scholarly journals Relationship between Breast Cancer Surgical Treatment and Psychiatric Symptomatology: Which Sociodemographic and Clinical Factors Could Influence It? A Preliminary Study

2022 ◽  
Vol 12 (1) ◽  
pp. 9
Author(s):  
Ilaria Baldelli ◽  
Matteo Gari ◽  
Andrea Aguglia ◽  
Andrea Amerio ◽  
Valeria Berrino ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Perceived Stress ◽  
Rating Scales ◽  
Breast Surgery ◽  
Occupational Status ◽  
Structured Interview ◽  
Point Of View ◽  
Psychiatric Symptomatology ◽  
Age Of Diagnosis ◽  
History Of

This study aimed to investigate psychiatric symptomatology in a sample of patients affected by breast cancer undergoing surgery, evaluating the potential mediators on perceived stress levels, depression and hopelessness. The study was conducted on eighty-five patients with breast cancer, admitted consecutively to the Breast Unit of the IRCCS Ospedale Policlinico San Martino, between May 2018 and December 2019. Sociodemographic (age of diagnosis, gender, marital and occupational status, educational level, having children) and clinical (type and side of surgery, previous breast surgery, neoadjuvant chemotherapy and axillary dissection) characteristics were investigated through a semi-structured interview. The following rating scales were administered: Beck Depression Inventory, Beck Hopelessness Scale, and Perceived Stress Scale. Our findings indicate that the presence of children and of a partner was associated with a lower total score on the clinical dimensions evaluated. Furthermore, we found demolitive surgery to be a mediator between perceived stress and hopelessness, while history of previous breast surgery was found to be a mediator between demolitive surgery and perceived stress. In conclusion, patients affected by breast cancer undergoing more complex and demolitive surgery or with history of previous breast surgery should be mostly monitored from a psychological and psychiatric point of view from the beginning of treatments to evaluate the first manifestations of psychiatric symptomatology.

scholarly journals Oncoplastic breast surgery techniques - a new look at surgical treatment of breast cancer

2018 ◽  
Vol 31 (3) ◽  
pp. 131-134
Author(s):  
Krzysztof Kozak ◽  
Rafal Wojcik ◽  
Maciej Czerwonka ◽  
Slawomir Mandziuk ◽  
Barbara Madej-Czerwonka
Keyword(s):  
Breast Cancer ◽  
Surgical Treatment ◽  
Statistical Data ◽  
Breast Surgery ◽  
Point Of View ◽  
Oncoplastic Breast Surgery ◽  
Reconstruction Surgery ◽  
Common Cancer ◽  
Breast Centers ◽  
The Aesthetic

Abstract Breast cancer is the most common cancer among Polish women [1], thus, the problem of surgical treatment of breasts, especially with regard to conserving and/or reconstruction surgery, is extensively discussed. Currently, in Poland, efforts are made to increase the number of oncologic and reconstructive breast centers which offer specialized treatment of this cancer, the so-called ‘Breast Units’ [1]. This paper analyzes methods of reconstructions, discusses the techniques used in particular types of surgeries and additionally informs the reader of the oncological aspects of the procedures. Based on literature, statistical data of breast reconstructions from Poland and the world are presented. Moreover, complications and psychological aspects of mammary gland surgery are dealt with, and the aesthetic effects of breast reconstructions are discussed. To support of our findings, we also present selected clinical cases from the oncological and reconstructive point of view.

scholarly journals Economic and Social Aspects of Secondary Lymphedema following Treatment of Breast Cancer

2021 ◽  
Vol 12 (2) ◽  
pp. 35-38
Author(s):  
K. Pitr
Keyword(s):  
Breast Cancer ◽  
Structured Interview ◽  
Point Of View ◽  
Insurance Companies ◽  
Second Grade ◽  
Family Status ◽  
Rehabilitation Team ◽  
Secondary Lymphedema ◽  
Health Insurance Companies

Introduction The quality of life of female patients who have undergone mentally and physically demanding treatment of cancer is often affected by the emergence of secondary lymphedema. The purpose of our work is to evaluate this complexity not only from an objective but also subjective point of view. Methods Qualitative focusstudy in 18 patients under 60 years of age conducted by way of a structured interview during 2019 at the lymphological workplace. Results The economic burden for patients is on the average CZK 683 per month (about $360 USD per year), the treatment is paid for fully by health insurance companies. Lymphedema is a significant barrier in an occupation, more in women after treatment of the second grade of cancer than the first one. Lymphedema is a bigger obstacle for women with lower education, physically working. Family status does not have a significant effect on the treatment of cancer. Conclusions The study has confirmed the difficulty of treatment ofsecondary lymphedema after the treatment of breast cancer, both from financial and professional points of view. The medical staff should take into account these factors or expand the rehabilitation team and thus ensure better compliance in therapy.

Depression following Myocardial Infarction

1992 ◽  
Vol 22 (1) ◽  
pp. 33-46 ◽  
Author(s):  
Alfred W. Forrester ◽  
John R. Lipsey ◽  
Mark L. Teitelbaum ◽  
J. Raymond Depaulo ◽  
Paula L. Andrzejewski ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Depressive Disorders ◽  
Rating Scales ◽  
Psychiatric Morbidity ◽  
Structured Interview ◽  
Physical Impairment ◽  
Prior History ◽  
Clinical Interviews ◽  
History Of ◽  
Depressive Syndromes

Objective: Although many investigators have studied mood disorders following myocardial infarction, the prevalence, severity, and persistence of depression have been disputed, and standard rating scales and criteria for depressive disorders have infrequently been utilized. The authors' goal was to determine how frequently depressive disorders occur after myocardial infarction, and to investigate predisposing factors for such disorders. Method: Structured clinical interviews were administered to 129 inpatients within ten days of myocardial infarction. Patients were also evaluated using standardized rating scales for depression, social function, cognition, and physical impairment. DSM-III diagnoses were derived from the structured interview. Results: Major depressive syndromes were present in 19 percent ( n = 25) of the patients and were associated with prior history of mood disorder, female sex, large infarcts, and functional physical impairment. Conclusion: Major depression is common in the acute post-myocardial infarction period. Such disorders confer significant psychiatric morbidity and, if sustained, require psychiatric intervention.

scholarly journals NGS Panel Testing of Triple-Negative Breast Cancer Patients in Cyprus: A Study of BRCA-Negative Cases

Cancers ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3140
Author(s):  
Maria Zanti ◽  
Maria A. Loizidou ◽  
Kyriaki Michailidou ◽  
Panagiota Pirpa ◽  
Christina Machattou ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative ◽  
Growth Factor Receptor ◽  
Breast Cancer Patients ◽  
Panel Testing ◽  
Pathogenic Variants ◽  
Age Of Diagnosis ◽  
History Of ◽  
Epidermal Growth ◽  
Estrogen Receptor Negative

In Cyprus, approximately 9% of triple-negative (estrogen receptor-negative, progesterone receptor-negative, and human epidermal growth factor receptor 2-negative) breast cancer (TNBC) patients are positive for germline pathogenic variants (PVs) in BRCA1/2. However, the contribution of other genes has not yet been determined. To this end, we aimed to investigate the prevalence of germline PVs in BRCA1/2-negative TNBC patients in Cyprus, unselected for family history of cancer or age of diagnosis. A comprehensive 94-cancer-gene panel was implemented for 163 germline DNA samples, extracted from the peripheral blood of TNBC patients. Identified variants of uncertain clinical significance were evaluated, using extensive in silico investigation. Eight PVs (4.9%) were identified in two high-penetrance TNBC susceptibility genes. Of these, seven occurred in PALB2 (87.5%) and one occurred in TP53 (12.5%). Interestingly, 50% of the patients carrying PVs were diagnosed over the age of 60 years. The frequency of non-BRCA PVs (4.9%) and especially PALB2 PVs (4.3%) in TNBC patients in Cyprus appears to be higher compared to other populations. Based on these results, we believe that PALB2 and TP53 along with BRCA1/2 genetic testing could be beneficial for a large proportion of TNBC patients in Cyprus, irrespective of their age of diagnosis.

scholarly journals Knowledge of secondary-school female students on breast cancer and breast self-examination in Jeddah, Saudi Arabia

2000 ◽  
Vol 6 (2-3) ◽  
pp. 338-344 ◽  
Author(s):  
W. A. Millat
Keyword(s):  
Breast Cancer ◽  
Secondary School ◽  
Breast Surgery ◽  
Positive Family History ◽  
Female Students ◽  
School Students ◽  
Breast Self Examination ◽  
History Of ◽  
Self Examination ◽  
Self Administered Questionnaire

A self-administered questionnaire was given to 6380 female secondary-school students [mean age = 18.1 years]in Jeddah to identify their knowledge of breast cancer and attitude towards breast self-examination [BSE]. Knowledge of risk factors and presentation was very low. Over 80% of students failed to answer 50% of the questions correctly. A higher knowledge level was associated with older age, marriage and having children. Also students who had undergone mammography, had been exposed to breast surgery or had a positive family history of breast cancer showed significantly higher knowledge levels. Only 39.6% reported ever hearing of BSE and only 14.4% and 7.1% respectively knew the correct frequency and timing. However, 82.4% had a positive attitude towards learning BSE

scholarly journals Predictors of outcome of mammography in the National Health Service Breast Screening Programme

2002 ◽  
Vol 9 (2) ◽  
pp. 74-82 ◽  
Author(s):  
E. Banks ◽  
G. Reeves ◽  
V. Beral ◽  
D. Bull ◽  
B. Crossley ◽  
...  
Keyword(s):  
Breast Cancer ◽  
National Health Service ◽  
Family History ◽  
False Positive ◽  
Breast Screening ◽  
Screening Programme ◽  
Breast Surgery ◽  
Breast Screening Programme ◽  
History Of ◽  
National Health Service Breast

BACKGROUND: Little is known about the factors influencing the risk of recall for assessment, invasive diagnostic procedures, and early rescreening after screening mammography. METHODS: From June 1996 to March 1998 women attending screening at 10 National Health Service Breast Screening Programme (NHSBSP) centres completed a self administered questionnaire and were followed up for their screening outcome. RESULTS: 1969 (3.3%) out of 60 443 women aged 50–64 who had never used hormone replacement therapy (HRT) were recalled for assessment but were not diagnosed with breast cancer (defined here as false positive recall). After adjustment for the variation between centres, false positive recall was decreased significantly among women who were likely to have had a previous NHSBSP mammogram (odds ratio (OR) 0.49, 95% confidence interval (95% CI) 0.38 to 0.63 for likely versus unlikely), who were postmenopausal (OR 0.65, 95% CI 0.56 to 0.76 for postmenopausal v premenopausal) and increased significantly for women reporting previous breast surgery (OR 1.64, 95% CI 1.42 to 1.89). Although false positive recall decreased significantly with parity and increasing body mass index, these effects were not large and no significant variation was found with age, education, family history of breast cancer, oral contraceptive use, sterilisation, exercise, smoking, or alcohol consumption. Altogether 655 (1.1%) women had an invasive diagnostic procedure; no personal characteristics were predictive of this outcome, 286(0.5%) were referred for early rescreening, and this was increased significantly by nulliparity and a family history of breast cancer. INTERPRETATION: Premenopausal women, those without a previous NHSBSP mammogram, and women with previous breast surgery have an increased risk of false positive recall by the NHSBSP.

Immunohistochemical analisys in Breast Carcinoma Treated with Conservative Surgery

2019 ◽  
Vol 70 (7) ◽  
pp. 2632-2638
Author(s):  
Tiberiu Stefanita Tenea Cojan ◽  
Ionela Mihaela Vladu ◽  
Diana Clenciu ◽  
Dan Ionica Vilcea ◽  
Cecil Sorin Mirea ◽  
...  
Keyword(s):  
Breast Cancer ◽  
World Health Organisation ◽  
Conservative Surgery ◽  
Common Type ◽  
Point Of View ◽  
World Health ◽  
Immunohistochemical Expression ◽  
Cancer Society ◽  
Common Cancer ◽  
History Of

Breast cancer is the most common type of cancer in women worldwide and the second most common cancer overall, making it a major international concern from both socio and economical point of view. World Health Organisation (WHO) estimated that worldwide over 508.000 women died in 2011 due to breast cancer. American Cancer Society�s (ACS) study conducted in 2017 showed important numbers about the burden of breast cancer. Therefore, they estimated a number of 252,710 new breast cancer to be diagnosed in women and 2,470 in men in 2017- only in America. On 1st of January , there were about 3.5million US women with a history of breast cancer. The paper presents the correlations between recurrences of the tumor in breast cancer trated with conservative surgery and their immunohistochemical expression.

Gender differences and age of diagnosis in ADHD

2011 ◽  
Vol 26 (S2) ◽  
pp. 262-262 ◽  
Author(s):  
D. Almagor ◽  
L.W. Joseph ◽  
R. Ansari ◽  
S. Subramaniam
Keyword(s):  
Gender Differences ◽  
Structured Interview ◽  
Clinical Population ◽  
Disruptive Behaviours ◽  
Age Of Diagnosis ◽  
History Of ◽  
Parametric Testing ◽  
The Mean ◽  
Clinical Measures ◽  
First Diagnosis

IntroductionFemale patients tend to be more often diagnosed with ADHD inattentive subtype. Many of these females deny an earlier childhood history of hyperactivity or disruptive behaviours and hence may have been clinically overlooked in childhood, while their male counterparts may have presented with ADHD combined subtype which tends to be more easily identified and diagnosed.ObjectivesParticipants will learn about gender differences in ADHD diagnosis and epidemiology.AimsTo examine gender differences in the age of first diagnosis of ADHD in a clinical population.MethodsThe study sample consisted of 118 males and 61 females (ages 17–69). Each patient was evaluated and diagnosed by an experienced psychiatrist. Clinical measures (administered by a trained psychometrist) included the CAARS (self and observer versions), BRIEF (self and informant versions), CAADID (history and structured interview), ASRS, CPT, Beck Anxiety and Beck Depression Inventories. Patients were referred by family physicians to a large out-patient metropolitan psychiatry program specializing in ADHD. Information regarding childhood diagnosis was collected retrospectively during the clinical interview.ResultsIn this study the mean age of diagnosis (ADHD) for males was 31.2 years versus 32.1 for females. Neither t-test (p = 0.44) nor non-parametric testing using Mann-Whitney U Test (p = 0.67) showed any statistical differences between the two groups.ConclusionsIn the present study there were no difference in the mean age of first diagnosis between male and female subjects. In the present study Further studies are needed to clarify this question. Selection factor may have been a factor in these results.

scholarly journals Hereditary Susceptibility to Breast Cancer: Significance of Age of Onset in Family History and Contribution of BRCA1 and BRCA2

1999 ◽  
Vol 15 (1-3) ◽  
pp. 89-92 ◽  
Author(s):  
Thomas S. Frank ◽  
Amie M. Deffenbaugh ◽  
Mark Hulick ◽  
Kathryn Gumpper
Keyword(s):  
Breast Cancer ◽  
Ovarian Cancer ◽  
Family History ◽  
Early Onset ◽  
Age Of Onset ◽  
Early Onset Breast Cancer ◽  
Brca1 And Brca2 ◽  
Degree Relative ◽  
Age Of Diagnosis ◽  
History Of

OBJECTIVE: To correlate mutations in BRCA1 and BRCA2 with family history of breast cancer in a first-degree relative for women diagnosed with breast cancer before age 45 who do not have a personal or family history of ovarian cancer.METHODS: Family history for women with breast cancer diagnosed before age 45 was provided by ordering physicians via a test requisition form designed for this purpose. Gene analysis was performed by dye primer sequencing for the entire coding regions of BRCA1 and BRCA2. Because a personal and family history of ovarian cancer are known to be significantly associated with mutations, women with either were excluded from analysis.RESULTS: Overall, deleterious mutations in BRCA1 or BRCA2 were identified in 85 of 440 women (19%) with breast cancer under 45. Mutations were identified in 73 of 276 women (26%) with a first degree family history of breast cancer compared to 12 of 164 without (7%) (P <.0001). When results were analyzed by the age of diagnosis in first degree relatives, mutations were identified in 56 of 185 women (30%) with at least one first degree relative with breast cancer diagnosed before age 50 compared with 17 of 91 women (19%), where the first degree family history of breast cancer was at or over age 50 (P = .042).CONCLUSION: Among women with breast cancer diagnosed before age 45, a first-degree relative diagnosed with the disease under age 50 is an indicator of a mutation in BRCAl or BRCA2 even in the absence of a family history of ovarian cancer. Therefore, women diagnosed with early-onset breast cancer should be asked about the age of onset in any first-degree relative diagnosed with the disease, as well as about any family history of ovarian cancer. Mutations in BRCA2 account for a substantial proportion of hereditary breast cancer. Therefore, studies that are limited to BRCA1 or that do not analyze by age of onset of breast cancer in relatives may underestimate the contribution of mutations in BRCAl and BRCA2 to women with early onset breast cancer.

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