scholarly journals The status of and future research into Myalgic Encephalomyelitis and Chronic Fatigue Syndrome: the need of accurate diagnosis, objective assessment, and acknowledging biological and clinical subgroups

2014 ◽  
Vol 5 ◽  
Author(s):  
Frank N. M. Twisk
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Objective Assessment ◽  
Chronic Fatigue ◽  
Accurate Diagnosis ◽  
Myalgic Encephalomyelitis ◽  
Future Research ◽  
Fatigue Syndrome ◽  
The Status

scholarly journals A Preliminary Comparative Assessment of the Role of CD8+ T Cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and Multiple Sclerosis

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Ekua W. Brenu ◽  
Simon Broadley ◽  
Thao Nguyen ◽  
Samantha Johnston ◽  
Sandra Ramos ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
T Cells ◽  
Chronic Fatigue Syndrome ◽  
Cd8 T Cells ◽  
Preliminary Investigation ◽  
Chronic Fatigue ◽  
Myalgic Encephalomyelitis ◽  
Effector Memory ◽  
Fatigue Syndrome ◽  
The Status

Background. CD8+ T cells have putative roles in the regulation of adaptive immune responses during infection. The purpose of this paper is to compare the status of CD8+ T cells in Multiple Sclerosis (MS) and Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME).Methods. This preliminary investigation comprised 23 CFS/ME patients, 11 untreated MS patients, and 30 nonfatigued controls. Whole blood samples were collected from participants, stained with monoclonal antibodies, and analysed on the flow cytometer. Using the following CD markers, CD27 and CD45RA (CD45 exon isoform 4), CD8+ T cells were divided into naïve, central memory (CM), effector memory CD45RA− (EM), and effector memory CD45RA+ (EMRA) cells.Results. Surface expressions of BTLA, CD127, and CD49/CD29 were increased on subsets of CD8+ T cells from MS patients. In the CFS/ME patients CD127 was significantly decreased on all subsets of CD8+ T cells in comparison to the nonfatigued controls. PSGL-1 was significantly reduced in the CFS/ME patients in comparison to the nonfatigued controls.Conclusions. The results suggest significant deficits in the expression of receptors and adhesion molecules on subsets of CD8+ T cells in both MS and CFS/ME patients. These deficits reported may contribute to the pathogenesis of these diseases. However, larger sample size is warranted to confirm and support these encouraging preliminary findings.

scholarly journals Lessons From Heat Stroke for Understanding Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

2021 ◽  
Vol 12 ◽  
Author(s):  
Dominic Stanculescu ◽  
Nuno Sepúlveda ◽  
Chin Leong Lim ◽  
Jonas Bergquist
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Cell Injury ◽  
Heat Stroke ◽  
Chronic Fatigue ◽  
Myalgic Encephalomyelitis ◽  
Future Research ◽  
Coagulation Disorder ◽  
Gene Expressions ◽  
Fatigue Syndrome ◽  
Central Nervous System Dysfunction

We here provide an overview of the pathophysiological mechanisms during heat stroke and describe similar mechanisms found in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Both conditions are characterized by disturbed homeostasis in which inflammatory pathways play a central role. Splanchnic vasoconstriction, increased gut permeability, gut-related endotoxemia, systemic inflammatory response, central nervous system dysfunction, blood coagulation disorder, endothelial-cell injury, and mitochondrial dysfunction underlie heat stroke. These mechanisms have also been documented in ME/CFS. Moreover, initial transcriptomic studies suggest that similar gene expressions are altered in both heat stroke and ME/CFS. Finally, some predisposing factors for heat stroke, such as pre-existing inflammation or infection, overlap with those for ME/CFS. Notwithstanding important differences - and despite heat stroke being an acute condition - the overlaps between heat stroke and ME/CFS suggest common pathways in the physiological responses to very different forms of stressors, which are manifested in different clinical outcomes. The human studies and animal models of heat stroke provide an explanation for the self-perpetuation of homeostatic imbalance centered around intestinal wall injury, which could also inform the understanding of ME/CFS. Moreover, the studies of novel therapeutics for heat stroke might provide new avenues for the treatment of ME/CFS. Future research should be conducted to investigate the similarities between heat stroke and ME/CFS to help identify the potential treatments for ME/CFS.

scholarly journals Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)—A Systemic Review and Comparison of Clinical Presentation and Symptomatology

Medicina ◽  
2021 ◽  
Vol 57 (5) ◽  
pp. 418
Author(s):  
Timothy L. Wong ◽  
Danielle J. Weitzer
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Literature Search ◽  
Clinical Presentation ◽  
Chronic Fatigue ◽  
Myalgic Encephalomyelitis ◽  
Systemic Review ◽  
Future Research ◽  
Medical Illness ◽  
Case Definitions ◽  
Fatigue Syndrome

Background and Objectives: Long COVID defines a series of chronic symptoms that patients may experience after resolution of acute COVID-19. Early reports from studies with patients with long COVID suggests a constellation of symptoms with similarities to another chronic medical illness—myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). A review study comparing and contrasting ME/CFS with reported symptoms of long COVID may yield mutualistic insight into the characterization and management of both conditions. Materials and Methods: A systemic literature search was conducted in MEDLINE and PsycInfo through to 31 January 2021 for studies related to long COVID symptomatology. The literature search was conducted in accordance with PRISMA methodology. Results: Twenty-one studies were included in the qualitative analysis. Long COVID symptoms reported by the included studies were compared to a list of ME/CFS symptoms compiled from multiple case definitions. Twenty-five out of 29 known ME/CFS symptoms were reported by at least one selected long COVID study. Conclusions: Early studies into long COVID symptomatology suggest many overlaps with clinical presentation of ME/CFS. The need for monitoring and treatment for patients post-COVID is evident. Advancements and standardization of long COVID research methodologies would improve the quality of future research, and may allow further investigations into the similarities and differences between long COVID and ME/CFS.

scholarly journals Systematic Review of the Epidemiological Burden of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Across Europe: Current Evidence and EUROMENE Research Recommendations for Epidemiology

2020 ◽  
Vol 9 (5) ◽  
pp. 1557 ◽  
Author(s):  
Fernando Estévez-López ◽  
Kathleen Mudie ◽  
Xia Wang-Steverding ◽  
Inger Johanne Bakken ◽  
Andrejs Ivanovs ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Grey Literature ◽  
Reporting Quality ◽  
Chronic Fatigue ◽  
Myalgic Encephalomyelitis ◽  
Current Evidence ◽  
Future Research ◽  
Institute Of Medicine ◽  
Case Definitions ◽  
Fatigue Syndrome

This review aimed at determining the prevalence and incidence of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) in Europe. We conducted a primary search in Scopus, PubMed and Web of Science for publications between 1994 and 15 June 2019 (PROSPERO: CRD42017078688). Additionally, we performed a backward-(reference lists) and forward-(citations) search of the works included in this review. Grey literature was addressed by contacting all members of the European Network on ME/CFS (EUROMENE). Independent reviewers searched, screened and selected studies, extracted data and evaluated the methodological and reporting quality. For prevalence, two studies in adults and one study in adolescents were included. Prevalence ranged from 0.1% to 2.2%. Two studies also included incidence estimates. In conclusion, studies on the prevalence and incidence of ME/CFS in Europe were scarce. Our findings point to the pressing need for well-designed and statistically powered epidemiological studies. To overcome the shortcomings of the current state-of-the-art, EUROMENE recommends that future research is better conducted in the community, reviewing the clinical history of potential cases, obtaining additional objective information (when needed) and using adequate ME/CFS case definitions; namely, the Centers for Disease Control & Prevention−1994, Canadian Consensus Criteria, or Institute of Medicine criteria.

scholarly journals Differing case definitions point to the need for an accurate diagnosis of myalgic encephalomyelitis/chronic fatigue syndrome

2017 ◽  
Vol 5 (1) ◽  
pp. 1-4 ◽  
Author(s):  
Luis Nacul ◽  
Caroline C. Kingdon ◽  
Erinna W. Bowman ◽  
Hayley Curran ◽  
Eliana M. Lacerda
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Chronic Fatigue ◽  
Accurate Diagnosis ◽  
Myalgic Encephalomyelitis ◽  
Case Definitions ◽  
Fatigue Syndrome
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