scholarly journals Prediction of Beck Depression Inventory Score in EEG: Application of Deep-Asymmetry Method

2021 ◽  
Vol 11 (19) ◽  
pp. 9218
Author(s):  
Min Kang ◽  
Seokhwan Kang ◽  
Youngho Lee
Keyword(s):  
Deep Learning ◽  
Beck Depression Inventory ◽  
Beck Depression Inventory Score ◽  
Ongoing Research ◽  
Coping Methods ◽  
Brain Waves ◽  
Interpretable Model ◽  
Severity Of Depression ◽  
And Coping ◽  
Deep Learning Model

There is ongoing research on using electroencephalography (EEG) to predict depression. In particular, the deep learning method in which brain waves are used as inputs of a convolutional neural network (CNN) is being widely researched and has shown remarkable performance. We built a regression model to predict the severity score (Beck Depression Inventory [BDI]) of depressed patients as an extension of the deep-asymmetry method, which has shown promising performance in depression classification. Predicting the severity of depression is very important because the treatment and coping methods are different for each severity level. We imaged brain waves using the deep-asymmetry method, used them to train a two-dimensional CNN-based deep learning model, and achieved satisfactory performance. The EEG image-based CNN approach will make an important contribution to creating a highly interpretable model for predicting depression in the future.

scholarly journals ScanNet: An interpretable geometric deep learning model for structure-based protein binding site prediction

2021 ◽  
Author(s):  
Jérôme Tubiana ◽  
Dina Schneidman-Duhovny ◽  
Haim J. Wolfson
Keyword(s):  
Deep Learning ◽  
Small Molecules ◽  
Binding Sites ◽  
Comparative Modeling ◽  
Learning Model ◽  
Functional Sites ◽  
Site Prediction ◽  
Interpretable Model ◽  
Deep Learning Model

Predicting the functional sites of a protein from its structure, such as the binding sites of small molecules, other proteins or antibodies sheds light on its function in vivo. Currently, two classes of methods prevail: Machine Learning (ML) models built on top of handcrafted features and comparative modeling. They are respectively limited by the expressivity of the handcrafted features and the availability of similar proteins. Here, we introduce ScanNet, an end-to-end, interpretable geometric deep learning model that learns features directly from 3D structures. ScanNet builds representations of atoms and amino acids based on the spatio-chemical arrangement of their neighbors. We train ScanNet for detecting protein-protein and protein-antibody binding sites, demonstrate its accuracy - including for unseen protein folds - and interpret the filters learned. Finally, we predict epitopes of the SARS-CoV-2 spike protein, validating known antigenic regions and predicting previously uncharacterized ones. Overall, ScanNet is a versatile, powerful, and interpretable model suitable for functional site prediction tasks. A webserver for ScanNet is available from http://bioinfo3d.cs.tau.ac.il/ScanNet/

scholarly journals ScanNet: An interpretable geometric deep learning model for structure-based protein binding site prediction

2021 ◽  
Author(s):  
Jérôme Tubiana ◽  
Dina Schneidman-Duhovny ◽  
Haim Wolfson
Keyword(s):  
Deep Learning ◽  
Small Molecules ◽  
Binding Sites ◽  
Comparative Modeling ◽  
Learning Model ◽  
Functional Sites ◽  
Site Prediction ◽  
Interpretable Model ◽  
Deep Learning Model

Abstract Predicting the functional sites of a protein from its structure, such as the binding sites of small molecules, other proteins or antibodies sheds light on its function in vivo. Currently, two classes of methods prevail: Machine Learning (ML) models built on top of handcrafted features and comparative modeling. They are respectively limited by the expressivity of the handcrafted features and the availability of similar proteins. Here, we introduce ScanNet, an end-to-end, interpretable geometric deep learning model that learns features directly from 3D structures. ScanNet builds representations of atoms and amino acids based on the spatio-chemical arrangement of their neighbors. We train ScanNet for detecting protein-protein and protein-antibody binding sites, demonstrate its accuracy - including for unseen protein folds - and interpret the filters learned. Finally, we predict epitopes of the SARS-CoV-2 spike protein, validating known antigenic regions and predicting previously uncharacterized ones. Overall, ScanNet is a versatile, powerful, and interpretable model suitable for functional site prediction tasks. A webserver for ScanNet is available from http://bioinfo3d.cs.tau.ac.il/ScanNet/

Improving Sentiment Analysis using Hybrid Deep Learning Model

2020 ◽  
Vol 13 (4) ◽  
pp. 627-640 ◽  
Author(s):  
Avinash Chandra Pandey ◽  
Dharmveer Singh Rajpoot
Keyword(s):  
Neural Network ◽  
Deep Learning ◽  
Sentiment Analysis ◽  
Classification Accuracy ◽  
Short Term Memory ◽  
Computational Cost ◽  
Extraction Process ◽  
Learning Model ◽  
Sentiment Classification ◽  
Deep Learning Model

Background: Sentiment analysis is a contextual mining of text which determines viewpoint of users with respect to some sentimental topics commonly present at social networking websites. Twitter is one of the social sites where people express their opinion about any topic in the form of tweets. These tweets can be examined using various sentiment classification methods to find the opinion of users. Traditional sentiment analysis methods use manually extracted features for opinion classification. The manual feature extraction process is a complicated task since it requires predefined sentiment lexicons. On the other hand, deep learning methods automatically extract relevant features from data hence; they provide better performance and richer representation competency than the traditional methods. Objective: The main aim of this paper is to enhance the sentiment classification accuracy and to reduce the computational cost. Method: To achieve the objective, a hybrid deep learning model, based on convolution neural network and bi-directional long-short term memory neural network has been introduced. Results: The proposed sentiment classification method achieves the highest accuracy for the most of the datasets. Further, from the statistical analysis efficacy of the proposed method has been validated. Conclusion: Sentiment classification accuracy can be improved by creating veracious hybrid models. Moreover, performance can also be enhanced by tuning the hyper parameters of deep leaning models.

scholarly journals Deep Learning Model Comparison for Vision-Based Classification of Full/Empty-Load Trucks in Earthmoving Operations

2019 ◽  
Vol 9 (22) ◽  
pp. 4871 ◽  
Author(s):  
Quan Liu ◽  
Chen Feng ◽  
Zida Song ◽  
Joseph Louis ◽  
Jian Zhou
Keyword(s):  
Deep Learning ◽  
Model Comparison ◽  
Surveillance Systems ◽  
Comparison Study ◽  
Learning Models ◽  
The Core ◽  
Dump Trucks ◽  
Deep Learning Model ◽  
Contact Field

Earthmoving is an integral civil engineering operation of significance, and tracking its productivity requires the statistics of loads moved by dump trucks. Since current truck loads’ statistics methods are laborious, costly, and limited in application, this paper presents the framework of a novel, automated, non-contact field earthmoving quantity statistics (FEQS) for projects with large earthmoving demands that use uniform and uncovered trucks. The proposed FEQS framework utilizes field surveillance systems and adopts vision-based deep learning for full/empty-load truck classification as the core work. Since convolutional neural network (CNN) and its transfer learning (TL) forms are popular vision-based deep learning models and numerous in type, a comparison study is conducted to test the framework’s core work feasibility and evaluate the performance of different deep learning models in implementation. The comparison study involved 12 CNN or CNN-TL models in full/empty-load truck classification, and the results revealed that while several provided satisfactory performance, the VGG16-FineTune provided the optimal performance. This proved the core work feasibility of the proposed FEQS framework. Further discussion provides model choice suggestions that CNN-TL models are more feasible than CNN prototypes, and models that adopt different TL methods have advantages in either working accuracy or speed for different tasks.

scholarly journals Explaining deep neural networks for knowledge discovery in electrocardiogram analysis

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Steven A. Hicks ◽  
Jonas L. Isaksen ◽  
Vajira Thambawita ◽  
Jonas Ghouse ◽  
Gustav Ahlberg ◽  
...  
Keyword(s):  
Decision Making ◽  
Deep Learning ◽  
Deep Neural Networks ◽  
Clinical Decision Making ◽  
Medical Knowledge ◽  
Clinical Decision ◽  
Medical Data ◽  
Medical Doctors ◽  
Medical Tests ◽  
Deep Learning Model

AbstractDeep learning-based tools may annotate and interpret medical data more quickly, consistently, and accurately than medical doctors. However, as medical doctors are ultimately responsible for clinical decision-making, any deep learning-based prediction should be accompanied by an explanation that a human can understand. We present an approach called electrocardiogram gradient class activation map (ECGradCAM), which is used to generate attention maps and explain the reasoning behind deep learning-based decision-making in ECG analysis. Attention maps may be used in the clinic to aid diagnosis, discover new medical knowledge, and identify novel features and characteristics of medical tests. In this paper, we showcase how ECGradCAM attention maps can unmask how a novel deep learning model measures both amplitudes and intervals in 12-lead electrocardiograms, and we show an example of how attention maps may be used to develop novel ECG features.

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