scholarly journals Decline in Emotional Face Recognition Among Elderly People May Reflect Mild Cognitive Impairment

2021 ◽  
Vol 12 ◽  
Author(s):  
Ryuta Ochi ◽  
Akira Midorikawa
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cognitive Function ◽  
Facial Expressions ◽  
Face Perception ◽  
Elderly Subjects ◽  
Emotional Facial Expressions ◽  
Face Matching ◽  
The Face ◽  
Selection Tasks

BackgroundAs with cognitive function, the ability to recognize emotions changes with age. In the literature regarding the relationship between recognition of emotion and cognitive function during aging, the effects of predictors such as aging, emotional state, and cognitive domains on emotion recognition are unclear. This study was performed to clarify the cognitive functions underlying recognition of emotional facial expressions, and to evaluate the effects of depressive mood on recognition of emotion in elderly subjects, as well as to reproduce the effects of aging on the recognition of emotional facial expressions.Materials and MethodsA total of 26 young (mean age = 20.9 years) and 30 elderly subjects (71.6 years) participated in the study. All subjects participated in face perception, face matching, emotion matching, and emotion selection tasks. In addition, elderly subjects were administered a multicomponent cognitive test: the Neurobehavioral Cognitive Status Examination (Cognistat) and the Geriatric Depression Scale-Short Version. We analyzed these factors using multiple linear regression.ResultsThere were no significant differences between the two groups in the face perception task, but in the face matching, emotion matching, and emotion selection tasks, elderly subjects showed significantly poorer performance. Among elderly subjects, multiple regression analyses showed that performance on the emotion matching task was predicted by age, emotional status, and cognitive function, but paradoxical relationships were observed between recognition of emotional faces and some verbal functions. In addition, 47% of elderly participants showed cognitive decline in one or more domains, although all of them had total Cognistat scores above the cutoff.ConclusionIt might be crucial to consider preclinical pathological changes such as mild cognitive impairment when testing for age effects in elderly populations.

scholarly journals Intermittent Fasting Enhanced the Cognitive Function in Older Adults with Mild Cognitive Impairment by Inducing Biochemical and Metabolic changes: A 3-Year Progressive Study

Nutrients ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2644 ◽  
Author(s):  
Theng Choon Ooi ◽  
Asheila Meramat ◽  
Nor Fadilah Rajab ◽  
Suzana Shahar ◽  
Intan Safinar Ismail ◽  
...  
Keyword(s):  
Older Adults ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cognitive Function ◽  
Successful Aging ◽  
Ketone Bodies ◽  
Fasting Blood Glucose ◽  
Elderly Subjects ◽  
Intermittent Fasting

Intermittent fasting (IF) refers to various dietary regimens that cycle between a period of non-fasting and a period of total fasting. This study aimed to determine the effects of IF on cognitive function among elderly individuals who practice IF who have mild cognitive impairment (MCI). A total of 99 elderly subjects with MCI of Malay ethnicity without any terminal illness were recruited from a larger cohort study, LRGS TUA. The subjects were divided into three groups, comprising those who were regularly practicing IF (r-IF), irregularly practicing IF (i-IF), and non-fasters (n-IF). Upon 36 months of follow-up, more MCI subjects in the r-IF group reverted to successful aging with no cognitive impairment and diseases (24.3%) compared to those in i-IF (14.2%) and n-IF groups (3.7%). The r-IF group’s subjects exhibited significant increment in superoxide dismutase (SOD) activity and reduction in body weight, levels of insulin, fasting blood glucose, malondialdehyde (MDA), C-reactive protein (CRP), and DNA damage. Moreover, metabolomics analysis showed that IF may modulate cognitive function via various metabolite pathways, including the synthesis and degradation of ketone bodies, butanoate metabolism, pyruvate metabolism, and glycolysis and gluconeogenesis pathways. Overall, the MCI-afflicted older adults who practiced IF regularly had better cognitive scores and reverted to better cognitive function at 36 months follow-up.

DHA supplementation improves cognitive function via enhancing Aβ-mediated autophagy in Chinese elderly with mild cognitive impairment: a randomised placebo-controlled trial

2017 ◽  
Vol 89 (4) ◽  
pp. 382-388 ◽  
Author(s):  
Yan-Ping Zhang ◽  
Yinyin Lou ◽  
Jing Hu ◽  
Rujuan Miao ◽  
Fei Ma
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cognitive Function ◽  
Corn Oil ◽  
Digit Span ◽  
Controlled Trial ◽  
Intervention Group ◽  
Estimating Equation ◽  
Elderly Subjects ◽  
Double Blind

BackgroundHigher docosahexaenoic acid (DHA) intake is inversely correlated with relative risk of Alzheimer’s disease. The potential benefits of DHA supplementation in people with mild cognitive impairment (MCI) have not been fully examined.ObjectiveOur study aimed to assess the effect of a 24-month DHA supplementation on cognitive function and amyloid beta (Aβ)-mediated autophagy in elderly subjects with MCI.MethodsThis was a randomised, double-blind, placebo-controlled trial in Tianjin, China. A total of 240 individuals with MCI were identified and randomly divided into intervention (DHA 2 g/day, n=120) and control (corn oil as placebo, n=120) groups. Cognitive function and blood Aβ-related biomarkers were measured at baseline, 6, 12, 18 and 24 months. Data were analysed using generalised estimating equation.ResultsA total of 217 participants (DHA: 109, placebo: 108) completed the trial. During the follow-up, scores of full-scale IQ, verbal IQ and subdomains of information and digit span were significantly higher in the intervention group than the convention group (p<0.05). In the intervention group, blood Aβ-42 level and expression of Aβ protein precursor mRNA were decreased (p<0.05), while Beclin-1 and LC3-II levels and expression of LC3-II mRNA were increased (p<0.05).ConclusionDaily oral DHA supplementation (2 g/day) for 24 months may improve cognitive function and change blood biomarker-related Aβ-mediated autophagy in people with MCI. Larger longer-term confirmatory studies are warranted.Trial registration numberChiCTR-IOR-15006058.

scholarly journals Benefits in Cognitive Function, Blood Pressure, and Insulin Resistance Through Cocoa Flavanol Consumption in Elderly Subjects With Mild Cognitive Impairment

Hypertension ◽  
2012 ◽  
Vol 60 (3) ◽  
pp. 794-801 ◽  
Author(s):  
Giovambattista Desideri ◽  
Catherine Kwik-Uribe ◽  
Davide Grassi ◽  
Stefano Necozione ◽  
Lorenzo Ghiadoni ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Blood Pressure ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cognitive Function ◽  
Elderly Subjects

scholarly journals Effect of Aerobic Exercise on HbA1c and Cognitive Function in Prediabetes Patients with Mild Cognitive Impairment

2020 ◽  
Author(s):  
Fatemeh Khodaee ◽  
Hojjatollah Nikbakht ◽  
Mandana Gholami ◽  
Mohammad Ali Babaee-Beigi4 ◽  
Khosrow Ebrahim
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cognitive Function ◽  
Aerobic Exercise ◽  
Exercise Program ◽  
Elderly Subjects ◽  
P Value ◽  
Exercise Specialist ◽  
And Control ◽  
State Examination

Objective: This study aimed to investigate the effects of moderate to high-intensity aerobic exercise on HbA1c (Glycated hemoglobin), FBS (fasting blood sugar) and cognitive function in mild cognitive impairment prediabetes patients. Materials and Methods: Seventeen elderly mild cognitive impairment (age 55-70) men and women were selected and were randomly divided into 2 groups as aerobic (n=10) and control (n=10). Six subjects were excluded during the study. Finally, 14 subjects were continued the exercise program. Assessments were done at baseline and 12 weeks after intervention. The 12-weeks aerobic exercise program consisted of 90 min sessions in length 3 days per week under the supervision of the exercise specialist. Cognitive function, HbA1c, and FBS were evaluated. The differences in all variables (one way ANOVA), correlation (Pearson single correlation) and relative changes between baseline and 12 weeks (paired T-tests) were investigated. Results: HbA1c, FBS decreased significantly in the aerobic group whereas cognitive function increased significantly after 12 weeks aerobic ( P -value< 0.05 for all). Also, the change of cognitive function was significantly associated with a change of FBS (r= -0.84) after a 12-week aerobic exercise ( P -value: 0.011). Differences between groups in HbA1c, FBS and cognitive function (Mini-Mental State Examination) were not significant. Conclusion: Aerobic exercise may improve HbA1c, FBS and subsequently cognitive function in prediabetes elderly subjects. Therefore, a decrease in glycemic indicators could lead to improve cognitive function.

scholarly journals Effect of Synaid on cognitive functions and mood in elderly subjects with self-perceived loss of memory after COVID-19 infection

2021 ◽  
Vol 17 (6) ◽  
pp. 1797-1799
Author(s):  
Marilisa Bove ◽  
Federica Fogacci ◽  
Silvia Quattrocchi ◽  
Maddalena Veronesi ◽  
Arrigo Cicero
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cognitive Function ◽  
Elderly Patients ◽  
Cognitive Functions ◽  
Term Effect ◽  
Elderly Subjects ◽  
Long Term Effect ◽  
At Home

IntroductionThere is growing attention towards the possible long-term effect of COVID-19 on neuropsychiatric disorders.Material and methodsWe tested the effect of a combined nutraceutical (Synaid) with known nootropic effects in 40 elderly patients with self-perceived cognitive decline after SARS-CoV-2 infection, treated at home or in hospital.ResultsAfter 3 months of treatment, Synaid significantly improved functional status, MMSE and the main psychological disorders associated with mild cognitive impairment, both in patients previously cared for at home and in hospital because of SARS-CoV-2 infection.ConclusionsSynaid was well tolerated and effective in improving cognitive function and psychosocial parameters after SARS-CoV-2 infection.

Association of Circulating Cholesterol Level with Cognitive Function and Mild Cognitive Impairment in the Elderly: A Community-based Population Study

2020 ◽  
Vol 17 (6) ◽  
pp. 556-565
Author(s):  
Yujie Guo ◽  
Pengfei Li ◽  
Xiaojun Ma ◽  
Xiaochen Huang ◽  
Zhuoheng Liu ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cognitive Function ◽  
Cholesterol Level ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Cross Sectional ◽  
Increased Risk ◽  
Aging Adults ◽  
Female Subjects

Background: The present study was designed to examine the association of circulating cholesterol with cognitive function in non-demented community aging adults. Methods: This was a cross-sectional study including 1754 Chinese adults aged 55-80 years. The association between serum cholesterol levels and cognitive function was examined. Participants were categorized into four groups according to the quartile of circulating TC (total cholesterol), High Density Lipoprotein Cholesterol (HDL-c), Low Density Lipoprotein Cholesterol (LDL-c) levels and HDLc/ LDL-c ratio. The difference in cognitive performance among the groups was compared. Logistic regression model was used to determine the association of circulating cholesterol level with the risk of Mild Cognitive Impairment (MCI). Results: Mild increase of serum LDL-c level correlated with better visual and executive, language, memory and delayed recall abilities. Higher circulating TC and HDL-c levels were found to be associated with poorer cognitive function, especially in aging female subjects. Higher circulating TC, HDL-c and HDL/LDL ratio indicated an increased risk of MCI, especially in female subjects. Conclusion: Slight increase in circulating LDL-c level might benefit cognitive function in aging adults. However, higher circulating TC and HDL-c levels might indicate a decline of cognitive function, especially in aging female subjects.

Sign in / Sign up

Export Citation Format

Share Document