scholarly journals Heparin-Binding Protein in Critically Ill Children With Severe Community-Acquired Pneumonia

2021 ◽  
Vol 9 ◽  
Author(s):  
Caizhi Huang ◽  
Cong Zhang ◽  
Jie Zhang ◽  
Lin Zhang ◽  
Yi Mo ◽  
...  
Keyword(s):  
Severe Sepsis ◽  
Critically Ill ◽  
Binding Protein ◽  
Community Acquired Pneumonia ◽  
Critically Ill Children ◽  
Heparin Binding ◽  
Heparin Binding Protein ◽  
Number Of Patients ◽  
Severe Community Acquired Pneumonia ◽  
D Dimer

Objective: The aim of this study was to investigate possible associations between Heparin-binding protein (HBP) and the development of respiratory failure (RF) and sepsis in critically ill children with severe community-acquired pneumonia (CAP).Methods: This study enrolled 157 children with severe CAP admitted to Intensive Care Unit (ICU). At ICU admission, the levels of HBP and other biomarkers, including C-reactive protein, interleukin-6 (IL-6), procalcitonin, white blood cells, neutrophil percentage, and D-dimer, were determined.Results: Of the enrolled patients, 106 developed RF (35 with RF at enrollment and 71 with RF after enrollment), while 51 did not developed RF. The number of patients progressing to sepsis in those with or without RF were 34 (21 with severe sepsis) and 14, respectively. The plasma level of HBP at admission was more than eightfold higher than the upper normal value. HBP, IL-6, and D-dimer could significantly predict the development of RF, and a high level of HBP (odds ratio = 1.008, 95% confidence interval: 1.003–1.013) was independently associated with the development of RF in this population. Compared with other biomarkers, HBP was the best indicator of progression to severe sepsis, with an area under the receiver operating characteristic curve of 0.85, the best specificity at 96.30%, and a positive predictive value of 92.86% at the optimal cut-off value of 340.29 ng/mL. The HBP level was also positively correlated with other conventional biomarkers.Conclusion: HBP might represent a better predictor of disease progression in children with severe CAP than currently used biomarkers.

scholarly journals Heparin-binding protein as a biomarker of gastrointestinal dysfunction in critically ill patients: a retrospective cross-sectional study in China

BMJ Open ◽  
2020 ◽  
Vol 10 (7) ◽  
pp. e036396
Author(s):  
Jia-Kui Sun ◽  
Xiao Shen ◽  
Xin-Pei Sun ◽  
Xiang Wang ◽  
Wen-Hao Zhang ◽  
...  
Keyword(s):  
Critically Ill ◽  
Critically Ill Patients ◽  
Binding Protein ◽  
Cross Sectional Study ◽  
Heparin Binding ◽  
Sectional Study ◽  
Gastrointestinal Dysfunction ◽  
Cross Sectional ◽  
Heparin Binding Protein ◽  
Number Of Patients

ObjectiveTo investigate the association of plasma heparin-binding protein (HBP) with the development of acute gastrointestinal injury (AGI) in critically ill patients.DesignClinical retrospective cross-sectional study.SettingA general teaching hospital in China.ParticipantsAdult patients (age ≥18 years) admitted to our department with an intensive care unit (ICU) stay ≥5 days.Main outcome measuresHBP levels were recorded twice or more within 5 days after admission. The initial AGI grades and the worst AGI grades within 5 days after admission, the number of patients receiving total enteral nutrition (TEN) and the number of patients with feeding intolerance (FI) and with sepsis were also recorded, along with some clinical severity and outcome variables.ResultsFrom June 2018 to May 2019, 221 patients were enrolled in this study. We divided patients into four groups based on the HBP values: HBP ≤20 ng/mL, 20<HBP ≤50 ng/mL, 50<HBP ≤100 ng/mL and HBP >100 ng/mL. Significant differences were found in the ratios of AGI deterioration and TEN and the incidence rates of FI and sepsis among the four groups. Differences were also found among the groups regarding the worst AGI grades. The area under receiver operating characteristic curves for AGI deterioration, severe AGI (grades II or above), TEN and FI were 0.738 (p=0.001), 0.774 (p<0.001), 0.810 (p<0.001) and 0.729 (p=0.001), respectively. The optimal HBP cut-off values for AGI deterioration and severe AGI were 53.27 ng/mL and 41.26 ng/mL, respectively. However, no differences in ICU duration or 28-day mortality were found.ConclusionsHBP levels were associated with gastrointestinal dysfunction in critically ill patients. Increased HBP was positively correlated with sepsis but it was not correlated with 28-day mortality.

scholarly journals Heparin-binding protein (HBP) in critically ill patients with influenza A (H1N1) infection

2013 ◽  
Vol 19 (12) ◽  
pp. 1122-1128 ◽  
Author(s):  
K.-M. Kaukonen ◽  
R. Linko ◽  
H. Herwald ◽  
L. Lindbom ◽  
E. Ruokonen ◽  
...  
Keyword(s):  
Critically Ill ◽  
Critically Ill Patients ◽  
Influenza A ◽  
Binding Protein ◽  
Heparin Binding ◽  
H1n1 Infection ◽  
Heparin Binding Protein ◽  
Influenza A H1n1

scholarly journals Heparin-binding protein improves prediction of severe sepsis in the emergency department

Critical Care ◽  
2013 ◽  
Vol 17 (Suppl 4) ◽  
pp. P3 ◽  
Author(s):  
Adam Linder ◽  
Ryan Arnold ◽  
Marco Zindovic ◽  
Igor Zindovic ◽  
Anna Lange-Jendeberg ◽  
...  
Keyword(s):  
Emergency Department ◽  
Severe Sepsis ◽  
Binding Protein ◽  
Heparin Binding ◽  
Heparin Binding Protein

scholarly journals Elevated plasma levels of heparin-binding protein in intensive care unit patients with severe sepsis and septic shock

Critical Care ◽  
2012 ◽  
Vol 16 (3) ◽  
pp. R90 ◽  
Author(s):  
Adam Linder ◽  
Per Åkesson ◽  
Malin Inghammar ◽  
Carl-Johan Treutiger ◽  
Anna Linnér ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Septic Shock ◽  
Severe Sepsis ◽  
Intensive Care ◽  
Plasma Levels ◽  
Binding Protein ◽  
Heparin Binding ◽  
Elevated Plasma ◽  
Heparin Binding Protein ◽  
Sepsis And Septic Shock

scholarly journals Heparin-binding protein levels correlated with aggravation and multi-organ damage in severe COVID-19

2020 ◽  
pp. 00741-2020
Author(s):  
Mingshan Xue ◽  
Yifeng Zeng ◽  
Hui-Qi Qu ◽  
Teng Zhang ◽  
Ning Li ◽  
...  
Keyword(s):  
Respiratory Failure ◽  
Disease Progression ◽  
Critically Ill ◽  
Binding Protein ◽  
Pulmonary Ventilation ◽  
Clinical Manifestations ◽  
Multiple Organ ◽  
Inflammatory Factor ◽  
Heparin Binding ◽  
Heparin Binding Protein

BackgroundCritically ill COVID-19 patients may suffer persistent systemic inflammation and multiple organ failure, leading to a poor prognosis.Research QuestionTo examine the relevance of the novel inflammatory factor heparin-binding protein (HBP) in critically ill COVID-19 patients, and evaluate the correlation of the biomarker with disease progression.Study Design and MethodsEighteen critically ill COVID-19 patients who suffered from respiratory failure and sepsis, including 12 cases who experienced a rapidly deteriorating clinical condition and 6 cases without deterioration, were investigated. They were compared with 15 age- and sex- matched COVID-19 negative patients with respiratory failure. Clinical data were collected and HBP levels were investigated.ResultsHBP was significantly increased in critically ill COVID-19 patients following disease aggravation and tracked with disease progression. HBP elevation preceded the clinical manifestations for up to 5 days and was closely correlated with patients’ pulmonary ventilation and perfusion status.InterpretationHBP levels are associated with COVID-19 disease progression in critically ill patients. As a potential mediator of disease aggravation and multiple organ injuries that are triggered by continuing inflammation and oxygen deficits, HBP warrants further study as a disease biomarker and potential therapeutic target.

scholarly journals Heparin-binding protein and procalcitonin in the diagnosis of pathogens causing community-acquired pneumonia in adult patients: a retrospective study

PeerJ ◽  
2021 ◽  
Vol 9 ◽  
pp. e11056
Author(s):  
Rentian Cai ◽  
Huihui Li ◽  
Zhen Tao
Keyword(s):  
Viral Infection ◽  
Roc Curve ◽  
Operating Characteristic ◽  
Binding Protein ◽  
Nonparametric Tests ◽  
Community Acquired Pneumonia ◽  
Heparin Binding ◽  
Inflammation Markers ◽  
Heparin Binding Protein ◽  
Leukocyte Counts

The performance of inflammatory markers in community-acquired pneumonia (CAP) caused by different pathogens has not been fully studied. We sought to find the differences in the concentrations of procalcitonin (PCT) and heparin-binding protein (HBP) between patients with CAP caused by different pathogens. We enrolled 162 patients with CAP, divided into three groups on the basis of bacterial (n = 108), fungal (n = 21) and viral (n = 33) infection. Complete leukocyte counts and the concentration of HBP and PCT were measured, and the differences were compared with nonparametric tests. The receiver operating characteristic (ROC) curve was used to evaluate the significant differences in the sensitivity and specificity of the indicators. The leukocyte and neutrophils counts and the concentrations of HBP and PCT in the viral group were significantly lower than those in the other two groups (p < 0.001). The area under the ROC curve (AUC) of the concentration of HBP and PCT as well as leukocyte and neutrophils counts were 0.927, 0.892, 0.832 and 0.806 for distinguishing bacterial from viral infection, respectively. The best cut-off value was 20.05 ng/mL for HBP, with a sensitivity of 0.861 and specificity of 0.939. The best cut-off value was 0.195 ng/mL for PCT, with a sensitivity of 0.991 and specificity of 0.636. The best cut-off value was 5.195 × 109/L and 4.000 × 109/L for leukocyte and neutrophils counts, with sensitivity of 0.694 and 0.880 and specificity of 0.667 and 0.636, respectively. The AUC of HBP, PCT and leukocyte and neutrophil counts for distinguishing fungal from viral infection were 0.851, 0.883, 0.835 and 0.830, respectively. The best cut-off values were 29.950 ng/mL, 0.560 ng/mL, 5.265 × 109/L and 3.850 × 109/L, with sensitivity of 0.667, 0.714, 0.905 and 0.952 and specificity of 0.970, 0.879 0.667 and 0.606, respectively. There were no significant differences in the three indicators between the bacterial and fungal infection groups. The concentration of CRP showed no significant differences among the three groups. Consequently, the stronger immune response characterized by higher inflammation markers including HBP and PCT can help distinguish bacterial and fungal CAP from viral CAP.

Sign in / Sign up

Export Citation Format

Share Document