The Relationship Between Improvement in Insomnia Severity and Long-Term Outcomes in the Treatment of Chronic Fatigue

Background and Purpose: Epidemiological studies have shown racial and ethnic minorities to have higher stroke risk and worse outcomes than non-Hispanic Whites. In this cohort study, we analyzed the STAR (Stroke Thrombectomy and Aneurysm Registry) database, a multi-institutional database of patients who underwent mechanical thrombectomy for acute large vessel occlusion stroke to determine the relationship between mechanical thrombectomy outcomes and race. Methods: Patients who underwent mechanical thrombectomy between January 2017 and May 2020 were analyzed. Data included baseline characteristics, vascular risk factors, complications, and long-term outcomes. Functional outcomes were assessed with respect to Hispanic status delineated as non-Hispanic White (NHW), non-Hispanic Black (NHB), or Hispanic patients. Multivariate analysis was performed to identify variables associated with unfavorable outcome or modified Rankin Scale ≥3 at 90 days. Results: Records of 2115 patients from the registry were analyzed. Median age of Hispanic patients undergoing mechanical thrombectomy was 60 years (72–84), compared with 63 years (54–74) for NHB, and 71 years (60–80) for NHW patients ( P <0.001). Hispanic patients had a higher incidence of diabetes (41%; P <0.001) and hypertension (82%; P <0.001) compared with NHW and NHB patients. Median procedure time was shorter in Hispanics (36 minutes) compared to NHB (39 minutes) and NHW (44 minutes) patients ( P <0.001). In multivariate analysis, Hispanic patients were less likely to have favorable outcome (odds ratio, 0.502 [95% CI, 0.263–0.959]), controlling for other significant predictors (age, admission National Institutes Health Stroke Scale, onset to groin time, number of attempts, procedure time). Conclusions: Hispanic patients are less likely to have favorable outcome at 90 days following mechanical thrombectomy compared to NHW or NHB patients. Further prospective studies are required to validate our findings.

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The Relationship between Hand Therapy and Long-Term Outcomes after Distal Radius Fracture in Older Adults

Plastic & Reconstructive Surgery ◽

10.1097/prs.0000000000005829 ◽

2019 ◽

Vol 144 (2) ◽

pp. 230e-237e ◽

Cited By ~ 2

Author(s):

Kevin C. Chung ◽

Sunitha Malay ◽

Melissa J. Shauver ◽

Kevin C. Chung ◽

H. Myra Kim ◽

...

Keyword(s):

Older Adults ◽

Distal Radius Fracture ◽

Distal Radius ◽

Radius Fracture ◽

Hand Therapy ◽

Long Term Outcomes ◽

The Relationship

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Implications of rapidity of response to initial therapy in multiple myeloma.

Journal of Clinical Oncology ◽

10.1200/jco.2013.31.15_suppl.8606 ◽

2013 ◽

Vol 31 (15_suppl) ◽

pp. 8606-8606

Author(s):

Krishna Bilas Ghimire ◽

Vincent Rajkumar ◽

Angela Dispenzieri ◽

Martha Lacy ◽

Morie Gertz ◽

...

Keyword(s):

Multiple Myeloma ◽

High Risk ◽

Initial Therapy ◽

M Protein ◽

Newly Diagnosed ◽

Long Term Outcomes ◽

High Risk Disease ◽

M Spike ◽

The Relationship

8606 Background: The rapidity of response to initial therapy in multiple myeloma (MM) depends on a variety of factors. There is limited data on its implications on long term outcomes in patients (pts) with newly diagnosed MM. Methods: We retrospectively examined the outcomes in a cohort of 454 pts with newly diagnosed MM between Jan 2000- Dec 2011 undergoing induction therapy. Results: The median age at diagnosis was 66 yrs (29-92). Pts had measurable serum M-spike (>= 1 g/dL), dFLC (>=10 mg/dl) or 24 hour urinary M protein excretion (UrM; >=200 mg) in 70, 63 and 39% respectively. We first examined the relationship between the response to first cycle of therapy and overall survival (OS). We divided pts into quartiles based on their % reduction in the serum M spike, dFLC or UrM. The median OS (Table) was poorest for pts with the least reduction of serum M protein (P<0.001) and of dFLC. The cutoffs for Q1 was 25, 40and 40% decrease for serum M spike, dFLC and 24 hr UrM respectively. Among various baseline characteristics only higher age was predictive of a poor (Q1) response. Given the trend toward worse OS among the Q 4 group (maximum decrease in serum M spike), we examined the relationship to cytogenetic risk. Among 232 pts with FISH data available, proportion of pts with high-risk disease was 27, 12, 22 and 31% respectively in quartiles 1 - 4). In a multivariate analysis, quartile 1 and 4 of serum M-protein response and the high-risk FISH were independent risk factors associated inferior OS. Conclusions: Both shallow and very deep response to therapy in cycle 1 is a strong indicator of eventual disease outcome and should be considered as marker of high-risk disease, likely through different mechanisms. For the shallow responders, prospective trials should assess if a change in therapeutic management will alter the outcome of these pts. The rapid deep responders also appear represent a different high-risk biology, emphasizing the fact that pts with high-risk disease often have excellent initial responses, but poor long term outcomes. [Table: see text]

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Speech Is Silver, Nonverbal Behavior Is Gold: How Implicit Partner Evaluations Affect Dyadic Interactions in Close Relationships

Psychological Science ◽

10.1177/0956797618785899 ◽

2018 ◽

Vol 29 (11) ◽

pp. 1731-1741 ◽

Cited By ~ 4

Author(s):

Ruddy Faure ◽

Francesca Righetti ◽

Magdalena Seibel ◽

Wilhelm Hofmann

Keyword(s):

Dyadic Interaction ◽

Long Term Outcomes ◽

Multimethod Research ◽

Relational Processes ◽

Gut Feelings ◽

Significant Step ◽

The Relationship ◽

Do So

Growing evidence suggests that the seeds of relationship decay can be detected via implicit partner evaluations even when explicit evaluations fail to do so. However, little is known about the concrete daily relational processes that explain why these gut feelings are such important determinants of relationships’ long-term outcomes. The present integrative multimethod research yielded a novel finding: that participants with more positive implicit partner evaluations exhibited more constructive nonverbal (but not verbal) behavior toward their partner in a videotaped dyadic interaction. In turn, this behavior was associated with greater satisfaction with the conversation and with the relationship in the following 8-day diary portion of the study. These findings represent a significant step forward in understanding the crucial role of automatic processes in romantic relationships. Together, they provide novel evidence that relationship success appears to be highly dependent on how people spontaneously behave in their relationship, which may be ultimately rooted in their implicit partner evaluations.

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PCN16 THE RELATIONSHIP BETWEEN SHORT-TERM RESPONSE AND LONG-TERM OUTCOMES IN PATIENTS WITH CHRONIC PHASE CHRONIC MYELOGENOUS LEUKAEMIA

Value in Health ◽

10.1016/s1098-3015(10)68927-9 ◽

2007 ◽

Vol 10 (3) ◽

pp. A128

Author(s):

MJ Taylor ◽

HJ Kan ◽

C Davis

Keyword(s):

Chronic Myelogenous Leukaemia ◽

Chronic Phase ◽

Myelogenous Leukaemia ◽

Long Term Outcomes ◽

Short Term ◽

The Relationship ◽

Term Response

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A9303 The relationship between urine albumin to creatinine ratio and long-term outcomes in patients with atrial fibrillation

Journal of Hypertension ◽

10.1097/01.hjh.0000548725.66691.c2 ◽

2018 ◽

Vol 36 ◽

pp. e178

Author(s):

Wu Shuang ◽

Yan-min Yang

Keyword(s):

Atrial Fibrillation ◽

Creatinine Ratio ◽

Long Term Outcomes ◽

Urine Albumin ◽

The Relationship

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Abstract MP28: Heart Rate At Hospital Discharge Is Associated With Adverse Long Term Outcomes In Patients With Heart Failure

Circulation ◽

10.1161/circ.129.suppl_1.mp28 ◽

2014 ◽

Vol 129 (suppl_1) ◽

Author(s):

Ihab B Alomari ◽

Xin Zhao ◽

Adrian F Hernandez ◽

Zubin J Eapen ◽

Gregg C Fonarow ◽

...

Keyword(s):

Heart Failure ◽

Heart Rate ◽

Risk Factor ◽

Independent Predictor ◽

Long Term Outcomes ◽

Medicare Data ◽

Multivariable Analyses ◽

The Mean ◽

The Relationship

Background: Heart rate (HR) has been identified as a risk factor for adverse long-term outcomes in patients with and without heart disease. However, the relationship between discharge HR and outcomes in patients receiving guideline based therapy for HF remains unknown. Hypothesis: Heart rate at hospital discharge in patients with HF is an independent predictor of mortality and readmission rates at 1 year. Methods: Using the American Heart Association Get With The Guidelines Heart Failure national quality assurance registry linked with Medicare data, long term outcomes for patients ≥65 years of age hospitalized from 2005-2011 were obtained. Univariable and multivariable analyses were performed to examine the relationship between 1-year outcomes (death or all cause readmission) and discharge HR. Heart rate was analyzed as a categorical (tertiles) or continuous variable. Crude and adjusted odds ratios and 95% confidence intervals for the association between discharge HR and the risk of death or hospitalization by 1-year were obtained from logistic regression modeling. Results: The analysis sample was comprised of 45,672 patients with a valid link to Medicare data and 1 year outcome status. The mean age was 80 ±8 years; % male was 45.7; and the mean ejection fraction was 43.5 ±16. Median discharge HRs for the first, second and third tertiles significantly differed (61, 72 and 87 bpm, respectively, p <0.0001). In univariable and multivariable analyses adjusted for clinical and hospital level variables there was a statistically significant relationship between 1 year outcomes and discharge HR (Table). Conclusion: In hospitalized patients with HF, HR at the time of discharge is an independent predictor of mortality. Despite optimal adherence to current guideline based therapy, the odds for all-cause mortality increased by 13% for every 10 beat increases in HR. The use of HR both as a prognostic variable, as well as potentially modifiable risk factor, may be of value in risk-stratification algorithms at discharge.

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