scholarly journals Guide to Plant-PET Imaging Using 11CO2

2021 ◽  
Vol 12 ◽  
Author(s):  
Jens Mincke ◽  
Jan Courtyn ◽  
Christian Vanhove ◽  
Stefaan Vandenberghe ◽  
Kathy Steppe
Keyword(s):  
Imaging Technique ◽  
High Sensitivity ◽  
Emission Tomography ◽  
Plant Science ◽  
Compartmental Modeling ◽  
Research Groups ◽  
Positron Emission ◽  
Limited Application ◽  
Pet Scans ◽  
Clear Description

Due to its high sensitivity and specificity for tumor detection, positron emission tomography (PET) has become a standard and widely used molecular imaging technique. Given the popularity of PET, both clinically and preclinically, its use has been extended to study plants. However, only a limited number of research groups worldwide report PET-based studies, while we believe that this technique has much more potential and could contribute extensively to plant science. The limited application of PET may be related to the complexity of putting together methodological developments from multiple disciplines, such as radio-pharmacology, physics, mathematics and engineering, which may form an obstacle for some research groups. By means of this manuscript, we want to encourage researchers to study plants using PET. The main goal is to provide a clear description on how to design and execute PET scans, process the resulting data and fully explore its potential by quantification via compartmental modeling. The different steps that need to be taken will be discussed as well as the related challenges. Hereby, the main focus will be on, although not limited to, tracing 11CO2 to study plant carbon dynamics.

Comparison of Na18F and 18F-Deoxyglucose Positron Emission Tomography in Patients with Multiple Myeloma.

Blood ◽  
2004 ◽  
Vol 104 (11) ◽  
pp. 3457-3457
Author(s):  
Jacques Troncy ◽  
Sylvie Mercier ◽  
Pascal Roy ◽  
Mauricette Michallet ◽  
Charles M. Dumontet ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Multiple Myeloma ◽  
Imaging Technique ◽  
Imaging Techniques ◽  
Emission Tomography ◽  
Bone Lesions ◽  
X Rays ◽  
X Ray ◽  
Positron Emission ◽  
Pet Scans

Abstract Staging of patients with myeloma currently takes into account the number of bone lesions identified with standard X-rays. Magnetic Resonance Imaging (MRI) appears to be a more sensitive imaging technique in patients with multiple myeloma (MM) but it is not adapted to the investigation of the entire skeleton. Positron Emission Tomography (PET) imaging appears promising but this approach remains to be validated in patients with MM. Most patients with neoplasia have been performed with 18F-2-deoxy-D-glucose (FDG), a functional marker suggested to identify “active” tumor sites and useful to assess bone or extra-osseous tissue. Conversely Na18F binding is strictly limited to bone. To determine the potential usefulness of these two markers we performed a comparative analysis of these two imaging techniques in patients with MM. Nine patients with progressive MM, including bone lesions, underwent x-ray imaging, MRI, 18FDG and Na18F scanning. Both PET scans were performed within a one-week time frame in each patient. The number and localizations of suspect lesions identified by each type of imaging technique was assessed independently then compared. 18FDG and Na18F data were compared to X-ray/MRI data for skull, spine, pelvis and femur/humerus localizations. Localizations were considered positive in case of increased fixation with 18FDG or increased or decreased fixation with Na18F. Comparison of FDG data with X-ray/MRI showed that FDG allowed the detection of only 3 of 35 types of localizations identified by X-ray/MRI, whatever the localization (skull, femur/humerus, spine and pelvis) observed on X-ray/MRI. 18FDG showed three lesions which had not been identified by X-ray/MRI, as well as 8 costal localizations and 1 extra-osseous localization. Comparison of Na18F data with X-ray/MRI showed that Na18F allowed the detection of 17 of 35 types of localizations. In particular, Na18F identified 13 of the 19 spinal localizations observed with x-ray/MRI but only 2 of 9 skull lesions. Na18F identified 11 localizations which had not been identified by X-ray/MRI. Furthermore Na18F also identified costal localizations in all patients. Qualitative analysis of PET scans showed that background was significantly lower with Na18F imaging than with 18FDG imaging. In conclusion 18FDG and Na18F provide significantly different results in patients with progressive MM. 18FDG imaging was poorly correlated with X-rayMRI while Na18F imaging was particularly useful to identify costal and spinal lesions. PET scan could be a useful method in the staging of MM patients at diagnosis or to determine response. Figure Figure

scholarly journals Approaching Complete Inhibition of P-Glycoprotein at the Human Blood–Brain Barrier: An (R)-[11C]Verapamil PET Study

2015 ◽  
Vol 35 (5) ◽  
pp. 743-746 ◽  
Author(s):  
Martin Bauer ◽  
Rudolf Karch ◽  
Markus Zeitlinger ◽  
Cécile Philippe ◽  
Kerstin Römermann ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Blood Brain Barrier ◽  
Distribution Volume ◽  
Emission Tomography ◽  
Brain Barrier ◽  
Whole Brain ◽  
P Glycoprotein ◽  
Blood Brain ◽  
Positron Emission ◽  
Pet Scans

As P-glycoprotein (Pgp) inhibition at the blood–brain barrier (BBB) after administration of a single dose of tariquidar is transient, we performed positron emission tomography (PET) scans with the Pgp substrate ( R)-[11C]verapamil in five healthy volunteers during continuous intravenous tariquidar infusion. Total distribution volume ( VT) of ( R)-[11C]verapamil in whole-brain gray matter increased by 273 ± 78% relative to baseline scans without tariquidar, which was higher than previously reported VT increases. During tariquidar infusion whole-brain VT was comparable to VT in the pituitary gland, a region not protected by the BBB, which suggested that we were approaching complete Pgp inhibition at the human BBB.

6-[ 18 f]Fluorodopamine Positron Emission Tomographic (PET) Scanning in the Diagnostic Localization of Pheochromocytoma

Hypertension ◽  
2000 ◽  
Vol 36 (suppl_1) ◽  
pp. 714-715
Author(s):  
David S Goldstein ◽  
Graeme Eisenhofer ◽  
Sheng-Ting Li ◽  
Karel Pacak
Keyword(s):  
Nuclear Imaging ◽  
High Sensitivity ◽  
Good Sensitivity ◽  
Positron Emission Tomographic ◽  
Resonance Imaging ◽  
Positron Emission ◽  
Pet Scanning ◽  
Pet Scans ◽  
Initial Results ◽  
Limited Sensitivity

P119 The diagnosis and treatment of pheochromocytoma (PHEO) depend on means to localize the tumor. Computed tomography and magnetic resonance imaging have good sensitivity but poor specificity, and nuclear imaging has limited sensitivity. Here we report initial results of 6-[ 18 F]Fluorodopamine PET scanning in patients with known or suspected PHEO. Of 23 patients, 13 had the tumor. Ten had normal plasma levels of metanephrines, excluding PHEO. All 13 patients with PHEO had abnormal fluorodopamine PET scans that identified the tumors. The 10 patients without PHEO had negative PET scans. Fluorodopamine PET scanning detects PHEO with high sensitivity.

scholarly journals The utility of pharmacological and radiological interventions to optimize diagnostic information from PET/CT

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
David Dudoignon ◽  
David A. Pattison ◽  
Damien Legallois ◽  
Rodney J. Hicks ◽  
Nicolas Aide
Keyword(s):  
Emission Tomography ◽  
Main Body ◽  
Pharmacological Interventions ◽  
Imaging Protocols ◽  
Affect Image Quality ◽  
Positron Emission ◽  
Pet Ct ◽  
Pictorial Essay ◽  
Pet Probes ◽  
Pet Scans

Abstract Background Positron Emission Tomography with Computed Tomography (PET/CT) is widely used in the assessment of many diseases, particularly including cancer. However, many factors can affect image quality and diagnostic performance of PET scans using FDG or other PET probes. Main body The aim of this pictorial essay is to review PET/CT protocols that can be useful to overcome these confounding factors in routine clinical situations, with a particular focus on pharmacological interventions and problem-oriented CT acquisition protocols. Conclusion Imaging protocols and representative cases will be discussed, in addition to potential contraindications and precautions to be taken.

scholarly journals Metal-Based Complexes as Pharmaceuticals for Molecular Imaging of the Liver

2019 ◽  
Vol 12 (3) ◽  
pp. 137 ◽  
Author(s):  
Julia Greiser ◽  
Wolfgang Weigand ◽  
Martin Freesmeyer
Keyword(s):  
Magnetic Resonance Imaging ◽  
Positron Emission Tomography ◽  
Metal Complexes ◽  
Imaging Technique ◽  
Imaging Modality ◽  
Emission Tomography ◽  
Resonance Imaging ◽  
Positron Emission ◽  
Magnetic Resonance Imaging Mri ◽  
Uptake Mechanisms

This article reviews the use of metal complexes as contrast agents (CA) and radiopharmaceuticals for the anatomical and functional imaging of the liver. The main focus was on two established imaging modalities: magnetic resonance imaging (MRI) and nuclear medicine, the latter including scintigraphy and positron emission tomography (PET). The review provides an overview on approved pharmaceuticals like Gd-based CA and 99mTc-based radiometal complexes, and also on novel agents such as 68Ga-based PET tracers. Metal complexes are presented by their imaging modality, with subsections focusing on their structure and mode of action. Uptake mechanisms, metabolism, and specificity are presented, in context with advantages and limitations of the diagnostic application and taking into account the respective imaging technique.

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