Incidence, Survival, and Mortality Trends of Cancers Diagnosed in Adolescents and Young Adults (15–39 Years): A Population-Based Study in The Netherlands 1990–2016

Adolescent and young adult (AYA) cancer patients, aged 15–39 years at primary cancer diagnosis, form a distinct, understudied, and underserved group in cancer care. This study aimed to assess long-term trends in incidence, survival, and mortality of AYA cancer patients within the Netherlands. Data on all malignant AYA tumours diagnosed between 1990–2016 (n = 95,228) were obtained from the Netherlands Cancer Registry. European age-standardised incidence and mortality rates with average annual percentage change (AAPC) statistics and five-year relative survival rates were calculated. The overall cancer incidence increased from 54.6 to 70.3 per 100,000 person-years (AAPC: +1.37%) between 1990–2016, and increased for both sexes individually and for most cancer types. Five-year relative survival overall improved from 73.7% in 1990–1999 to 86.4% in 2010–2016 and improved for both sexes and most cancer types. Survival remained poor (<60%) for rhabdomyosarcoma, lung, stomach, liver, bladder, and pancreatic carcinomas, among others. Mortality rates among male AYAs overall declined from 10.8 to 6.6 (AAPC: −1.64%) and from 14.4 to 10.1 per 100,000 person-years (AAPC: −1.81%) for female AYAs since 1990. Mortality rates remained unchanged for male AYAs aged 20–24 and 25–29 years. In conclusion, over the past three decades, there has been a considerable increase in cancer incidence among AYAs in the Netherlands. Meanwhile, the survival improved and the mortality overall declined. Survival at five-years now well exceeds above 80%, but did not do so for all cancer types.

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Patterns of breast, prostate and cervical cancer incidence and mortality in Colombia: An administrative registry data analysis

10.21203/rs.3.rs-44815/v1 ◽

2020 ◽

Author(s):

Juliana Alexandra Hernández Vargas ◽

Paula Ximena Ramírez Barbosa ◽

Ana Milena Gil Quijano ◽

Ana María Valbuena García ◽

Lizbeth Acuña Merchán ◽

...

Keyword(s):

Cervical Cancer ◽

Cancer Incidence ◽

Public Health Problem ◽

Mortality Rates ◽

Eastern Region ◽

Global Public Health ◽

Cervical Cancer Incidence ◽

Mortality Trends ◽

Cross Sectional ◽

Incidence And Mortality

Abstract Background Cancer is widely recognized as a global public health problem. Breast, prostate and cervical cancer are among the most frequent types in developing countries. Assessing their incidence and mortality by regions and municipalities is important to guide evidence-based health policy. Our aim was to describe the incidence and mortality trends for breast, cervical and prostate cancer across regions and municipalities in Colombia during 2018. Methods We performed a cross-sectional analysis with data from people with breast, prostate or cervical cancer, reported to the National Administrative Cancer Registry during 2018. A descriptive analysis was performed. Age-standardized incidence and mortality rates were estimated at national, regional and municipal levels. Finally, we identify the regions and municipalities with significantly higher or lower incidence and mortality rates compared to national estimations. Results Breast cancer was the most frequent type among all new cases and deaths in Colombia. Breast, prostate and cervical cancer incidence and mortality rates were: 18,69 (CI 95%: 18,15–19,25) and 10,48 (CI 95%: 10,07–10,91); 11,34 (CI 95%: 10,90 − 11,78) and 7,58 (CI 95%: 7,22 − 7,96); 5,93 (CI 95%: 5,62 − 6,25) and 4,31 (CI 95%: 4,05 − 4,58), respectively. Eastern region had both, incidence and mortality rates, significantly lower than national for all types of cancer. By municipalities, there were a heterogeneous pattern. Nonetheless, Agua de Dios (Cundinamarca), had one of the highest incidence rates for all types. Conclusions We observed clear differences in cancer incidence and mortality across regions and municipalities, depending on each type of cancer. Our findings are important to improve screening coverage, early detection and treatment in the country.

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Patterns of breast, prostate and cervical cancer incidence and mortality in Colombia: An administrative registry data analysis

10.21203/rs.3.rs-44815/v2 ◽

2020 ◽

Author(s):

Juliana Alexandra Hernández Vargas ◽

Paula Ximena Ramírez Barbosa ◽

Ana Milena Gil Quijano ◽

Ana María Valbuena García ◽

Lizbeth Acuña Merchán ◽

...

Keyword(s):

Cervical Cancer ◽

Cancer Incidence ◽

Public Health Problem ◽

Mortality Rates ◽

Eastern Region ◽

Global Public Health ◽

Cervical Cancer Incidence ◽

Mortality Trends ◽

Cross Sectional ◽

Incidence And Mortality

Abstract Background: Cancer is widely recognized as a global public health problem. Breast, prostate, and cervical cancer are among the most frequent types in developing countries. Assessing their incidence and mortality by regions and municipalities is important to guide evidence-based health policy. Our aim was to describe the incidence and mortality trends for breast, cervical, and prostate cancer across regions and municipalities in Colombia during 2018.Methods: We performed a cross-sectional analysis with data from people with breast, prostate, or cervical cancer, reported to the National Administrative Cancer Registry during 2018. A descriptive analysis was performed. Age-standardized incidence and mortality rates were estimated at national, regional, and municipal levels. Finally, we identify the regions and municipalities with significantly higher or lower incidence and mortality rates compared to national estimations. Results: Breast cancer was the most frequent type among all new cases and deaths in Colombia. Breast, prostate and cervical cancer incidence and mortality rates per 100,000 were: 18.69 (CI 95%: 18.15-19.25) and 10.48 (CI 95%: 10.07-10.91); 11.34 (CI 95%: 10.90-11.78) and 7.58 (CI 95%: 7.22-7.96); 5.93 (CI 95%: 5.62-6.25) and 4.31 (CI 95%: 4.05-4.58), respectively. Eastern region had both, incidence and mortality rates, significantly lower than national for all types of cancer. By municipalities, there was a heterogeneous pattern. Nonetheless, Agua de Dios (Cundinamarca), had one of the highest incidence rates for all types. Conclusions: We observed clear differences in cancer incidence and mortality across regions and municipalities, depending on each type of cancer. Our findings are important to improve screening coverage, early detection, and treatment in the country.

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Patterns of breast, prostate and cervical cancer incidence and mortality in Colombia: an administrative registry data analysis

BMC Cancer ◽

10.1186/s12885-020-07611-9 ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Juliana Alexandra Hernández Vargas ◽

Paula Ximena Ramírez Barbosa ◽

Ana Milena Gil Quijano ◽

Ana María Valbuena ◽

Lizbeth Acuña ◽

...

Keyword(s):

Cervical Cancer ◽

Cancer Incidence ◽

Public Health Problem ◽

Mortality Rates ◽

Eastern Region ◽

Global Public Health ◽

Cervical Cancer Incidence ◽

Mortality Trends ◽

Cross Sectional ◽

Incidence And Mortality

Abstract Background Cancer is widely recognized as a global public health problem. Breast, prostate, and cervical cancer are among the most frequent types in developing countries. Assessing their incidence and mortality by regions and municipalities is important to guide evidence-based health policy. Our aim was to describe the incidence and mortality trends for breast, cervical, and prostate cancer across regions and municipalities in Colombia during 2018. Methods We performed a cross-sectional analysis with data from people with breast, prostate, or cervical cancer, reported to the National Administrative Cancer Registry during 2018. A descriptive analysis was performed. Age-standardized incidence and mortality rates were estimated at national, regional, and municipal levels. Finally, we identify the regions and municipalities with significantly higher or lower incidence and mortality rates compared to national estimations. Results Breast cancer was the most frequent type among all new cases and deaths in Colombia. Breast, prostate and cervical cancer incidence and mortality rates per 100,000 were: 18.69 (CI 95%: 18.15–19.25) and 10.48 (CI 95%: 10.07–10.91); 11.34 (CI 95%: 10.90–11.78) and 7.58 (CI 95%: 7.22–7.96); 5.93 (CI 95%: 5.62–6.25) and 4.31 (CI 95%: 4.05–4.58), respectively. Eastern region had both, incidence and mortality rates, significantly lower than national for all types of cancer. By municipalities, there was a heterogeneous pattern. Nonetheless, Agua de Dios (Cundinamarca), had one of the highest incidence rates for all types. Conclusions We observed clear differences in cancer incidence and mortality across regions and municipalities, depending on each type of cancer. Our findings are important to improve screening coverage, early detection, and treatment in the country.

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Survival rates of children and young adolescents with CNS tumors improved in the Netherlands since 1990: A population-based study

Neuro-Oncology Advances ◽

10.1093/noajnl/vdab183 ◽

2021 ◽

Author(s):

Raoull Hoogendijk ◽

Jasper van der Lugt ◽

Dannis van Vuurden ◽

Leontien Kremer ◽

Pieter Wesseling ◽

...

Keyword(s):

The Netherlands ◽

Malignant Tumors ◽

Survival Rates ◽

Population Based ◽

Cns Tumors ◽

Mortality Trends ◽

Netherlands Cancer Registry ◽

Incidence And Mortality ◽

Pilocytic Astrocytomas ◽

Over Time

Abstract Introduction Survival of children with central nervous system (CNS) tumors varies largely between countries. For the Netherlands, detailed population-based estimation of incidence, survival and mortality of pediatric CNS tumors are lacking but are needed to evaluate progress. Methods All CNS tumors diagnosed in patients <18 years during 1990-2017 were selected from the Netherlands Cancer Registry. Other than pilocytic astrocytomas, non-malignant tumors were included since 2000. Incidence and mortality trends were evaluated by Average Annual Percentage Change (AAPC). Changes over time in Five-year Observed Survival (5-year OS) were evaluated by Poisson regression models adjusted for follow-up time. Results Between 1990 and 2017, 2057 children were diagnosed with a malignant CNS tumor and 885 with a pilocytic astrocytoma. During 2000-17, 695 children were diagnosed with other non-malignant CNS tumors. Incidence rates of malignant tumors remained stable, while pilocytic astrocytomas and other non-malignant tumors increased by 2.0% and 2.4% per year, respectively. 5-year OS rates improved for all groups; however, improvement for malignant tumors was not constant over time. The contribution of malignant tumors located at the optic nerve tumors was 1% in 2000-09. However, shifting from pilocytic astrocytomas, increased to 6% in 2010-17, impacting survival outcomes for malignant tumors. Conclusion Survival rates of CNS tumors improved over time, but was not accompanied by a decreasing mortality rate. The observed temporary survival deterioration for malignant tumors appears to be related to changes in diagnostics and registration practices. Whether differences in treatment regimens contribute to this temporary decline in survival needs to be verified.

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Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2017

Cancer Research and Treatment ◽

10.4143/crt.2020.206 ◽

2020 ◽

Vol 52 (2) ◽

pp. 335-350 ◽

Cited By ~ 26

Author(s):

Seri Hong ◽

Young-Joo Won ◽

Young Ran Park ◽

Kyu-Won Jung ◽

Hyun-Joo Kong ◽

...

Keyword(s):

Cancer Incidence ◽

Temporal Trends ◽

Survival Rates ◽

Relative Survival ◽

Mortality Rates ◽

Incidence Rates ◽

Comprehensive Cancer Control ◽

Dramatic Improvement ◽

Cancer Statistics ◽

Incidence And Mortality

PurposeThis study reports the cancer statistics and temporal trends in Korea on a nationwide scale, including incidence, survival, prevalence, and mortality in 2017.Materials and MethodsThe incidence, survival, and prevalence rates of cancer were evaluated using data from the Korea National Cancer Incidence Database from 1999 to 2017 with follow-up until December 31, 2018. Deaths from cancer were assessed using cause-of-death data from 1983 to 2017, obtained from Statistics Korea. Crude and age-standardized rates (ASRs) for incidence, mortality, and prevalence, and 5-year relative survival rates were calculated and trend analysis was performed.ResultsIn 2017, newly diagnosed cancer cases and deaths from cancer numbered 232,255 (ASR, 264.4 per 100,000) and 78,863 (ASR, 76.6 per 100,000), respectively. The overall cancer incidence rates increased annually by 3.5% from 1999 to 2011 and decreased by 2.7% annually thereafter. Cancer mortality rates have been decreasing since 2002, by 2.8% annually. The 5-year relative survival rate for all patients diagnosed with cancer between 2013 and 2017 was 70.4%, which contributed to a prevalence of approximately 1.87 million cases by the end of 2017.ConclusionThe burden of cancer measured by incidence and mortality rates have improved in Korea, with the exception of a few particular cancers that are associated with increasing incidence or mortality rates. However, cancer prevalence is increasing rapidly, with the dramatic improvement in survival during the past several years. Comprehensive cancer control strategies and efforts should continue, based on the changes of cancer statistics.

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Long follow-up time and different sensitivities of cancer types may have obscured the effect of 25-hydroxyvitamin D on cancer incidence and mortality rates

American Journal of Clinical Nutrition ◽

10.3945/ajcn.114.102129 ◽

2015 ◽

Vol 102 (1) ◽

pp. 230-230 ◽

Cited By ~ 1

Author(s):

William B Grant

Keyword(s):

Cancer Incidence ◽

Mortality Rates ◽

Hydroxyvitamin D ◽

Incidence And Mortality ◽

25 Hydroxyvitamin D ◽

Cancer Types

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A Web Tool for Age–Period–Cohort Analysis of Cancer Incidence and Mortality Rates

Cancer Epidemiology Biomarkers & Prevention ◽

10.1158/1055-9965.epi-14-0300 ◽

2014 ◽

Vol 23 (11) ◽

pp. 2296-2302 ◽

Cited By ~ 84

Author(s):

Philip S. Rosenberg ◽

David P. Check ◽

William F. Anderson

Keyword(s):

Cancer Incidence ◽

Cohort Analysis ◽

Mortality Rates ◽

Web Tool ◽

Incidence And Mortality

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Descriptive-epidemiological characteristics of lung cancer in Serbia

Medicinski pregled ◽

10.2298/mpns0802016m ◽

2008 ◽

Vol 61 (1-2) ◽

pp. 16-21 ◽

Cited By ~ 1

Author(s):

Natasa Maksimovic ◽

Kyriakos Spanopoulos

Keyword(s):

Lung Cancer ◽

Direct Method ◽

Age Groups ◽

Malignant Tumour ◽

Mortality Rates ◽

Malignant Tumours ◽

Mortality Trends ◽

Incidence And Mortality ◽

The Republic ◽

Epidemiological Characteristics

Introduction. Lung cancer represents the most common malignant tumour among men, and appears more and more frequently among women in many countries worldwide. The aims of this descriptive epidemiological study were to evaluate the mortality trends of all malignant tumours and lung cancer in Central Serbia from 1990 to 1999, and to estimate the incidence, mortality and the basic demographic characteristics of lung cancer in Central Serbia in 1999. Material and methods. The source of data concerning cancer cases in 1999 was the Cancer Registry of Central Serbia, while data of the Republic Statistics Institute were used for the analysis of mortality trends for the period 1990-1999. All rates were standardized by the direct method, to the world standard population. Confidence intervals for mortality rates were assessed with 95% level of probability. Linear regression coefficient was determined by Fisher's test. Results. The mortality rates showed rising tendencies for both lung cancer (y=-1876.26+0.96x, p=0.028 for men; y=654.78U).33x, p-0.001 for women) and all malignant tumours (y=-4139.88+2.15x, p=0.163 for men; y=3649.68 + 1.88x, p=0.016 for women), with statistically significant increase being observed for all trends, except all malignant tumours among men. In the year 1999, lung cancer ranked first among men and third among women, with 29.2% and 10.3% of cancer mortality respectively. The age-specific mortality rates were much higher in men in all age groups. Mortality increased with age and the highest rates were found in the age group 70-74 for both sexes. The highest incidence and mortality rates were reported in Belgrade, Moravicki and Sumadijski district. .

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Colorectal Cancer in Young and Older Adults in Uruguay: Changes in Recent Incidence and Mortality Trends

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18158232 ◽

2021 ◽

Vol 18 (15) ◽

pp. 8232

Author(s):

Carina Musetti ◽

Mariela Garau ◽

Rafael Alonso ◽

Marion Piñeros ◽

Isabelle Soerjomataram ◽

...

Keyword(s):

Colorectal Cancer ◽

Older Adults ◽

Cancer Incidence ◽

Age Groups ◽

Incidence Rates ◽

Mortality Trends ◽

Screening Programs ◽

Lifestyle Risk Factors ◽

Incidence And Mortality ◽

Colorectal Cancer Incidence

Uruguay has the highest colorectal cancer incidence rates in Latin America. Previous studies reported a stable incidence and a slight increase in mortality among males. We aimed to assess colorectal cancer incidence (2002–2017) and mortality trends (1990–2017) by age groups and sex, using data from the National Cancer Registry. Annual percent changes (APCs) were estimated using joinpoint regression models. We included 27,561 colorectal cancer cases and 25,403 deaths. We found an increasing incidence among both males and females aged 40–49, with annual increases of 3.1% (95%CI: 1.21–5.03) and 2.1% (95%CI: 0.49–3.66), respectively, and an increasein the rate in older males (70+) of 0.60% (95%CI: 0.02–1.20) per year between 2002 and 2017. Mortality remained stable among those younger than 50, whereas it decreased for older females aged 50–69 and 70+ (APC: −0.61% (−1.07–0.14) and −0.68% (−1.02–0.34), respectively), and increased for the oldest males (70+; APC: 0.74 (0.47–1.01)). In conclusion, we found rising colorectal cancer incidence accompanied by stable mortality in young adults. Sex disparities were also found among the older adults, with a more favorable pattern for females. Exposures to dietary and lifestyle risk factors, and inequalities in access to and awareness of screening programs, are probably among the main underlying causes and deserve further investigation.

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