scholarly journals Prognostic Impact of PD-L1 Expression in Malignant Salivary Gland Tumors as Assessed by Established Scoring Criteria: Tumor Proportion Score (TPS), Combined Positivity Score (CPS), and Immune Cell (IC) Infiltrate

Cancers ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 873 ◽  
Author(s):  
Hanno M. Witte ◽  
Niklas Gebauer ◽  
Daniela Lappöhn ◽  
Vincent G. Umathum ◽  
Armin Riecke ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Poor Prognosis ◽  
Immune Cell ◽  
Salivary Gland Tumors ◽  
Malignant Neoplasms ◽  
Prognostic Impact ◽  
Checkpoint Inhibition ◽  
Duct Carcinoma ◽  
Salivary Gland Carcinomas ◽  
Malignant Salivary Gland Tumors

Background: Malignant neoplasms of the salivary glands are rare, and therapeutic options are limited. Results from recently published studies indicate a possible use for checkpoint inhibition in a subset of patients, but there are no established criteria for programme cell death ligand 1 (PD-L1) scoring in salivary gland carcinomas (SGCs). Methods: In this retrospective study, we present a cohort of 94 SGC patients with full clinical follow-up. We included 41 adenoid cystic carcinomas (AdCC), 21 mucoepidermoid carcinomas (MEC), 16 acinic cell carcinomas (ACC), 12 adenocarcinomas, not otherwise specified (AC, NOS), 2 epithelial-myoepithelial carcinomas (EMC), one salivary duct carcinoma (SDC), and one carcinoma ex pleomorphic adenoma (CA ex PA). Subsequent histopathological analysis was performed with special emphasis on the composition of the immune cell infiltrate (B-/T-lymphocytes). We assessed PD-L1 (SP263) on full slides by established scoring criteria: tumor proportion score (TPS), combined positivity score (CPS) and immune cell (IC) score. Results: We identified significantly elevated CD3+, TP, CP, and IC scores in AC, NOS compared to AdCC, MEC, and ACC. CPS correlated with node-positive disease. Moreover, AC, NOS displayed IC scores of 2 or 3 in the majority (67%) of cases (p = 0.0031), and was associated with poor prognosis regarding progression-free (PFS) (p < 0.0001) and overall survival (OS) (p < 0.0001). CPS correlated with strong nuclear or null p53 staining in AC, NOS but not in other SGCs. Long-lasting partial remission could be achieved in one AC, NOS patient who received Pembrolizumab as third-line therapy. Conclusions: The current study is the first to investigate the use of established scoring criteria for PD-L1 expression in malignant salivary gland tumors. Our findings identify unique characteristics for AC, NOS among the family of SGCs, as it is associated with poor prognosis and might represent a valuable target for immune checkpoint inhibition.

DNA base excision repair and nucleotide excision repair proteins in malignant salivary gland tumors

2021 ◽  
Vol 121 ◽  
pp. 104987
Author(s):  
Fernanda Aragão Felix ◽  
Leorik Pereira da Silva ◽  
Maria Luiza Diniz de Sousa Lopes ◽  
Ana Paula Veras Sobral ◽  
Roseana de Almeida Freitas ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Nucleotide Excision Repair ◽  
Base Excision Repair ◽  
Excision Repair ◽  
Salivary Gland Tumors ◽  
Dna Base Excision Repair ◽  
Dna Base ◽  
Nucleotide Excision ◽  
Base Excision ◽  
Malignant Salivary Gland Tumors

scholarly journals Anticancer Effects of Sublingual Type I IFN in Combination with Chemotherapy in Implantable and Spontaneous Tumor Models

Cells ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 845
Author(s):  
Maria Ciccolella ◽  
Sara Andreone ◽  
Jacopo Mancini ◽  
Paola Sestili ◽  
Donatella Negri ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Biological Effects ◽  
Salivary Gland Tumors ◽  
Sublingual Administration ◽  
Type I ◽  
Type I Ifn ◽  
Tumor Models ◽  
Antitumor Effects ◽  
Duct Carcinoma ◽  
Administration Routes

Salivary gland tumors are a heterogeneous group of neoplasms representing less than 10% of all head and neck tumors. Among salivary gland tumors, salivary duct carcinoma (SDC) is a rare, but highly aggressive malignant tumor resembling ductal breast carcinoma. Sublingual treatments are promising for SDC due to the induction of both local and systemic biological effects and to reduced systemic toxicity compared to other administration routes. In the present study, we first established that the sublingual administration of type I IFN (IFN-I) is safe and feasible, and exerts antitumor effects both as monotherapy and in combination with chemotherapy in transplantable tumor models, i.e., B16-OVA melanoma and EG.7-OVA lymphoma. Subsequently, we proved that sublingual IFN-I in combination with cyclophosphamide (CTX) induces a long-lasting reduction of tumor mass in NeuT transgenic mice that spontaneously develop SDC. Most importantly, tumor shrinkage in NeuT transgenic micewas accompanied by the emergence of tumor-specific cellular immune responses both in the blood and in the tumor tissue. Altogether, these results provide evidence that sublingual IFN holds promise in combination with chemotherapy for the treatment of cancer.

scholarly journals Immunohistochemical Detection of Proliferative Marker Ki-67 in Benign and Malignant Salivary Gland Tumors

2018 ◽  
Vol 19 (4) ◽  
pp. 375-383
Author(s):  
Smita Bussari ◽  
Sindhu M Ganvir ◽  
Manish Sarode ◽  
Prabhakar A Jeergal ◽  
Anjum Deshmukh ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Salivary Gland Tumors ◽  
Immunohistochemical Detection ◽  
Ki 67 ◽  
Proliferative Marker ◽  
Malignant Salivary Gland Tumors

The Myoepithelial Immunophenotype in 135 Benign and Malignant Salivary Gland Tumors Other Than Pleomorphic Adenoma

1999 ◽  
Vol 123 (9) ◽  
pp. 801-806 ◽  
Author(s):  
Anil R. Prasad ◽  
Adnan T. Savera ◽  
Allen M. Gown ◽  
Richard J. Zarbo
Keyword(s):  
Smooth Muscle ◽  
Salivary Gland ◽  
Salivary Gland Tumors ◽  
Low Grade ◽  
Salivary Duct ◽  
Not Otherwise Specified ◽  
Adenoid Cystic ◽  
Myoepithelial Differentiation ◽  
Specific Proteins ◽  
Malignant Salivary Gland Tumors

Abstract Background.—We have previously studied the immunoreactivity of 3 novel smooth muscle–specific proteins, α-smooth muscle actin, smooth muscle myosin heavy chains, and calponin, to assess myoepithelial differentiation in pleomorphic adenomas. Objective.—To further expand our knowledge of myoepithelial differentiation in other benign and malignant salivary gland tumors. Design.—Formalin-fixed paraffin sections of 135 salivary gland tumors with associated normal glands were stained with monoclonal antibodies using the avidin-biotin complex immunoperoxidase method and enzymatic and microwave heat–induced epitope retrieval. Results.—In adenoid cystic carcinomas and epithelial-myoepithelial carcinomas, all 3 markers exclusively highlighted the myoepithelial cell components and the epithelial cells were entirely negative. No immunostaining was detected in canalicular adenomas, oncocytomas, Warthin tumors, acinic cell carcinomas, mucoepidermoid carcinomas, squamous cell carcinomas, and polymorphous low-grade adenocarcinomas. Salivary duct carcinomas and adenocarcinomas, not otherwise specified had a distinctive pattern of uniform periductal staining of reactive myofibroblastic cells, and in salivary duct carcinomas some ducts retained a peripheral immunoreactive myoepithelial cell layer. Conclusion.—Immunoreactivity for these 3 smooth muscle–specific proteins confirms the known neoplastic myoepithelial component of adenoid cystic carcinomas and epithelial-myoepithelial carcinomas. The consistently positive staining pattern in adenoid cystic carcinomas may be diagnostically useful in discriminating histologically similar but consistently negative polymorphous low-grade adenocarcinomas. Periductal linear staining in adenocarcinoma, not otherwise specified and salivary duct carcinomas is distinctive and appears to represent a tight cuff of myofibroblasts associated with the infiltrating glands.

scholarly journals Prognostic factors and overall survival in a 15-year followup of patients with malignant salivary gland tumors: a retrospective analysis of 193 patients

2020 ◽  
Author(s):  
Osias Vieira de Oliveira Filho ◽  
Talita Jordânia Rocha do Rêgo ◽  
Felipe Herbert de Oliveira Mendes ◽  
Thinali Sousa Dantas ◽  
Maria do Perpétuo Socorro Saldanha Cunha ◽  
...  
Keyword(s):  
Overall Survival ◽  
Salivary Gland ◽  
Prognostic Factors ◽  
Retrospective Analysis ◽  
Salivary Gland Tumors ◽  
Malignant Salivary Gland Tumors
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