scholarly journals The Association of Drug-Use Characteristics and Active Coping Styles With Positive Affect in Patients With Heroin-Use Disorder and Methamphetamine-Use Disorder During the COVID-19 Pandemic

2021 ◽  
Vol 9 ◽  
Author(s):  
Yingying Wang ◽  
Jinsong Zuo ◽  
Long Wang ◽  
Qianjin Wang ◽  
Xin Wang ◽  
...  
Keyword(s):  
Drug Use ◽  
Positive Affect ◽  
Predictive Factors ◽  
Coping Styles ◽  
Heroin Use ◽  
Methamphetamine Use ◽  
Heroin Use Disorder ◽  
Male Patients ◽  
Methamphetamine Use Disorder

Background: Positive affect (PA) is crucial for individuals to cope with the current pandemic and buffer the lingering fears after it, especially for patients with substance-use disorders (SUDs). The current study aimed to explore PA and its related factors during the COVID-19 pandemic in male patients with the heroin-use disorder (HUD) and patients with the methamphetamine-use disorder (MAUD), respectively.Methods: A total of 325 male patients with SUDs (106 with HUD and 219 with MAUD, all were single-substance users) in a compulsory rehabilitation center underwent semi-structured interviews during the pandemic. The demographic information, drug-use characteristics, active coping styles (ACSs, by Simple Coping Style Questionnaire), and PA (by the Positive and Negative Affect Scale) of participants were collected and recorded.Results: There were significant differences between the two groups in age, the proportion of full-time workers before the epidemic, duration of drug use, the proportion of patients with long-term withdrawal during the epidemic, cravings, ACS, and PA. Correlation and multiple linear regression analysis showed that duration of drug use, ACS, and stable jobs were significant predictive factors for PA in patients with HUD, while long-term withdrawal, ACS, and stable jobs during the epidemic were significant predictive factors for PA in patients with MAUD.Conclusions: Our study demonstrated the factors for PA in patients with HUD and MAUD during the pandemic. The results provided a basis for the comprehensive understanding of the PA of patients with SUDs and the development of targeted treatments.

scholarly journals The long-term outcome of patients with heroin use disorder/dual disorder (chronic psychosis) after admission to enhanced methadone maintenance

2018 ◽  
Vol 17 (1) ◽  
Author(s):  
Angelo G. I. Maremmani ◽  
Alessandro Pallucchini ◽  
Luca Rovai ◽  
Silvia Bacciardi ◽  
Vincenza Spera ◽  
...  
Keyword(s):  
Methadone Maintenance ◽  
Term Outcome ◽  
Heroin Use ◽  
Long Term Outcome ◽  
Heroin Use Disorder ◽  
Dual Disorder ◽  
Chronic Psychosis

scholarly journals Quality of Life in Patients With Methamphetamine Use Disorder: Relationship to Impulsivity and Drug Use Characteristics

2020 ◽  
Vol 11 ◽  
Author(s):  
Yingying Wang ◽  
Jinsong Zuo ◽  
Wei Hao ◽  
Hongxian Shen ◽  
Xiaojie Zhang ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Drug Use ◽  
Methamphetamine Use ◽  
Methamphetamine Use Disorder

scholarly journals Epigenetic Regulatory Dynamics in Models of Methamphetamine-Use Disorder

Genes ◽  
2021 ◽  
Vol 12 (10) ◽  
pp. 1614
Author(s):  
Subramaniam Jayanthi ◽  
Michael T. McCoy ◽  
Jean Lud Cadet
Keyword(s):  
Gene Expression ◽  
Brain Regions ◽  
Reward Processing ◽  
Post Translational Modifications ◽  
Methamphetamine Use ◽  
Underlying Mechanisms ◽  
Induced Changes ◽  
Methamphetamine Use Disorder ◽  
Disease Exposure

Methamphetamine (METH)-use disorder (MUD) is a very serious, potentially lethal, biopsychosocial disease. Exposure to METH causes long-term changes to brain regions involved in reward processing and motivation, leading vulnerable individuals to engage in pathological drug-seeking and drug-taking behavior that can remain a lifelong struggle. It is crucial to elucidate underlying mechanisms by which exposure to METH leads to molecular neuroadaptive changes at transcriptional and translational levels. Changes in gene expression are controlled by post-translational modifications via chromatin remodeling. This review article focuses on the brain-region specific combinatorial or distinct epigenetic modifications that lead to METH-induced changes in gene expression.

scholarly journals The Conceptual Framework of Dual Disorders and Its Flaws

2020 ◽  
Vol 9 (7) ◽  
pp. 2098
Author(s):  
Matteo Pacini ◽  
Angelo G. I. Maremmani ◽  
Icro Maremmani
Keyword(s):  
Cultural Context ◽  
Clinical Approach ◽  
Dual Disorders ◽  
Heroin Use ◽  
Heroin Use Disorder ◽  
Scientific Approach ◽  
Dual Disorder ◽  
Multiple Treatments ◽  
Opioid Medications

When psychiatric illness and substance use disorder coexist, the clinical approach to the patient is, unsurprisingly, awkward. This fact is due to a cultural context and, more directly, to the patient’s psychiatric condition and addiction behaviors—a situation that does not favor a scientific approach. In dual disorder facilities, several types of professionals work together: counselors, social workers, psychologists, and psychiatrists. Treatment approaches vary from one service to another and even within the same service. It is crucial to provide dual disorder patients with multiple treatments, comprising hospitalization, rehabilitative and residential programs, case management, and counselling. Still, when treating dual disorder (DD) heroin use disorder (HUD) patients, it is advisable to follow a hierarchical algorithm. First, we must deal with addiction: by detoxification, whenever possible. This means starting most patients on anti-craving pharmacological maintenance, though aversion therapy may be appropriate for a few of them. Opiate antagonists may be used with heroin-addicted patients as long as those patients are only mildly ill. In contrast, agonist opioid medications, i.e., buprenorphine and methadone suit moderately and severely ill patients, respectively. Achieving control of mood instability or psychotic episodes is the next step, to be followed by a prevention strategy to counteract residual cravings and dominate mood disorders or psychotic episodes through long-term pharmacological maintenance that is focused on a double target.

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