Heritability Estimation and Environmental Risk Assessment for Type 2 Diabetes Mellitus in a Rural Region in Henan, China: Family-Based and Case-Control Studies

Objective: The prevalence of type 2 diabetes mellitus (T2DM) varies greatly in different regions and populations. This study aims to assess the heritability and environmental risk factors of T2DM among rural Chinese adults.Methods: Thousand five hundred thirty three participants from 499 extended families, which included 24 nuclear families, were recruited in the family-based study to assess the heritable risk of T2DM. Heritability of T2DM was estimated by the Falconer method. Using conditional logistic regression model, couple case-control study involving 127 couples were applied to assess the environmental risk factors of T2DM.Results: Compared with the Henan Rural Cohort, T2DM was significantly clustered in the nuclear families (OR: 8.389, 95% CI: 5.537–12.711, P < 0.001) and heritability was 0.74. No association between the heredity of T2DM and sex was observed between the extended families and the Henan Rural Cohort. Besides, results from the couple case-control study showed that physical activity (OR: 0.482, 95% CI: 0.261–0.893, P = 0.020) and fat intake (OR: 3.036, 95% CI: 1.070–8.610, P = 0.037) was associated with T2DM, and the proportion of offspring engaged in medium and high physical activity was higher than that of mothers in mother-offspring pairs.Conclusion: People with a family history of T2DM may have a higher risk of developing T2DM, however, there was no difference in genetic risk between males and females. Adherence to active physical activity and low fat intake can reduce the risk of T2DM.

Download Full-text

Vitamin D receptor methylation attenuates the association between physical activity and type 2 diabetes mellitus: a case‐control study

Journal of Diabetes ◽

10.1111/1753-0407.13239 ◽

2021 ◽

Author(s):

Songcheng Yu ◽

Yinhua Feng ◽

Chenling Qu ◽

Fei Yu ◽

Zhenxing Mao ◽

...

Keyword(s):

Physical Activity ◽

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Vitamin D ◽

Type 2 Diabetes Mellitus ◽

Vitamin D Receptor ◽

Case Control Study ◽

Case Control ◽

Control Study

Download Full-text

Genetic polymorphisms associated with pediatric‐onset type 2 diabetes: A family‐based transmission disequilibrium test and case‐control study

Pediatric Diabetes ◽

10.1111/pedi.12818 ◽

2019 ◽

Vol 20 (3) ◽

pp. 239-245

Author(s):

América L. Miranda‐Lora ◽

Mario Molina‐Díaz ◽

Miguel Cruz ◽

Rocío Sánchez‐Urbina ◽

Nancy L. Martínez‐Rodríguez ◽

...

Keyword(s):

Type 2 Diabetes ◽

Genetic Polymorphisms ◽

Transmission Disequilibrium Test ◽

Case Control Study ◽

Case Control ◽

Transmission Disequilibrium ◽

Family Based ◽

Control Study ◽

Pediatric Onset

Download Full-text

Physical Activity of Type 2 Diabetes Mellitus Patients and Non-Diabetes Participants in Yangon, Myanmar: A Case-Control Study Applying the International Physical Activity Questionnaires (IPAQ-S)

Diabetes Metabolic Syndrome and Obesity Targets and Therapy ◽

10.2147/dmso.s291468 ◽

2021 ◽

Vol Volume 14 ◽

pp. 1729-1739

Author(s):

Ishtiaq Ahmad ◽

Myo Nyein Aung ◽

Satomi Ueno ◽

Ei Thinzar Khin ◽

Tint Swe Latt ◽

...

Keyword(s):

Physical Activity ◽

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Case Control Study ◽

Case Control ◽

Activity Questionnaires ◽

Control Study

Download Full-text

Sex differences in heritable and environmental risk of abdominal obesity: family-based study and case-control study of rural adults in China

10.21203/rs.3.rs-413365/v1 ◽

2021 ◽

Author(s):

Songcheng Yu ◽

Yinhua Feng ◽

Chenling Qu ◽

Xing Li ◽

Wenqian Huo ◽

...

Keyword(s):

Physical Activity ◽

Sex Differences ◽

Family History ◽

Abdominal Obesity ◽

Rural Areas ◽

Case Control Study ◽

Female Offspring ◽

Case Control ◽

Family Based ◽

Control Study

Abstract Background: Abdominal obesity (AO) has shown a dramatic increase trend in the past decades. But there were few studies on sex differences in the risk of AO, especially the heritable risk. This study aimed to investigate the sex differences of AO risk in China rural areas.Methods: A family-based study coupled with the Henan Rural Cohort was carried out, including 1,533 people and 39,259 people, respectively. Questionnaires were applied in including included demographics, dietary intake and physical activity. Combined family-based study with the Henan Rural Cohort, sex differences in heritable risk of AO was analyzed among rural people. Chi-square test was applied to study the heritable risk of AO. Environmental factors for AO were assessed in couple case-control study. Logistic regression analysis was carried out to assess the association of lifestyles with AO.Results: Women had higher risk to develop AO than men in Henan Rural Cohort (OR: 3.070, 95% CI: 2.943, 3.203, P<0.001). The female first-degree relatives were more susceptible to AO than those in the Henan Rural Cohort (OR: 1.854, 95% CI: 1.318, 2.608, P<0.001). Moreover, female offspring had higher risk to develop AO than male offspring when their mothers suffered from AO (OR: 1.797, 95% CI: 1.111, 2.907, P=0.016), and this risk increased if their grandmothers suffered from AO (OR: 6.750, 95% CI: 1.667, 27.336, P=0.007). In addition, low physical activity increased the risk to develop AO for women when compared with their husbands (OR: 2.253, 95% CI: 1.283, 3.957, P=0.005). Conclusion: This study indicated females are heritably susceptible to AO than men, especially for those who have maternal family history and reinforce the benefits of increasing physical activity for protecting females from suffering from AO. Proactive action based on maternal family history is a cost-effective strategy for the prevention of AO, although larger family-based studies are required to verify the conclusion.

Download Full-text