scholarly journals Age and Gender-Specific Reference Intervals for Uric Acid Level in Children Aged 5–14 Years in Southeast Zhejiang Province of China: Hyperuricemia in Children May Need Redefinition

2021 ◽  
Vol 9 ◽  
Author(s):  
Chengjun Dai ◽  
Chaoban Wang ◽  
Fangqin Xia ◽  
Zishuo Liu ◽  
Yiqi Mo ◽  
...  
Keyword(s):  
Uric Acid ◽  
Linear Regression ◽  
Uric Acid Level ◽  
Acid Level ◽  
Linear Regression Analysis ◽  
Age Groups ◽  
Multiple Linear Regression Analysis ◽  
Reference Intervals ◽  
Specific Reference ◽  
Uric Acid Concentration

Context: Hyperuricemia is defined when the plasma uric acid concentration is above 416 μmol/L (7 mg/dl) in male adults, or 357 μmol/L (6 mg/dl) in female adults. However, there are no explicit criteria yet for children.Objective: It is necessary to set up reference intervals for the uric acid level in different age groups among children.Materials and Methods: A total of 5,439 individuals (3,258 males, 2,181 females) were included in the final statistical analysis. Reference values of all age groups were determined by statistical descriptions. Multiple linear regression analysis was applied to determine the relationship between uric acid level, BMI, and age.Results: The level of uric acid increased with age. Gender differences in uric acid level occurred after the onset of puberty. Additionally, linear regression revealed a positive correlation between the uric acid level and BMI.Discussion and Conclusion: The reference range of the uric acid level in children is inconsistent with the previous viewpoint. Body mass index plays an important role in uric acid metabolism.

scholarly journals Prevalence of asymptomatic hyperuricemia and its association with prediabetes, dyslipidemia and subclinical inflammation markers among young healthy adults in Qatar

2022 ◽  
Vol 22 (1) ◽  
Author(s):  
Yasemin Al Shanableh ◽  
Yehia Y. Hussein ◽  
Abdul Haseeb Saidwali ◽  
Maryam Al-Mohannadi ◽  
Budoor Aljalham ◽  
...  
Keyword(s):  
Young Adults ◽  
Uric Acid ◽  
Linear Regression ◽  
Multiple Linear Regression ◽  
Correlation Coefficient ◽  
Uric Acid Level ◽  
Acid Level ◽  
Linear Regression Analysis ◽  
Subclinical Inflammation ◽  
Cross Sectional

Abstract Aim The aim of this study is to investigate the prevalence of asymptomatic hyperuricemia in Qatar and to examine its association with changes in markers of dyslipidemia, prediabetes and subclinical inflammation. Methods A cross-sectional study of young adult participants aged 18 - 40 years old devoid of comorbidities collected between 2012 and 2017. Exposure was defined as uric acid level, and outcomes were defined as levels of different blood markers. De-identified data were collected from Qatar Biobank. T-tests, correlation tests and multiple linear regression were all used to investigate the effects of hyperuricemia on blood markers. Statistical analyses were conducted using STATA 16. Results The prevalence of asymptomatic hyperuricemia is 21.2% among young adults in Qatar. Differences between hyperuricemic and normouricemic groups were observed using multiple linear regression analysis and found to be statistically and clinically significant after adjusting for age, gender, BMI, smoking and exercise. Significant associations were found between uric acid level and HDL-c p = 0.019 (correlation coefficient -0.07 (95% CI [-0.14, -0.01]); c-peptide p = 0.018 (correlation coefficient 0.38 (95% CI [0.06, 0.69]) and monocyte to HDL ratio (MHR) p = 0.026 (correlation coefficient 0.47 (95% CI [0.06, 0.89]). Conclusions Asymptomatic hyperuricemia is prevalent among young adults and associated with markers of prediabetes, dyslipidemia, and subclinical inflammation.

scholarly journals Prevalence of Asymptomatic Hyperuricemia and its Association with Prediabetes, Dyslipidemia and Subclinical Inflammation Markers among Young Healthy Adults in Qatar

2021 ◽  
Author(s):  
Yasemin Al Shanableh ◽  
Yehia Y. Hussein ◽  
Abdul Haseeb Said Wali ◽  
Maryam Al-Mohannadi ◽  
Budoor Aljalham ◽  
...  
Keyword(s):  
Young Adults ◽  
Uric Acid ◽  
Linear Regression ◽  
Multiple Linear Regression ◽  
Correlation Coefficient ◽  
Uric Acid Level ◽  
Acid Level ◽  
Linear Regression Analysis ◽  
Subclinical Inflammation ◽  
Cross Sectional

Aim: To investigate the prevalence of asymptomatic hyperuricemia in Qatar and to examine its association with changes in markers of dyslipidemia, prediabetes and subclinical inflammation. Methods: A cross-sectional study of young adult participants aged 18 - 40 years old devoid of comorbidities. Exposure was defined as uric acid level, and outcomes were defined as levels of different blood markers. De-identified data were collected from Qatar BioBank. T-tests, correlation tests and multiple linear regression were all used to investigate the effects of hyperuricemia on blood markers. Statistical analyses were conducted using STATA 16. Results: The prevalence of asymptomatic hyperuricemia is 21.2% among young adults in Qatar. Differences between hyperuricemic and normouricemic groups were observed using multiple linear regression analysis and found to be statistically and clinically significant after adjusting for age, gender, BMI, smoking and exercise. Significant associations were found between uric acid level and HDL-c p = 0.019 (correlation coefficient -0.07 (95% CI [-0.14, -0.01]); c-peptide p = 0.018 (correlation coefficient 0.38 (95% CI [0.06, 0.69]) and monocyte to HDL ration (MHR) p = 0.026 (correlation coefficient 0.47 (95% CI [0.06, 0.89]). Conclusion: Asymptomatic hyperuricemia is prevalent among young adults and associated with markers of prediabetes, dyslipidemia, and subclinical inflammation.

scholarly journals Age- and sex-specific reference intervals for blood urea nitrogen in Chinese general population

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Qingquan Liu ◽  
Yiru Wang ◽  
Zhi Chen ◽  
Xiaolin Guo ◽  
Yongman Lv
Keyword(s):  
Blood Urea Nitrogen ◽  
Linear Regression Analysis ◽  
Reference Value ◽  
Multiple Linear Regression Analysis ◽  
Reference Intervals ◽  
Specific Reference ◽  
Cross Sectional ◽  
Urea Nitrogen ◽  
Specific Distribution ◽  
Age And Sex

AbstractBlood urea nitrogen (BUN) is a nitrogenous end product of protein metabolism. This study aims to explore the age- and sex-specific distribution of BUN among healthy Chinese adults. A total of 24,006 BUN values from healthy adults (14,148 males and 9858 females) were included in the cross-sectional study. Males had a higher median BUN value compared to females (4.6 mmol/L vs. 4.1 mmol/L). BUN values showed a positive correlation with body mass index (BMI), cholesterol, and blood sugar (P < 0.0001). However, eGFR showed a negative correlation with the BUN reference value (P < 0.0001) in both sexes. Multiple linear regression analysis confirmed that the positive associations of BUN levels and age were statistically significant after adjusting confounding factors (P < 0.001). Thus, the serum BUN values increased by 0.21 mmol/L for males and 0.282 mmol/L for females per 10 years. The BUN values corresponding to the 1st, 2.5th, 50th, 97.5th, and 99th percentiles for any specific age in both sex were also calculated. These results indicate that the serum BUN reference value is significantly affected by age and gender, and thus, its interpretation is age- and sex-dependent.

scholarly journals Uric Acid Provides Protective Role in Red Blood Cells by Antioxidant Defense: A Hypothetical Analysis

2019 ◽  
Vol 2019 ◽  
pp. 1-12 ◽  
Author(s):  
Yunxiao Song ◽  
Li Tang ◽  
Jianping Han ◽  
Yanting Gao ◽  
Binghua Tang ◽  
...  
Keyword(s):  
Uric Acid ◽  
Linear Regression ◽  
Linear Regression Analysis ◽  
Hemoglobin Concentration ◽  
Multiple Linear Regression Analysis ◽  
Protective Role ◽  
Normal Male ◽  
Mean Corpuscular Hemoglobin ◽  
Corpuscular Hemoglobin ◽  
Cross Sectional

Uric acid (UA) is a major antioxidant molecule in the human blood, and it has been linked with cell longevity. However, it is unclear whether serum UA levels are associated with red blood cell (RBC) indexes. This cross-sectional study included 10,759 Chinese subjects, recruited from the Shanghai Xuhui Central Hospital from January 2014 to December 2017. The participants were categorized into gender groups and then further divided into three different subgroups according to their UA reference range as follows: low (male (UA<0.202 mmol/l), female (UA<0.143 mmol/l)), normal (male (0.417 mmol/l>UA≥0.202 mmol/l), female (0.339 mmol/l>UA≥0.143 mmol/l)), and high (male (UA≥0.417 mmol/l), female (UA≥0.339 mmol/l)). The associations of UA levels with RBC parameters were analyzed using 1-way ANOVA, Pearson correlations, and multivariate linear regression. The levels of mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, RBCs, and hemoglobin were lowest in the low UA group, followed by the normal UA group and high UA group (p<0.001). Pearson analysis showed that there was a statistically significant correlation between UA levels with mean corpuscular hemoglobin, mean corpuscular hemoglobin concentrations, mean corpuscular volumes, RBC counts, and hemoglobin (p<0.05). Multiple linear regression analysis suggested that there were statistically significant positive correlations between UA levels and RBC counts (B=0.245, p<0.001, 95% CI=0.003 to 0.092), as well as UA levels and hemoglobin concentrations (B=0.138, p<0.001, 95% CI=0.002 to 0.082). Furthermore, similar results were observed in both the male and female subgroups. The serum UA levels may be independently associated with RBC parameters, regardless of sex, and UA may protect RBCs owing to its antioxidant effect.

scholarly journals Serum uric acid levels in acute myocardial infarction

2017 ◽  
Vol 4 (4) ◽  
pp. 1010
Author(s):  
Padma V. ◽  
Amogh Banupriya
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Uric Acid Concentration ◽  
Killip Class ◽  
Serum Uric Acid Concentration

Background: Higher uric acid is a negative prognostic factor in patients with mild to severe heart failure. Studies have shown that there is a close correlation between serum uric acid concentration and Killip classification in patients of acute myocardial infarction and uric acid levels are higher in patients with higher Killips class.Methods: We studied 100 patients with acute myocardial infarction and compared with 100 controls. Serum uric acid level was measured on day 0, 3 and 7 of MI and results were analysed.Results: Average uric acid level in male cases was 5.6 and female cases was 5.2, male controls were 4.2 and female controls was 3.6. Females had a higher mortality when compared with male patients. One female died due to MI on day 0, one male and two females died on day 3 and four males and four females died on day 7. All patients who died had higher uric acid levels.Conclusions: Serum uric acid levels are higher in patients of acute myocardial infarction as compared to normal healthy persons. Serum uric levels increases in patients with higher Killip class. Combination of Killip class and serum uric acid level after acute myocardial infarction is a good predictor of mortality after acute myocardial infarction.

scholarly journals Correlation Analysis of Ocular Symptoms and Signs in Patients with Dry Eye

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Hang Song ◽  
Mingzhou Zhang ◽  
Xiaodan Hu ◽  
Kaixiu Li ◽  
Xiaodan Jiang ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Linear Regression ◽  
Correlation Analysis ◽  
Multiple Linear Regression ◽  
Dry Eye ◽  
Ocular Surface ◽  
Linear Regression Analysis ◽  
Age Groups ◽  
Multiple Linear Regression Analysis ◽  
Main Duct

Purpose. To analyze the correlations between the ocular surface signs and symptoms in patients with dry eye.Methods.In this observational study, 176 dry eye patients, including 60 males and 116 females, were enrolled and their dry eye symptoms and ocular signs were observed. Partial correlation analysis was conducted between OSDI score and each ocular surface sign, and the correlations were further discussed in different age groups. Then multiple linear regression analysis was used to further explore the influence of these signs on OSDI score.Results. Our correlation analyses showed that rounding of lid margins, notching of lid margins, vascularity of lid margins, hyperkeratinization, plugging of orifices, main duct dropout, and conjunctival congestion all had a positive correlation with OSDI score, while main duct number (central 1 cm) and BUT had a negative one. Further analysis suggested that these correlations varied in different age groups. Multiple linear regression analysis indicated that main duct number (central 1 cm), rounding of lid margins, and hyperkeratinization significantly affected OSDI score.Conclusions. Close attention should be paid to the morphology and structure of the eyelid margin and the function of meibomian gland in the diagnosis, treatment, and follow-up of dry eye diseases.

Trimester-Specific Reference Intervals of Serum Urea, Creatinine, and Uric Acid Among Healthy Pregnant Women in Zhengzhou, China

2020 ◽  
Author(s):  
Yuhua Gao ◽  
Jia Jia ◽  
Xianan Liu ◽  
Shuren Guo ◽  
Liang Ming
Keyword(s):  
Uric Acid ◽  
Kidney Disease ◽  
Pregnant Women ◽  
Age Groups ◽  
Serum Levels ◽  
Reference Intervals ◽  
Specific Reference ◽  
Serum Urea ◽  
Age Related ◽  
In Pregnancy

Abstract Objective To verify the differences in serum levels of urea, creatinine, and uric acid (UA) between pregnant and nonpregnant women and establish specific reference intervals of serum urea, creatinine, and UA for pregnant women, and thus help for the detection of kidney disease in pregnancy. Methods Based on the selection criteria, 1312 apparently healthy pregnant women and 1301 nonpregnant women were enrolled in this study. The levels of serum urea, creatinine, and UA were compared between the pregnant and nonpregnant women. The differences in the 3 indicators among different age groups and trimesters in pregnant women were studied. Finally, reference intervals were established by nonparametric methods according to the recommendation of Clinical and Laboratory Standards Institute guideline C28-A3. Results Compared with nonpregnant women, pregnant women had a significantly lower level of serum urea, creatinine, and UA (all P &lt;.01), and no significant age-related differences in the 3 indicators were observed among the pregnant women (P &gt;.05). However, the levels of these indicators were significantly different among the 3 trimesters (all P &lt;.01 or P =.01). Accordingly, trimester-specific reference intervals of serum urea (1.6–4.4 mmol/L; 1.6–4.2 mmol/L; 1.6–4.4 mmol/L), creatinine (36–68 μmol/L; 34–66 μmol/L; 36–68 μmol/L), and UA (122–297 μmol/L; 129–327 μmol/L; 147–376 μmol/L) for trimesters 1, 2, and 3, respectively, were established. Conclusion These newly established reference intervals will be valuable for the detection and monitoring of kidney disease in pregnancy.

scholarly journals Age- and sex-dependent reference intervals for uric acid estimated by the truncated minimum chi-square (TMC) approach, a new indirect method

2020 ◽  
Vol 44 (3) ◽  
pp. 157-163
Author(s):  
Rainer Haeckel ◽  
Werner Wosniok ◽  
Antje Torge ◽  
Ralf Junker
Keyword(s):  
Uric Acid ◽  
Diurnal Variation ◽  
Acid Concentration ◽  
Metabolic Diseases ◽  
Age Groups ◽  
Reference Interval ◽  
Reference Intervals ◽  
Uric Acid Concentration ◽  
Chi Square ◽  
Age And Sex

Abstract Background Although the concentration of uric acid in serum or plasma is known to depend on sex and age and is subject to diurnal variation, the influence of these covariates on the reference interval (RI) is often neglected. Consequently, the values in the literature vary considerably. Therefore, we reinvestigated the reference limits and their dependence on covariates. Methods A new indirect approach was applied which derives a continuous function between age and RIs avoiding the usual “jumps” between various age groups. Results It is confirmed that the uric acid concentration in women is lower than in men. The RIs increase with age, in women more than in men. Between 80 and 90 years of age, the upper RI limit (RL) approximately reaches the same level in both sexes. Because the uric acid concentration may indicate renal insufficiency, the concentrations of creatinine and cystatin C were also measured. Both measurands showed the same behaviour as uric acid. Therefore, the age and sex dependency should be considered if the uric acid concentration is used as an indicator for hyperuricaemia (e.g. caused by gout or other metabolic diseases). Furthermore, a diurnal variation was observed. Conclusions Due to the variations of various covariates (age, sex, daytime, analytical systems), it is recommended that each laboratory should estimate its own RIs.

PENGARUH FAKTOR-FAKTOR INTERNAL PERBANKAN TERHADAP NON PERFORMING FINANCING PADA BANK UMUM SYARIAH

2019 ◽  
Vol 6 (2) ◽  
pp. 115-130
Author(s):  
Eka Ambara Harci Putranta ◽  
Lilik Ambarwati
Keyword(s):  
Linear Regression ◽  
Multiple Linear Regression ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Capital Adequacy ◽  
Annual Reports ◽  
Regression Methods ◽  
Capital Adequacy Ratio ◽  
Negative Effect ◽  
Independent Variable

The study aims to analyze the influence of internal banking factors in the form of: Capital Adequency Ratio (CAR), Financing to Deposit Ratio (FDR) and Total Assets (TA) to Non Performing Financing at Sharia Banks. This research method used multiple linear regression analysis with the help of SPSS 16.00 software which is used to see the influence between the independent variables in the form of Capital Adequacy Ratio (CAR), Financing to Deposit Ratio (FDR) and Total Assets (TA) to Non Performing Financing. The sample of this study was 3 Islamic Commercial Banks, so there were 36 annual reports obtained through purposive sampling, then analyzed using multiple linear regression methods. The results showed that based on the F Test, the independent variable had an effect on the NPF, indicated by the F value of 17,016 and significance of 0,000, overall the independent variable was able to explain the effect of 69.60%. While based on the partial t test, showed that CAR has a significant negative effect, Total assets have a significant positive effect with a significance value below 0.05 (5%). Meanwhile FDR does not affect NPF.

ANALISIS PENGARUH INFLASI, KURS DAN IHSG TERHADAP RETURN REKSA DANA SAHAM PT NIKKO SECURITIES INDONESIA PERIODE 2014-2017

2019 ◽  
Vol 2 (2) ◽  
pp. 103
Author(s):  
Muhammad Rois Rois ◽  
Manarotul Fatati Fatati ◽  
Winda Ihda Magfiroh
Keyword(s):  
Regression Analysis ◽  
Exchange Rate ◽  
Linear Regression ◽  
Multiple Linear Regression ◽  
Stock Price ◽  
Price Index ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Equity Fund ◽  
Stock Price Index

This study aims to determine the effect of Inflation, Exchange Rate and Composite Stock Price Index (IHSG) to Return of PT Nikko Securities Indonesia Stock Fund period 2014-2017. The study used secondary data obtained through documentation in the form of PT Nikko Securities Indonesia Monthly Net Asset (NAB) report. Data analysis is used with quantitative analysis, multiple linear regression analysis using eviews 9. Population and sample in this research are PT Nikko Securities Indonesia. The result of multiple linear regression analysis was the coefficient of determination (R2) showed the result of 0.123819 or 12%. This means that the Inflation, Exchange Rate and Composite Stock Price Index (IHSG) variables can influence the return of PT Nikko Securities Indonesia's equity fund of 12% and 88% is influenced by other variables. Based on the result of the research, the variables of inflation and exchange rate have a negative and significant effect toward the return of PT Nikko Securities Indonesia's equity fund. While the variable of Composite Stock Price Index (IHSG) has a negative but not significant effect toward Return of Equity Fund of PT Nikko Securities Indonesia

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