Carriage Dynamics of Pneumococcal Serotypes in Naturally Colonized Infants in a Rural African Setting During the First Year of Life

Streptococcus pneumoniae (the pneumococcus) carriage precedes invasive disease and influences population-wide strain dynamics, but limited data exist on temporal carriage patterns of serotypes due to the prohibitive costs of longitudinal studies. Here, we report carriage prevalence, clearance and acquisition rates of pneumococcal serotypes sampled from newborn infants bi-weekly from weeks 1 to 27, and then bi-monthly from weeks 35 to 52 in the Gambia. We used sweep latex agglutination and whole genome sequencing to serotype the isolates. We show rapid pneumococcal acquisition with nearly 31% of the infants colonized by the end of first week after birth and quickly exceeding 95% after 2 months. Co-colonization with multiple serotypes was consistently observed in over 40% of the infants at each sampling point during the first year of life. Overall, the mean acquisition time and carriage duration regardless of serotype was 38 and 24 days, respectively, but varied considerably between serotypes comparable to observations from other regions. Our data will inform disease prevention and control measures including providing baseline data for parameterising infectious disease mathematical models including those assessing the impact of clinical interventions such as pneumococcal conjugate vaccines.

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ADENOVIRUS COMPLEMENT-FIXING ANTIBODY TITERS FROM BIRTH THROUGH THE FIRST YEAR OF LIFE

PEDIATRICS ◽

10.1542/peds.32.4.497 ◽

1963 ◽

Vol 32 (4) ◽

pp. 497-500

Author(s):

Rosa Lee Nemir ◽

Donna O'Hare ◽

Stanley Goldstein ◽

Charles B. Hilton

Keyword(s):

Cytopathic Effect ◽

Gradual Increase ◽

Newborn Infants ◽

First Year ◽

Placental Barrier ◽

Culture Studies ◽

Antibody Titers ◽

Level 1 ◽

One Year ◽

First Year Of Life

Complement fixing antibody titers to the adenoviruses were determined in 251 newborn infants, using cord blood. Approximately 95% of these were found to have CF titers of 1:16 or over, the majority (75%) were 1:32 or more. Material from the pharyngeal and rectal swabs of these infants on tissue culture studies (542) on HeLa and amnion cells showed no cytopathic effect in oven 96% of these infants. A longitudinal study of 114 of these infants was made at 3 months intervals; 67 have been observed for one year. At 3 months, only 12% still showed CF antibody titers, and these were chiefly at a low level, 1:16. At the subsequent 3-month interval observations, a gradual rise in CF antibodies were found. At one year of age, approximately 37% had titers of 1:32 on over. The findings of this report support the statement that CF antibodies to adenovirus pass the placental barrier. There is a gradual increase in the percentage of infants with positive CF antibodies after 3 months.

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Breastfeeding, maternal asthma and wheezing in the first year of life: a longitudinal birth cohort study

European Respiratory Journal ◽

10.1183/13993003.02019-2016 ◽

2017 ◽

Vol 49 (5) ◽

pp. 1602019 ◽

Cited By ~ 19

Author(s):

Meghan B. Azad ◽

Lorena Vehling ◽

Zihang Lu ◽

David Dai ◽

Padmaja Subbarao ◽

...

Keyword(s):

Birth Cohort ◽

Respiratory Health ◽

Birth Cohort Study ◽

P Value ◽

First Year ◽

Dependent Manner ◽

Complementary Foods ◽

Adjusted Rate ◽

First Year Of Life ◽

The Impact

The impact of breastfeeding on respiratory health is uncertain, particularly when the mother has asthma. We examined the association of breastfeeding and wheezing in the first year of life.We studied 2773 infants from the Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort. Caregivers reported on infant feeding and wheezing episodes at 3, 6 and 12 months. Breastfeeding was classified as exclusive, partial (supplemented with formula or complementary foods) or none.Overall, 21% of mothers had asthma, 46% breastfed for at least 12 months and 21% of infants experienced wheezing. Among mothers with asthma, breastfeeding was inversely associated with infant wheezing, independent of maternal smoking, education and other risk factors (adjusted rate ratio (aRR) 0.52; 95% CI 0.35–0.77 for ≥12 versus <6 months breastfeeding). Compared with no breastfeeding at 6 months, wheezing was reduced by 62% with exclusive breastfeeding (aRR 0.38; 95% CI 0.20–0.71) and by 37% with partial breastfeeding supplemented with complementary foods (aRR 0.63; 95% CI 0.43–0.93); however, breastfeeding was not significantly protective when supplemented with formula (aRR 0.89; 95% CI 0.61–1.30). Associations were not significant in the absence of maternal asthma (p-value for interaction <0.01).Breastfeeding appears to confer protection against wheezing in a dose-dependent manner among infants born to mothers with asthma.

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The development of the cortisol response to dyadic stressors in Black and White infants

Development and Psychopathology ◽

10.1017/s0954579418001232 ◽

2018 ◽

Vol 30 (5) ◽

pp. 1995-2008 ◽

Cited By ~ 11

Author(s):

Andrew Dismukes ◽

Elizabeth Shirtcliff ◽

Christopher W. Jones ◽

Charles Zeanah ◽

Katherine Theall ◽

...

Keyword(s):

Urban Life ◽

First Year ◽

Strange Situation ◽

Cortisol Reactivity ◽

Hypothalamic Pituitary Adrenal ◽

Black And White ◽

First Year Of Life ◽

The Impact ◽

Still Face Paradigm ◽

Strange Situation Procedure

AbstractAcute reactivity of the stress hormone cortisol is reflective of early adversity and stress exposure, with some studies finding that the impact of adversity on the stress response differs by race. The objectives of the current study were to characterize cortisol reactivity to two dyadically based stress paradigms across the first year of life, to examine cortisol reactivity within Black and White infants, and to assess the impact of correlates of racial inequity including socioeconomic status, experiences of discrimination, and urban life stressors, as well as the buffering by racial socialization on cortisol patterns. Salivary cortisol reactivity was assessed at 4 months of age during the Still Face paradigm (N = 207) and at 12 months of age across the Strange Situation procedure (N = 129). Infants demonstrated the steepest recovery after the Still Face paradigm and steepest reactivity to the Strange Situation procedure. Race differences in cortisol were not present at 4 months but emerged at 12 months of age, with Black infants having higher cortisol. Experiences of discrimination contributed to cortisol differences within Black infants, suggesting that racial discrimination is already “under the skin” by 1 year of age. These findings suggest that race-related differences in hypothalamic–pituitary–adrenal reactivity are present in infancy, and that the first year of life is a crucial time period during which interventions and prevention efforts for maternal–infant dyads are most likely able to shape hypothalamic–pituitary–adrenal reactivity thereby mitigating health disparities early across the life course.

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LONGITUDINAL EEG-CLINICAL CORRELATIONS IN CHILDREN FROM BIRTH TO 4 YEARS OF AGE

PEDIATRICS ◽

10.1542/peds.41.5.945 ◽

1968 ◽

Vol 41 (5) ◽

pp. 945-954

Author(s):

Fernando Torres ◽

Michael E. Blaw

Keyword(s):

Statistical Significance ◽

Newborn Infants ◽

Normal Subjects ◽

First Year ◽

Advanced Stages ◽

The Difference ◽

Focal Abnormality ◽

First Year Of Life ◽

Single Focus

One hundred-thirty children who had an EEG during their first days of life and who were registered in a clinical longitudinal study were followed with concurrent clinical and EEG examinations every 4 months for the first year of life and at 2, 3, and 4 years of age. Thirty children had EEG characteristics which are frequently considered abnormal in their neonatal record. Twenty-three children had clinical abnormalities during the 4-year period covered by the study. There was no significant correlation between a single EEG and clinical abnormalities at any age. Newborn infants with more than one focal abnormality in their EEG presented clinical abnormalities more frequently than those with a single focus. The difference, however, did not attain statistical significance. Children with an abnormal EEG at birth and an additional abnormal record later, had a higher incidence of clinical abnormalities than those with only an abnormal neonatal EEG. However, this finding is of questionable significance because the children who had clinical abnormalities had a larger number of EEG's than the normal subjects. It is expected that continued follow-up of these children at more advanced stages of their development may give a positive EEG-clinical correlation which was not found in this study.

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Impact of intrapartum antibiotics on the infant gastrointestinal microbiome: a narrative review

Archives of Disease in Childhood ◽

10.1136/archdischild-2021-322590 ◽

2021 ◽

pp. archdischild-2021-322590

Author(s):

Laura Diamond ◽

Rachel Wine ◽

Shaun K Morris

Keyword(s):

Gestational Age ◽

Beta Diversity ◽

Mode Of Delivery ◽

Alpha Diversity ◽

First Year ◽

Feeding Method ◽

Alpha And Beta Diversity ◽

Ovid Medline ◽

First Year Of Life ◽

The Impact

BackgroundThe composition of the infant gastrointestinal (GI) microbiome has been linked to adverse long-term health outcomes and neonatal sepsis. Several factors are known to impact the composition of the microbiome, including mode of delivery, gestational age, feeding method and exposure to antibiotics. The impact of intrapartum antibiotics (IPAs) on the infant microbiome requires further research.ObjectiveWe aimed to evaluate the impact of IPAs on the infant GI microbiome.MethodsWe searched Ovid MEDLINE and Embase Classic+Embase for articles in English reporting on the microbiome of infants exposed to IPAs from the date of inception to 3 January 2021. Primary outcomes included abundance and colonisation of Bifidobacterium and Lactobacillus, as well as alpha and beta diversity.Results30 papers were included in this review. In the first year of life, following exposure to IPAs, 30% (6/20) of infant cohorts displayed significantly reduced Bifidobacterium, 89% (17/19) did not display any significant differences in Lactobacillus colonisation, 21% (7/34) displayed significantly reduced alpha diversity and 35% (12/34) displayed alterations in beta diversity. Results were further stratified by delivery, gestational age (preterm or full term) and feeding method.ConclusionsIPAs impact the composition of the infant GI microbiome, resulting in possible reductions Bifidobacterium and alpha diversity, and possible alterations in beta diversity. Our findings may have implications for maternal and neonatal health, including interventions to prevent reductions in health-promoting bacteria (eg, probiotics) and IPA class selection.

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Influence of volume dependency and timing of airway occlusions on the Hering-Breuer reflex in infants

Journal of Applied Physiology ◽

10.1152/jappl.1998.85.6.2033 ◽

1998 ◽

Vol 85 (6) ◽

pp. 2033-2039 ◽

Cited By ~ 20

Author(s):

Patricia S. Rabbette ◽

Janet Stocks

Keyword(s):

Respiratory Mechanics ◽

Newborn Infants ◽

Tidal Range ◽

First Year ◽

Similar Response ◽

Inspiratory Time ◽

Tidal Breathing ◽

Age Related ◽

The Difference ◽

First Year Of Life

Both end-inspiratory (EIO) and end-expiratory (EEO) airway occlusions are used to calculate the strength of the Hering-Breuer inflation reflex (HBIR) in infants. However, the influence of the timing of such occlusions is unknown, as is the extent to which changes in volume within and above the tidal range affect this reflex. The purpose of this study was to compare both techniques and to evaluate the volume dependency of the HBIR in healthy, sleeping infants up to 1 yr of age. The strength of the HBIR was expressed as the ratio of expiratory or inspiratory time during EIO or EEO, respectively, to that recorded during spontaneous breathing, i.e., as the “inhibitory ratio” (IR). Paired measurements of the EIO and EEO in 26 naturally sleeping newborn and 15 lightly sedated infants at ∼1 yr showed no statistically significant differences in the IR according to technique: mean (95% CI) of the difference (EIO − EEO) being −0.02 (−0.17, 0.13) during the first week of life and 0.04 (−0.14, 0.22) at 1 yr. During tidal breathing, a volume threshold of ∼4 ml/kg was required to evoke the HBIR. Marked volume and age dependency were observed. In newborn infants, occlusions at ∼10 ml/kg during sighs always resulted in an IR > 4, whereas a similar response was only evoked at 25 ml/kg in older infants. Age-related changes in the volume threshold may reflect maturational changes in the control of breathing and respiratory mechanics throughout the first year of life.

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Mediterranean diet adherence during pregnancy and risk of wheeze and eczema in the first year of life: INMA (Spain) and RHEA (Greece) mother–child cohort studies

British Journal Of Nutrition ◽

10.1017/s0007114513001426 ◽

2013 ◽

Vol 110 (11) ◽

pp. 2058-2068 ◽

Cited By ~ 49

Author(s):

Leda Chatzi ◽

Raquel Garcia ◽

Theano Roumeliotaki ◽

Mikel Basterrechea ◽

Haizea Begiristain ◽

...

Keyword(s):

Mediterranean Diet ◽

Dairy Products ◽

Meta Analysis ◽

Maternal Diet ◽

First Year ◽

Processed Meat ◽

High Intake ◽

Meat Intake ◽

First Year Of Life ◽

The Impact

Maternal diet during pregnancy might influence the development of childhood allergic disorders. The aim of the present study was to evaluate the impact of Mediterranean diet (MD) adherence during pregnancy on wheeze and eczema in the first year of life in two population-based mother–child cohorts in Spain and Greece. We studied 1771 mother–newborn pairs from the Spanish multi-centre ‘INMA’ (INfancia y Medio Ambiente) study (Gipuzkoa, Sabadell and Valencia) and 745 pairs from the ‘RHEA’ study in Crete, Greece. The symptoms of wheeze and eczema were based on the criteria of the International Study of Asthma and Allergies in Childhood. Maternal diet during pregnancy was assessed by FFQ and MD adherence was evaluated through an a priori score. Multivariate log-binomial regression models were used to adjust for several confounders in each cohort and summary estimates were obtained by a meta-analysis. MD adherence was not associated with the risk of wheeze and eczema in any cohort, and similar results were identified in the meta-analysis approach. High meat intake (relative risk (RR) 1·22, 95 % CI 1·00, 1·49) and ‘processed’ meat intake (RR 1·18, 95 % CI 1·02, 1·37) during pregnancy were associated with an increased risk of wheeze in the first year of life, while a high intake of dairy products was significantly associated with a decreased risk of infantile wheeze (RR 0·83, 95 % CI 0·72, 0·96). The results of the present study show that high meat intake during pregnancy may increase the risk of wheeze in the first year of life, while a high intake of dairy products may decrease it.

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Determinants of Infant Susceptibility to Malaria During the First Year of Life in South Western Cameroon

Open Forum Infectious Diseases ◽

10.1093/ofid/ofv012 ◽

2015 ◽

Vol 2 (1) ◽

Cited By ~ 14

Author(s):

Tobias O. Apinjoh ◽

Judith K. Anchang-Kimbi ◽

Regina N. Mugri ◽

Clarisse Njua-Yafi ◽

Rolland B. Tata ◽

...

Keyword(s):

Rainy Season ◽

Intermittent Preventive Treatment ◽

Preventive Treatment ◽

Malaria Prevalence ◽

Immunoglobulin M ◽

Malaria Episode ◽

Enzyme Linked Immunosorbent Assay ◽

First Year ◽

First Year Of Life ◽

The Impact

Abstract Background. Falciparum malaria is an important pediatric infectious disease that frequently affects pregnant women and alters infant morbidity. However, the impact of some prenatal and perinatal risk factors such as season and intermittent preventive treatment during pregnancy (IPTp) on neonatal susceptibility has not been fully elucidated. Methods. A cohort of 415 infants born to women who were positive and negative for malaria was monitored in a longitudinal study in Southwestern Cameroon. The clinical and malaria statuses were assessed throughout, whereas paired maternal-cord and 1-year-old antimalarial antibodies were assayed by enzyme-linked immunosorbent assay. Infant susceptibility to malaria was ascertained after accounting for IPTp and season in the statistical analysis. Results. Malaria prevalence was higher in women (P = .039) who delivered during the rainy season and their infants (P = .030) compared with their dry season counterparts. Infants born to women who were positive for malaria (6.40 ± 2.83 months) were older (P = .028) than their counterparts who were negative for malaria (5.52 ± 2.85 months) when they experienced their first malaria episode. Infants born in September–November (adjusted odds ratio [OR] = 0.31, 95% confidence interval [CI] = 0.13–0.72) and to mothers on 1 or no IPTp-sulfadoxine/pyrimethamine (SP) dose (adjusted OR = 0.51, 95% CI = 0.28–0.91) were protected, whereas those born in the rainy season (adjusted OR = 2.82, 95% CI = 1.21–6.55) were susceptible to malaria. Conclusions. Intermittent preventive treatment during pregnancy and month of birth have important implications for infant susceptibility to malaria, with 2 or more IPTp-SP dosage possibly reducing immunoglobulin M production.

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Reduced Efficacy of Intermittent Preventive Treatment of Malaria in Malnourished Children

Antimicrobial Agents and Chemotherapy ◽

10.1128/aac.01723-08 ◽

2009 ◽

Vol 53 (5) ◽

pp. 1753-1759 ◽

Cited By ~ 13

Author(s):

Ina Danquah ◽

Ekkehart Dietz ◽

Philipp Zanger ◽

Klaus Reither ◽

Peter Ziniel ◽

...

Keyword(s):

Protective Efficacy ◽

Intermittent Preventive Treatment ◽

Preventive Treatment ◽

Child Growth ◽

Northern Ghana ◽

First Year ◽

Malnourished Children ◽

Increased Risk ◽

First Year Of Life ◽

The Impact

ABSTRACT Intermittent preventive treatment in infants with sulfadoxine-pyrimethamine (IPTi-SP) reduces malaria episodes by 20 to 59% across Africa. This protective efficacy, however, may be affected by the high frequency of malnutrition in African infants. We analyzed the impact of malnutrition as defined by anthropometry on the incidence of malaria and on the protective efficacy of IPTi in a cohort of 1,200 children in northern Ghana, where malaria is hyperendemic. These children received IPTi-SP or placebo at 3, 9, and 15 months of age and were monitored until 24 months of age. Malnutrition was present in 32, 40, and 50% of children at ages 3, 9, and 15 months, respectively. It was associated with increased risks of severe anemia and death but not an increased risk of malaria. Although malaria slightly contributed to chronic malnutrition, IPTi did not substantially improve child growth. Importantly, the protective efficacies of IPTi in malnourished children were roughly half or even less of those observed in nonmalnourished children. In the first year of life, IPTi reduced the incidence of malaria to a significantly lesser extent in infants who received both doses in a malnourished condition (25%; 95% confidence interval [CI], −7 to 48%) compared to that of nonmalnourished children (46%; 95% CI, 30 to 58%; P = 0.049). Moreover, in contrast to nutritionally advantaged children, the rate of severe malaria appeared to be increased in malnourished children who took IPTi. IPTi might exhibit reduced efficacy in regions of abundant malnutrition. Concomitant nutrition programs may be needed in these places to achieve the desired impact.

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PECULIARITIES OF DIAGNOSTICS AND TREATMENT OF PARAPROCTITIS IN CHILDREN

Russian Journal of Pediatric Surgery ◽

10.18821/1560-9510-2020-24-1-29-34 ◽

2020 ◽

Vol 24 (1) ◽

pp. 29-34

Author(s):

A. I. Kuzmin ◽

A. G. Munin ◽

M. A. Barskaya ◽

M. I. Terekhina ◽

Vladislav A. Zavyalkin ◽

...

Keyword(s):

Ultrasound Examination ◽

Fistula Formation ◽

First Year ◽

Perianal Area ◽

Anal Glands ◽

Surgical Infection ◽

Intestinal Dysbiosis ◽

One Step ◽

First Year Of Life ◽

The Impact

Relevance. Children with acute and chronic paraproctitis constitute 1-3% of hospitalized subjects with purulent surgical infection. Purpose. To study specific features of paraproctitis in children and to analyze outcomes of treatment. Material and methods. Case-histories of 218 children with acute and chronic paraproctitis were analyzed. Microbiological culture for pathogen identification was taken from paraproctitis focus, breast milk, from feces for conditionally pathogenic flora. The researchers also studied anamnesis, type of feeding, results of ultrasound examination of the perianal area and histological test of the material taken during surgery. Results. Patients with subcutaneous and subcutaneous-submucous paraproctitis constituted 95.5% [1]. The majority of patients with subcutaneous and subcutaneous-submucous paraproctitis - up to 62,5% - were children of the first 6 months of their life. The researchers defined age and etiopathogenic aspects of paraproctitis in children; the impact of provoking factors at acute paraproctitis as well as the specificity of chronic paraprocitis course and its treatment. 76 patients with acute paraproctitis had bottle and mixed feeding for the first 6 months of their life with further developed intestinal dysbiosis. In 112 children, conditionally pathogenic microorganisms were identified in 91 (81,2%) at the first year of their life. Ultrasound examination was sensitive for acute and chronic paraproctitis in about 90% [2, 3]. With the developed intestinal dysbiosis and immunological features of children at their first year of life , the process of acute paraproctitis was caused by the causal anal crypt and abnormal ducts of anal glands. It is considered to be the first step in fistula formation (fistulous abscess) [4-6]. The Gabriel surgery performed in acute paraproctitis was pathogenically verified because due to it one of the pathogenic steps was erradicated- pararectal fistula formation [7-11]. Disease relapse (pararectal fistula) was met in 7 patients. In average, hospitalization lasted for 7.1 days in acute paraproctitis and 8.4 in chronic paraproctitis. Conclusion. On analyzing etiopahogenic features of acute subcutaneous and subcutaneous-submucous paraproctitis, the authors recommend to perform a one-step surgical intervention.

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