scholarly journals Age- and Sex-Related Cortical Gray Matter Volume Differences in Adolescent Cannabis Users: A Systematic Review and Meta-Analysis of Voxel-Based Morphometry Studies

2021 ◽  
Vol 12 ◽  
Author(s):  
Aliyah Allick ◽  
Grace Park ◽  
Kwon Kim ◽  
Michelle Vintimilla ◽  
Krutika Rathod ◽  
...  
Keyword(s):  
Systematic Review ◽  
Gray Matter ◽  
Meta Analysis ◽  
Gray Matter Volume ◽  
Superior Temporal Gyrus ◽  
Voxel Based Morphometry ◽  
Whole Brain ◽  
Male Youth ◽  
Matter Volume ◽  
Age And Sex

Introduction: Adolescent-onset cannabis use is rising in the era of marijuana legalization. Recent imaging studies have identified neuroanatomical differences between adult cannabis users and controls that are more prominent in early-onset users. Other studies point to sex-dependent effects of cannabis.Methods: A systematic review following PRISMA guidelines and subsequent effect-size seed-based d mapping (SDM) meta-analyses were conducted to investigate relationships between age (across the 12-to-21-year-old developmental window), sex, and gray matter volume (GMV) differences between cannabis using (CU) and typically developing (TD) youth.Results: Our search identified 1,326 citations, 24 of which were included in a qualitative analysis. A total of 6 whole-brain voxel-based morphometry (VBM) studies comparing regional GMV between 357 CU [mean (SD) age = 16.68 (1.28); 71% male] and 404 TD [mean (SD) age = 16.77 (1.36); 63% male] youth were included in the SDM-meta-analysis. Meta-analysis of whole-brain VBM studies identified no regions showing significant GMV difference between CU and TD youth. Meta-regressions showed divergent effects of age and sex on cortical GMV differences in CU vs. TD youth. Age effects were seen in the superior temporal gyrus (STG), with older-aged CU youth showing decreased and younger-aged CU youth showing increased STG GMV compared to age-matched TD youth. Parallel findings in the STG were also observed in relation to duration of CU (years) in supplemental meta-regressions. Regarding sex effects, a higher proportion of females in studies was associated with increased GMV in the middle occipital gyrus in CU vs. TD youth.Conclusions: These findings suggest that GMV differences between CU and TD youth, if present, are subtle, and may vary as a function of age, cumulative cannabis exposure, and sex in young people. Whether age- and sex-related GMV differences are attributable to common predispositional factors, cannabis-induced neuroadaptive changes, or both warrant further investigation.

A meta-analysis of voxel-based morphometry studies on gray matter volume alteration in juvenile myoclonic epilepsy

2013 ◽  
Vol 106 (3) ◽  
pp. 370-377 ◽  
Author(s):  
Bei Cao ◽  
YingYing Tang ◽  
JianPeng Li ◽  
Xiang Zhang ◽  
Hui-Fang Shang ◽  
...  
Keyword(s):  
Gray Matter ◽  
Meta Analysis ◽  
Gray Matter Volume ◽  
Juvenile Myoclonic Epilepsy ◽  
Myoclonic Epilepsy ◽  
Voxel Based Morphometry ◽  
Matter Volume

Reduced gray matter volume in patients with retinal detachment: evidence from a voxel-based morphometry study

2019 ◽  
Vol 61 (3) ◽  
pp. 395-403
Author(s):  
Biao Li ◽  
Yu-Xin Liu ◽  
Hai-Jun Li ◽  
Qing Yuan ◽  
Pei-Wen Zhu ◽  
...  
Keyword(s):  
White Matter ◽  
Retinal Detachment ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Cingulate Gyrus ◽  
Voxel Based Morphometry ◽  
White Matter Volume ◽  
Whole Brain ◽  
Matter Volume ◽  
Brain White Matter

Background We know little about the pathogenesis and diagnosis of retinal detachment. Purpose To assess spontaneous changes in the cerebral cortex of patients with retinal detachment using voxel-based morphometry and to explore the relationship between retinal detachment and clinical behavioral performance. Material and Methods Patients (14 men, 6 women; average age = 49.15 ± 10.32 years) with rhegmatogenous retinal detachment (duration of 24.05 ± 19.61 days) and 20 matched healthy controls were recruited. All participants underwent repeated functional magnetic resonance imaging scans. The original three-dimensional T1 brain images were analyzed using voxel-based morphometry and whole brain white matter volume and whole brain gray matter volume were compared with those of the control group. A receiver operating characteristic (ROC) curve was used to classify the mean gray matter volume values of the patients with retinal detachment compared with the controls. Results Compared with the controls, whole brain gray matter volume was significantly reduced in patients with retinal detachment, as evidenced by changes in the right inferior frontal gyrus, right superior temporal gyrus, right anterior cingulate gyrus, and right cuneus. In addition, the posterior lobe of the cerebellum, left hippocampus, left cingulate gyrus, and left middle temporal gyrus were also obviously atrophied. Furthermore, whole brain white matter volume of the patients with retinal detachment showed a slight reduction. The ROC curve analysis of each brain region showed that the accuracy of the area under the curve was high. Conclusion We proved that patients with retinal detachment had unusual changes in the gray matter volume and white matter volume in vision-related brain regions, which could reveal potential pathological mechanisms of retinal detachment.

scholarly journals A meta-analysis of gray matter volume differences between bilinguals and monolinguals

2019 ◽  
Author(s):  
Anastasiya Danylkiv ◽  
Anthony James Krafnick
Keyword(s):  
Language Learning ◽  
Gray Matter ◽  
Meta Analysis ◽  
Gray Matter Volume ◽  
Anterior Lobe ◽  
Whole Brain ◽  
Bilingual Advantage ◽  
Anatomical Changes ◽  
Matter Volume ◽  
Pediatric Study

Bilingualism is of great interest to the neuroscience of language, and understanding the anatomical changes associated with second language learning help inform theories of bilingual advantage across the lifespan. While the literature on structural differences between bilinguals and monolinguals is robust, relatively few studies of gray matter volume (GMV) have directly compared bilinguals with monolinguals in a whole-brain analysis. Overall, this and heterogeneity of study samples and methodology have led to a lack of clear anatomical support for major theories. Here, we engage in an activation likelihood estimate (ALE) meta-analysis of voxel-based morphometry (VBM) studies of GMV for cases that directly compare bilingual and monolingual subjects in a whole-brain analysis. The analysis (sixteen foci, from ten contrasts across eight studies) resulted in one cluster located primarily within the anterior lobe of the right cerebellum. However, when the one pediatric study was removed, the analysis revealed no consistent results across the studies included in this meta-analysis. This suggests that for VBM studies of bilingual and monolingual adults there is considerable heterogeneity of results that complicate the understanding of the bilingual brain. Future studies will need to include larger, more well-defined samples and interrogate more fine-grained anatomical features such as cortical thickness and surface area in order to more fully examine the anatomical changes associated with bilingualism across the lifespan.

scholarly journals Gray matter volume alterations in patients with strabismus and amblyopia: voxel-based morphometry study

2022 ◽  
Vol 12 (1) ◽  
Author(s):  
Ting Su ◽  
Pei-Wen Zhu ◽  
Biao Li ◽  
Wen-Qing Shi ◽  
Qi Lin ◽  
...  
Keyword(s):  
Gray Matter ◽  
Gray Matter Volume ◽  
Superior Temporal Gyrus ◽  
Curve Analysis ◽  
Parahippocampal Gyrus ◽  
Voxel Based Morphometry ◽  
Roc Curve Analysis ◽  
Matter Volume ◽  
The Mean ◽  
The Right

AbstractThis study proposes the use of the voxel-based morphometry (VBM) technique to investigate structural alterations of the cerebral cortex in patients with strabismus and amblyopia (SA). Sixteen patients with SA and sixteen healthy controls (HCs) underwent magnetic resonance imaging. Original whole brain images were analyzed using the VBM method. Pearson correlation analysis was performed to evaluate the relationship between mean gray matter volume (GMV) and clinical manifestations. Receiver operating characteristic (ROC) curve analysis was applied to classify the mean GMV values of the SA group and HCs. Compared with the HCs, GMV values in the SA group showed a significant difference in the right superior temporal gyrus, posterior and anterior lobes of the cerebellum, bilateral parahippocampal gyrus, and left anterior cingulate cortex. The mean GMV value in the right superior temporal gyrus, posterior and anterior lobes of the cerebellum, and bilateral parahippocampal gyrus were negatively correlated with the angle of strabismus. The ROC curve analysis of each cerebral region confirmed the accuracy of the area under the curve. Patients with SA have reduced GMV values in some brain regions. These findings might help to reveal the potential pathogenesis of SA and its relationship with the atrophy of specific regions of the brain.

scholarly journals Greater hippocampal gray matter volume in subjective hyperosmia: a voxel-based morphometry study

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Pengfei Han ◽  
Franz Paul Stiller-Stut ◽  
Alexander Fjaeldstad ◽  
Thomas Hummel
Keyword(s):  
Gray Matter ◽  
Emotional Experience ◽  
Gray Matter Volume ◽  
Brain Regions ◽  
Precentral Gyrus ◽  
Voxel Based Morphometry ◽  
Whole Brain ◽  
Superior Frontal Gyrus ◽  
Matter Volume ◽  
Olfactory Ability

Abstract Subjective hyperosmia refers to a self-reported olfactory ability that is superior to a normal, intact sense of smell (normosmia), and is associated with olfactory emotional experience. The current study used voxel-based morphometry to investigate the gray matter volume (GMV) in people with self-rated hyperosmia (subjective hyperosmia, SH, N = 18) in comparison to people with self-rated normal olfaction (subjective normosmia, SN, N = 14). Participants’ olfactory function were assessed by the extensive olfactory test battery, the “Sniffin’ Sticks” test. Within the predicted brain regions (regions-of-interest analyses), the SH participants showed larger GMV of the left hippocampus as compared to SN participants (FWE corrected p < 0.05). Further, the whole-brain search indicated that SH had larger GMV of the bilateral hippocampus, the right hypothalamus, the left precuneus, and the left superior frontal gyrus as compared to the SN group. ROI analyses showed positive correlations between the left hippocampal GMV and odor threshold or discrimination scores across all participants. In addition, the whole-brain analysis suggested that the self-rated olfactory ability was positively associated with GMV in the cerebellum, superior frontal gyrus and the precentral gyrus among SH participants. In conclusion, the current results suggest that SH was associated with increased GMV in several brain regions that were previously shown to be involved in the processing of cognitive aspects of odors.

scholarly journals Gray matter abnormalities in Tourette Syndrome: a meta-analysis of voxel-based morphometry studies

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Xinyue Wan ◽  
Simin Zhang ◽  
Weina Wang ◽  
Xiaorui Su ◽  
Jun Li ◽  
...  
Keyword(s):  
Tourette Syndrome ◽  
Gray Matter ◽  
Clinical Characteristics ◽  
Meta Analysis ◽  
Gray Matter Volume ◽  
Brain Regions ◽  
Voxel Based Morphometry ◽  
Matter Volume ◽  
Meta Regression ◽  
Meta Regression Analysis

AbstractTourette syndrome (TS) is a neurobehavioral disorder for which the neurological mechanism has not been elucidated. Voxel-based morphometry (VBM) studies have revealed abnormalities in gray matter volume (GMV) in patients with TS; however, consistent results have not been obtained. The current study attempted to provide a voxel wise meta-analysis of gray matter changes using seed-based d mapping (SDM). We identified ten relevant studies that investigated gray matter alterations in TS patients and performed a meta-analysis using the SDM method to quantitatively estimate regional gray matter abnormalities. Next, we examined the relationships between GMV abnormalities and demographic and clinical characteristics. Our results demonstrated that TS patients had smaller GMV in the bilateral inferior frontal gyri and greater GMV in the cerebellum, right striatum (putamen), and bilateral thalami (pulvinar nucleus) than healthy controls. A meta-regression analysis did not identify correlations between GMV changes and demographic or clinical variables. This meta-analysis confirmed significant and consistent GMV changes in several brain regions of TS patients, primarily in the cortico-striato-thalamo-cortical network.

Reproducibility of Brain Volume Changes in Longitudinal Voxel-Based Morphometry Between Non-Accelerated and Accelerated Magnetic Resonance Imaging

2021 ◽  
pp. 1-10
Author(s):  
Hidemasa Takao ◽  
Shiori Amemiya ◽  
Osamu Abe ◽  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Magnetic Resonance ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Elderly Subjects ◽  
Voxel Based Morphometry ◽  
Volume Changes ◽  
Matter Volume ◽  
Healthy Elderly

Background: Scan acceleration techniques, such as parallel imaging, can reduce scan times, but reliability is essential to implement these techniques in neuroimaging. Objective: To evaluate the reproducibility of the longitudinal changes in brain morphology determined by longitudinal voxel-based morphometry (VBM) between non-accelerated and accelerated magnetic resonance images (MRI) in normal aging, mild cognitive impairment (MCI), and Alzheimer’s disease (AD). Methods: Using data from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) 2 database, comprising subjects who underwent non-accelerated and accelerated structural T1-weighted MRI at screening and at a 2-year follow-up on 3.0 T Philips scanners, we examined the reproducibility of longitudinal gray matter volume changes determined by longitudinal VBM processing between non-accelerated and accelerated imaging in 50 healthy elderly subjects, 54 MCI patients, and eight AD patients. Results: The intraclass correlation coefficient (ICC) maps differed among the three groups. The mean ICC was 0.72 overall (healthy elderly, 0.63; MCI, 0.75; AD, 0.63), and the ICC was good to excellent (0.6–1.0) for 81.4%of voxels (healthy elderly, 64.8%; MCI, 85.0%; AD, 65.0%). The differences in image quality (head motion) were not significant (Kruskal–Wallis test, p = 0.18) and the within-subject standard deviations of longitudinal gray matter volume changes were similar among the groups. Conclusion: The results indicate that the reproducibility of longitudinal gray matter volume changes determined by VBM between non-accelerated and accelerated MRI is good to excellent for many regions but may vary between diseases and regions.

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