  
Kumi Hirokawa ◽  
Hiroyuki Shimizu
Keyword(s):  
Sex Differences ◽  
Sex Difference ◽  
Undergraduate Students ◽  
Men And Women ◽  
Coffee Drinking ◽  
Japanese Students ◽  
Drinking Habits

The purpose of the present study was to examine sex differences in preferences for coffee sweetness. The participants were 59 Japanese undergraduate students. Men preferred sweeter coffee than women, while both men and women showed almost the same preference for acidic beverage sweetness. The sex difference in preferences for coffee sweetness may be related to coffee-drinking habits.

scholarly journals Sex Difference in Plasma Deoxyribonuclease Activity in Rats

2021 ◽  
pp. 913-920
Author(s):  
Ľ Janovičová ◽  
B. Gromová ◽  
D. Drobná ◽  
B. Konečná ◽  
E. Renczés ◽  
...  
Keyword(s):  
Sex Differences ◽  
Sex Difference ◽  
Extracellular Dna ◽  
Female Rats ◽  
Male Rats ◽  
Dnase Activity ◽  
Adult Rats ◽  
Opposite Sex ◽  
Diffusion Assay ◽  
Deoxyribonuclease Activity

Extracellular DNA (ecDNA) activates immune cells and is involved in the pathogenesis of diseases associated with inflammation such as sepsis, rheumatoid arthritis or metabolic syndrome. DNA can be cleaved by deoxyribonucleases (DNases), some of which are secreted out of cells. The aim of this experiment was to describe plasma DNase activity in relation to extracellular DNA in adult rats, to analyse potential sex differences and to prove whether they are related to endogenous testosterone. Adult Lewis rats (n=28) of both sexes were included in the experiment. Male rats were gonadectomized or sham-operated and compared to intact female rats. Plasma ecDNA and DNase activity were measured using fluorometry and single radial enzyme diffusion assay, respectively. Concentrations of nuclear ecDNA and mitochondrial ecDNA were determined using real-time PCR. Females had 60% higher plasma DNase activity than males (p=0.03). Gonadectomy did not affect plasma DNase in males. Neither the concentration of total ecDNA, nor nuclear or mitochondrial DNA in plasma differed between the groups. No significant correlations between DNase and ecDNA were found. From previous studies on mice, it was expected, that male rats will have higher DNase activity. In contrast, our study in rats showed the opposite sex difference. This sex difference seems not to be caused by endogenous testosterone. Interestingly, no sex differences were observed in plasma ecDNA suggesting a complex or missing association between plasma ecDNA and DNase. The observed sex difference in plasma DNase should be taken into account in animal models of ecDNA-associated diseases.

Sex Differences Concerning Prosocial Behavior in Social Dilemmas Are (Partially) Mediated by Risk Preferences But Not Social Preferences

2020 ◽  
pp. 1-14
Author(s):  
Angela R. Dorrough ◽  
Andreas Glöckner
Keyword(s):  
Sex Differences ◽  
Prosocial Behavior ◽  
Sex Difference ◽  
Gender Inequality ◽  
Social Preferences ◽  
Meta Analysis ◽  
Social Dilemmas ◽  
Men And Women ◽  
Null Effect ◽  
The Difference

Abstract. Previous results on the prosociality of men and women in social dilemmas are mixed. Studies find more prosocial behavior for men and women; and a meta-analysis ( Balliet et al., 2011 ) reports an overall null effect. Including samples ( N = 1,903) from 10 countries that vary concerning gender inequality (e.g., China, Colombia, Sweden), we investigated sex differences in social dilemmas and drivers of these potential differences. We found that men behaved more prosocially, in that they transferred more of their endowment to their interaction partner. This sex difference was descriptively observed for all countries and was partially mediated by differences in risk but not social preferences. Gender inequality did not predict the difference in magnitude of sex differences between countries.

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