scholarly journals The Role of White Matter Disconnection in the Symptoms Relating to the Anarchic Hand Syndrome: A Single Case Study

2021 ◽  
Vol 11 (5) ◽  
pp. 632
Author(s):  
Valentina Pacella ◽  
Giuseppe Kenneth Ricciardi ◽  
Silvia Bonadiman ◽  
Elisabetta Verzini ◽  
Federica Faraoni ◽  
...  
Keyword(s):  
White Matter ◽  
Single Case ◽  
Brain Lesion ◽  
Structural Connectivity ◽  
Disconnection Syndrome ◽  
Neuroimaging Data ◽  
Neuropsychological Investigation ◽  
Anterior Posterior

The anarchic hand syndrome refers to an inability to control the movements of one’s own hand, which acts as if it has a will of its own. The symptoms may differ depending on whether the brain lesion is anterior, posterior, callosal or subcortical, but the relative classifications are not conclusive. This study investigates the role of white matter disconnections in a patient whose symptoms are inconsistent with the mapping of the lesion site. A repeated neuropsychological investigation was associated with a review of the literature on the topic to identify the frequency of various different symptoms relating to this syndrome. Furthermore, an analysis of the neuroimaging regarding structural connectivity allowed us to investigate the grey matter lesions and white matter disconnections. The results indicated that some of the patient’s symptoms were associated with structures that, although not directly damaged, were dysfunctional due to a disconnection in their networks. This suggests that the anarchic hand may be considered as a disconnection syndrome involving the integration of multiple antero-posterior, insular and interhemispheric networks. In order to comprehend this rare syndrome better, the clinical and neuroimaging data need to be integrated with the clinical reports available in the literature on this topic.

scholarly journals The Role of White Matter Disconnection in the Symptoms Relating to the Anarchic Hand Syndrome: A Single Case Study

2021 ◽  
Author(s):  
Valentina Pacella ◽  
Giuseppe Kenneth Ricciardi ◽  
Silvia Bonadiman ◽  
Elisabetta Verzini ◽  
Federica Faraoni ◽  
...  
Keyword(s):  
White Matter ◽  
Single Case ◽  
Brain Lesion ◽  
Structural Connectivity ◽  
Disconnection Syndrome ◽  
Neuroimaging Data ◽  
Neuropsychological Investigation ◽  
Anterior Posterior

The anarchic hand syndrome refers to an inability to control the movements of one’s own hand which acts as if it had a will of its own. The symptoms may differ depending on whether the brain lesion is anterior, posterior, callosal or subcortical, but the relative classifications are not conclusive. This study investigates the role of white matter disconnections in a patient whose symptoms are inconsistent with the mapping of the lesion site. A repeated neuropsychological investigation was associated with a review of the literature on the topic to identify the frequency of various different symptoms relating to this syndrome. Furthermore, an analysis of the neuroimaging regarding structural connectivity allowed us to investigate the grey matter lesions and white matter disconnections. The results indicated that some of the patient’s symptoms were associated with structures that, although not directly damaged, were dysfunctional due to a disconnection in their networks. This suggests that the anarchic hand may be considered as a disconnection syndrome involving the integration of multiple antero-posterior, insular and interhemispheric networks. In order to comprehend this rare syndrome better, the clinical and neuroimaging data need to be integrated with the clinical reports available in the literature on the topic.

scholarly journals Brain disconnections link structural connectivity with function and behaviour

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Michel Thiebaut de Schotten ◽  
Chris Foulon ◽  
Parashkev Nachev
Keyword(s):  
White Matter ◽  
Brain Lesion ◽  
Structural Connectivity ◽  
Brain Lesions ◽  
Brain Areas ◽  
Brain Functions ◽  
The Past ◽  
Lesion Studies ◽  
Open Question

Abstract Brain lesions do not just disable but also disconnect brain areas, which once deprived of their input or output, can no longer subserve behaviour and cognition. The role of white matter connections has remained an open question for the past 250 years. Based on 1333 stroke lesions, here we reveal the human Disconnectome and demonstrate its relationship to the functional segregation of the human brain. Results indicate that functional territories are not only defined by white matter connections, but also by the highly stereotyped spatial distribution of brain disconnections. While the former has granted us the possibility to map 590 functions on the white matter of the whole brain, the latter compels a revision of the taxonomy of brain functions. Overall, our freely available Atlas of White Matter Function will enable improved clinical-neuroanatomical predictions for brain lesion studies and provide a platform for explorations in the domain of cognition.

scholarly journals Brain disconnections link structural connectivity with function and behaviour

2020 ◽  
Author(s):  
Michel Thiebaut de Schotten ◽  
Chris Foulon ◽  
Parashkev Nachev
Keyword(s):  
White Matter ◽  
Brain Lesion ◽  
Structural Connectivity ◽  
Brain Lesions ◽  
Brain Areas ◽  
Brain Functions ◽  
The Past ◽  
Lesion Studies ◽  
Open Question

AbstractBrain lesions do not just disable but also disconnect brain areas, which once deprived of their input or output, can no longer subserve behaviour and cognition. The role of white matter connections has remained an open question for the past 250 years. Based on 1333 stroke lesions we reveal the human Disconnectome and demonstrate its relationship to the functional segregation of the human brain. Results indicate that functional territories are not only defined by white matter connections, but also by the highly stereotyped spatial distribution of brain disconnections. While the former has granted us the possibility to map 590 functions on the white matter of the whole brain, the latter compels a revision of the taxonomy of brain functions. Overall, our freely available Functional Atlas of the White Matter will enable improved clinical-neuroanatomical predictions for brain lesion studies and provide a platform for novel explorations in the domain of cognition.

Artefacts and the Dynamics of Truces in Organizational Routines

2018 ◽  
Author(s):  
Nicolás J.B. Wiedemann ◽  
Leona Wiegmann ◽  
Juergen Weber
Keyword(s):  
Single Case ◽  
Single Case Study ◽  
Organizational Routines ◽  
Process Perspective ◽  
Temporary Settlement

Organizational routines can constitute a temporary settlement of individual actors’ diverging interests, described as a truce that enables the routine as a collective accomplishment to proceed. In this regard, scholars have recognized the central but ambiguous role of artefacts; they may be used to coordinate the interactions in routines but may also be mobilized to serve individual interests. Following this line of thinking, this chapter assumes a process perspective to advance our understanding of how such temporal settlements are continuously formed and in particular, the role artefacts play in this process. Based on a single case study over a period of thirty-three months, it analyses the use of a newly implemented artefact that inadvertently impeded smooth routine functioning as the artefact provided content that gave actors leeway to act out their interests in enacting the routine.

scholarly journals Can We Generalize from Case Studies?

2015 ◽  
Vol 15 (3) ◽  
pp. 152-175 ◽  
Author(s):  
Paul F. Steinberg
Keyword(s):  
Case Studies ◽  
Single Case ◽  
Case Study Research ◽  
Political Systems ◽  
Ceteris Paribus ◽  
Large N ◽  
Climate Change Politics ◽  
The Comparative Study

This article considers the role of generalization in comparative case studies, using as exemplars the contributions to this special issue on climate change politics. As a research practice, generalization is a logical argument for extending one’s claims beyond the data, positing a connection between events that were studied and those that were not. No methodological tradition is exempt from the requirement to demonstrate a compelling logic of generalization. The article presents a taxonomy of the logics of generalization underlying diverse research methodologies, which often go unstated and unexamined. I introduce the concept of resonance groups, which provide a causeway for cross-system generalization from single case studies. Overall the results suggest that in the comparative study of complex political systems, case study research is, ceteris paribus, on par with large-N research with respect to generalizability.

scholarly journals Integrality of care: challenges for the nurse practice

2017 ◽  
Vol 70 (3) ◽  
pp. 504-510 ◽  
Author(s):  
Solange Meira de Sousa ◽  
Elizabeth Bernardino ◽  
Karla Crozeta ◽  
Aida Maris Peres ◽  
Maria Ribeiro Lacerda
Keyword(s):  
Teaching Hospital ◽  
Participant Observation ◽  
Single Case ◽  
Team Work ◽  
Nursing Management ◽  
Care Needs ◽  
Units Of Analysis ◽  
Integration Of Services

ABSTRACT Objective: to understand the role of the nurse in the collegiate management model of a teaching hospital, in the integrality of care perspective. Method: a single case study with multiple units of analysis, with the theoretical proposition "integrality of care is a result of the care offered to the user by multiple professionals, including the nurse". Data were obtained in a functional unit of a teaching hospital through interviews with 13 nurses in a non-participant observation and document analysis. Results: from the analytical categories emerged subcategories that allowed understanding that the nurse promotes integrality of care through nursing management, team work and integration of services. Final considerations: the theoretical proposition was confirmed and it was verified that the nursing management focus on attending to health care needs and is a strategy to provide integrality of care.

scholarly journals Regeringsautonomi og delegeringstab i dansk EU-politik: Et principal-agent teoretisk perspektiv

Politik ◽  
2010 ◽  
Vol 13 (3) ◽  
Author(s):  
Rasmus Bruun Pedersen
Keyword(s):  
Research Design ◽  
Single Case ◽  
Maastricht Treaty ◽  
Single Case Study ◽  
Government Behavior ◽  
Eu Integration ◽  
Treaty Negotiations ◽  
Role Of Information

Where do states’ positions on EU-integration come from? Despite a large number of studies we simply do not know which factors determine states’ positions in specific cases and why. This article analyses position making between ‘governments’ and ‘parliaments’ during the Maastricht Treaty negotiations. Furthermore, an analysis of the role of information asymmetries as intermediating factors in generating ‘influence on position’ will be carried out. The question asked is: Do governments enjoy relative autonomy vis-à-vis the Folketing that enables them to develop ‘positions’ they feel are in ‘the national interest’ or is Parliament able to control government behavior? The conclusions indicate that Parliaments control governmental positions, but also that governments, are able to exploit the negotiations to pursue certain ‘policy drifts’. The research design used is an in-dept single case study that analyses the level of inFluence on a multitude of different issues varied over the conflict level between the actors. 

scholarly journals Comparing the temporal relationship of structural and functional connectivity changes in different adult human brain networks: a single-case study

2018 ◽  
Vol 3 ◽  
pp. 50 ◽  
Author(s):  
Takamitsu Watanabe ◽  
Geraint Rees
Keyword(s):  
Functional Connectivity ◽  
Human Brain ◽  
Large Scale ◽  
Single Case ◽  
Brain Networks ◽  
Structural Connectivity ◽  
Time Lags ◽  
Single Case Study ◽  
Adult Human

Background: Despite accumulated evidence for adult brain plasticity, the temporal relationships between large-scale functional and structural connectivity changes in human brain networks remain unclear. Methods: By analysing a unique richly detailed 19-week longitudinal neuroimaging dataset, we tested whether macroscopic functional connectivity changes lead to the corresponding structural alterations in the adult human brain, and examined whether such time lags between functional and structural connectivity changes are affected by functional differences between different large-scale brain networks. Results: In this single-case study, we report that, compared to attention-related networks, functional connectivity changes in default-mode, fronto-parietal, and sensory-related networks occurred in advance of modulations of the corresponding structural connectivity with significantly longer time lags. In particular, the longest time lags were observed in sensory-related networks. In contrast, such significant temporal differences in connectivity change were not seen in comparisons between anatomically categorised different brain areas, such as frontal and occipital lobes. These observations survived even after multiple validation analyses using different connectivity definitions or using parts of the datasets. Conclusions: Although the current findings should be examined in independent datasets with different demographic background and by experimental manipulation, this single-case study indicates the possibility that plasticity of macroscopic brain networks could be affected by cognitive and perceptual functions implemented in the networks, and implies a hierarchy in the plasticity of functionally different brain systems.

Haute cuisine and country of origin

2019 ◽  
Vol 122 (1) ◽  
pp. 136-150 ◽  
Author(s):  
Angelo Presenza ◽  
Antonio Messeni Petruzzelli
Keyword(s):  
Single Case ◽  
Relative Effectiveness ◽  
Country Of Origin ◽  
Competitive Strategies ◽  
Case Study Methodology ◽  
Content Type ◽  
Study Methodology ◽  
Practical Implications

Purpose The purpose of this paper is to shed new light on the role of country of origin (COO) for the competitiveness of luxury restaurants. The main goal is to understand how an haute cuisine (HC) chef can develop a personal cooking style and language based on the exploitation of COO in such a highly institutionalized field. Design/methodology/approach A single case study methodology is applied based on the analysis of the Italian HC chef Niko Romito. Findings Findings of this paper highlight the existence of pervasive use of strategies based on the search, recombination and codification of procedure that take direct inspiration by national and regional traditional gastronomic resources and recipes. Research limitations/implications Research implications refer to the interpretation of how a chef can work by formulating and developing competitive strategies through the recombination, reinterpretation and codification of local and typical gastronomic resources and cooking recipes. Practical implications The paper provides managerial insights into the relative effectiveness to use COO as a strategic resource for HC restaurants. Originality/value A model is presented and the three gears that form the COO chain of chef Romito are explained. This model will help academics and practitioners to better understand the ways need to be followed to improve firms’ competitiveness fostering COO.

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