scholarly journals Construction of the Enterococcal Strain Expressing Immunogenic Fragment of SARS-Cov-2 Virus

2022 ◽  
Vol 12 ◽  
Author(s):  
Alexander Suvorov ◽  
Tatiana Gupalova ◽  
Yulia Desheva ◽  
Tatiana Kramskaya ◽  
Elena Bormotova ◽  
...  
Keyword(s):  
Low Cost ◽  
Health Care Systems ◽  
Genetically Modified ◽  
Probiotic Strain ◽  
D2 Domain ◽  
Therapeutic Molecules ◽  
Interesting Candidate ◽  
Human Sera ◽  
Care Systems ◽  
Iga Response

Contemporary SARS-Cov-2 pandemic, besides its dramatic global influence on the human race including health care systems, economies, and political decisions, opened a window for the global experiment with human vaccination employing novel injectable vaccines providing predominantly specific IgG response with little knowledge of their impact on the mucosal immunity. However, it is widely accepted that protection against the pathogens at the gates of the infection - on mucosal surfaces—predominantly rely on an IgA response. Some genetically modified bacteria, including probiotics, represent attractive vehicles for oral or nasal mucosal delivery of therapeutic molecules. Probiotic-based vaccines for mucous membranes are easy to produce in large quantities; they have low cost, provide quite a long T-cell memory, and gut IgA response to oral vaccines is highly synchronized and strongly oligoclonal. Here we present a study demonstrating construction of the novel SARS-Cov-2 vaccine candidate employing the gene fragment of S1 SARS-Cov-2 gene. This DNA fragment was inserted in frame into major pili protein gene with d2 domain of enterococcal operon encoding for pili. The DNA sequencing proved the presence of the insert in enterococcal genome. RNA transcription, immunoprecipitation, and immune electron microscopy with human sera obtained from the SARS-Cov-2 patients demonstrated expression of SARS-Cov-2 antigens in bacteria. Taken together the data obtained allowed considering this genetically modified probiotic strain as an interesting candidate for vaccine against SARS-Cov-2.

Cost-effectiveness of reduction mammaplasty

2004 ◽  
Vol 20 (3) ◽  
pp. 269-273 ◽  
Author(s):  
Andrew J. Taylor ◽  
David Tate ◽  
Yvonne Brandberg ◽  
Lennart Blomqvist
Keyword(s):  
Cost Effectiveness ◽  
Low Cost ◽  
Health Care Systems ◽  
Reduction Mammaplasty ◽  
Cost Effective ◽  
Quality Adjusted Life Year ◽  
Decision Makers ◽  
Care Systems ◽  
The Cost ◽  
New Evidence

Objectives:The purpose of this study is to provide a comparison of the benefits of reduction mammaplasty (RM) for women with heavy breasts often termed macromastia or breast hypertrophy (BH) surgery. The rationale is to provide information to allow decision-makers to make judgments about the cost-effectiveness of this intervention and make comparisons with other interventions which are commonly undertaken within publicly financed health-care systems.Methods:Data from a previous outcomes study in Sweden is re-analyzed to derive quality of life measures, from which a mean level of benefit outcome is derived and a cost per quality-adjusted life year is calculated (cost per QALY).Results:The low Cost per QALY suggests that reduction mammaplasty is cost-effective when compared with other treatments which are commonly undertaken.Conclusions:The authors suggest that the evidence in favor of funding reduction mammaplasty is strong and that decision-makers review their policy in light of this new evidence.

Opportunities and Challenges in an Ever Generic World

2009 ◽  
Vol 6 (4) ◽  
pp. 303-313 ◽  
Author(s):  
Alan Sheppard
Keyword(s):  
Health Care ◽  
Economic Crisis ◽  
Low Cost ◽  
Health Care Systems ◽  
Pharmaceutical Market ◽  
Care Systems ◽  
Low Cost Manufacturing ◽  
The Impact

The global generics industry is about to embark on a decade of seismic change, and the impact to both patients and health-care systems cannot be overstated. This paper provides an overview of the global pharmaceutical market in the context of today's economic crisis, and a corresponding outline of key trends shaping the global generics market. It then focuses-in on an examination of the trend toward centralized contracting and how it will benefit those generics manufacturers with a broad portfolio and low-cost manufacturing base.

Emerging International Directions for Psychosocial Care

2021 ◽  
pp. 813-818
Author(s):  
Jeff Dunn ◽  
Melissa Henry ◽  
Maggie Watson
Keyword(s):  
Health Care ◽  
Low Cost ◽  
Health Care Systems ◽  
Psychosocial Care ◽  
Evidence Based ◽  
Middle Income ◽  
Care Services ◽  
Care Systems ◽  
Oncology Care ◽  
Training Resources

Low-middle-income (LMI) countries are emerging as a priority target for the development of psycho-oncology care. This chapter describes some well-recognized barriers to progress along with ideas on how evidence-based practice can be imported from developed health care systems into the LMI context. Important to this process is the need to tailor care services to national, regional, and cultural needs in order to take account of communication issues that are idiosyncratic to different LMI health care contexts. The use of low-cost technologies to support implementation of psycho-oncology care services is discussed as well as the need for training resources to be made available to local/national psycho-oncology professionals as the most important future resource. In this way key leaders within LMI countries can be upskilled and provide snowball dissemination of skills to professionals in their own countries. Future priorities are described along with ideas for implementation.

Text Messages to Support Caregivers: Report of Implementation into a Health Care System (Preprint)

2021 ◽  
Author(s):  
Jennifer Lynn Martindale-Adams ◽  
Carolyn Davis Clark ◽  
Jessica Roxy Martin ◽  
Charles R Henderson ◽  
Linda Olivia Nichols
Keyword(s):  
Health Care ◽  
Health Care System ◽  
Text Messaging ◽  
Low Cost ◽  
Health Care Systems ◽  
Text Messages ◽  
Loved One ◽  
Management Protocol ◽  
Care Systems ◽  
Care System

BACKGROUND While there are many interventions to support caregivers, text messaging has the capability to be an adjunct to clinical practice on a wide-spread basis. The Department of Veterans Affairs Annie text messaging system was developed to assist Veterans with self-care. OBJECTIVE This paper reports on the first system-wide implementation of a text messaging protocol for caregivers in a national health care system with an Annie stress management protocol for caregivers of Veterans. METHODS After pilot testing, in late 2019, a year-long protocol for caregivers with three messages a week focusing on education, motivation/inspiration, and activities to alleviate stress was begun. An online evaluation occurs at six months. RESULTS As of September 2021, 3807 caregivers had participated in the stress protocol. Caregivers report that the messages have been useful in increasing their confidence, managing their stress, and helping them take care of themselves and their loved one. This success has led to bereavement, taking care of you, COVID-19 precautions and symptoms, and dementia behaviors protocols, with a total of 5643 caregivers enrolled as of September 2021. CONCLUSIONS Caregivers frequently feel overlooked by the health care system but caregivers report that the messages make them feel cared for and less lonely. Text messaging, incorporated into clinical settings and health care systems, represents a seamless, low-cost way to provide useful and meaningful support to caregivers.

scholarly journals Textile Concentric Ring Electrodes: Influence of Position and Electrode Size on Cardiac Activity Monitoring

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Gema Prats-Boluda ◽  
Yiyao Ye-Lin ◽  
Francisco Pradas-Novella ◽  
Eduardo Garcia-Breijo ◽  
Javier Garcia-Casado
Keyword(s):  
Low Cost ◽  
Health Care Systems ◽  
Cardiac Activity ◽  
Signal Amplitude ◽  
Activity Monitoring ◽  
Concentric Ring ◽  
Spatial Selectivity ◽  
Care Systems ◽  
Wave Morphology ◽  
Signal Detectability

Continuous ECG monitoring can play an important role in the rapid detection of pathological signatures and arrhythmias. Current systems use electrodes with limitations in wearable long-term applications and spatial selectivity. In this work, two sizes of textile concentric ring electrodes (TCRE42 and TCRE50) were developed and tested for monitoring cardiac activity. The low-cost devices were found to be easy to implement and to potentially have the advantages of textile electrodes for being lightweight, stretchable, adjustable, washable, and long-lasting. Both TCREs yielded similar signal detectability of different ECG waves. The optimal P wave recording area (OPA) for detecting signals was on the upper right chest. Although the absolute signal amplitude of TCRE records was smaller than that of lead II, normalized amplitude in the OPA is similar for T wave and higher for P wave. The TCREs also allowed better analysis of P wave morphology and were able to detect more right and left atrial depolarization waves. TCRE48 showed slightly better detectability, normalized amplitude, and spatial selectivity than TCRE50 within the OPA. The authors consider the TCRE suitable for use in ubiquitous mobile health care systems, especially for atrial activity monitoring and diagnosis.

160: Cost-Effectiveness of Medical Management Strategies of Nephrolithiasis in Different Health Care Systems

2004 ◽  
Vol 171 (4S) ◽  
pp. 42-43 ◽  
Author(s):  
Yair Latan ◽  
David M. Wilhelm ◽  
David A. Duchene ◽  
Margaret S. Pearle
Keyword(s):  
Health Care ◽  
Cost Effectiveness ◽  
Medical Management ◽  
Health Care Systems ◽  
Management Strategies ◽  
Care Systems

J 5 — A Data Processing System for Medical Information

1967 ◽  
Vol 06 (01) ◽  
pp. 1-6
Author(s):  
P. Hall ◽  
Ch. Mellner ◽  
T. Danielsson
Keyword(s):  
Medical Records ◽  
Medical Information ◽  
Health Care Systems ◽  
Processing System ◽  
Linear Pattern ◽  
Flexible Form ◽  
Care Systems ◽  
Pattern Recognition Analysis ◽  
Numeric Information

A system for medical information has been developed. The system is a general and flexible one which without reprogramming or new programs can accept any alphabetic and/or numeric information. Coded concepts and natural language can be read, stored, decoded and written out. Medical records or parts of records (diagnosis, operations, therapy, laboratory tests, symptoms etc.) can be retrieved and selected. The system can process simple statistics but even make linear pattern recognition analysis.The system described has been used for in-patients, outpatients and individuals in health examinations.The use of computers in hospitals, health examinations or health care systems is a problem of storing information in a general and flexible form. This problem has been solved, and now it is possible to add new routines like booking and follow-up-systems.

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