scholarly journals The Role of Co-Stimulatory Molecules in Chagas Disease

Cells ◽  
2018 ◽  
Vol 7 (11) ◽  
pp. 200 ◽  
Author(s):  
Bruna Pinto ◽  
Nayara Medeiros ◽  
Tereza Fontes-Cal ◽  
Isabela Naziazeno ◽  
Rodrigo Correa-Oliveira ◽  
...  
Keyword(s):  
Chagas Disease ◽  
Latin American ◽  
Clinical Symptoms ◽  
Adaptive Immune Response ◽  
Chronic Phase ◽  
T Cell Response ◽  
Life Threatening ◽  
And Function ◽  
The Relationship

Chagas disease, caused by Trypanosoma cruzi, is a potentially life-threatening tropical disease endemic to Latin American countries that affects approximately 8 million people. In the chronic phase of the disease, individuals are classified as belonging to the indeterminate clinical form or to the cardiac and/or digestive forms when clinical symptoms are apparent. The relationship between monocytes and lymphocytes may be an important point to help clarify the complexity that surrounds the clinical symptoms of the chronic phase of Chagas disease. The co-stimulatory signals are essential to determining the magnitude of T cell response to the antigen. The signals are known to determine the regulation of subsequent adaptive immune response. However, little is known about the expression and function of these molecules in Chagas disease. Therefore, this review aims to discuss the possible role of main pathways of co-stimulatory molecule-receptor interactions in this pathology that could be crucial to understand the disease dynamics.

scholarly journals The Relationship between Personal Resources and Depression in a Sample of Victims of Cyberbullying: Comparison of Groups with and without Symptoms of Depression

2020 ◽  
Vol 17 (24) ◽  
pp. 9307
Author(s):  
Lourdes Rey ◽  
Cirenia Quintana-Orts ◽  
Sergio Mérida-López ◽  
Natalio Extremera
Keyword(s):  
Mental Health ◽  
Emotional Intelligence ◽  
Depressive Symptoms ◽  
Clinical Symptoms ◽  
Personal Resources ◽  
Symptoms Of Depression ◽  
And Function ◽  
The Relationship ◽  
Adolescent Victims

Previous research has highlighted the relationship between being cybervictimised and the presence of clinical symptoms, such as depression. To date, however, there has been no comparative analysis of the personal resources profiles of adolescent victims of cyberbullying with and without depressive symptoms. The current study analysed the relationship between positive personal resources and clinical symptoms in 251 adolescent victims of cyberbullying at several Spanish high schools. It examined how several positive personal resources varied in adolescent victims of cyberbullying who displayed symptoms of depression (n = 89) or did not (n = 162). Victims of cyberbullying who displayed depressive symptoms reported lower levels of personal resources (emotional intelligence, gratitude, optimism, and forgiveness) than those who did not. Logistic regression provided evidence that gratitude was the strongest predictor of depressive symptoms in victims of cyberbullying, followed by emotional intelligence and optimism. These findings expand the existing literature on the role of personal resources in mental health and highlight the need for their development in youths to help them cope more effectively and function better after being cyberbullied.

scholarly journals Treatment with Benznidazole during the Chronic Phase of Experimental Chagas' Disease Decreases Cardiac Alterations

2005 ◽  
Vol 49 (4) ◽  
pp. 1521-1528 ◽  
Author(s):  
Simone Garcia ◽  
Carolina O. Ramos ◽  
Juliana F. V. Senra ◽  
Fabio Vilas-Boas ◽  
Maurício M. Rodrigues ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Chagas Disease ◽  
Latin American ◽  
Chronic Phase ◽  
Cardiac Conduction ◽  
Intraventricular Conduction ◽  
Conduction Disturbances ◽  
Chagasic Cardiomyopathy ◽  
Chronic Chagas Disease

ABSTRACT Chagas' disease, caused by Trypanosoma cruzi infection, is one of the main causes of death due to heart failure in Latin American countries. Benznidazole, the chemotherapeutic agent most often used for the treatment of chagasic patients, is highly toxic and has limited efficacy, especially in the chronic phase of the disease. In the present study we used a mouse model of chronic Chagas' disease to investigate the effects of benznidazole treatment during the chronic phase on disease progression. The hearts of benznidazole-treated mice had decreased parasitism and myocarditis compared to the hearts of untreated chagasic mice. Both groups of Trypanosoma cruzi-infected mice had significant alterations in their electrocardiograms compared to those of the healthy mice. However, untreated mice had significantly higher cardiac conduction disturbances than benznidazole-treated mice, including intraventricular conduction disturbances, atrioventricular blocks, and extrasystoles. The levels of antibodies against T. cruzi antigens (epimastigote extract, P2β, and trans-sialidase) as well as antibodies against peptides of the second extracellular loops of β1-adrenergic and M2-muscarinic cardiac receptors were also lower in the sera from benznidazole-treated mice than in the sera from untreated mice. These results demonstrate that treatment with benznidazole in the chronic phase of infection prevents the development of severe chronic cardiomyopathy, despite the lack of complete parasite eradication. In addition, our data highlight the role of parasite persistence in the development of chronic Chagas' disease and reinforce the importance of T. cruzi elimination in order to decrease or prevent the development of severe chagasic cardiomyopathy.

scholarly journals Absence of Bim sensitizes mice to experimental Trypanosoma cruzi infection

2021 ◽  
Vol 12 (7) ◽  
Author(s):  
Marcela Hernández-Torres ◽  
Rogério Silva do Nascimento ◽  
Monica Cardozo Rebouças ◽  
Alexandra Cassado ◽  
Kely Catarine Matteucci ◽  
...  
Keyword(s):  
T Cells ◽  
Trypanosoma Cruzi ◽  
Chagas Disease ◽  
Parasite Load ◽  
Peritoneal Macrophages ◽  
T Cell Response ◽  
No Production ◽  
Similar Reduction ◽  
Ifn Γ

AbstractChagas disease is a life-threatening disorder caused by the protozoan parasite Trypanosoma cruzi. Parasite-specific antibodies, CD8+ T cells, as well as IFN-γ and nitric oxide (NO) are key elements of the adaptive and innate immunity against the extracellular and intracellular forms of the parasite. Bim is a potent pro-apoptotic member of the Bcl-2 family implicated in different aspects of the immune regulation, such as negative selection of self-reactive thymocytes and elimination of antigen-specific T cells at the end of an immune response. Interestingly, the role of Bim during infections remains largely unidentified. To explore the role of Bim in Chagas disease, we infected WT, Bim+/−, Bim−/− mice with trypomastigotes forms of the Y strain of T. cruzi. Strikingly, our data revealed that Bim−/− mice exhibit a delay in the development of parasitemia followed by a deficiency in the control of parasite load in the bloodstream and a decreased survival compared to WT and Bim+/− mice. At the peak of parasitemia, peritoneal macrophages of Bim−/− mice exhibit decreased NO production, which correlated with a decrease in the pro-inflammatory Small Peritoneal Macrophage (SPM) subset. A similar reduction in NO secretion, as well as in the pro-inflammatory cytokines IFN-γ and IL-6, was also observed in Bim−/− splenocytes. Moreover, an impaired anti-T. cruzi CD8+ T-cell response was found in Bim−/− mice at this time point. Taken together, our results suggest that these alterations may contribute to the establishment of a delayed yet enlarged parasitic load observed at day 9 after infection of Bim−/− mice and place Bim as an important protein in the control of T. cruzi infections.

“Borderland” as a way of preserving and asserting identity. The historical experience of the Native American cultures of Latin America in a universal context

2021 ◽  
pp. 83
Author(s):  
Yakov Shemyakin
Keyword(s):  
Latin America ◽  
Native American ◽  
Latin American ◽  
Historical Experience ◽  
Cultural System ◽  
Relationship Of ◽  
The Relationship ◽  
Linguistic Reality

The article substantiates the thesis that modern Native American cultures of Latin America reveal all the main features of "borderland" as a special state of the socio-cultural system (the dominant of diversity while preserving the unity sui generis, embodied in the very process of interaction of heterogeneous traditions, structuring linguistic reality in accordance with this dominant, the predominance of localism in the framework of the relationship between the universal and local dimensions of the life of Latin American societies, the key role of archaism in the system of interaction with the heritage of the 1st "axial time», first of all, with Christianity, and with the realities of the "second axial time" - the era of modernization. The author concludes that modern Indian cultures are isomorphic in their structure to the "borderline" Latin American civilization, considered as a "coalition of cultures" (K. Levi-Strauss), which differ significantly from each other, but are united at the deepest level by an extremely contradictory relationship of its participants.

scholarly journals Enhanced plasminogen-activator production by leukocytes in the human and murine Chediak-Higashi syndrome

Blood ◽  
1985 ◽  
Vol 65 (5) ◽  
pp. 1275-1281 ◽  
Author(s):  
G de Saint Basile ◽  
A Fischer ◽  
MD Dautzenberg ◽  
A Durandy ◽  
F Le Deist ◽  
...  
Keyword(s):  
Plasminogen Activator ◽  
Mononuclear Cells ◽  
Chronic Phase ◽  
Polymorphonuclear Cells ◽  
Clotting Factors ◽  
Coagulation Abnormalities ◽  
Life Threatening ◽  
Coagulation Status ◽  
Chediak Higashi Syndrome

Abstract We have studied the coagulation status of eight patients with the Chediak-Higashi syndrome (CHS), both in the chronic and the accelerated phase of the disease. It has been shown that during the accelerated phase there are coagulation abnormalities. These abnormalities include a peripheral thrombocytopenia, minor alterations of liver clotting factors, and mainly a profound hypofibrinogenemia and hypoplasminogenemia, which cause life-threatening bleedings. These disorders are of complex origin, but a fibrinolytic process, possibly primary, appears to play a significant role, since the present evidence for intravascular coagulation is not definitive. The accelerated phase of the CHS is characterized by a visceral infiltration by macrophages and lymphocytes. Therefore, we have investigated the possible role of the macrophages in the fibrinolytic process. We have found an excessive plasminogen activator (PA) production by CHS mononuclear cells in the accelerated phase and to a lesser extent in the chronic phase, except in one patient in whom no anomaly was found. Single-cell studies revealed an increased number of PA-producing cells among the monocyte- macrophage lineage rather than a higher level of production per cell. Polymorphonuclear cells (PMN) from patients with CHS were also shown to contain more PA. Slight but significant abnormalities in PA production were observed in obligatory heterozygotes (five out of nine), indicating the inherited nature of the excessive PA production. Finally, an enhanced PA production was similarly demonstrated using beige mice macrophages. The exacerbated production of PA by macrophages in the accelerated phase of the CHS can account to some extent for the coagulation abnormalities that have been observed.

scholarly journals Enhanced plasminogen-activator production by leukocytes in the human and murine Chediak-Higashi syndrome

Blood ◽  
1985 ◽  
Vol 65 (5) ◽  
pp. 1275-1281
Author(s):  
G de Saint Basile ◽  
A Fischer ◽  
MD Dautzenberg ◽  
A Durandy ◽  
F Le Deist ◽  
...  
Keyword(s):  
Plasminogen Activator ◽  
Mononuclear Cells ◽  
Chronic Phase ◽  
Polymorphonuclear Cells ◽  
Clotting Factors ◽  
Coagulation Abnormalities ◽  
Life Threatening ◽  
Coagulation Status ◽  
Chediak Higashi Syndrome

We have studied the coagulation status of eight patients with the Chediak-Higashi syndrome (CHS), both in the chronic and the accelerated phase of the disease. It has been shown that during the accelerated phase there are coagulation abnormalities. These abnormalities include a peripheral thrombocytopenia, minor alterations of liver clotting factors, and mainly a profound hypofibrinogenemia and hypoplasminogenemia, which cause life-threatening bleedings. These disorders are of complex origin, but a fibrinolytic process, possibly primary, appears to play a significant role, since the present evidence for intravascular coagulation is not definitive. The accelerated phase of the CHS is characterized by a visceral infiltration by macrophages and lymphocytes. Therefore, we have investigated the possible role of the macrophages in the fibrinolytic process. We have found an excessive plasminogen activator (PA) production by CHS mononuclear cells in the accelerated phase and to a lesser extent in the chronic phase, except in one patient in whom no anomaly was found. Single-cell studies revealed an increased number of PA-producing cells among the monocyte- macrophage lineage rather than a higher level of production per cell. Polymorphonuclear cells (PMN) from patients with CHS were also shown to contain more PA. Slight but significant abnormalities in PA production were observed in obligatory heterozygotes (five out of nine), indicating the inherited nature of the excessive PA production. Finally, an enhanced PA production was similarly demonstrated using beige mice macrophages. The exacerbated production of PA by macrophages in the accelerated phase of the CHS can account to some extent for the coagulation abnormalities that have been observed.

An exploration of adolescent nonsuicidal self-injury and religious coping

2014 ◽  
Vol 26 (3) ◽  
pp. 345-349 ◽  
Author(s):  
Nicholas J. Westers ◽  
Mark Rehfuss ◽  
Lynn Olson ◽  
Constance M. Wiemann
Keyword(s):  
Religious Coping ◽  
Self Injury ◽  
Negative Religious Coping ◽  
Religious Constructs ◽  
And Function ◽  
Role Of Religion ◽  
The Relationship ◽  
Pearson Correlations ◽  
Nonsuicidal Self Injury

Abstract Many adolescents who engage in nonsuicidal self-injury (NSSI) self-identify as religious, but the role of religion in their NSSI is not known. This exploratory study examined the relationship between religious coping and religiousness among adolescents who self-injure and the function of their NSSI. Thirty adolescents aged 12–19 years who had engaged in NSSI participated in an interview and completed questionnaires. Multiple regressions were used to examine the relationship between religious coping and NSSI, and Pearson correlations were used to assess the relationship between religiousness and function of NSSI. Greater use of positive religious coping was associated with lower likelihood of engaging in NSSI to rid oneself of unwanted emotions, whereas greater use of negative religious coping was associated with greater likelihood of engaging in NSSI for this reason as well as to avoid punishment or unwanted responsibility. Higher religiousness was associated with greater use of NSSI to communicate with or gain attention from others, whereas lower religiousness was associated with greater use of NSSI to relieve unwanted emotions. Having a greater understanding of how religious constructs are related to the various functions served by NSSI may inform treatment of this population, particularly among religious youth who self-injure.

Job flexibility and job satisfaction among Mexican professionals: a socio-cultural explanation

2018 ◽  
Vol 40 (5) ◽  
pp. 921-942 ◽  
Author(s):  
Miguel A. Baeza ◽  
Jorge A. Gonzalez ◽  
Yong Wang
Keyword(s):  
Job Satisfaction ◽  
Latin American ◽  
Content Type ◽  
Women Employees ◽  
Mexican Society ◽  
Job Flexibility ◽  
Cultural Explanation ◽  
The Relationship ◽  
Latin American Countries

Purpose The purpose of this paper is to study how job flexibility influences job satisfaction among Mexican professionals, and focus on the role of key socio-cultural moderators relevant to Mexican society. Design/methodology/approach The paper explore how this relationship may be more important for women, employees with dependents such as children and elder parents and younger generations of professionals (e.g. Millennials). Findings The authors find that job flexibility is positively related to job satisfaction. This relationship is stronger for employees without dependents, as well as for younger generations of professionals (e.g. Millennials). Surprisingly, the relationship between job flexibility and job satisfaction does not differ by gender. The findings explain why job flexibility is more conductive to job satisfaction for employees without dependents, who tend to belong to younger generations. Originality/value Overall, the findings present important implications for managing job flexibility in Mexico and other Latin American countries, particularly for younger professionals.

scholarly journals Emerging Roles of Exosomes in T1DM

2020 ◽  
Vol 11 ◽  
Author(s):  
Haipeng Pang ◽  
Shuoming Luo ◽  
Yang Xiao ◽  
Ying Xia ◽  
Xia Li ◽  
...  
Keyword(s):  
Autoimmune Disorder ◽  
Elevated Blood Glucose Level ◽  
The Status ◽  
Life Threatening ◽  
Novel Biomarkers ◽  
Therapeutic Tools ◽  
Underlying Mechanisms ◽  
The Relationship

Type 1 diabetes mellitus (T1DM) is a complex autoimmune disorder that mainly affects children and adolescents. The elevated blood glucose level of patients with T1DM results from absolute insulin deficiency and leads to hyperglycemia and the development of life-threatening diabetic complications. Although great efforts have been made to elucidate the pathogenesis of this disease, the precise underlying mechanisms are still obscure. Emerging evidence indicates that small extracellular vesicles, namely, exosomes, take part in intercellular communication and regulate interorgan crosstalk. More importantly, many findings suggest that exosomes and their cargo are associated with the development of T1DM. Therefore, a deeper understanding of exosomes is beneficial for further elucidating the pathogenic process of T1DM. Exosomes are promising biomarkers for evaluating the risk of developingty T1DM, monitoring the disease state and predicting related complications because their number and composition can reflect the status of their parent cells. Additionally, since exosomes are natural carriers of functional proteins, RNA and DNA, they can be used as therapeutic tools to deliver these molecules and drugs. In this review, we briefly introduce the current understanding of exosomes. Next, we focus on the relationship between exosomes and T1DM from three perspectives, i.e., the pathogenic role of exosomes in T1DM, exosomes as novel biomarkers of T1DM and exosomes as therapeutic tools for T1DM.

scholarly journals Expression of CD markers in JAK2V617F positive myeloproliferative neoplasms: Prognostic significance

2018 ◽  
Author(s):  
Saeid Shahrabi ◽  
Ali Ehsanpour ◽  
Somayyeh Heidary ◽  
Mohammad Shahjahani ◽  
Masumeh Maleki Behzad
Keyword(s):  
Clinical Outcomes ◽  
Prognostic Biomarker ◽  
Myeloproliferative Neoplasms ◽  
Expression Patterns ◽  
Prognostic Significance ◽  
Leukemic Transformation ◽  
And Function ◽  
The Relationship ◽  
Cd Markers

Myeloproliferative neoplasms (MPNs) are clonal stem cell disorders characterized by the presence of JAK2V617F mutation. Thrombohemorrhagic as well as autoimmune or inflammatory phenomena are common clinical outcomes of these disorders. Recent studies have shown that abnormality in frequency and function of blood cells manifested by an alteration in CD markers’ expression patterns play a key role in these complications. So, there may be a relationship between CD markers’ expressions and prognosis of JAK2V617F positive MPNs. Therefore, in this review, we have focused on these abnormalities from the perspective of changing expressions of CD markers and assessment of the relationship between these changes with prognosis of JAK2V617F positive MPNs. It can be stated that the abnormal expression of a large number of CD markers can be used as a prognostic biomarker for clinical outcomes including thrombohememorrhagic events, as well as autoimmune and leukemic transformation in JAK2V617F positive MPNs. Considering the possible role of CD markers’ expressions in JAK2V617F MPNs prognosis, further studies are needed to confirm the relationship between the expression of CD markers with prognosis to be able to find an appropriate therapeutic approach via targeting CD markers.

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