scholarly journals Case Report: Clinical Analysis of Fulminant Mycoplasma pneumoniae Pneumonia in Children

2021 ◽  
Vol 9 ◽  
Author(s):  
Tongqiang Zhang ◽  
Chunjiao Han ◽  
Wei Guo ◽  
Jing Ning ◽  
Chunquan Cai ◽  
...  
Keyword(s):  
Mycoplasma Pneumoniae ◽  
Early Identification ◽  
Distress Syndrome ◽  
Underlying Disease ◽  
Clinical Analysis ◽  
Multiple Organ ◽  
Plastic Bronchitis ◽  
Younger Age ◽  
Mycoplasma Pneumoniae Pneumonia

Fulminant Mycoplasma pneumoniae pneumonia (FMPP) accounts for 0.5–2% of all MPP cases, which is considered as MPP combined with severe complications such as hypoxemia, acute respiratory distress syndrome, or acute respiratory failure. It primarily affects young adults with no underlying disease. Although some studies have proved the severity of FMPP, the details about clinical diagnosis and treatment of FMPP in children have been rarely reported. In this case study, we described three cases who suffered from FMPP. These children not only developed acute lung injury and multiple organ involvement within 7 days of treatment, but were also found plastic bronchitis by bronchoscopy. Finally, all the patients were treated successfully with azithromycin, glucocorticoid, and bronchoscopy lavage. We conclude that this case study would contribute to raise awareness with respect to FMPP, which may occur at a younger age with faster disease progression and common extrapulmonary manifestations. It also reinforces the importance of early identification and prompt intervention to save life of children and reduces sequelae. Further studies are needed about mechanism of FMPP.

scholarly journals Pranic Healing as a Complimentary Therapy in averting Multiple Organ Failure: A Case Report

2019 ◽  
Author(s):  
ANURADHA NITTUR ◽  
Rajesh Srivastava
Keyword(s):  
Case Report ◽  
Multiple Organ Failure ◽  
Organ Failure ◽  
Distress Syndrome ◽  
Conventional Medicine ◽  
Multiple Organ ◽  
Ventilator Support ◽  
Energy Therapy ◽  
Multiple Diagnosis

The case report has been presented to demonstrate the response to Pranic Healing intervention by a patient with Acute Respiratory Distress Syndrome (ARDS), heading towards multiple organ failure, triggered by secondary haemophagocyticlymphohistiocytosis (HLH)The29 yr old patient had been on ventilator support, immunocompromised and in a critical state with multiple diagnosis and multiple hospitalizations for nearly eight months. He had stopped responding to conventional medicine and acupuncture. Complimentary Therapy in the form of Pranic Healing, a no touch, no drug energy therapy was provided to the patient for three months. Pranic Healing along with standardised medical care helped the patient recover rapidly and he was discharged within six weeks of starting Pranic Healing therapy. The case study provides a promising example of Pranic Healing intervention in averting multiple organ failure and promoting regeneration of vital organs.

scholarly journals A Child of Severe Mycoplasma pneumoniae pneumonia with Multiple Organ Failure Treated with ECMO and CRRT

2019 ◽  
Vol 26 (1) ◽  
pp. 71
Author(s):  
Woojin Hwang ◽  
Yoonjin Lee ◽  
Eunjee Lee ◽  
Jiwon M. Lee ◽  
Hong Ryang Kil ◽  
...  
Keyword(s):  
Multiple Organ Failure ◽  
Organ Failure ◽  
Mycoplasma Pneumoniae ◽  
Multiple Organ ◽  
Mycoplasma Pneumoniae Pneumonia

Clinical, radiographic and hematological characteristics of Mycoplasma pneumoniae pneumonia

2010 ◽  
Vol 0 (0) ◽  
Author(s):  
Letícia Alves Vervloet ◽  
Paulo Augusto Moreira Camargos ◽  
Damião Ranulfo Fernandes Soares ◽  
Gabriel Antônio de Oliveira ◽  
Janúncio Nunes de Oliveira
Keyword(s):  
Mycoplasma Pneumoniae ◽  
Mycoplasma Pneumoniae Pneumonia

scholarly journals Macrolide-Resistant and Macrolide-Sensitive Mycoplasma pneumoniae Pneumonia in Children Treated Using Early Corticosteroids

2021 ◽  
Vol 10 (6) ◽  
pp. 1309
Author(s):  
Hye Young Han ◽  
Ki Cheol Park ◽  
Eun-Ae Yang ◽  
Kyung-Yil Lee
Keyword(s):  
Mycoplasma Pneumoniae ◽  
Serological Test ◽  
Corticosteroid Treatment ◽  
23S Rrna ◽  
Laboratory Parameters ◽  
The Mean ◽  
Domain V ◽  
Positive Results ◽  
Mycoplasma Pneumoniae Pneumonia

We have found that early corticosteroid therapy was effective for reducing morbidity during five Korea-wide epidemics. We evaluated the clinical and laboratory parameters of 56 children who received early corticosteroid treatment for pneumonia that was caused by macrolide-resistant Mycoplasma pneumoniae (M. pneumoniae) or macrolide-sensitive M. pneumoniae between July 2019 and February 2020. All subjects had dual positive results from a PCR assay and serological test, and received corticosteroids within 24–36 h after admission. Point mutation of residues 2063, 2064, and 2067 was identified in domain V of 23S rRNA. The mean age was 6.8 years and the male:female ratio was 1.2:1 (31:25 patients). Most of the subjects had macrolide-resistant M. pneumoniae (73%), and all mutated strains had the A2063G transition. No significant differences in clinical and laboratory parameters were observed between macrolide-resistant and macrolide-sensitive M. pneumoniae groups that were treated with early dose-adjusted corticosteroids. Higher-dose steroid treatment may be needed for patients who have fever that persists for >48 h or increased biomarkers such as lactate dehydrogenase concentration at follow-up despite a usual dose of steroid therapy.

scholarly journals Clinical characteristics of refractory mycoplasma pneumoniae pneumonia in children treated with glucocorticoid pulse therapy

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Zhenli Zhu ◽  
Tongqiang Zhang ◽  
Wei Guo ◽  
Yaoyao Ling ◽  
Jiao Tian ◽  
...  
Keyword(s):  
Clinical Features ◽  
Mycoplasma Pneumoniae ◽  
Pulse Therapy ◽  
Roc Curve Analysis ◽  
Related Factors ◽  
Laboratory Findings ◽  
Usage Rate ◽  
Group I ◽  
Group Ii ◽  
Mycoplasma Pneumoniae Pneumonia

Abstract Background To observe the effect of corticosteroids in the treatment of children with refractory Mycoplasma pneumoniae pneumonia (RMPP) under different doses, to summarize the clinical features of children treated with glucocorticoid pulse therapy. Methods The clinical data of 125 children with RMPP hospitalized in Tianjin Children’s Hospital from September 2018 to October 2019 were retrospectively analyzed. They were divided into two groups according to the dose of hormone. Compare the clinical features, laboratory findings, and imaging between the two groups, and use meaningful related indicators as ROC curves to find reference indicators for pulse therapy. Results (1) The median age of the group II was older than that of the group I(P < 0.05). (2) We found more severe presentations, higher incidence of extra-pulmonary complications and more serious radiological findings in group II, which needed oxygen more often, higher the hormone, higher usage rate of gamma globulin, higher usage rate of bronchoscopy, and higher incidence of plastic bronchitis(P < 0.05). (3) WBC, CRP, LDH, FER, D-D dimer, APTT, TT, PCT, IL-6 and the percentage of neutrophils in peripheral blood in Group II were higher than those in Group I(P < 0.05). (4) In ROC curve analysis, CRP, LDH, FER, and neutrophils of leukocyte classification were independent related factors that could be used as valuable predictors of methylprednisolone pulse therapy for RMPP in children. The cut-off values were CRP44.45 mg/L, LDH590IU/L, FER411ng/L, and neutrophils in leukocyte classification were 73.75%, respectively. Conclusion CRP ≥ 44.45 mg/L, LDH ≥ 590 IU/L, FER ≥ 411 ng/L, neutrophil≥73.75%, lung consolidation, and pleural effusion may be predictors that guide the treatment of RMPP with pulse dose of GC.

scholarly journals Microbiologic and Immunologic Evaluation of a Single High Dose of Azithromycin for Treatment of Experimental Mycoplasma pneumoniae Pneumonia

2005 ◽  
Vol 49 (9) ◽  
pp. 3970-3973 ◽  
Author(s):  
Ana María Ríos ◽  
Mónica Fonseca-Aten ◽  
Asunción Mejías ◽  
Susana Chávez-Bueno ◽  
Kathy Katz ◽  
...  
Keyword(s):  
Mycoplasma Pneumoniae ◽  
High Dose ◽  
Single High Dose ◽  
Cytokines And Chemokines ◽  
Lung Histopathology ◽  
Mycoplasma Pneumoniae Pneumonia

ABSTRACT We evaluated the efficacy of azithromycin therapy given as a single high dose or divided over 5 days for the treatment of mild experimental Mycoplasma pneumoniae pneumonia. Although both azithromycin regimens significantly reduced quantitative cultures, lung histopathology, and pulmonary cytokines and chemokines, there were no significant differences between the two regimens.

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