scholarly journals Exploring the Regulation Mechanism of Xihuang Pill, Olibanum and β-Boswellic Acid on the Biomolecular Network of Triple-Negative Breast Cancer Based on Transcriptomics and Chemical Informatics Methodology

2020 ◽  
Vol 11 ◽  
Author(s):  
Kailin Yang ◽  
Liuting Zeng ◽  
Anqi Ge ◽  
Tingting Bao ◽  
Tao Xu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Regulation Mechanism ◽  
Boswellic Acid ◽  
Biomolecular Network ◽  
Chemical Informatics

scholarly journals 11-Keto-α-Boswellic Acid, a Novel Triterpenoid from Boswellia spp. with Chemotaxonomic Potential and Antitumor Activity against Triple-Negative Breast Cancer Cells

Molecules ◽  
2021 ◽  
Vol 26 (2) ◽  
pp. 366
Author(s):  
Michael Schmiech ◽  
Judith Ulrich ◽  
Sophia Johanna Lang ◽  
Berthold Büchele ◽  
Christian Paetz ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mass Spectrometry ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
High Resolution Mass Spectrometry ◽  
Natural Occurrence ◽  
Boswellic Acid ◽  
Boswellic Acids ◽  
Anti Inflammatory

Boswellic acids, and particularly 11-keto-boswellic acids, triterpenoids derived from the genus Boswellia (Burseraceae), are known for their anti-inflammatory and potential antitumor efficacy. Although boswellic acids generally occur as α-isomers (oleanane type) and β-isomers (ursane type), 11-keto-boswellic acid (KBA) was found only as the β-isomer, β-KBA. Here, the existence and natural occurrence of the respective α-isomer, 11-keto-α-boswellic acid (α-KBA), is demonstrated for the first time. Initially, α-KBA was synthesized and characterized by high-resolution mass spectrometry (HR-MS) and nuclear magnetic resonance (NMR) spectroscopy, and a highly selective, sensitive, and accurate high-performance liquid chromatography coupled with tandem mass spectrometry (HPLC-MS/MS) method was developed by Design of Experiments (DoE) using a pentafluorophenyl stationary phase. This method allowed the selective quantification of individual 11-keto-boswellic acids and provided evidence for α-KBA in Boswellia spp. oleogum resins. The contents of α-KBA as well as further boswellic acids and the composition of essential oils were used to chemotaxonomically classify 41 Boswellia oleogum resins from 9 different species. Moreover, α-KBA exhibited cytotoxicity against three treatment-resistant triple-negative breast cancer (TNBC) cell lines in vitro and also induced apoptosis in MDA-MB-231 xenografts in vivo. The respective β-isomer and the acetylated form demonstrate higher cytotoxic efficacies against TNBC cells. This provides further insights into the structure-activity relationship of boswellic acids and could support future developments of potential anti-inflammatory and antitumor drugs.

scholarly journals Quantitative and visualized analysis of 5,097 triple-negative breast cancer (TNBC) publications by using multiple machine learning algorithms: TNBC is an excellent forerunner in cancer research

2021 ◽  
Author(s):  
Kangtao Wang ◽  
Chanjuan Zheng ◽  
Lian Xue ◽  
Dexin Deng ◽  
Fengbo Tan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Machine Learning ◽  
Cancer Research ◽  
Aggressive Behavior ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Machine Learning Algorithms ◽  
Current Status ◽  
Regulation Mechanism ◽  
Annual Growth Rate

Abstract Background: Triple-negative breast cancer (TNBC) is a subtype of breast cancer proposed at the beginning of this century, which is still the most challenging breast cancer subtype due to its aggressive behavior, including early relapse, metastatic spread, and poor survival. This study explores current research status and deficiencies from a macro perspective on TNBC publications by using machine learning methods. Methods: All publications under the MeSH term "Triple Negative Breast Neoplasms" in PubMed were searched and downloaded as of December 2020. R and Python were used to extract MeSH terms, geographic information and other abstracts from metadata. The Latent Dirichlet Allocation algorithm was applied to identify specific research topics. The Louvain algorithm was used to establish a topic network, identifying the relationship between the topics. Results: A total of 5,097 publications were identified, with an average annual growth rate of 33.5%. Only 88 countries and regions in the world participated in TNBC research. The publications contain about 25% of clinical trial-related research. The rapid clinical progress will provide an excellent example for diagnosing and treating other tumors, suggesting that TNBC is an excellent forerunner in cancer research. Publications of pathogenic mechanisms and drugs are most studied. Using the Topic model, we found that the publications were mainly focused on three aspects: treatment plan research, new biomarkers research, and the regulation mechanism for TNBC aggressive behavior. Conclusion: This study quantitively summarizes the current status of TNBC research from a macro perspective and will aid in redirecting basic and clinical research toward a better outcome of TNBC.

Identification of new therapeutic leads for triple negative breast cancer subtypes

Planta Medica ◽  
2015 ◽  
Vol 81 (11) ◽  
Author(s):  
AJ Robles ◽  
L Du ◽  
S Cai ◽  
RH Cichewicz ◽  
SL Mooberry
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Breast Cancer Subtypes ◽  
Cancer Subtypes ◽  
Therapeutic Leads

Immediate and long-term results of the first line chemotherapy in patients with metastatic triple negative breast cancer. Final analysis of randomized study

2020 ◽  
pp. 75-80
Author(s):  
S.A. Lyalkin ◽  
◽  
L.A. Syvak ◽  
N.O. Verevkina ◽  
◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Randomized Study ◽  
Progression Free Survival ◽  
First Line ◽  
Free Survival ◽  
Group 2 ◽  
Line Chemotherapy ◽  
Group 1

The objective: was to evaluate the efficacy of the first line chemotherapy in patients with metastatic triple negative breast cancer (TNBC). Materials and methods. Open randomized study was performed including 122 patients with metastatic TNBC. The efficacy and safety of the first line chemotherapy of regimens АТ (n=59) – group 1, patients received doxorubicine 60 мг/м2 and paclitaxel 175 мг/м2 and ТР (n=63) – group 2, patients received paclitaxel 175 мг/м2 and carboplatin AUC 5 were evaluated. Results. The median duration of response was 9.5 months (4.5–13.25 months) in patients received AT regimen and 8.5 months (4.7–12.25 months), in TP regimen; no statistically significant differences were observed, р=0.836. The median progression free survival was 7 months (95% CI 5–26 months) in group 1 and 7.5 months (95% CI 6–35 months) in group 2, p=0.85. Both chemotherapy regimens (AT and TP) had mild or moderate toxicity profiles (grade 1 or 2 in most patients). No significant difference in gastrointestinal toxicity was observed. The incidence of grade 3–4 neutropenia was higher in patients of group 2 (TP regimen): 42.8% versus 27% (р<0.05). Conclusions. Both regimens of chemotherapy (AT and TP) are appropriate to use in the first line setting in patients with metastatic TNBC. Key words: metastatic triple negative breast cancer, chemotherapy, progression free survival, chemotherapy toxicity.

Sign in / Sign up

Export Citation Format

Share Document