Effect of Computer-Aided Navigation Techniques on the Accuracy of Endodontic Access Cavities: A Systematic Review and Meta-Analysis

The present systematic review and meta-analysis aims to determine the effect of computer-aided navigation techniques on the accuracy of endodontic access cavities. Materials and methods: A systematic literature review and meta-analysis of clinical studies, based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations, was performed that evaluated the root canal location rate of computer-aided navigation techniques applied to endodontic access cavities. Four different databases were used to consult the literature: PubMed-Medline, Scopus, Cochrane, and Web of Science. After discarding duplicate articles and applying inclusion criteria, 14 articles were selected for qualitative analysis and 13 for quantitative analysis. Results: the root canal location success rate started at 98.1% (CI: 95.7–100%) of the cases performed through a computer-aided navigation technique. The prediction interval ranged from 93.3% to 100%. The meta-analysis did not detect heterogeneity between the combined studies (Q-test = 17.3; p = 0.185; I2 = 25%). No statistically significant differences were found between computer-aided static navigation techniques (success rate: 98.5%) and computer-aided dynamic navigation techniques (success rate: 94.5%) (Q test = 0.57; p = 0.451), nor between in vitro studies (success rate: 96.2%) and in vivo studies (success rate: 100%) (Q test = 2.53; p-value = 0.112). An odds success ratio of 13.1 (CI: 95%; 3.48, 49.1) encourages the use of computer-aided navigation techniques over conventional endodontic access cavity procedures. Conclusions: the endodontic access cavities created using static and dynamic computer-aided navigation techniques are highly accurate in locating the root canal system.

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Efficacy of Computer-Aided Static Navigation Technique on the Accuracy of Endodontic Microsurgery. A Systematic Review and Meta-Analysis

Journal of Clinical Medicine ◽

10.3390/jcm10020313 ◽

2021 ◽

Vol 10 (2) ◽

pp. 313

Author(s):

Álvaro Zubizarreta-Macho ◽

César Castillo-Amature ◽

José María Montiel-Company ◽

Jesús Mena-Álvarez

Keyword(s):

Systematic Review ◽

Confidence Interval ◽

Success Rate ◽

Prediction Interval ◽

Meta Analysis ◽

Root Apex ◽

Control Group ◽

P Value ◽

Endodontic Microsurgery ◽

Computer Aided

The aim of this systematic review and meta-analysis was to analyze the efficacy of the computer-aided static navigation technique on the accuracy of root apex location in endodontic microsurgery. Material and Methods: A systematic literature review and meta-analysis, based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations, of clinical studies that evaluated the apex location rate of the computer-aided static navigation techniques applied to endodontic microsurgery. A total of four databases were consulted in the literature search: Pubmed-Medline, Scopus, Cochrane, and Web of Science. After eliminating duplicated articles and applying the inclusion criteria, seven articles were selected for the qualitative and the quantitative analysis. Results: The root apex location success rate stated at 96.8% (confidence interval (CI): 93.0–100%) of the cases performed through a computer-aided static navigation technique. The prediction interval ranges from 91.4% to 100%. The meta-analysis did not detect heterogeneity between the combined studies (Q-test = 6.15; p-value = 0.407; I2 = 2.4%). The computer-aided static navigation techniques showed a root apex location success rate 27 times higher than conventional endodontic microsurgery procedures (Q test = 0.80; p = 0.671; I2 = 0%). Three studies of computer-aided static navigation techniques and control group were compared using a random effects model with the Mantel-Haenszel method with a statistically significant odds success ratio of 27.7, with a 95% confidence interval between 11.3 and 68.1 (z test = 7.23; p < 0.0001). Conclusions: According to in vitro studies analyzed, endodontic microsurgeries performed through computer-aided static navigation techniques show a high precision.

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In Vivo and In Vitro Effectiveness of Rotary Nickel-Titanium vs Manual Stainless Steel Instruments for Root Canal Therapy: Systematic Review and Meta-analysis

Journal of Evidence Based Dental Practice ◽

10.1016/j.jebdp.2017.08.001 ◽

2018 ◽

Vol 18 (1) ◽

pp. 59-69 ◽

Cited By ~ 15

Author(s):

Massimo Del Fabbro ◽

Kelvin Ian Afrashtehfar ◽

Stefano Corbella ◽

Ahmed El-Kabbaney ◽

Isabella Perondi ◽

...

Keyword(s):

Systematic Review ◽

Stainless Steel ◽

Root Canal ◽

Meta Analysis ◽

Nickel Titanium ◽

Root Canal Therapy

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Bioactive Compounds from Kefir and Their Potential Benefits on Health: A Systematic Review and Meta-Analysis

Oxidative Medicine and Cellular Longevity ◽

10.1155/2021/9081738 ◽

2021 ◽

Vol 2021 ◽

pp. 1-34

Author(s):

Carla P. Vieira ◽

Anisio Iuri L. S. Rosario ◽

Carini A. Lelis ◽

Bruna Samara S. Rekowsky ◽

Anna Paula A. Carvalho ◽

...

Keyword(s):

Systematic Review ◽

Bioactive Compounds ◽

Meta Analysis ◽

Health Effect ◽

In Vivo Studies ◽

Therapeutic Effects ◽

Microbial Composition ◽

Functional Potential

Despite evidence of health benefits from kefir administration, a systematic review with meta-analysis on bioactive compounds associated with these benefits is still absent in the literature. Kefir is fermented milk resulting from the metabolism of a complex microbiota in symbiosis. Recent researches have investigated the bioactive compounds responsible for the preventive and therapeutic effects attributed to kefir. However, differences in functional potential between industrial and artisanal kefir are still controversial. Firstly, we identified differences in the microbial composition among both types of kefir. Available evidence concerning the action of different bioactive compounds from kefir on health, both from in vitro and in vivo studies, was subsequently summarized to draw a primary conclusion of the dose and the intervention time for effect, the producer microorganisms, the precursor in the milk, and the action mechanism. Meta-analysis was performed to investigate the statistically significant differences ( P < 0.05 ) between intervention and control and between both types of kefir for each health effect studied. In summary, the bioactive compounds more commonly reported were exopolysaccharides, including kefiran, bioactive peptides, and organic acids, especially lactic acid. Kefir bioactive compounds presented antimicrobial, anticancer, and immune-modulatory activities corroborated by the meta-analysis. However, clinical evidence is urgently needed to strengthen the practical applicability of these bioactive compounds. The mechanisms of their action were diverse, indicating that they can act by different signaling pathways. Still, industrial and artisanal kefir may differ regarding functional potential—OR of 8.56 (95% CI: 2.27–32.21, P ≤ .001 )—according to the observed health effect, which can be associated with differences in the microbial composition between both types of kefir.

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Biocompatibility of Root Canal Sealers: A Systematic Review of In Vitro and In Vivo Studies

Materials ◽

10.3390/ma12244113 ◽

2019 ◽

Vol 12 (24) ◽

pp. 4113 ◽

Cited By ~ 5

Author(s):

Diogo Afonso Fonseca ◽

Anabela Baptista Paula ◽

Carlos Miguel Marto ◽

Ana Coelho ◽

Siri Paulo ◽

...

Keyword(s):

Systematic Review ◽

Root Canal ◽

Biological Effects ◽

Tissue Response ◽

In Vivo Studies ◽

Cochrane Library ◽

Toxic Potential ◽

Root Canal Sealers

(1) Aim: To perform a systematic review of the literature on the biocompatibility of root canal sealers that encompasses the various types of sealers that are commercially available as well as both in vitro and in vivo evidence. (2) Methods: This systematic review has been registered in PROSPERO (ID 140445) and was carried out according to PRISMA guidelines using the following databases: PubMed, Cochrane Library, ClinicalTrials.gov, Science Direct, and Web of Science Core Collection. Studies published between 2000 and 11 June 2019 that evaluated cytotoxicity (cell viability/proliferation) and biocompatibility (tissue response) of root canal sealers were included. (3) Results: From a total of 1249 studies, 73 in vitro and 21 in vivo studies were included. In general, studies suggest that root canal sealers elicit mild to severe toxic effects and that several factors may influence biocompatibility, e.g., material setting condition and time, material concentration, and type of exposure. Bioactive endodontic sealers seem to exhibit a lower toxic potential in vitro. (4) Conclusions: The available evidence shows that root canal sealers exhibit variable toxic potential at the cellular and tissue level. However, the methodological heterogeneity among studies included in this systematic review and the somewhat conflicting results do not allow a conclusion on which type of sealer presents higher biocompatibility. Further research is crucial to achieve a better understanding of the biological effects of root canal sealers.

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Antibacterial activity and bond strength of silver nanoparticles modified orthodontic bracket adhesive: a systematic review and meta-analysis of in-vitro and in-vivo studies

International Journal of Adhesion and Adhesives ◽

10.1016/j.ijadhadh.2021.103040 ◽

2021 ◽

pp. 103040

Author(s):

Mohammad Khursheed Alam ◽

Rayan Alsuwailem ◽

Ahmed Ali Alfawzan

Keyword(s):

Systematic Review ◽

Silver Nanoparticles ◽

Antibacterial Activity ◽

Bond Strength ◽

Meta Analysis ◽

In Vivo Studies ◽

Orthodontic Bracket

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Transplantation of Adipose-derived Cells for Periodontal Regeneration: A Systematic Review

Current Stem Cell Research & Therapy ◽

10.2174/1574888x13666181105144430 ◽

2019 ◽

Vol 14 (6) ◽

pp. 504-518 ◽

Cited By ~ 3

Author(s):

Dilcele Silva Moreira Dziedzic ◽

Bassam Felipe Mogharbel ◽

Priscila Elias Ferreira ◽

Ana Carolina Irioda ◽

Katherine Athayde Teixeira de Carvalho

Keyword(s):

Systematic Review ◽

Animal Models ◽

Platelet Rich Plasma ◽

Periodontal Regeneration ◽

In Vitro Studies ◽

In Vivo Studies ◽

Cell Sources ◽

Study Designs

This systematic review evaluated the transplantation of cells derived from adipose tissue for applications in dentistry. SCOPUS, PUBMED and LILACS databases were searched for in vitro studies and pre-clinical animal model studies using the keywords “ADIPOSE”, “CELLS”, and “PERIODONTAL”, with the Boolean operator “AND”. A total of 160 titles and abstracts were identified, and 29 publications met the inclusion criteria, 14 in vitro and 15 in vivo studies. In vitro studies demonstrated that adipose- derived cells stimulate neovascularization, have osteogenic and odontogenic potential; besides adhesion, proliferation and differentiation on probable cell carriers. Preclinical studies described improvement of bone and periodontal healing with the association of adipose-derived cells and the carrier materials tested: Platelet Rich Plasma, Fibrin, Collagen and Synthetic polymer. There is evidence from the current in vitro and in vivo data indicating that adipose-derived cells may contribute to bone and periodontal regeneration. The small quantity of studies and the large variation on study designs, from animal models, cell sources and defect morphology, did not favor a meta-analysis. Additional studies need to be conducted to investigate the regeneration variability and the mechanisms of cell participation in the processes. An overview of animal models, cell sources, and scaffolds, as well as new perspectives are provided for future bone and periodontal regeneration study designs.

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Contribution of XP‐Endo files to the root canal filling removal: A systematic review and meta‐analysis of in vitro studies

Australian Endodontic Journal ◽

10.1111/aej.12503 ◽

2021 ◽

Author(s):

Emel Uzunoglu‐Özyürek ◽

Selen Küçükkaya Eren ◽

Sevilay Karahan

Keyword(s):

Systematic Review ◽

Root Canal ◽

Meta Analysis ◽

In Vitro Studies ◽

Root Canal Filling

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A systematic review and meta-analysis of spermatozoa cryopreservation, in vitro and in vivo fertility practices in water buffalo

Veterinary Research Communications ◽

10.1007/s11259-021-09789-0 ◽

2021 ◽

Author(s):

Syed Aftab Hussain Shah ◽

Syed Murtaza Hassan Andrabi

Keyword(s):

Systematic Review ◽

Water Buffalo ◽

Meta Analysis

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Glycemic Index of Gluten-Free Bread and Their Main Ingredients: A Systematic Review and Meta-Analysis

Foods ◽

10.3390/foods10030506 ◽

2021 ◽

Vol 10 (3) ◽

pp. 506

Author(s):

Bernardo Romão ◽

Ana Luísa Falcomer ◽

Gabriela Palos ◽

Sandra Cavalcante ◽

Raquel Braz Assunção Botelho ◽

...

Keyword(s):

Systematic Review ◽

Glycemic Index ◽

Resistant Starch ◽

Web Of Science ◽

Meta Analysis ◽

Gluten Free ◽

Inclusion Criteria ◽

Glycemic Profile

This study aimed to perform a systematic review and meta-analysis of the glycemic index (GI) of gluten-free bread (GFB) and its main ingredients. The systematic review followed PRISMA guidelines, using seven electronic databases (PubMed, EMBASE, Scopus, Science Direct, Web of Science, gray literature research with Google Scholar, and patents with Google Patent tool), from inception to November 2020. Eighteen studies met the inclusion criteria evaluating 132 GFB samples. Five articles tested GI in vivo, eleven in vitro; and two studies tested both methods. The analysis showed that 60.7% (95% CI: 40.2–78.1%) of the samples presented high glycemic indexes, evidencing a high glycemic profile for GFB. Only 18.2% (95% CI: 11.7–27.2%) of the bread samples presented in the studies were classified as a low GI. Meta-analysis presented moderate/low heterogenicity between studies (I2 = 61% and <1% for both high and low GIs) and reinforced the proportion of high GIs. Lower GIs were found in formulations based on Colocasia esculenta flour or enriched with fiber, yogurt and curd cheese, sourdough, psyllium, hydrocolloids, enzymes, fructans, and resistant starch, highlighting the efficacy of these ingredients to lower GFBs’ GI. GFB tends to present high GI, impacting the development of chronic diseases when consumed.

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