Trajectories of Adherence to Biologic Disease-Modifying Anti-Rheumatic Drugs in Tuscan Administrative Databases: The Pathfinder Study

Scanty information on clustering longitudinal real-world data is available in the medical literature about the adherence implementation phase in rheumatoid arthritis (RA). To identify and characterize trajectories by analyzing the implementation phase of adherence to biologic Disease-Modifying Anti-Rheumatic Drugs (DMARDs), we conducted a retrospective cohort drug-utilization study using Tuscan administrative databases. RA patients were identified by a validated algorithm, including the first biologic DMARD supply from 2010 to 2015, RA specialist visit in the year before or after the first supply date and RA diagnosis in the five years before or in the year after the first supply date. We observed users for three years or until death, neoplasia, or pregnancy. We evaluated adherence quarterly through the Medication Possession Ratio. Firstly, we identified adherence trajectories and described the baseline characteristics; then, we focused on the trajectory most populated to distinguish the related sub-trajectories. We identified 952 first ever-biologic DMARD users in RA (712 females, mean age 52.7 years old, standard deviation 18.8). The biologic DMARD mostly supplied was etanercept (387 users) followed by adalimumab (233). Among 935 users with at least 3 adherence values, we identified 49 fully-adherent users, 829 continuous users, and 57 early-discontinuing users. Significant differences were observed among the index drugs. After focusing on the continuous users, three sub-trajectories were identified: continuous-steady users (556), continuous-alternate users (207), and continuous-declining users (66). No relevant differences emerged at the baseline. The majority of first ever-biologic DMARD users showed a continuous adherence behavior in RA. The role of adherence potential predictors and the association with effectiveness and safety outcomes should be explored by further studies.

Juxtaposition on Discrete Covid-19 Vaccines: For Rudimentary and Pivotal Cognizance

This paper accomplishes an introduction to diverse types of vaccines against coronavirus. Many countries, researchers and pharmaceutical companies worked abundantly so that they could discover a safe and effective vaccine against COVID-19. In response to this, vaccines were discovered on a fast track mode and companies registered for an emergency use authorization, so that it would be helpful to society during pandemic. Manufacturers and various regulatory units are working tirelessly to develop, manufacture and deploy safe and effective vaccines. Scanty information is added on divergent COVID vaccines encompassing information related to the developer, vaccine class, description, efficacy rate, dosing, storage, permitted age groups and authorizations issued.

​Study on Housing Management Practices Followed by Dairy Farmers in Northern Telangana State of India

Background: Adequate housing is essential for wellbeing and welfare of any kind of livestock, which keeps them comfort and healthy thereby increases production and reproduction performance by exploiting their fullest genetic potential. As scanty information available on farmers practices on animal housing, the present study was undertaken to assess housing management practices followed by dairy farmers in Northern Telangana state of India. Methods: Data were collected from randomly selected 240 dairy farmers from 24 villages of 8 mandals from 4 districts. A pretested semi-structured questionnaire in precise language was employed for collecting data through interview and face to face discussion with the dairy farmers duly avoiding ambiguous, dichotomous and non-variant items for proper interpretation. Result: Majority (59.58%) respondents kept animals in kutcha houses and 74.58% sheds located to nearby their dwellings. Majority (50.42%) of the sheds were in east-west direction and 82.08% of the respondents followed single line system of housing. Majority 91.25, 95.42, 84.16, 67.92 and 69.58% of the respondents protected animals against extreme weather conditions, maintained cleanliness, had earthen floor, backward slope in the floor and wooden pillars, respectively. Majority of animal houses had thatched roof (50.42%) and without walls (82.08%) and majority of them (89.58%) provided mangers but only 11.25% had pucca type mangers. Only a few respondents (14.58%) provided pucca drainage system and most of the farmers (58.75%) had manure pit adjacent to their animal houses. The study concludes that, the dairy farmers of the study area are well aware of advantages of keeping animals in hygienic animal houses under adverse tropical climatic conditions of the study area and providing them periodical trainings and visits to modern organised dairy farms helps them to optimize productivity from dairy animals.

Cutaneous Nevi in Down Syndrome Patients: Prospective study

Background: Down Syndrome (DS) has been described in association with various dermatoses,however, there is scanty information in the literature regarding the frequency of cutaneous nevi among Down syndrome patients. The objective of the study: To define the frequency of different cutaneousnevi in DS patients, andto precise their different phenotypes. Patients and methods: we prospectively examined 180 Down syndrome patients. All patients underwent full body skin examination noting the type, number, size, and distribution of different nevi. Results: Different types of nevi were noted among Down syndrome patients; café au lait macules, melanocytic nevocellular nevi, and Mongolian spot were the most frequent ones. Juvenile elastoma, Becker’s nevus, nevus spilus, labial melanocytic macule, and capillary vascular malformation were also seen. Conclusion: Various types of cutaneous nevi not previously described in Down syndrome, was observed in our patients such as Becker’s nevus, nevus spilus and Juvenile elastoma.

Quantum-Chemical Search for Keto Tautomers of Azulenols in Vacuo and Aqueous Solution

Keto-enol prototropic conversions for carbonyl compounds and phenols have been extensively studied, and many interesting review articles and even books appeared in the last 50 years. Quite a different situation takes place for derivatives of biologically active azulene, for which only scanty information on this phenomenon can be found in the literature. In this work, quantum-chemical studies have been undertaken for symmetrically and unsymmetrically substituted azulenols (constitutional isomers of naphthols). Stabilities of two enol (OH) rotamers and all possible keto (CH) tautomers have been analyzed in the gas phase {DFT(B3LYP)/6-311+G(d,p)} and also in aqueous solution {PCM(water)//DFT(B3LYP)/6-311+G(d,p)}. Contrary to naphthols, for which the keto forms can be neglected, at least one keto isomer (C1H, C2H, and/or C3H) contributes significantly to the tautomeric mixture of each azulenol to a higher degree in vacuo (non-polar environment) than in water (polar amphoteric solvent). The highest amounts of the CH forms have been found for 2- and 5-hydroxyazulenes, and the smallest ones for 1- and 6-hydroxy derivatives. The keto tautomer(s), together with the enol rotamers, can also participate in deprotonation reaction leading to a common anion and influence its acid-base properties. The strongest acidity in vacuo exhibits 6-hydroxyazulene, and the weakest one displays 1-hydroxyazulene, but all azulenols are stronger acids than phenol and naphthols. Bond length alternation in all DFT-optimized structures has been measured using the harmonic oscillator model of electron delocalization (HOMED) index. Generally, the HOMED values decrease for the keto tautomers, particularly for the ring containing the labile proton. Even for the keto tautomers possessing energetic parameters close to those of the enol isomers, the HOMED indices are low. However, some kind of parallelism exists for the keto forms between their relative energies and HOMEDs estimated for the entire molecules.

Warrants of cryopreservation in assisted reproductive technology amidst COVID-19 pandemic

Cryopreservation plays a central role in assisted reproductive technology (ART) by allowing in vitro fertilization (IVF) cycle segmentation, banking of supernumerary gametes, embryos, and fertility preservation. The identification of viral receptors on gametes and embryos raises serious concerns for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) patients who are interested in preserving fertility. The complications caused by the SARS-CoV-2 on IVF and embryo safety are yet to be explored. Scanty information is available so far regarding the risk of cryopreservation of biological materials used in ART. Here, we highlight the risks of cryopreservation in ART and safety measures to follow amidst the COVID-19 pandemic.

Arm and Forearm Bones of the Adult Blue Bull (Boselaphus tragocamelus): A Morphological and Morphometrical Study

Background: There is scanty information on the morphology and morphometry of the arm and forearm bones (humerus, radius, ulna) of the adult blue bull; therefore, the present study was designed to provide details on the morphology and morphometry of the arm and forearm bones of adult blue bull.Methods: The present study was conducted on the arm and forearm bones of six adult blue bull of either sex (n=6, male and n=6, female). The bone specimens were collected from Jodhpur zoo after taking official permission from the Principal Chief Conservator of Forest (PCCF), Government of Rajasthan. The collected bones were processed as per the standard hot water maceration technique. The macerated bones were soaked in 3% hydrogen peroxide followed by five days of sun-drying.Result: The humerus and radius was the long bones, whereas the ulna was aborted long bone. The humerus was a long, less twisted and strong bone with two extremities and four surfaces. The radius was fused to the ulna in the entire length, except for two interosseous spaces, namely, proximal interosseous spaces and distal interosseous spaces. The present study revealed that all the obtained parameters of arm and forearm bones (humerus, radius, ulna) showed a significant statistical difference (p less than 0.05*) between the males and females of adult blue bull. It can be concluded that the bones of the arm and forearm of the adult blue bull resembled that of small and large ruminants; however, they differed from other domestic and wild animals.

Turbulent Ethnopolitical Processes in the Eastern Taurica in the Sixth and Seventh Centuries

This paper presents the results of archaeological researches allowing the one to reconstruct ethnopolitical processes in the eastern Taurica in the sixth and seventh centuries. By the sixth century, the eastern Crimean steppes were depopulated and used for seasonal migrations of the Hunnic tribes. The Byzantine Empire made a significant influence on the ethnopolitical processes in the Bosporos in the sixth and seventh centuries when annexed this country in 527/528. Archaeological researches supply scanty information about the urban buildings of the Bosporan capital in the sixth century. Alternative archaeological situation developed with the preserved Early Byzantine layers of the Bosporan town of Tyritake, where continuous many-year-long archaeological research uncovered large areas. According to the archaeological materials and a few epigraphic finds, Bosporan Greeks constituted the overwhelming majority of the population of Tyritake in the sixth century as before, being mostly the persons of moderate means, engaged in fishing and agricultural production, crafts and petty trade. After the raid of the Turks in 576, Bosporos and Tyritake declined, with only isolated residential houses reconstructed in certain areas in these towns; these houses lived to the third quarter of the seventh century when they were burned down by the Khazars. Bosporos constantly experienced the pressure from nomadic hordes, which, over the centuries, moved here and there, replacing each other, along the great tract of the steppes. The turbulence of ethnopolitical processes in the Eastern Taurica especially intensified in the Early Byzantine Period. Following the Khazar devastation, all the Bosporan settlements were depopulated, and the insignificant remnants of the former population concentrated in the fire-ravaged town of Bosporos, which for centuries became an out-of-the-way provincial town forming a part of different polities.

Prevalence of banana Xanthomonas wilt in Nithi, Tharaka-Nithi County in Kenya

Banana (Musa spp.) is a nutrient rich crop grown in small and large scale across the globe. It is rich in carbohydrates, vitamins and minerals thus, it may serve as the source of nutrition in low resourced regions such as Tharaka Nithi County, Kenya. However, banana production in many areas is faced with biotic constraints such as banana Xanthomonas wilt (BXW) disease caused by Xanthomonas campestris pv. musacearum. The pathogen attacks photosynthetic leaves and young fruits, reducing palatability and marketability. There is currently scanty information on prevalence of BXW in Nithi region of Tharaka Nithi County. Additionally, it remains unclear whether farmers in the region are knowledgeable on occurrence of BXW disease, symptoms and management practices. The prevalence of BXW was assessed through survey method in five villages (Kiang’ondu, Marima, Mitheru, Kibumbu and Giampampo) in Nithi. Percentage BXW prevalence in the studied villages was not significantly different (p>0.05). However, slightly higher BXW prevalence value of 21.14% was recorded at Giampampo village and was lower at Mitheru 11.24%. There was significant relationship (X2 (8, N = 46) = 19.93, p= 0.0034) between banana variety grown and occurrence of banana diseases. There was significant relationship (X2 (8, N = 46) = 31.165, p = 0.0053) between banana variety grown and susceptibility to diseases. The relationship between years of growing banana in the same farm and occurrence of banana diseases was significant (X2(6,N= 46) = 8.761,p= <0.0001. The relationship between occurrence of banana diseases and season of the year was significant (X2(8,N= 46) = 32.4591, p= <0.0001). The relationship between occurrence of banana diseases and management option in Nithi was significant (X2(4,N= 46) = 6.9758,p= 0.0025). Majority of the farmers (92%) were unaware of existence of BXW in the region. Farmers expressed lack of knowledge on managing BXW diseases in their banana farms with the majority not being able to identify common diseases of banana. Based on these observations, there is need to educate farmers on best banana farming practices, disease identification and management.

First report on honeydew excretion by the melon thrips, Thrips palmi karny (Thysanoptera : Thripidae) and its biochemical analysis

Sap sucking insects like thrips, aphids, mealybugs, whiteflies exploit the sugar rich phloem for growth and development. The excess sugar in the phloem sap creates osmotic imbalance leading to loss of water from haemolymph to gut lumen. In order to maintain osmolarity, sap sucking insects have developed structural adaptation (filter chamber) and also excrete excess sugar as honeydew through various orifices. The excreted honeydew is known to play very vital ecological role such as natural enemy calling (attracting parasitoids). In this regard scanty information is available on this important aspect for different sap sucking insects. In this study we are reporting for the first time on the composition of honeydew from the major horticultural thrips, Thrips palmi reared on French bean (Phaseolus vulgaris). LC-MS-MS analysis revealed the presence of 15 different sugars majorly inositol, fructose, maltose, glucose and sorbitol @ (130.9 ±0.47μg); (95.1±0.45μg); (60.7 ±0.28μg); (54.2 ±0.40μg) and (28.1 ±0.35μg), respectively.