scholarly journals Case Report: Fatal Neurotoxicity Following Resmethrin Poisoning in a Child

2021 ◽  
Vol 9 ◽  
Author(s):  
Lilin Huang ◽  
Shumei Peng ◽  
Ronghan Li ◽  
Dongping Huang ◽  
Danyu Xie
Keyword(s):  
Fatal Case ◽  
Type I ◽  
Liquid Chromatography Mass Spectrometry ◽  
Increased Intracranial Pressure ◽  
Accidental Ingestion ◽  
Low Intensity ◽  
Cranial Ct ◽  
Csf Analysis ◽  
Brain Dead ◽  
Specific Symptoms

Resmethrin, a type I pyrethroid insecticide, can activate sodium channels, causing neurotoxicity in both mammals and insects. Possible routes of poisoning include inhalation, dermal contact and ingestion. There are no specific symptoms for resmethrin poisoning. Until now, no antidote has been available for resmethrin. Resmethrin poisoning is rarely reported in children. Here, we report a fatal case of resmethrin poisoning that might have been caused by accidental ingestion by a 26-month-old child. He presented with neurotoxic symptoms that included vomiting, recurrent seizures, and coma. The cranial CT showed extensive lesions of low intensity in the bilateral white matter, thalamus, brainstem, and cerebellum. Lumbar punctures showed increased intracranial pressure (ICP > 25 mmHg). Cerebrospinal fluid (CSF) tests revealed that protein was elevated to 289.2 mg/dL without pleocytosis. Resmethrin was detected in his blood by liquid chromatography-mass spectrometry, which confirmed the diagnosis of resmethrin poisoning. The child developed brain stem herniation and then was declared brain dead at the 77th h after admission. Resmethrin poisoning can be fatal, and it requires immediate diagnosis and treatment. Previous studies reported that cranial CT and CSF analyses were all normal in patients with pyrethroid poisoning. This case might extend the knowledge of neuroimaging and CSF analysis in children with resmethrin poisoning.

Effect of Early Low-Intensity Exercise on Rat Hind-Limb Muscles Following Acute Ischemic Stroke

2006 ◽  
Vol 7 (3) ◽  
pp. 163-174 ◽  
Author(s):  
Myoung-Ae Choe ◽  
Gyeong Ju An ◽  
Yoon-Kyong Lee ◽  
Ji Hye Im ◽  
Smi Choi-Kwon ◽  
...  
Keyword(s):  
Hind Limb ◽  
Gastrocnemius Muscle ◽  
Exercise Group ◽  
Cross Sectional Area ◽  
Type I ◽  
Sectional Area ◽  
Muscle Type ◽  
Cross Sectional ◽  
Low Intensity ◽  
Low Intensity Exercise

This study examined the effects of daily low-intensity exercise following acute stroke on mass, Type I and II fiber cross-sectional area, and myofibrillar protein content of hind-limb muscles in a rat model. Adult male Sprague-Dawley rats were randomly assigned to 1 of 4 groups (n = 7-9 per group): stroke (occlusion of the right middle cerebral artery [RMCA]), control (sham RMCA procedure), exercise, and stroke-exercise. Beginning 48 hours post-stroke induction/sham operation, rats in the exercise group had 6 sessions of exercise in which they ran on a treadmill at grade 10 for 20 min/day at 10 m/min. At 8 days poststroke, all rats were anesthetized and soleus, plantaris, and gastrocnemius muscles were dissected from both the affected and unaffected sides. After 6 sessions of exercise following acute ischemic stroke, the stroke-exercise group showed the following significant (p < .05) increases compared to the stroke-only group: body weight and dietary intake, muscle weight of affected soleus and both affected and unaffected gastrocnemius muscle, Type I fiber cross-sectional area of affected soleus and both affected and unaffected gastrocnemius muscle, Type II fiber cross-sectional area of the unaffected soleus, both affected and unaffected plantaris and gastrocnemius muscle, Type II fiber distribution of affected gastrocnemius muscle, and myofibrillar protein content of both affected and unaffected soleus muscle. Daily low-intensity exercise following acute stroke attenuates hind-limb muscle atrophy in both affected and unaffected sides. The effects of exercise are more pronounced in the soleus and gastrocnemius as compared to the plantaris muscle.

Effects of a Brief Transdiagnostic Cognitive Behavioural Group Therapy on Disorder Specific Symptoms

2018 ◽  
Vol 47 (1) ◽  
pp. 1-15 ◽  
Author(s):  
Hafrún Kristjánsdóttir ◽  
Baldur Heiðar Sigurðsson ◽  
Paul Salkovskis ◽  
Engilbert Sigurðsson ◽  
Magnús Blöndahl Sighvatsson ◽  
...  
Keyword(s):  
Anxiety Disorders ◽  
Treatment Effects ◽  
Mental Health Problems ◽  
Effect Sizes ◽  
Low Intensity ◽  
Cognitive Behavioural ◽  
Wide Range ◽  
Common Mental Health Problems ◽  
Specific Symptoms ◽  
Group Therapies

Background:In recent years, cognitive behavioural group therapies (CBGT) have been increasingly deployed as a strategy to increase the efficiency and cost-effectiveness in treatment of common mental health problems. The vast majority of these therapies are disorder specific, but in the last few years there has been growing interest in transdiagnostic CBGT.Aims:The aim of this study was twofold: to evaluate the treatment effects of transdiagnostic CBGT on disorder specific symptoms and what (if any) differences would be observed in the treatment effects with regard to general as opposed to disorder specific symptoms measured pre- and post-treatment.Method:The participants were 233 adult patients diagnosed with depression and/or anxiety disorders. They underwent a 6-week transdiagnostic CBGT. To compare treatment effects on general and disorder specific symptoms, raw scores on all measures were converted to standardized scores.Results:Pre–post differences were significant and there was no evidence that treatment was differentially effective for general and disorder specific symptoms. Effect sizes ranged from medium to large.Conclusion:The 6-week transdiagnostic CBGT is feasible for a wide range of mood and anxiety disorders. The results indicate that low-intensity transdiagnostic group therapies may have similar effects on both general and disorder specific symptoms.

scholarly journals Comparison of Treatment Results for Mallet Finger Fractures in Children Between Low-Intensity Pulsed Ultrasound Stimulation and Ishiguro’s Method

Hand ◽  
2017 ◽  
Vol 13 (1) ◽  
pp. 80-85 ◽  
Author(s):  
Tsuyoshi Ota ◽  
Soichiro Itoh ◽  
Yoshihiko Matsuyama
Keyword(s):  
Articular Surface ◽  
Type I ◽  
Mallet Finger ◽  
Pulsed Ultrasound ◽  
Treatment Results ◽  
Low Intensity Pulsed Ultrasound ◽  
Low Intensity ◽  
Fractures In Children ◽  
Mallet Fracture ◽  
Pin Fixation

Background: We compared the treatment results for displaced mallet finger fractures in children between low-intensity pulsed ultrasound (LIPUS) stimulation and Ishiguro’s method, which involves extension block and arthrodesis of the distal interphalangeal (DIP) joint with pinning. Methods: Eleven cases (5 females and 6 males; average age, 13.5 years) of mallet finger were operated with Ishiguro’s method, and 8 cases (3 females and 5 males; average age, 13.0 years) were treated with LIPUS stimulation. Lateral radiographs were used to determine the distance of fragment displacement and the percentage of the articular surface involved in the fragments. Functional outcomes in flexion and extension and those estimated using Crawford’s evaluation criteria at the final visits were assessed in each group. Results: The duration needed for fracture healing was longer, however, active extension and flexion of the DIP joint were significantly larger in the LIPUS group compared with those in the pinning group. Functional recovery was excellent in all cases in the LIPUS group; however, recovery was good in 3 cases and excellent in 8 cases in the pinning group. Extension of the DIP joint was significantly larger when pins were removed in 35 or lesser days postoperatively compared with cases in which pin fixation was continued for more than 35 days. Conclusions: LIPUS therapy may be recommended as an option to treat type I mallet finger in children for whom initiation of treatment was delayed up to 8 weeks. When Ishiguro’s method is applied to the displaced mallet fracture in children, arthrodesis of the DIP joint for more than 5 weeks should be avoided to prevent flexion contracture.

scholarly journals Results of surgical treatment of patients with basilar invagination associated with type I Chiari malformation

2021 ◽  
Vol 23 (1) ◽  
pp. 83-90
Author(s):  
D. S. Epifanov ◽  
V. B. Lebedev ◽  
A. A. Zuev
Keyword(s):  
Surgical Treatment ◽  
Clinical Picture ◽  
Chiari Malformation ◽  
Neurological Status ◽  
Craniovertebral Junction ◽  
Basilar Invagination ◽  
Type I ◽  
Posterior Decompression ◽  
National Medical ◽  
Specific Symptoms

Introduction. Each of the pathologies is rare and can lead to compression of the brainstem and spinal cord, with the development of a “mixed” clinical picture. The tactics of treating such patients differs from one author to another.The objective is to present the author’s experience in treating patients with basilar invagination associated with type I Chiari malformation and to analyze the literature on the methods of surgical treatment of this pathology.Materials and methods. From 2014 to 2019, 3 patients with a basilar invagination and type I Chiari malformation were surgically treated at the N. I. Pirogov National Medical and Surgical Center. Indications for surgical intervention were long-term progressive neurological disorders, lack of effect from conservative therapy. Patients underwent anterior transnasal and posterior decompression of nerve structures followed by stabilization.Results. All patients were evaluated 12 months after surgery. All patients in neurological status showed positive dynamics. According to magnetic resonance imaging of the craniovertebral junction, 2 patients showed positive dynamics: regression of the myelopathy, a decrease in the diameter of the syringomyelic cyst.Conclusion. The criteria for anterior transnasal decompression are the predominance of bulbar disorders and / or paresis in the extremities in the clinical picture; posterior decompression of nerve structures, indicated in the presence of specific symptoms of type I Chiari malformation and / or syringomyelia. Taking into account the results of the latest published studies it can be assumed that stabilization is a necessary option in the treatment of patients with this pathology.

Esquizencefalia bilateral gigante de labio abierto

2022 ◽  
Vol 30 (3) ◽  
pp. 95-99
Author(s):  
Karina Sarango-Amay ◽  
Alberth Muñoz-Gualan
Keyword(s):  
Cerebral Cortex ◽  
Intracranial Pressure ◽  
Male Patient ◽  
In Utero ◽  
Type I ◽  
Type Ii ◽  
Brain Malformation ◽  
Increased Intracranial Pressure ◽  
Congenital Brain Malformation

Schizencephaly is a rare congenital brain malformation characterized by clefts in the cerebral cortex, it is classified in Type I (open lip) and Type II (close-lip). Patients with schizencephaly present seizures, hydrocephalus, motor and mental deficits. Ultrasound is used for in-utero and newborns patients’ diagnosis, and MRI or CT for already born patients. The management of schizencephaly is conservative, with rehabilitation in motor or mental deficits, medication or surgery for seizures and shunt in hydrocephalus with increased intracranial pressure. In the literature, only few giant bilateral cases have been reported. We report a case of giant bilateral open lip schizencephaly, in a 10-day old male patient, presenting with mild hypotonia and no seizures. This case is rare because the relatively benign features compared to other reported cases.

Contractile function and low-intensity exercise effects of old dystrophic (mdx) mice

1998 ◽  
Vol 274 (4) ◽  
pp. C1138-C1144 ◽  
Author(s):  
Alan Hayes ◽  
David A. Williams
Keyword(s):  
Muscular Dystrophy ◽  
Contractile Function ◽  
Weight Bearing ◽  
Contractile Properties ◽  
Mdx Mice ◽  
Type I ◽  
Dystrophic Muscle ◽  
Low Intensity ◽  
Duchenne's Muscular Dystrophy ◽  
Low Intensity Exercise

Old mdx mice display a severe myopathy almost identical to Duchenne’s muscular dystrophy. This study examined the contractile properties of old mdxmuscles and investigated any effects of low-intensity exercise. Isometric contractile properties of the extensor digitorum longus (EDL) and soleus muscles were tested in adult (8–10 mo) and old (24 mo, split into sedentary and exercised groups) mdx mice. The EDL and soleus from old mdx mice exhibited decreased absolute twitch and tetanic forces, and the soleus exhibited a >50% decrease in relative forces (13.4 ± 0.4 vs. 6.0 ± 0.9 N/cm2) compared with adult mice. Old mdx muscles also showed longer contraction times and a higher percentage of type I fibers. Normal and mdx mice completed 10 wk of swimming, but mdx mice spent significantly less time swimming than normal animals (7.8 ± 0.4 vs. 15.8 ± 1.1 min, respectively). However, despite their severe dystrophy, mdx muscles responded positively to the low-intensity exercise. Relative tetanic tensions were increased (∼25% and ∼45% for the EDL and soleus, respectively) after the swimming, although absolute forces were unaffected. Thus these results indicate that, even with a dystrophin-deficient myopathy, mdx muscles can still respond to low-intensity exercise. This study shows that the contractile function of muscles of old mdx mice displays many similarities to that of human dystrophic patients and provides further evidence that the use of non-weight-bearing, low-intensity exercises, such as swimming, has no detrimental effect on dystrophic muscle and could be a useful therapeutic aid for sufferers of muscular dystrophy.

scholarly journals How Not to Miss the Mild Forms of Mucopolysaccharidosis Type I in Patients With Articular Manifestations of the Disease?

2019 ◽  
Vol 17 (6) ◽  
pp. 473-479 ◽  
Author(s):  
Natalia V. Buchinskaya ◽  
Mikhail M. Kostik ◽  
Oksana L. Kolobova ◽  
Larisa N. Melnikova
Keyword(s):  
Joint Stiffness ◽  
Simple Algorithm ◽  
Type I ◽  
Mucopolysaccharidosis Type ◽  
Mucopolysaccharidosis Type I ◽  
Simple Test ◽  
Specific Symptom ◽  
Specific Symptoms ◽  
Rheumatological Diseases ◽  
Mps I

Mucopolysaccharidosis type I (MPS I) is a hereditary metabolic disease that manifests itself in childhood by systemic damage to tissues and organs, a constantly progressive course leading to disability. Diagnosis of mild forms of the disease is particularly difficult due to the absence of specific symptoms. A specific symptom of the mild forms of MPS I (as for other types of MPS) is joint stiffness in children combined with hernia, frequent infections, or valvular defects. Stiffness in MPS I is often interpreted as a manifestation of rheumatological diseases (arthrogriposis, juvenile idiopathic arthritis). The article offers a simple algorithm for diagnosing MPS I, which helps to eliminate the disease using a simple test for determining the activity of an enzyme called alpha-L-iduronidase in a dried blood spot.

scholarly journals Study protocol of the multi-centre, randomized controlled trial of the Frankfurt Early Intervention Program A-FFIP versus early intervention as usual for toddlers and preschool children with Autism Spectrum Disorder (A-FFIP study)

2019 ◽  
Author(s):  
Janina Kitzerow ◽  
Christine M. Freitag ◽  
Matthes Hackbusch ◽  
Katrin Jensen ◽  
Meinhard Kieser ◽  
...  
Keyword(s):  
Early Intervention ◽  
Social Communication ◽  
Intervention Program ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Early Intervention Program ◽  
Low Intensity ◽  
Randomized Controlled ◽  
One Year ◽  
Specific Symptoms

Abstract Background: Naturalistic developmental behavioural interventions (NDBI) have been shown to improve autism-specific symptoms in young children with Autism Spectrum Disorder (ASD). NDBI approaches, such as the ASD-specific Frankfurt Early Intervention Program for ASD (A-FFIP), are based on ASD-specific developmental and learning aspects. A-FFIP is a low-intensity intervention which can easily be implemented in the local health care / social welfare system. The aim of the present study is to establish one-year efficacy of the manualised early intervention program A-FFIP in toddlers and preschool children with ASD. It is hypothesized that A-FFIP will result in improved ASD-specific symptoms compared to early intervention as usual (EIAU). Child and family specific secondary outcomes, as well as moderators and mediators of outcome will be explored. Methods/design: A prospective multi-centre, parallel-group, randomized, controlled, phase-III trial comparing A-FFIP versus EIAU. A total of 134 children (A-FFIP: 67, EIAU: 67) aged 24–66 months at baseline assessment meeting criteria for ASD (DSM-5) will be included. The primary outcome is the absolute change of the total score of the Brief Observation of Social Communication Change (BOSCC-AT) between baseline (T2) and one-year follow-up (T6). The treatment effect will be tested adjusted for relevant covariates applying a mixed model for repeated measures. Secondary outcomes are BOSCC social communication and repetitive behaviour scores, single ASD symptoms, language, cognition, psychopathology, parental well-being and family quality of life. Predictors, moderators and mediating mechanisms will be explored. Discussion: If efficacy of the manualised A-FFIP early intervention is established, the current study has the potential to change clinical practice strongly towards the implementation of low-intensity, evidence based, natural early intervention in ASD. Early intervention in ASD requires specialist training, which subsequently needs to be developed or included into current training curricula.

Infantile Water Intoxication After a Swimming Lesson

PEDIATRICS ◽  
1982 ◽  
Vol 70 (4) ◽  
pp. 599-600 ◽  
Author(s):  
Gerald N. Goldberg ◽  
Elmer S. Lightner ◽  
Wayne Morgan ◽  
Sid Kemberling
Keyword(s):  
Intracranial Pressure ◽  
Signs And Symptoms ◽  
Water Intoxication ◽  
Increased Intracranial Pressure ◽  
Accidental Ingestion ◽  
Near Drowning ◽  
Early Infant

This report emphasizes a danger inherent in early infant swimming programs, ie, the need to observe the infant closely for ingestion of excessive amounts of water. A physician faced with a history compatible with near-drowning or possible aspiration of water must consider the diagnosis of acute water intoxication. Accidental ingestion of water can produce hyponatremia with resulting signs and symptoms of acute water intoxication, ie, lethargy, vomiting, seizures, and increased intracranial pressure.

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