scholarly journals Digital Analysis of Subtrochlear Sclerosis in Elbows Submitted for Dysplasia Screening

2021 ◽  
Vol 8 ◽  
Author(s):  
Ana Válega ◽  
Sofia Alves-Pimenta ◽  
Fintan J. McEvoy ◽  
Dorte H. Nielsen ◽  
Mário Ginja
Keyword(s):  
Subchondral Bone ◽  
Pixel Intensity ◽  
Kennel Club ◽  
Elbow Dysplasia ◽  
Left Limb ◽  
Significant Difference ◽  
Bone Sclerosis ◽  
The Mean ◽  
The Right ◽  
Imagej Software

Ulnar trochlear notch (UTN) subchondral bone sclerosis is observed in elbow dysplasia (ED) associated with the medial coronoid disease. However, its evaluation is based on a simple visual examiner assessment of bone radio-opacity level and is considered subjective. The purpose of this study was to objectively characterize the radiographic opacity of the ulnar trochlear notch (UTN) subchondral bone in mediolateral elbow projections classified, using the International Elbow Working Group guidelines. Records and mediolateral flexed elbow images from the Danish Kennel Club database for the ED screening scheme between 2012 and 2018 were available. Of the dogs in the database, those with an ED-negative status in the left limb were identified. From these, 20 dogs each having a status free from ED, or with Grade 1, 2, or 3 in the right limb, were randomly chosen. Joints with primary ununited anconeal process were excluded from the sample. A template was developed using the ImageJ software, for computer UTN sclerosis analysis. It was overlaid onto each image to define five regions of interest (ROIs): ROI-1, distal UTN; ROI-2, middle UTN; ROI-3, caudal UTN; ROI-4, cortical bone; and ROI-5, bone marrow. Mean pixel intensity for each UTN ROI was divided by the mean pixel intensity of ROI-4 to normalize the data. The mean ± standard deviation (SD) of the normalized pixel intensity in the disease joints (ED Grades 1, 2, and 3) was 1.18 ± 0.17, 1.03 ± 0.12, and 0.92 ± 0.09 for ROIs 1, 2, and 3, respectively. The corresponding values for the contralateral normal left joints were 1.16 ± 0.17, 1.01 ± 0.1, and 0.91 ± 0.08. There was a significant difference (P < 0.05) in the normalized mean pixel intensity in dysplastic vs. non-dysplastic elbow joints for ROIs 1 and 2. The raw mean pixel intensity from right and left cortical and marrow bone ROIs sometimes showed relatively large differences. Digital radiography is associated with exposure and post-processing variabilities. Differences in apparent radio-opacity (as indicated by pixel intensity) though statistically significant in dysplastic joints compared with contralateral normal joints are slight and are thus problematic for computer-aided assessments of UTN sclerosis.

scholarly journals POS0586 RHEUMATOID ARTHRITIS IS AN INFLAMMATORY DISEASE WITH A HIGH CARDIOVASCULAR RISK

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 526.1-526
Author(s):  
L. Nacef ◽  
H. Riahi ◽  
Y. Mabrouk ◽  
H. Ferjani ◽  
K. Maatallah ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Risk Factors ◽  
Cardiovascular Risk ◽  
Carotid Artery ◽  
Internal Carotid ◽  
Subclinical Atherosclerosis ◽  
External Carotid ◽  
Significant Difference ◽  
The Mean ◽  
The Right

Background:Hypertension, diabetes, and dyslipidemia are traditional risk factors of cardiac events. Carotid ultrasonography is an available way to detect subclinical atherosclerosis.Objectives:This study aimed to compare the intima-media thickness in RA patients based on their personal cardiovascular (CV) history of hypertension (hypertension), diabetes, and dyslipidemia.Methods:The present study is a prospective study conducted on Tunisian RA patients in the rheumatology department of Mohamed Kassab University Hospital (March and December 2020). The characteristics of the patients and those of the disease were collected.The high-resolution B-mode carotid US measured the IMT, according to American Society of Echocardiography guidelines. The carotid bulb below its bifurcation and the internal and external carotid arteries were evaluated bilaterally with grayscale, spectral, and color Doppler ultrasonography using proprietary software for carotid artery measurements. IMT was measured using the two inner layers of the common carotid artery, and an increased IMT was defined as ≥0.9 mm. A Framingham score was calculated to predict the cardiovascular risk at 10-year.Results:Forty-seven patients were collected, 78.7% of whom were women. The mean age was 52.5 ±11.06 [32-76]. The rheumatoid factor (RF) was positive in 57.8% of cases, and anti-citrullinated peptide antibodies (ACPA) were positive in 62.2% of cases. RA was erosive in 81.6% of cases. Hypertension (hypertension) was present in 14.9% of patients, diabetes in 12.8% of patients, and dyslipidemia in 12.8% of patients. Nine patients were active smokers. The mean IMT in the left common carotid (LCC) was 0.069 ±0.015, in the left internal carotid (LIC) was 0.069 ±0.015, in the left external carotid (LEC) was 0.060 ±0.023. The mean IMT was 0.068 ±0.01 in the right common carotid (RCC), 0.062 ±0.02 in the right internal carotid (RIC), and 0.060 ±0.016 in the right external carotid (REC). The IMT was significantly higher in the left common carotid (LCC) in patients with hypertension (p=0.025). There was no significant difference in the other ultrasound sites (LIC, LEC, RCC, RIC, and REC) according to the presence or absence of hypertension. The IMT was also significantly increased in patients with diabetes at LCC (p=0.017) and RIC (p=0.025). There was no significant difference in the IMT at different ultrasound sites between patients with and without dyslipidemia.Conclusion:Hypertension was significantly associated with the increase in IMT at the LCC level in RA patients. Diabetes had an impact on IMT in LCC and RIC. However, dyslipidemia did not affect the IMT at the different ultrasound sites.References:[1]S. Gunter and al. Arterial wave reflection and subclinical atherosclerosis in rheumatoid arthritis. Clinical and Experimental Rheumatology 2018; 36: Clinical E.xperimental.[2]Aslan and al. Assessment of local carotid stiffness in seronegative and seropositive rheumatoid arthritis. SCANDINAVIAN CARDIOVASCULAR JOURNAL, 2017.[3]Martin I. Wah-Suarez and al, Carotid ultrasound findings in rheumatoid arthritis and control subjects: A case-control study. Int J Rheum Dis. 2018;1–7.[4]Gobbic C and al. Marcadores subclínicos de aterosclerosis y factores de riesgo cardiovascular en artritis temprana. Subclinical markers of atherosclerosis and cardiovascular risk factors in early arthritis marcadores subclínicos de aterosclerose e fatores de risco cardiovascular na artrite precoce.Disclosure of Interests:None declared

scholarly journals Changes in the Stiffness of Thigh Muscles in the Left and Right Limbs During Six Weeks of Plyometric Training in Volleyball Players

2018 ◽  
Vol 25 (2) ◽  
pp. 20-24 ◽  
Author(s):  
Dariusz Mroczek ◽  
Edward Superlak ◽  
Marek Konefał ◽  
Krzysztof Maćkała ◽  
Paweł Chmura ◽  
...  
Keyword(s):  
Good Method ◽  
Optimal Level ◽  
Muscle Stiffness ◽  
Plyometric Training ◽  
Thigh Muscles ◽  
Left Limb ◽  
Significant Difference ◽  
Volleyball Players ◽  
Left And Right ◽  
The Right

Abstract Introduction. Monitoring muscle stiffness in athletes can be a good method of assessing fatigue caused by high training loads, and the early detection of fatigue can help prevent the occurrence of micro-trauma in the muscles that can cause contusions. The research carried out by Wilson et al. [1] confirmed that an optimal level of muscle stiffness is significantly correlated with high muscle loads. The aim of the current study was to determine changes in muscle stiffness of the left and right thighs during six weeks of plyometric training (PT) in volleyball players. Material and methods. The study involved 16 volleyball players from the second-league Opole University of Technology Club (age = 21.12 ± 1.66 years, height = 191.62 ± 5.73 cm, and weight = 86.25 ± 6.66 kg) with at least five years of competitive experience (7.5 ± 2.44 years). Muscle stiffness was measured during three stages of the plyometric training using a MYOTON PRO device (Estonia). Results. An RM-ANOVA analysis showed a significant difference in the resting stiffness of the semitendinosus (posterior thigh) muscles of the left and right limbs before the plyometric training began, but no significant differences were found in the stiffness of these muscles in the fourth or sixth weeks of training. The results of the measurement performed for the anterior muscles of the thigh did not reveal a significant difference in the stiffness of the left limb compared to that of the right limb in subsequent weeks of training. Conclusion. The loads used in plyometric training in volleyball players caused a decrease in the differences in muscle stiffness between the left and right limbs, and in both limbs, adaptation trended towards an increase or a decrease in stiffness.

scholarly journals Sexual Dimorphism in Laryngeal Volumetric Measurements Using Magnetic Resonance Imaging

2019 ◽  
Vol 99 (2) ◽  
pp. 132-136 ◽  
Author(s):  
Abdul-Latif Hamdan ◽  
Elie Khalifee ◽  
Georges Ziade ◽  
Sahar Semaan
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Statistical Significance ◽  
Resonance Imaging ◽  
Men And Women ◽  
Mean Width ◽  
Significant Difference ◽  
The Mean ◽  
The Right ◽  
Volumetric Measurements

The objective of this study is to investigate the dimensional and volumetric measurements in the thyroarytenoid (TA) muscle in men and women using magnetic resonance imaging (MRI). The hypothesis is that there is a gender-related difference in these measurements. A retrospective chart review of 76 patients who underwent MRI of the neck at the American University of Beirut Medical Center was conducted. The dimension and volume of the right and left TA muscle were measured on axial and coronal planes short tau inversion recovery images. Male and female groups were compared with respect to demographic data and MRI findings using parametric and nonparametric tests. The mean length of the thyro-arytenoid muscle in males was larger than that in females on the right (males 2.44 [0.29] cm vs females 1.70 [0.22] cm) and on the left (males 2.50 [0.28] cm vs females 1.72 [0.24] cm) reaching statistical significance ( P < .001). The mean width of the thyro-arytenoid muscle in males was larger than that in females on the right (males 0.68 [0.13] cm vs females 0.59 [0.11] cm) and on the left (males 0.68 [0.12] cm vs females 0.57 [0.12] cm) reaching statistical significance ( P < .001). The mean height of the thyro-arytenoid muscle in males was larger than that in females on the right (males 1.05 [0.21] cm vs females 0.95 [0.12] cm) and on the left (males 1.05 [0.21] cm vs females 0.95 [0.12] cm) reaching statistical significance ( P < .01 on the right and P < .05 on the left). The volume of the thyroarytenoid muscle in males was larger than that in females on the right (males 0.86 [0.25] mL vs females 0.48 [0.15] mL) and on the left (males 0.89 [0.27] mL vs females 0.48 [0.17] mL) reaching statistical significance ( P < .001). The results of this investigation clearly indicate a significant difference in these measurements between men and women.

Study of Renal Iron Overload by T2* MRI in a Large Cohort of Thalassemia Major Patients

Blood ◽  
2012 ◽  
Vol 120 (21) ◽  
pp. 5177-5177
Author(s):  
Antonella Meloni ◽  
Daniele De Marchi ◽  
Vincenzo Positano ◽  
Gaetano Giuffrida ◽  
Sabrina Armari ◽  
...  
Keyword(s):  
Iron Overload ◽  
Conflicts Of Interest ◽  
Left Kidney ◽  
Significant Negative Correlation ◽  
Thalassemia Major ◽  
Iron Deposition ◽  
Significant Difference ◽  
The Mean ◽  
The Right ◽  
T2 Mri

Abstract Abstract 5177 Background. Renal dysfunction has been reported in adult subjects with thalassemia major (TM) since 1975. One of the main cause is the iron overload consequent to regular transfusions. Multiecho T2* MRI is a well-established technique for cardiac and hepatic iron overload assessment, but there very few report concerning the kidneys. The aims of this study were to describe the T2* values of the kidneys in patients with TM, to investigate the correlation between renal and myocardial or hepatic siderosis and biventricular cardiac function. Methods. 119 TM patients (58 men, 30. 7 ± 8. 2 years) enrolled in the Myocardial Iron Overload (MIOT) networks underwent MRI. For the measurement of iron overload, multiecho T2* sequences were used. The left ventricle was segmented into a 16-segments standardized model and the T2* value on each segment was calculated as well as the global value. In the liver, the T2* value was assessed in a single region of interest (ROI) in a homogeneous area of the parenchyma. For each kidney, T2* values were calculated in three different ROIs and were averaged to obtain a representative value for the kidney. The mean T2* value over the kidneys was also calculated. Cine images were obtained to quantify biventricular morphological and functional parameters in a standard way. Results. T2* values in the right kidney were significant lower than in the left kidney (40. 3±11. 9 ms vs 44. 1±12. 7 ms, P<0. 0001). The mean T2* value over the kidneys was 42. 2±11. 9 ms and 40 patients (33. 6%) had a pathological value (T2*<36 ms, lower limit of normal evaluated on 20 healthy subjects). The mean T2* value did not show a significant difference amongst men ad women (43. 2±11. 7 ms versus 41. 3±12. 1 ms, P=0. 378). The mean T2* values increased with age in a significant manner (r=0. 321, P<0. 0001). There was a significant negative correlation between serum ferritin levels and mean renal T2* values (r=-0. 446, P<0. 0001). Significant positive correlations of the mean T2* values were demonstrated for liver (r=0. 511, P<0. 0001) and global heart (r=0. 262, P=0. 004) T2* values (Figure 1). No correlation was found between renal iron overload and bi-ventricular function parameters. Conclusions. Systemic T2* differences between left and right kidneys were found, with significant lower values in the right one. Mean T2* value increased with age. We confirmed that kidney iron deposition was not very common in TM, but it was correlated with iron deposition in liver and heart. Disclosures: No relevant conflicts of interest to declare.

Effect of exogenous gonadotrophins on ovarian morphology and oocyte maturation in the southern hairy nosed wombat Lasiohinus latifrons during the breeding season

2006 ◽  
Vol 18 (4) ◽  
pp. 477 ◽  
Author(s):  
C. H. McDonald ◽  
D. A. Taggart ◽  
W. G. Breed ◽  
G. V. Druery ◽  
G. A. Shimmin ◽  
...  
Keyword(s):  
Oocyte Maturation ◽  
Follicular Development ◽  
Germinal Vesicle ◽  
Control Group ◽  
Antral Follicles ◽  
Nuclear Maturation ◽  
Significant Difference ◽  
Ovarian Morphology ◽  
The Mean ◽  
The Right

The effect of the exogenous administration of porcine follicle-stimulating hormone (pFSH) and pregnant mare serum gonadotrophin (PMSG) on ovarian follicular development and oocyte maturation in the southern hairy nosed wombat Lasiorhinus latifrons was investigated. Three experimental groups were administered pFSH at various doses and for different treatment lengths, followed by 25 mg porcine luteinising hormone (pLH) 12 h after the last dose of pFSH. Another group was given PMSG followed 72 h later by 25 mg pLH. Animals were killed 24 h after pLH. The left ovary was fixed for histology and the morphology of the antral follicles was determined, whereas follicular oocytes in the right ovary were aspirated, fixed, stained with 4′,6′-diamidino-2-phenylindole, and viewed for nuclear maturation. There was no significant difference in the mean number of ovarian follicles >1 mm, or in the size class of follicles assessed between control and experimental groups. However, a trend was observed suggesting a possible increase in follicles >3.0 mm in experimental groups compared with control animals. In all females administered exogenous porcine gonadotrophins, but not controls, some of the mural granulosa cells of large tertiary antral follicles had markedly enlarged nuclei (approximately 14 µm in diameter). All oocytes from the control group remained at the germinal vesicle stage, whereas approximately 40% of oocytes retrieved from the pFSH groups and 82.4% retrieved from the PMSG-primed animals had undergone germinal vesicle break down, with a small number reaching meiosis II. The present study shows that exogenous administration of either pFSH or PMSG to hairy nosed wombats can induce follicular growth and oocyte maturation. Such findings could be useful in the development of reproductive technology in this species.

scholarly journals Growth-Related Differences in Maximum Laterotrusion and Retrusion between Children and Adults

2009 ◽  
Vol 79 (2) ◽  
pp. 265-270 ◽  
Author(s):  
Claudia A. Reicheneder ◽  
Peter Proff ◽  
Uwe Baumert ◽  
Tomas Gedrange
Keyword(s):  
Temporomandibular Joint ◽  
Null Hypothesis ◽  
Population Based ◽  
Adult Group ◽  
Population Based Study ◽  
Significant Difference ◽  
Left And Right ◽  
The Mean ◽  
The Right

Abstract Objective: To test the null hypothesis that there are no differences between children and adults in maximum laterotrusion and maximum retrusion on the right and left sides. Materials and Methods: This population-based study included 81 randomly selected children between the ages of 6 and 10 years and 67 adults. Kinematic variables were measured with the ultrasonic JMA-System for registration. Results: The mean maximum laterotrusion of the children's group (10.6 ± 1.5 mm on the left, 11.0 ± 1.7 mm on the right) was significantly smaller than that of the adult group (11.7 ± 2.0 mm on the left, 12.2 ± 1.7 mm on the right). The maximum laterotrusion of the children's group corresponded to about 90% on the left and right sides of that of the adult group. The mean maximum retrusion of the children's group was significantly bigger than that of the adult group. There, the adult values corresponded to 66.7% on the left and 50% on the right side of the children's values. No significant difference in maximum laterotrusion and retrusion was noted on the right and left sides, and no significant differences according to gender specificities were observed in either group. Conclusions: The hypothesis is rejected. In development of the temporomandibular joint, maximum laterotrusion on the right and left sides increases significantly with age, and maximum retrusion decreases significantly with age.

scholarly journals COMPARISON OF EYELID ANGLE MEASURED USING MANUAL AND DIGITAL IMAGE ANALYSIS METHOD

2021 ◽  
Author(s):  
Shravya N ◽  
Swetha Ravichandran ◽  
Rinu Thomas
Keyword(s):  
Image Analysis ◽  
Digital Image ◽  
Digital Image Analysis ◽  
Palpebral Fissure ◽  
Analysis Method ◽  
Image Analysis Method ◽  
Interpupillary Distance ◽  
Significant Difference ◽  
The Mean ◽  
Imagej Software

Aim: To compare the eyelid angle measured by using a manual method (Using protractor) and digital image analysis method (Using ImageJ software) at different distances of eye gaze. Methodology: This prospective cross-sectional study was conducted in the preclinical lab at Manipal College of Health Professions. Subjects with no eyelid abnormalities were included in the study and they were asked to fixate at different distances a) at 3 metre (Distance gaze) b) at 70 cm (Intermediategaze) and c) at 40 cm(Near gaze). Using a protractor, the eyelid angle measurements were repeated at various distances which comprised the manual measurement. In the image analysis method, images were captured during distance, intermediate and near gaze using smartphone placed on theside of the face. These images were then analysed using ImageJ software for determining eyelid angle using image analysis method. Palpebral fissure height, Palpebral fissure width, Interpupillary distance, Intercanthal width, Binocular width, Height of open upper lid were some additional anthropometry measurements that were done using meter scale and PD ruler. Results: The mean age of the participants was 20±0.5 years. Anthropometry measurements of the eyelid and Palpebral fissure were done using meter scaleand PD ruler. The mean and standard deviation of the measured parametersare as follows Interpupillary distance: 60.95±2.37 mm, Endo Inter canthal distance: 32.20±2.39 mm, Exo Inter cantal distance: 95.50±3.80 mm, Palpebralfissure height_OD: 12.11±1.32 mm, Palpebral fissure height_OS:12.16±1.46mm, PFW_OD: 32.00±1.10 mm, PFW_OS: 32.11±1.24 mm, Height of upper eyelids_OD: 10.26±1.66 mm and Height of upper eyelids_OS:10.42±1.83 mm. In the right eye, there was no statistically significant difference (p&gt;0.05) between manual protractor method and digital image analysismethod at distance but there was a statistically significant difference (p&lt;0.05)between manual protractor method and digital image analysis method atIntermediate and near. In left eye, there was statistically significant difference(p&lt;0.05) between manual protractor method and digital image analysis method at all three distances. Conclusion: There is a significant difference in eyelid angle measured using manual protractor method and digital image analysis method. The measurement of eyelid angle serves as a critical reference point during cosmetic and reconstructive surgical interventions of the eyelid and accurate measurements are essential for preoperative assessment, surgical planning and postoperative evaluation. Hence more studies on the validation of the anthropometry measurements and eyelid angle using digital image analysis areessential to use digital image analysis in routine eye care practice.

scholarly journals Intra operative assessment of the coronal balance in spinal deformity surgery : a technical note and retrospective study

2021 ◽  
Vol 87 (1) ◽  
pp. 175-179
Author(s):  
Thibault Dewilde ◽  
Sebastiaan Schelfaut ◽  
Sven Bamps ◽  
Matthias Papen ◽  
Pierre Moens
Keyword(s):  
Retrospective Study ◽  
Case Series ◽  
Technical Note ◽  
Coronal Alignment ◽  
Level Of Evidence ◽  
Coronal Balance ◽  
Scoliotic Deformity ◽  
Significant Difference ◽  
The Mean ◽  
The Right

Obtaining a spine that is well balanced after fusion for scoliotic deformity is primordial for the patients’ quality of life. A simple T-shaped instrument combined with standard intraoperative fluoroscopy can be of great help to evaluate the coronal alignment quickly. The aim of this study was to evaluate if a T-shaped device could predict the postoperative coronal balance. Before finalization of the rod fixation, the balance was checked by verifying the relationship between the T-shaped instrument and the upper instrumented vertebra (UIV), and final adjustments were made to correct the coronal balance. A retrospective study was conducted on 48 patients who underwent surgery to correct scoliotic deformity. Intraoperative and postoperative coronal alignment was measured independently by two observers. The mean intraoperative horizontal offset measured between T-shaped instrument and the center of the UIV was 1,69mm to the right with a standard deviation (SD) of 12,43 mm. On postoperative full spine radiographs, the mean offset between the centra sacral vertical line and the center of the UIV was 2,44mm to the left with a SD of 13,10mm. There is no significant difference in coronal balance between both measurements (p=0,12). With this technique we were able to predict the postoperative coronal balance in all but one patient (97,92%). We conclude that the use of a simple T-shaped instrument can provide adequate intraoperative assessment of coronal balance in correcting scoliotic deformity. Level of evidence : IV – case series

scholarly journals Evaluation of the Carrying Angle in the Ethnic Assamese Community

2020 ◽  
Vol 7 (51) ◽  
pp. 3090-3093
Author(s):  
Monjushree Chakravarty ◽  
Rashmi Rekha Bordaloi
Keyword(s):  
Upper Limbs ◽  
Ethnic Communities ◽  
First Semester ◽  
Medical College ◽  
North East ◽  
The North ◽  
Left Limb ◽  
The Mean ◽  
Carrying Angle ◽  
The Right

BACKGROUND Assam is in the North East of India. The earliest inhabitants of Assam were people who came from Southeast Asia. The ethnic communities constitute about 12 to 13 percent of the state population. The present study was undertaken to evaluate the carrying angle of the elbow in ethnic Assamese community. METHODS The study was conducted in the Department of Anatomy, Tezpur Medical College. Out of 225 students admitted in first semester M.B.B.S. in two consecutive years in Tezpur Medical College, 20 students belonged to different ethnic communities of Assam. The carrying angle of both the right and left upper limbs were measured in the twenty selected students. Evaluation was done following all legal formalities. RESULTS The mean carrying angle in males was 10.33 + / - 1.56 in the right limb and 12.11 + / - 1.72 in the left limb; in the females it was 11.73 + / - 2.73 on the right side and 11.45 + / - 3.26 degree on the left side. CONCLUSIONS The study was done to find the carrying angle of the elbow in the ethnic Assamese community. The results of this study will be of help in the diagnosis and treatment of deformity and injury around the elbow. KEYWORDS Carrying Angle, Elbow, Ethnic Assamese Community

scholarly journals Measurement of Iris Thickness at Different Regions in Healthy Chinese Adults

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Qingchen Li ◽  
Yuan Zong ◽  
Huiming Wen ◽  
Jian Yu ◽  
Changbo Zhou ◽  
...  
Keyword(s):  
Anterior Segment ◽  
Final Analysis ◽  
Middle Part ◽  
Chinese Adults ◽  
Swept Source ◽  
Significant Difference ◽  
The Mean ◽  
Healthy Chinese ◽  
And Gender ◽  
The Right

Purpose. To study the variation of iris thicknesses in different regions and explore the possible correlations with age and gender. Methods. Healthy Chinese adults were recruited; the anterior segment of their eyes was imaged by swept-source optical coherence tomography (SS-OCT). The horizontal scan of the right eye was selected, and the thicknesses of both the nasal and temporal irises were measured at 199 evenly spaced points. Results. A total of 233 subjects with an average age of 36.79 ± 10.04 years (range 19 to 62) were included in the final analysis. The mean iris thicknesses of the temporal and nasal sides were 364.79 ± 47.58 μm and 372.44 ± 43.75 μm, respectively. The mean nasal iris thickness was positively correlated with age (β = 0.9 μm/year; P  = 0.002), but the temporal one was not (β = 0.077 μm/year; P  = 0.806). At 139 points of the nasal iris and 146 points of the temporal iris, the iris thickness was significantly correlated with age ( P  < 0.05). The thicknesses of the peripheral and pupillary parts were positively correlated with age, while the middle part was negatively correlated with age. No significant difference was observed in the mean iris thickness between genders (temporal: t = 1.597, P  = 0.112; nasal: t = 1.870, P  = 0.063), but females had a thicker iris than males at 50 points in the temporal side and 49 points in the nasal side ( P  < 0.05); no point in males was observed to have thicker iris compared to females. Conclusion. Using SS-OCT and the novel method, thicknesses of the iris at different regions were measured. The thicknesses of the peripheral and pupillary irises increase with age, while the thicknesses of the middle part decrease.

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