scholarly journals Computer-Aided Diagnosis of Skin Diseases Using Deep Neural Networks

2020 ◽  
Vol 10 (7) ◽  
pp. 2488 ◽  
Author(s):  
Muhammad Naseer Bajwa ◽  
Kaoru Muta ◽  
Muhammad Imran Malik ◽  
Shoaib Ahmed Siddiqui ◽  
Stephan Alexander Braun ◽  
...  
Keyword(s):  
Neural Networks ◽  
Deep Learning ◽  
Deep Neural Networks ◽  
Skin Diseases ◽  
State Of The Art ◽  
Disease Diagnosis ◽  
Classification Performance ◽  
Computer Aided Diagnosis ◽  
Computer Aided ◽  
Aided Diagnosis

Propensity of skin diseases to manifest in a variety of forms, lack and maldistribution of qualified dermatologists, and exigency of timely and accurate diagnosis call for automated Computer-Aided Diagnosis (CAD). This study aims at extending previous works on CAD for dermatology by exploring the potential of Deep Learning to classify hundreds of skin diseases, improving classification performance, and utilizing disease taxonomy. We trained state-of-the-art Deep Neural Networks on two of the largest publicly available skin image datasets, namely DermNet and ISIC Archive, and also leveraged disease taxonomy, where available, to improve classification performance of these models. On DermNet we establish new state-of-the-art with 80% accuracy and 98% Area Under the Curve (AUC) for classification of 23 diseases. We also set precedence for classifying all 622 unique sub-classes in this dataset and achieved 67% accuracy and 98% AUC. On ISIC Archive we classified all 7 diseases with 93% average accuracy and 99% AUC. This study shows that Deep Learning has great potential to classify a vast array of skin diseases with near-human accuracy and far better reproducibility. It can have a promising role in practical real-time skin disease diagnosis by assisting physicians in large-scale screening using clinical or dermoscopic images.

scholarly journals Deep Learning-Based Computer-Aided Diagnosis System for Gastroscopy Image Classification Using Synthetic Data

2021 ◽  
Vol 11 (2) ◽  
pp. 760
Author(s):  
Yun-ji Kim ◽  
Hyun Chin Cho ◽  
Hyun-chong Cho
Keyword(s):  
Deep Learning ◽  
Disease Diagnosis ◽  
Computer Aided Diagnosis ◽  
Medical Data ◽  
Classification Model ◽  
Training Dataset ◽  
Generative Adversarial Networks ◽  
Original Training ◽  
Computer Aided ◽  
Aided Diagnosis

Gastric cancer has a high mortality rate worldwide, but it can be prevented with early detection through regular gastroscopy. Herein, we propose a deep learning-based computer-aided diagnosis (CADx) system applying data augmentation to help doctors classify gastroscopy images as normal or abnormal. To improve the performance of deep learning, a large amount of training data are required. However, the collection of medical data, owing to their nature, is highly expensive and time consuming. Therefore, data were generated through deep convolutional generative adversarial networks (DCGAN), and 25 augmentation policies optimized for the CIFAR-10 dataset were implemented through AutoAugment to augment the data. Accordingly, a gastroscopy image was augmented, only high-quality images were selected through an image quality-measurement method, and gastroscopy images were classified as normal or abnormal through the Xception network. We compared the performances of the original training dataset, which did not improve, the dataset generated through the DCGAN, the dataset augmented through the augmentation policies of CIFAR-10, and the dataset combining the two methods. The dataset combining the two methods delivered the best performance in terms of accuracy (0.851) and achieved an improvement of 0.06 over the original training dataset. We confirmed that augmenting data through the DCGAN and CIFAR-10 augmentation policies is most suitable for the classification model for normal and abnormal gastric endoscopy images. The proposed method not only solves the medical-data problem but also improves the accuracy of gastric disease diagnosis.

Convolutional Neural Networks in Computer-Aided Diagnosis of Colorectal Polyps and Cancer: A Review

2021 ◽  
Author(s):  
Kamyab Keshtkar
Keyword(s):  
Colorectal Cancer ◽  
Neural Networks ◽  
Deep Learning ◽  
Computer Aided Diagnosis ◽  
Colorectal Polyps ◽  
Support Vector ◽  
Training Process ◽  
Computer Aided ◽  
Conventional Models ◽  
Aided Diagnosis

As a relatively high percentage of adenoma polyps are missed, a computer-aided diagnosis (CAD) tool based on deep learning can aid the endoscopist in diagnosing colorectal polyps or colorectal cancer in order to decrease polyps missing rate and prevent colorectal cancer mortality. Convolutional Neural Network (CNN) is a deep learning method and has achieved better results in detecting and segmenting specific objects in images in the last decade than conventional models such as regression, support vector machines or artificial neural networks. In recent years, based on the studies in medical imaging criteria, CNN models have acquired promising results in detecting masses and lesions in various body organs, including colorectal polyps. In this review, the structure and architecture of CNN models and how colonoscopy images are processed as input and converted to the output are explained in detail. In most primary studies conducted in the colorectal polyp detection and classification field, the CNN model has been regarded as a black box since the calculations performed at different layers in the model training process have not been clarified precisely. Furthermore, I discuss the differences between the CNN and conventional models, inspect how to train the CNN model for diagnosing colorectal polyps or cancer, and evaluate model performance after the training process.

scholarly journals Medical Knowledge Graph in Chinese Using Deep Semantic Mobile Computation Based on IoT and WoT

2021 ◽  
Vol 2021 ◽  
pp. 1-13
Author(s):  
Wanheng Liu ◽  
Ling Yin ◽  
Cong Wang ◽  
Fulin Liu ◽  
Zhiyu Ni
Keyword(s):  
Neural Networks ◽  
Deep Learning ◽  
Deep Neural Networks ◽  
State Of The Art ◽  
Medical Knowledge ◽  
Disease Diagnosis ◽  
Knowledge Graph ◽  
Great Success ◽  
Smart Healthcare ◽  
Made In

In this paper, a novel medical knowledge graph in Chinese approach applied in smart healthcare based on IoT and WoT is presented, using deep neural networks combined with self-attention to generate medical knowledge graph to make it more convenient for performing disease diagnosis and providing treatment advisement. Although great success has been made in the medical knowledge graph in recent studies, the issue of comprehensive medical knowledge graph in Chinese appropriate for telemedicine or mobile devices have been ignored. In our study, it is a working theory which is based on semantic mobile computing and deep learning. When several experiments have been carried out, it is demonstrated that it has better performance in generating various types of medical knowledge graph in Chinese, which is similar to that of the state-of-the-art. Also, it works well in the accuracy and comprehensive, which is much higher and highly consisted with the predictions of the theoretical model. It proves to be inspiring and encouraging that our work involving studies of medical knowledge graph in Chinese, which can stimulate the smart healthcare development.

scholarly journals Assessment of the Robustness of Convolutional Neural Networks in Labeling Noise by Using Chest X-Ray Images From Multiple Centers

10.2196/18089 ◽  
2020 ◽  
Vol 8 (8) ◽  
pp. e18089
Author(s):  
Ryoungwoo Jang ◽  
Namkug Kim ◽  
Miso Jang ◽  
Kyung Hwa Lee ◽  
Sang Min Lee ◽  
...  
Keyword(s):  
Neural Networks ◽  
Deep Learning ◽  
Convolutional Neural Networks ◽  
Computer Aided Diagnosis ◽  
X Ray ◽  
The Public ◽  
Computer Aided ◽  
Chest X Ray ◽  
Public Datasets ◽  
Aided Diagnosis

Background Computer-aided diagnosis on chest x-ray images using deep learning is a widely studied modality in medicine. Many studies are based on public datasets, such as the National Institutes of Health (NIH) dataset and the Stanford CheXpert dataset. However, these datasets are preprocessed by classical natural language processing, which may cause a certain extent of label errors. Objective This study aimed to investigate the robustness of deep convolutional neural networks (CNNs) for binary classification of posteroanterior chest x-ray through random incorrect labeling. Methods We trained and validated the CNN architecture with different noise levels of labels in 3 datasets, namely, Asan Medical Center-Seoul National University Bundang Hospital (AMC-SNUBH), NIH, and CheXpert, and tested the models with each test set. Diseases of each chest x-ray in our dataset were confirmed by a thoracic radiologist using computed tomography (CT). Receiver operating characteristic (ROC) and area under the curve (AUC) were evaluated in each test. Randomly chosen chest x-rays of public datasets were evaluated by 3 physicians and 1 thoracic radiologist. Results In comparison with the public datasets of NIH and CheXpert, where AUCs did not significantly drop to 16%, the AUC of the AMC-SNUBH dataset significantly decreased from 2% label noise. Evaluation of the public datasets by 3 physicians and 1 thoracic radiologist showed an accuracy of 65%-80%. Conclusions The deep learning–based computer-aided diagnosis model is sensitive to label noise, and computer-aided diagnosis with inaccurate labels is not credible. Furthermore, open datasets such as NIH and CheXpert need to be distilled before being used for deep learning–based computer-aided diagnosis.

scholarly journals Classification of Dermoscopy Skin Lesion Color-Images Using Fractal-Deep Learning Features

2020 ◽  
Vol 10 (17) ◽  
pp. 5954
Author(s):  
Edgar Omar Molina-Molina ◽  
Selene Solorza-Calderón ◽  
Josué Álvarez-Borrego
Keyword(s):  
Deep Learning ◽  
Skin Lesion ◽  
Skin Diseases ◽  
Color Image ◽  
Computer Aided Diagnosis ◽  
Support Vector ◽  
Plurality Vote ◽  
Computer Aided ◽  
Deep Learning Features ◽  
Aided Diagnosis

The detection of skin diseases is becoming one of the priority tasks worldwide due to the increasing amount of skin cancer. Computer-aided diagnosis is a helpful tool to help dermatologists in the detection of these kinds of illnesses. This work proposes a computer-aided diagnosis based on 1D fractal signatures of texture-based features combining with deep-learning features using transferred learning based in Densenet-201. This proposal works with three 1D fractal signatures built per color-image. The energy, variance, and entropy of the fractal signatures are used combined with 100 features extracted from Densenet-201 to construct the features vector. Because commonly, the classes in the dataset of skin lesion images are imbalanced, we use the technique of ensemble of classifiers: K-nearest neighbors and two types of support vector machines. The computer-aided diagnosis output was determined based on the linear plurality vote. In this work, we obtained an average accuracy of 97.35%, an average precision of 91.61%, an average sensitivity of 66.45%, and an average specificity of 97.85% in the eight classes’ classification in the International Skin Imaging Collaboration (ISIC) archive-2019.

scholarly journals Assessment of the Robustness of Convolutional Neural Networks in Labeling Noise by Using Chest X-Ray Images From Multiple Centers (Preprint)

2020 ◽  
Author(s):  
Ryoungwoo Jang ◽  
Namkug Kim ◽  
Miso Jang ◽  
Kyung Hwa Lee ◽  
Sang Min Lee ◽  
...  
Keyword(s):  
Neural Networks ◽  
Deep Learning ◽  
Convolutional Neural Networks ◽  
Computer Aided Diagnosis ◽  
X Ray ◽  
The Public ◽  
Computer Aided ◽  
Chest X Ray ◽  
Public Datasets ◽  
Aided Diagnosis

BACKGROUND Computer-aided diagnosis on chest x-ray images using deep learning is a widely studied modality in medicine. Many studies are based on public datasets, such as the National Institutes of Health (NIH) dataset and the Stanford CheXpert dataset. However, these datasets are preprocessed by classical natural language processing, which may cause a certain extent of label errors. OBJECTIVE This study aimed to investigate the robustness of deep convolutional neural networks (CNNs) for binary classification of posteroanterior chest x-ray through random incorrect labeling. METHODS We trained and validated the CNN architecture with different noise levels of labels in 3 datasets, namely, Asan Medical Center-Seoul National University Bundang Hospital (AMC-SNUBH), NIH, and CheXpert, and tested the models with each test set. Diseases of each chest x-ray in our dataset were confirmed by a thoracic radiologist using computed tomography (CT). Receiver operating characteristic (ROC) and area under the curve (AUC) were evaluated in each test. Randomly chosen chest x-rays of public datasets were evaluated by 3 physicians and 1 thoracic radiologist. RESULTS In comparison with the public datasets of NIH and CheXpert, where AUCs did not significantly drop to 16%, the AUC of the AMC-SNUBH dataset significantly decreased from 2% label noise. Evaluation of the public datasets by 3 physicians and 1 thoracic radiologist showed an accuracy of 65%-80%. CONCLUSIONS The deep learning–based computer-aided diagnosis model is sensitive to label noise, and computer-aided diagnosis with inaccurate labels is not credible. Furthermore, open datasets such as NIH and CheXpert need to be distilled before being used for deep learning–based computer-aided diagnosis.

scholarly journals Quantifying the uncertainty of deep learning-based computer-aided diagnosis for patient safety

2019 ◽  
Vol 5 (1) ◽  
pp. 223-226
Author(s):  
Max-Heinrich Laves ◽  
Sontje Ihler ◽  
Tobias Ortmaier ◽  
Lüder A. Kahrs
Keyword(s):  
Monte Carlo ◽  
Patient Safety ◽  
Deep Learning ◽  
Epistemic Uncertainty ◽  
Computer Aided Diagnosis ◽  
Uncertainty Estimation ◽  
Test Time ◽  
Prediction Uncertainty ◽  
Computer Aided ◽  
Aided Diagnosis

AbstractIn this work, we discuss epistemic uncertainty estimation obtained by Bayesian inference in diagnostic classifiers and show that the prediction uncertainty highly correlates with goodness of prediction. We train the ResNet-18 image classifier on a dataset of 84,484 optical coherence tomography scans showing four different retinal conditions. Dropout is added before every building block of ResNet, creating an approximation to a Bayesian classifier. Monte Carlo sampling is applied with dropout at test time for uncertainty estimation. In Monte Carlo experiments, multiple forward passes are performed to get a distribution of the class labels. The variance and the entropy of the distribution is used as metrics for uncertainty. Our results show strong correlation with ρ = 0.99 between prediction uncertainty and prediction error. Mean uncertainty of incorrectly diagnosed cases was significantly higher than mean uncertainty of correctly diagnosed cases. Modeling of the prediction uncertainty in computer-aided diagnosis with deep learning yields more reliable results and is therefore expected to increase patient safety. This will help to transfer such systems into clinical routine and to increase the acceptance of machine learning in diagnosis from the standpoint of physicians and patients.

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