scholarly journals Pharmacokinetic, Clinical, and Myeloid Marker Responses to Acepromazine Sedation in Arabian Camels

2021 ◽  
Vol 8 ◽  
Author(s):  
Mahmoud Kandeel ◽  
Adel I. Almubarak ◽  
Jamal Hussen ◽  
Wael El-Deeb ◽  
Katharigatta N. Venugopala
Keyword(s):  
Heart Rate ◽  
Body Temperature ◽  
Volume Of Distribution ◽  
Blood Parameters ◽  
Sedation Score ◽  
Pharmacokinetics And Pharmacodynamics ◽  
Elimination Phase ◽  
Elimination Half ◽  
Before And After ◽  
The Mean

Sedatives and tranquilizers are important in the control of excited camels during camel transport. This study was conducted to investigate the clinical sedation of camels with acepromazine and its correlation with pharmacokinetics and pharmacodynamics. The sedation score, heart rate, respiration, body temperature, and pharmacokinetics were monitored before and after acepromazine injection, and myeloid marker expression was analyzed using membrane immunofluorescence and flow cytometry. The distribution (t1/2α) and elimination (t1/2β) half-lives were 0.1 and 9.4 h, respectively. The volume of distribution at steady state (Vss) was 20.01 L/kg, and the mean residence time (MRT) was 12.25 h. Sedation started rapidly within 10 min followed by persistent low-medium sedation for 2 h with an average sedation score of 1.2 ± 0.61, which might be associated with a slow elimination phase and prolonged MRT. Compared to horses, camels showed a lower clearance rate, higher volume of distribution, and higher elimination half-life. Slight changes in body temperature and heart and respiratory rate, as well as a lower hematocrit and changes in blood cell composition, suggest the careful application of acepromazine in animals with abnormal blood parameters or poor vital conditions.

scholarly journals Pharmacokinetics of Intravenous Piperacillin Administration in Patients Undergoing On-Line Hemodiafiltration

2009 ◽  
Vol 53 (8) ◽  
pp. 3266-3268 ◽  
Author(s):  
Kook-Hwan Oh ◽  
Chiweon Kim ◽  
Hankyu Lee ◽  
Hajeong Lee ◽  
Ji Yong Jung ◽  
...  
Keyword(s):  
Standard Deviation ◽  
Total Body Clearance ◽  
Volume Of Distribution ◽  
Pharmacokinetic Parameters ◽  
Recovery Method ◽  
Elimination Half ◽  
On Line ◽  
The Mean ◽  
Total Body ◽  
Body Clearance

ABSTRACT The pharmacokinetic characteristics of piperacillin sodium were studied in five volunteers undergoing on-line hemodiafiltration (HDF). The subjects were given 2 g of piperacillin sodium intravenously over 1 min and placed on on-line HDF for 4 h starting at 60 min after the piperacillin infusion. Noncompartmental models were employed for estimation of the pharmacokinetic parameters, and intradialytic piperacillin clearance was calculated by the recovery method. The mean volume of distribution and the elimination half-life were 0.27 ± 0.13 liter/kg (mean ± standard deviation) and 1.1 ± 0.6 h, respectively. The total body clearance of piperacillin was 0.19 ± 0.08 liter/h/kg. Piperacillin clearance through on-line HDF was 0.11 ± 0.06 liter/h/kg. The mean serum piperacillin concentration was 4.0 ± 1.9 μg/ml at the end of the 4-h on-line HDF session. The concentration of infused piperacillin recovered in the dialysate was 527 ± 236 mg (26.3% ± 11.8%). We suggest the replacement of 500 mg of piperacillin after each on-line HDF session.

scholarly journals Safety, toleration, and pharmacokinetics of intravenous azithromycin.

1996 ◽  
Vol 40 (11) ◽  
pp. 2577-2581 ◽  
Author(s):  
D R Luke ◽  
G Foulds ◽  
S F Cohen ◽  
B Levy
Keyword(s):  
Half Life ◽  
Active Drug ◽  
Slow Release ◽  
Volume Of Distribution ◽  
Pharmacokinetic Parameters ◽  
Time Curve ◽  
Concentration Time ◽  
Elimination Half ◽  
The Mean ◽  
Male Subjects

To date, the clinical pharmacology of large intravenous doses of azithromycin has not been described. In the present study, single 2-h intravenous infusions of 1, 2, and 4 g of azithromycin were administered to three parallel groups (in each group, six received active drug and two received placebo) of healthy male subjects. Toleration (assessed by scores of subject-administered visual analog scale tests spanning 0 [good] to 10 [poor]), safety, pharmacokinetics, and serum motilin levels were monitored for up to 240 h after the start of each intravenous infusion. Mean nausea scores of 0.0, 0.0, 1.0, and 0.5 and abdominal cramping scores of 0.0, 0.0, 0.4, and 0.4 for 12-h periods after doses of 0, 1, 2, and 4 g of azithromycin, respectively, suggested that azithromycin was well tolerated. Because of the standardized 1-mg/ml infusates, all subjects in the 4-g dosing group complained of an urgent need to urinate. There were no consistent trends in endogenous motilin levels throughout the study. The maximum concentration of azithromycin in serum (10 micrograms/ml after a 4-g dose) and the area under the concentration-time curve (82 micrograms.h/ml after a 4-g dose) were dose related. The mean pharmacokinetic parameters were an elimination half-life of 69 h, total systemic clearance of 10 ml/min/kg, and a volume of distribution at steady state of 33.3 liters/kg. The pharmacokinetic results suggest that the long half-life of azithromycin is due to extensive uptake and slow release of the drug from tissues rather than an inability to clear the drug. Single intravenous doses of up to 4 g of azithromycin in healthy subjects are generally well tolerated, and quantifiable concentrations may persist in serum for 10 days or more.

Pharmacokinetics of Once-Daily Ip Gentamicin in Capd Patients

1996 ◽  
Vol 16 (4) ◽  
pp. 379-384 ◽  
Author(s):  
Chai Luan Low ◽  
George R. Bailie ◽  
Anne Evans ◽  
George Eisele ◽  
Richard A. Venezia
Keyword(s):  
Renal Function ◽  
Open Study ◽  
Residual Renal Function ◽  
Volume Of Distribution ◽  
Peritoneal Membrane ◽  
Time Data ◽  
Once Daily ◽  
Concentration Time ◽  
Elimination Half ◽  
The Mean

Objective This study aimed to investigate the pharmacokinetic characteristics of once-daily intraperitoneal (IP) gentamicin in continuous ambulatory peritoneal dialysis (CAPD) patients. Design Prospective, nonrandomized, open study. Setting CAPD outpatient clinic in a teaching hospital. Patients Ten volunteer CAPD patients without peritonitis. Interventions Each patient received a single IP dose of 0.6 mg/kg of gentamicin. Blood and dialysate samples were collected at 0,0.5,1, 2, 3,6 (end of first dwell), and 24 hours after the administration of IP gentamicin. Any urine produced over the 24hour study period was also collected. The dialysate concentration/time data were fitted to a monoexponential curve for all patients. Results The bioavailability was 56±11% over a six hour dwell. The mean serum elimination half-life (t1/2) was 35.8 hours. The volume of distribution was 0.23±0.08 L/kg. Equilibration of gentamicin across the peritoneal membrane was rapid, with a t½ equilibration of 4.5 hours. The peritoneal clearance was 5.74±1.5 mL/min. Patients with residual renal function had significantly higher systemic gentamicin clearances (7.36±1.46 mL/min) than those of anuric patients (4.76±1.08 mL/min, p < 0.024). Conclusion Currently recommended doses of oncedaily IP gentamicin for the treatment of peritonitis may not produce the desired therapeutic serum and dialysate concentrations over 24 hours for effective treatment of peritonitis.

Effects of pentobarbital on temperature and heart rate of rats subjected to cold

1962 ◽  
Vol 203 (4) ◽  
pp. 758-761 ◽  
Author(s):  
C. L. Gemmill ◽  
K. M. Browning
Keyword(s):  
Heart Rate ◽  
Body Temperature ◽  
Standard Dose ◽  
The Body ◽  
Sodium Pentobarbital ◽  
Previous Exposure ◽  
Exposure To Cold ◽  
Before And After

A study at 5 C was made of body temperature and heart rate after a standard dose of sodium pentobarbital in normal, thyroidectomized, and hypermetabolic rats before and after subjection to 5 C for 46 hr. It was found that after subjection to cold in the normal rats, the body temperature and heart rate in some animals had more ability to recover after the barbiturate than in rats without previous exposure to cold. There was no ability to recover in the thyroidectomized animals either before or after subjection to cold. Most of the normal and thyroidectomized rats either with or without previous exposure to cold given sodium 3,3',5-l-triiodothyronine (T-3) had recoveries after the barbiturate. Some rats given T-3 and subjected to cold had a primary fall in temperature and heart rate that was followed by recovery and then a secondary fall.

Heart rate and body temperature during free diving of Weddell seals

1987 ◽  
Vol 253 (2) ◽  
pp. R344-R351 ◽  
Author(s):  
R. D. Hill ◽  
R. C. Schneider ◽  
G. C. Liggins ◽  
A. H. Schuette ◽  
R. L. Elliott ◽  
...  
Keyword(s):  
Heart Rate ◽  
Body Temperature ◽  
Adult Male ◽  
Fetal Heart Rate ◽  
Fetal Heart ◽  
Weddell Seal ◽  
The Body ◽  
Weddell Seals ◽  
The Mean ◽  
Slow Onset

We have developed and successfully used the first microprocessor-controlled monitors for collection of data on depth, heart rate, and body temperature of one fetal and five adult male freely swimming Weddell seals. Adult seals almost invariably experienced a prompt bradycardia at the start of each dive, and the mean heart rate during diving was significantly lower for dives greater than 20 min (P greater than 0.999). The heart rate was also significantly greater during the ascent portion of dives when compared with the descent portion (P greater than 0.95). The fetal seal experienced a slow onset of bradycardia when its mother dived; during diving the fetal heart rate decreased by an average of 1.1 beats/min for each minute of the dive. The fetal heart rate generally took approximately 10 min to recover to predive levels after its mother resurfaced to breathe. The body temperature of one adult male Weddell seal showed a decrease of greater than 1.5 degrees C from resting levels before dives of greater than 15 min were initiated and a drop of over 2 degrees C before dives of greater than 30 min duration.

Dispersion of the P wave as a test for cardiac autonomic function in diabetic children

2008 ◽  
Vol 18 (6) ◽  
pp. 581-585 ◽  
Author(s):  
Ebru Y. Imamoglu ◽  
Funda Oztunc ◽  
Ayse G. Eroglu ◽  
Hasan Onal ◽  
Alper Guzeltas
Keyword(s):  
Heart Rate ◽  
Type 1 Diabetes ◽  
Orthostatic Hypotension ◽  
Valsalva Maneuver ◽  
P Wave ◽  
Resting Heart Rate ◽  
Diabetic Children ◽  
Before And After ◽  
The Mean

AbstractObjectiveWe aimed, in this study, to compare dispersion of the p wave in patients with type 1 diabetes to nondiabetic control subjects, and to investigate the relationship between the dispersion of the p wave and cardiac autonomic dysfunction in diabetic children.MethodsWe enrolled 49 patients with type 1 diabetes, and 32 age- and sex-matched healthy subjects, measuring the Valsalva ratio, resting heart rate, and orthostatic hypotension in all. The duration of the p wave was measured manually on a high-resolution computer screen. Dispersion, defined as the difference between maximum and minimum durations of the p waves, was also measured in the 12-lead electrocardiogram before and after the Valsalva maneuver.ResultsThe mean age of the patients and their controls were 14.2 ± 4.8 years, and 12.7 ± 4.5 years, respectively. The mean duration of diabetes had been 6.2 ± 4.6 years. Maximal and minimal values for the duration of the p wave were significantly decreased in the diabetic children, with the dispersion itself significantly increased. Values for the dispersion in the diabetic subjects were similar before and after the Valsalva maneuver, whereas dispersion was found significantly increased after this maneuver in the controls. The differences in the Valsalva ratio, resting heart rate, and orthostatic hypotension between the groups, on the other hand, were not found to be statistically significant.ConclusionThe noted increase in the dispersion of the p wave in diabetic children reveals the onset of cardiac electrophysiological heterogeneity before it is possible to detect parasympathetic and sympathetic dysfunction with other tests.

scholarly journals PENGARUH PERAWATAN METODE KANGURU TERHADAP PENINGKATAN SUHU TUBUH BAYI BERAT LAHIR RENDAH DI NICU RUMAH SAKIT GRANDMED LUBUK PAKAM TAHUN 2018

2019 ◽  
Vol 1 (2) ◽  
pp. 6-9
Author(s):  
Ika Nur Sapurtri ◽  
Dwi Handayani ◽  
Maharani Nazmi Nasution
Keyword(s):  
Birth Weight ◽  
Body Temperature ◽  
Low Birth Weight ◽  
Sampling Technique ◽  
Low Birth Weight Infants ◽  
Kangaroo Care ◽  
Low Birth Weight Babies ◽  
Before And After ◽  
Post Test ◽  
The Mean

Babies with low birth weight have a temperature that is unstable and prone to hypothermia (temperature <36,5ºC). Cold stress can increase mortality and hamper growth. The warmth of the mother's body or a known method of kangaroo care proved to be an effective heat source for infants born at term or low birth weight. This study aims to determine whether there is influence kangaroo care method to your body temperature low birth weight infants. This type of research is pre experiment with models (one group pre-post test design). The population of this research is all low birth weight babies. Sampling techniques in use purposive sampling, that the sampling technique was based on sample criteria specified by the researchers themselves. In this case the samples found as many as 22 people. Data analysis using paired sample t-test with a level of 95%. The results of this study gained an average prior to 34.7 kangaroo care method, after doing kangaroo care method 36.9. The mean before and after kangaroo care method 2.2273. Based on the analysis results showed pvalue (0.004) <α (0.05), It can be concluded no treatment effect kangaroo method to your body temperature low birth weight infants. Recommendations from this research is the kangaroo care method can be used as one LBW care that can be done by the mothers in raising and maintaining body temperature.

Body fluid shifts in the dog during hypothermia

1959 ◽  
Vol 197 (2) ◽  
pp. 499-501 ◽  
Author(s):  
Richard L. Farrand ◽  
Steven M. Horvath
Keyword(s):  
Heart Rate ◽  
Body Temperature ◽  
Blood Volume ◽  
Extracellular Volume ◽  
Total Blood Volume ◽  
Total Blood ◽  
Stable Period ◽  
Fluid Shifts ◽  
The Mean ◽  
Total Body

The rectal temperature of dogs was reduced to 27°C and stabilized at this level for a period of at least 3 hours. The heart rate, blood pressure, respiration rate, blood volumes, extracellular volume (thiocyanate space), and total body water (antipyrine space) were recorded during the reduction in temperature and the period of stable body temperature. No change was observed in the mean arterial pressure during any period of hypothermia; the heart rate decreased exponentially during the reduction in body temperature but remained constant during the stable period. Blood volume increased during the initial stages of hypothermia (33°C to 36°C) and remained at this level. Hematocrit and erythrocyte volume followed the same pattern as total blood volume, with no alteration in the plasma volume. There were no shifts in the extracellular or intracellular volumes at any time during the hypothermic state.

COMPARISON OF DEXMEDETOMIDINE AND FENTANYL ON INTUBATION CONDITIONS DURING AWAKE FIBREOPTIC BRONCHOSCOPIC INTUBATION- A RANDOMISED DOUBLE BLIND STUDY.

2021 ◽  
pp. 1-2
Author(s):  
Asha .A ◽  
E. Arunmozhi
Keyword(s):  
Heart Rate ◽  
Study Drug ◽  
Sedation Score ◽  
Double Blind ◽  
Group A ◽  
The Mean ◽  
Group B ◽  
Post Intubation ◽  
Ramsay Sedation Score ◽  
Mean Heart Rate

INTRODUCTION:Awake Fibreoptic Intubation is indicated in patients with anticipated diffcult airway, failed tracheal intubation, unstable cervical spine injury.Drugs used for conscious sediation includes Benzodiazepines, opioids, Propofol, either alone or in combination. All these drugs, though results in favourable intubating conditions, may also result in upper airway obstruction, hypoventilation, difcult airway instrumentation and oxygen desaturation. In order to address and overcome these issues, we compared the effects of parenteral dexmedetomidine and fentanyl on favourable conditions during awake breoptic bronchoscopic intubation. MATERIALS AND METHODS:A prospective,double blind,randomised study. 60 patients belonging to age group 25 to 60 years, ASA PS I & II posted for elective surgery under general anaesthesia with endotracheal intubation were randomly allocated into two groups, Group A(n=30) received injection dexmedetomidine, Group B(n=30) received injection fentanyl before awake breoptic bronchoscopic intubation. Hemodynamic parameters, cough score, postintubation tolerance score, ramsay sedation score were noted in both groups. The observed datas were analysed by SPSS version 21.0 software. RESULT: Demographic variable such as age,weight,ASA physical status were comparable in both the groups. The mean heart rate at 5mins,10mins after administration of study drug,intubation, 5mins postintubation are 76.73±5.51,73.63±5.99,76.37±8.11 and 75.03±7.94 respectively in Group A.The mean heart rate at 5mins,10mins after administration of study drug,intubation, 5mins postintubation are 78.57±5.04,76.93±5.11,103.30±4.21 and 99.37±4.02 respectively.The mean MAP at 5mins,10 mins after administration of study drug,intubation,5 mins post intubation are 86.80±2.33,85.77 ±2.56,87.83 ±5.73 and 87.30 ± 2.52mmHg respectively in Group A.The mean MAP at 5mins,10mins after administration of study drug,intubation,5 mins post intubation are 87.37±3.58,85.63 ±3.58,107.80 ±2.59 and 105.00 ±2.52 mmHg respectively. The post intubation SpO2 was 97.10 ±1.77 and 93.43± 1.17 % for Group A and Group B respectively.In Group A mean Ramsay sedation score is 2.87± 0.43 and in Group B the mean is 2.13 ±0.35. CONCLUSION:Dexmedetomidine group showed better hemodynamic stability and tolerance to awake endotracheal tube insertion through breoptic bronchoscope.Dexmedetomidine provides favourable intubating conditions during awake breoptic bronchoscope procedures with adequate sedation and without desaturation than fentanyl.

+(-)catechin raises body temperature, changes blood parameters, improves oocyte quality and reproductive performance of female mice

2019 ◽  
Author(s):  
A.A. Mohammed ◽  
A.A. Al-Hozab
Keyword(s):  
Heart Rate ◽  
Body Temperature ◽  
Oocyte Quality ◽  
Blood Parameters ◽  
Control Group ◽  
Blood Oxygen ◽  
Temperature Changes ◽  
Female Mice ◽  
Negative Side Effects ◽  
Solution Changes

The present study aimed to explore changes in physiological and reproductive performances upon supplementation of +(-) cactechin (200 vs. 2000 mg/kg BW) in mice. In addition, body temperature, heart rate, blood oxygen and glucose were explored after general anesthesia of +(-)cactechin animals. Sixty albino female mice were classified into three groups; control group (G1) versus two +(-) cactechin groups [G2 (200 mg/kg BW) and G3 (2000 mg/kg BW)] for 15 days in aqueous solution. Changes of body temperature, heart rate, blood parameters, oocyte quality and reproductive performances were determined and recorded. In addition, changes of body temperature, heart rate, blood oxygen and glucose were measured after anesthesia. The results indicated that +(-)catechin supplementation resulted in significant increase in body temperature, blood oxygen and WBCs in addition to significant hypoglycemia. The oocytes quality and reproductive performances were improved upon +(-)catechin supplementation. +(-)catechin supplementation did not improve the negative side effects of anesthesia. In conclusion, supplementation of +(-)catechin could benefit physiological and reproductive performances in mice.

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