scholarly journals Altered Neural Processing of Reward and Punishment in Women With Methamphetamine Use Disorder

2021 ◽  
Vol 12 ◽  
Author(s):  
Shuguang Wei ◽  
Zhaoxia Xue ◽  
Wujun Sun ◽  
Jie Han ◽  
Haiyan Wu ◽  
...  
Keyword(s):  
Negative Feedback ◽  
Positive Feedback ◽  
Monetary Incentive ◽  
Reward Condition ◽  
Event Related Potential ◽  
Neural Basis ◽  
Drug Use Disorders ◽  
Monetary Incentive Delay ◽  
Neutral Conditions ◽  
Reward And Punishment

It has been suggested that the altered function of reward and punishment is an important vulnerability factor leading to the development of drug use disorders. Previous studies have identified evidence of neurophysiological dysfunction in the reward process of individuals with substance use disorders. To date, only a few event-related potential (ERP) studies have examined the neural basis of reward and punishment processing in women with methamphetamine (MA) use disorders. The current ERP research aims to investigate the neurophysiological mechanisms of reward and punishment in women with MA use disorder using a monetary incentive delay task. Nineteen women with MA use disorder (MA group) and 20 healthy controls (HC group) were recruited in this study. The behavioral data showed that the reaction time (RT) was faster and the response accuracy (ACC) was higher for the potential reward and punishment conditions compared to neutral conditions. During the monetary incentive anticipation stage, the Cue-P3, and stimulus-preceding negativity (SPN) were larger in the MA group than in the HC group. The SPN under the potential reward condition was larger than that under the neutral condition in the MA group but not in the HC group. During the monetary incentive consummation stage, the feedback-related negativity and feedback P3 (FB-P3) following positive feedback were significantly larger than negative feedback in the potential reward condition for the HC group, but not for the MA group. However, the FB-P3 following negative feedback was significantly larger than positive feedback in the potential punishment condition for the MA group, but not the HC group. The results suggest that women with MUD have stronger expectations of generic reward and stronger response of generic harm avoidance, which could be targeted in designing interventions for women with MA use disorder.

scholarly journals Opportunities to sit and stand trigger equivalent reward-related brain activity

2019 ◽  
Author(s):  
Boris Cheval ◽  
Matthieu P Boisgontier ◽  
Mariane Bacelar ◽  
Robyn Feiss ◽  
Matthew W Miller
Keyword(s):  
Energy Expenditure ◽  
Cost Minimization ◽  
Brain Activity ◽  
Reward Condition ◽  
Event Related Potential ◽  
Energetic Cost ◽  
Recent Theory ◽  
Reward Positivity ◽  
Standing Up ◽  
Monetary Incentive Delay

A recent theory contends that behaviors minimizing energetic cost are rewarding (Cheval et al., 2018). However, direct experimental evidence supporting this theory is lacking. To fill this knowledge gap, we investigated the effect of energy expenditure on reward-related brain activity. Thirty-one participants were equipped with an electroencephalography (EEG) cap and performed a monetary incentive delay task. After attempting to quickly respond to a target, participants were given feedback instructing them to retrieve a token (reward condition) or to wait (no reward condition). In half of the rewarding trials, participants stood up to retrieve a token, thereby increasing energy expenditure. In the other half, participants just had to extend their arm to retrieve a token, thereby minimizing energy expenditure. The contingent negative variation (CNV) event-related potential (ERP) component preceding the motor response was used as an indicator of reward pursuit. The reward positivity (RewP) ERP component time-locked to feedback onset was used to determine reward valuation. Results showed that response time, CNV, and RewP were not influenced by energy expenditure (remaining seated vs. standing up). This null effect of conditions was confirmed using equivalence tests. These results do not support the theory of energetic cost minimization but the equivalent effect of sitting and standing on reward-related brain activity is new knowledge that could contribute to shed light on the neural processes underlying the pandemic of physical inactivity.

scholarly journals Increased Anxiety is Associated with Better Learning from Negative Feedback

2020 ◽  
pp. 147572572096576
Author(s):  
Daniella L. Jones ◽  
Jonathan D. Nelson ◽  
Bertram Opitz
Keyword(s):  
Negative Feedback ◽  
Positive Feedback ◽  
Mental Health Problems ◽  
Learning Task ◽  
Event Related Potential ◽  
Feedback Processing ◽  
Feedback Communication ◽  
Teacher Student ◽  
Penn State ◽  
State Worry

Anxiety is one of the most prevalent mental health problems; it is known to impede cognitive functioning. It is believed to alter preferences for feedback-based learning in anxious and non-anxious learners. Thus, the present study measured feedback processing in adults ( N = 30) with and without anxiety symptoms using a probabilistic learning task. Event-related potential (ERP) measures were used to assess how the bias for either positive or negative feedback learning is reflected by the feedback-related negativity component (FRN), an ERP extracted from the electroencephalogram. Anxious individuals, identified by means of the Penn State Worry Questionnaire, showed a diminished FRN and increased accuracy after negative compared to positive feedback. Non-anxious individuals exhibited the reversed pattern with better learning from positive feedback, highlighting their preference for positive feedback. Our ERP results imply that impairments with feedback-based learning in anxious individuals are due to alterations in the mesolimbic dopaminergic system. Our finding that anxious individuals seem to favor negative as opposed to positive feedback has important implications for teacher–student feedback communication.

scholarly journals Learning With and Without Feedback in Children With Developmental Language Disorder

2021 ◽  
pp. 1-16
Author(s):  
Yael Arbel ◽  
Isabel Fitzpatrick ◽  
Xinyi He
Keyword(s):  
Learning Outcomes ◽  
Negative Feedback ◽  
Performance Feedback ◽  
Positive Feedback ◽  
Language Disorder ◽  
Event Related Potential ◽  
School Age Children ◽  
Future Research ◽  
Developmental Language Disorder ◽  
Feedback Processing

Purpose Intervention provided to school-age children with developmental language disorder often relies on the provision of performance feedback, yet it is unclear whether children with this disorder benefit from feedback-based learning. The study evaluates the effect of performance feedback on learning in children with developmental language disorder. Method Thirteen 8- to 12-year-old children with developmental language disorder and 14 age- and gender-matched children with typical language development completed two learning tasks whose objective was to pair nonword novel names with novel objects. The two tasks differed in the presence of performance feedback to guide learning. Learning outcomes on immediate and follow-up tests were compared between the feedback-based and feedback-free tasks. Additionally, an electrophysiological marker of feedback processing was compared between children with and without developmental language disorder. Results Children with developmental language disorder demonstrated poorer learning outcomes on both tasks when compared with their peers, but both groups achieved better accuracy on the feedback-free task when compared with the feedback-based task. Within the feedback-based task, children were more likely to repeat a correct response than to change it after positive feedback but were as likely to repeat an error as they were to correct it after receiving negative feedback. While children with typical language elicited a feedback-related negativity with greater amplitude to negative feedback, this event-related potential had no amplitude differences between positive and negative feedback in children with developmental language disorder. Conclusions Findings indicate that 8- to 12-year-old children benefit more from a feedback-free learning environment and that negative feedback is not as effective as positive feedback in facilitating learning in children. The behavioral and electrophysiological data provide evidence that feedback processing is impaired in children with developmental language disorders. Future research should evaluate feedback-based learning in children with this disorder using other learning paradigms.

scholarly journals Men Show Higher Neural Sensitivity to Wins – Large or Small – than Women in the Monetary Incentive Delay Task

2020 ◽  
Author(s):  
Isha Dhingra ◽  
Sheng Zhang ◽  
Simon Zhornitsky ◽  
Wuyi Wang ◽  
Thang M Le ◽  
...  
Keyword(s):  
Sex Differences ◽  
Monetary Incentive ◽  
Sensitivity To Reward ◽  
Men And Women ◽  
Delay Task ◽  
Slope Test ◽  
Monetary Incentive Delay Task ◽  
Monetary Incentive Delay ◽  
Sensitivity To Punishment ◽  
Reward And Punishment

Abstract Background Men and women show differences in sensitivity to reward and punishment, which may impact behavior in health and disease. However, the neural bases of these sex differences remain under-investigated. Here, by combining functional magnetic resonance imaging (fMRI) and a Monetary Incentive Delay Task (MIDT), we examined sex differences in the neural responses to monetary wins and losses and how these regional activities vary with individual reward and punishment sensitivity. Methods Sixty-three healthy adults (27 women) participated in the fMRI study with a 3-Tesla scanner. Sensitivity to punishment (SP) and sensitivity to reward (SR) were assessed with the Sensitivity to Punishment and Sensitivity to Reward Questionnaire (SPSRQ). In the MIDT, participants pressed a button to collect either $1, 1¢, or nil, with the reaction time window titrated across trials to achieve ~67% success. Imaging data were processed with published routines and evaluated with a corrected threshold. Results The results showed higher SP score in women vs. men and higher SR score in men vs. women. Compared to women, men also showed higher response to the receipt of dollar or cent reward in the medial prefrontal cortex, in the area of the supplementary motor cortex. Regional responses to loss did not show sex differences. Further, in a whole-brain regression, activation of the caudate head during 1¢ loss was correlated positively with SR score in men but not in women, and the sex difference was confirmed by a slope test. Conclusions Together, men showed higher SR and neural sensitivity to the receipt of reward, big or small, than women. Individual differences in SR could be reflected by caudate response to a small loss in men. These findings highlight how men and women may differ in reward-related brain activations in the MIDT and add to the imaging literature of sex differences in cognitive and affective functions.

scholarly journals Suppression of personality variation in boldness during foraging in three-spined sticklebacks

2021 ◽  
Vol 75 (4) ◽  
Author(s):  
Hannah E. A. MacGregor ◽  
Aislinn Cottage ◽  
Christos C. Ioannou
Keyword(s):  
Negative Feedback ◽  
Risk Taking ◽  
Positive Feedback ◽  
Gasterosteus Aculeatus ◽  
Control Treatment ◽  
Refuge Use ◽  
Individual Level ◽  
Behavioural Type ◽  
State Behaviour

Abstract Consistent inter-individual variation in behaviour within a population, widely referred to as personality variation, can be affected by environmental context. Feedbacks between an individual’s behaviour and state can strengthen (positive feedback) or weaken (negative feedback) individual differences when experiences such as predator encounters or winning contests are dependent on behavioural type. We examined the influence of foraging on individual-level consistency in refuge use (a measure of risk-taking, i.e. boldness) in three-spined sticklebacks, Gasterosteus aculeatus, and particularly whether changes in refuge use depended on boldness measured under control conditions. In the control treatment trials with no food, individuals were repeatable in refuge use across repeated trials, and this behavioural consistency did not differ between the start and end of these trials. In contrast, when food was available, individuals showed a higher degree of consistency in refuge use at the start of the trials versus controls but this consistency significantly reduced by the end of the trials. The effect of the opportunity to forage was dependent on behavioural type, with bolder fish varying more in their refuge use between the start and the end of the feeding trials than shyer fish, and boldness positively predicted the likelihood of feeding at the start but not at the end of the trials. This suggests a state-behaviour feedback, but there was no overall trend in how bolder individuals changed their behaviour. Our study shows that personality variation can be suppressed in foraging contexts and a potential but unpredictable role of feedbacks between state and behaviour. Significance statement In this experimental study, we examined how foraging influences consistency in risk-taking in individual three-spined sticklebacks. We show that bolder individuals become less consistent in their risk-taking behaviour than shyer individuals during foraging. Some bolder individuals reinforce their risk-taking behaviour, suggesting a positive feedback between state and behaviour, while others converge on the behaviour of shyer individuals, suggesting a negative feedback. In support of a role of satiation in driving negative feedback effects, we found that bolder individuals were more likely to feed at the start but not at the end of the trials. Overall, our findings suggest that foraging can influence personality variation in risk-taking behaviour; however, the role of feedbacks may be unpredictable.

scholarly journals Bayesian analysis of time-varying interactions between stock returns and foreign equity flows

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Boubekeur Baba ◽  
Güven Sevil
Keyword(s):  
Stock Returns ◽  
Negative Feedback ◽  
Positive Feedback ◽  
Positive Response ◽  
Time Varying ◽  
Economic Uncertainty ◽  
Foreign Investors ◽  
New Findings ◽  
Net Flows ◽  
Feedback Trading

AbstractThis study discusses the trading behavior of foreign investors with respect to economic uncertainty in the South Korean stock market from a time-varying perspective. We employ a news-based measure of economic uncertainty along with the model of time-varying parameter vector autoregression with stochastic volatility. The empirical analysis reveals several new findings about foreign investors’ trading behaviors. First, we find evidence that positive feedback trading often appears during periods of high economic uncertainty, whereas negative feedback trading is exclusively observable during periods of low economic uncertainty. Second, the foreign investors’ feedback trading appears mostly to be well-timed and often leads the time-varying economic uncertainty except in periods of global crises. Third, lagged negative (positive) response of net flows to economic uncertainty is found to be coupled with lagged positive (negative) feedback trading. Fourth, the study documents an asymmetric response of foreign investors with regard to negative and positive shocks of economic uncertainty. Specifically, we find that they instantly turn to positive feedback trading after a negative contemporaneous response of net flows to shocks of economic uncertainty. In contrast, they move slowly toward negative feedback trading after a positive response of net flows to uncertainty shocks.

scholarly journals A13-2 Identification of negative feedback, positive feedback and feed foward sequences during tilt test in young women with syncope

EP Europace ◽  
2003 ◽  
Vol 4 (Supplement_2) ◽  
pp. B19-B19
Author(s):  
G.A. Ruiz ◽  
J.C. Perfetto ◽  
S. Gallino ◽  
R. Chirife ◽  
A. Guillardot ◽  
...  
Keyword(s):  
Young Women ◽  
Negative Feedback ◽  
Positive Feedback ◽  
Tilt Test

EFFECT OF HYPOTHALAMIC DEAFFERENTATION ON THE CONTROL OF LUTEINIZING HORMONE SECRETION

1970 ◽  
Vol 46 (1) ◽  
pp. 1-7 ◽  
Author(s):  
S. TALEISNIK ◽  
M. E. VELASCO ◽  
J. J. ASTRADA
Keyword(s):  
Luteinizing Hormone ◽  
Negative Feedback ◽  
Positive Feedback ◽  
Hormone Secretion ◽  
Feedback Effect ◽  
Luteinizing Hormone Secretion ◽  
Ovarian Steroids ◽  
Medial Hypothalamus ◽  
Lh Release ◽  
Positive Feedback Effect

SUMMARY The influence that the interruption of the neural afferents to the hypothalamus exerts on ovulation and on the release of luteinizing hormone (LH) was studied in the rat. Animals with retrochiasmatic sections interrupting the neural connexions between the medial hypothalamus and the preoptic area (POA) showed constant oestrus and failed to ovulate. Animals in which the dorsal neural afferents to the POA were transected had oestrous cycles and ovulated normally. The positive feedback effect of progesterone on LH release in spayed animals primed either with 20 μg. oestradiol benzoate or 2·5 mg. testosterone propionate 3 days before was studied. Transection of the dorsal afferents to the POA favoured an increase in plasma LH, but in animals with retrochiasmatic sections the response was abolished. However, the negative feedback effect of ovarian steroids operated after both types of transection because an increase in plasma LH occurred after ovariectomy. It is concluded that the negative feedback effect of ovarian steroids acts on the medial hypothalamus which can maintain a tonic release of gonadotrophins in the absence of steroids. In contrast, the POA involved in the positive feedback effect of progesterone is concerned with the phasic release of LH.

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