scholarly journals Irisin and Bone: From Preclinical Studies to the Evaluation of Its Circulating Levels in Different Populations of Human Subjects

Cells ◽  
2019 ◽  
Vol 8 (5) ◽  
pp. 451 ◽  
Author(s):  
Graziana Colaianni ◽  
Lorenzo Sanesi ◽  
Giuseppina Storlino ◽  
Giacomina Brunetti ◽  
Silvia Colucci ◽  
...  
Keyword(s):  
Bone Mineral ◽  
Human Subjects ◽  
Healthy Children ◽  
Mineral Density ◽  
Bone Status ◽  
Bone Mineral Status ◽  
Menopausal Women ◽  
Different Populations ◽  
Post Menopausal

Almost four years after the discovery of the anabolic action of irisin on bone in mice, ample clinical evidence is emerging in support of its additional physiological relevance in human bone. Irisin inversely correlates with sclerostin levels in adults with prediabetes and with vertebral fragility fractures in post-menopausal women. Furthermore, in athletes we observed a positive correlation between irisin and bone mineral density at different anatomical sites. Our group also described a positive association between serum irisin and bone status in healthy children and multivariate regression analysis showed that irisin is a stronger determinant of bone mineral status than bone alkaline phosphatase. In children with type 1 diabetes mellitus, serum irisin concentrations are positively associated with bone quality and with glycemic control following continuous subcutaneous insulin infusion. Additionally, our in vitro studies suggest the existence of a negative interplay between PTH and irisin biology and these results were also supported by the observation that post-menopausal women with primary hyperparathyroidism have lower levels of irisin compared to matched controls. In this review, we will focus on recent findings about circulating level of irisin in different populations of human subjects and its correlation with their bone status.

The effect of Irisin on bone cells in vivo and in vitro

2021 ◽  
Author(s):  
Cinzia Buccoliero ◽  
Angela Oranger ◽  
Graziana Colaianni ◽  
Patrizia Pignataro ◽  
Roberta Zerlotin ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Bone Mineral ◽  
Bone Cells ◽  
Healthy Children ◽  
Mineral Density ◽  
Skeletal Health ◽  
Bone Mineral Status

The myokine Irisin, produced during physical exercise, has an anabolic effect on bone, both in vitro and in vivo. Very recently, using a controlled in vitro 3D cell model to mimic the bone microenvironment aboard the International Space Station, it has been shown that Irisin treatment in microgravity prevents the down-regulation of the transcription factors Atf4, Runx2 and Osterix, as well as Collagen I and Osteoprotegerin proteins, crucial for osteoblast differentiation in physiologic conditions. Irisin action has also been investigated in human subjects, in which it correlates with bone health status, supporting its physiological importance also in human bone, both in healthy subjects and in patients suffering from diseases related to bone metabolism, such as hyperparathyroidism and type 1 diabetes. Low levels of circulating Irisin have been found in post-menopausal women affected by hyperparathyroidism. Furthermore, Irisin is positively correlated with bone strength in athletes and bone mineral density in football players. Moreover, in healthy children, Irisin is positively associated with bone mineral status and in children with type 1 diabetes, Irisin is positively correlated with improved glycemic control and skeletal health. In this review, we will focus on recent findings about Irisin action on microgravity induced bone loss and on osteocyte activity and survival through its αV/β5 integrin receptor.

Bio-impedance and quantitative ultrasound to measure bone mineral density in post-menopausal women from a rural Mexican community

2016 ◽  
Author(s):  
Fernando Blanco-Rodriguez ◽  
Nicole Ellis-Infante ◽  
Victor Lopez-Rivas ◽  
Sherlin May-Kim ◽  
Charlotte Pickett ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Quantitative Ultrasound ◽  
Mineral Density ◽  
Menopausal Women ◽  
Mexican Community ◽  
Post Menopausal ◽  
Measure Bone Mineral Density

scholarly journals Physical Activity Level of Post-menopausal Women with Low Bone Mineral Density

2016 ◽  
Vol 38 (05) ◽  
pp. 225-230 ◽  
Author(s):  
Glauber Dallanezi ◽  
Beatriz Freire ◽  
Eliana Nahás ◽  
Jorge Nahás-Neto ◽  
José Corrente ◽  
...  
Keyword(s):  
Physical Activity ◽  
Bone Mineral Density ◽  
Bone Mineral ◽  
Physical Activity Level ◽  
Activity Level ◽  
Mineral Density ◽  
Low Bone Mineral Density ◽  
Menopausal Women ◽  
Post Menopausal

Non-weight-bearing effect of trunk and peripheral fat mass on bone mineral density in pre- and post-menopausal women

Maturitas ◽  
2008 ◽  
Vol 60 (3-4) ◽  
pp. 244-247 ◽  
Author(s):  
Akiko Kuwahata ◽  
Yukie Kawamura ◽  
Yukie Yonehara ◽  
Takashi Matsuo ◽  
Ichiro Iwamoto ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Fat Mass ◽  
Weight Bearing ◽  
Mineral Density ◽  
Menopausal Women ◽  
Post Menopausal

Carotid plaque and lumbar bone mineral density status in post-menopausal women: An age-matched, analytical cross-sectional study

2019 ◽  
Vol 26 (1) ◽  
pp. 9-18
Author(s):  
Patraporn Sitthisombat ◽  
Sukree Soontrapa ◽  
Srinaree Kaewrudee ◽  
Jen Sothornwit ◽  
Nuntasiri Eamudomkarn ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Cardiovascular Disease ◽  
Lumbar Spine ◽  
Bone Mineral ◽  
Odds Ratio ◽  
Carotid Plaque ◽  
Spine Bone Mineral Density ◽  
Mineral Density ◽  
Menopausal Women ◽  
Post Menopausal

Objective To explore the association between carotid plaque and lumbar spine osteoporosis in post-menopausal women. Study design Age-matched, cross-sectional study. Main outcome measures Carotid plaque and carotid intima media thickness were measured with B-mode ultrasound. Lumbar spine bone mineral density was measured with dual-energy X-ray absorptiometry. Prevalence odds ratios and the respective 95% confidence intervals (95%CI) were calculated to determine the association. Results Seventy-two post-menopausal women with lumbar spine osteoporosis and 72 post-menopausal women with normal lumbar spine bone mineral density were enrolled. The adjusted prevalence odds ratio of carotid plaque presence in post-menopausal women with lumbar spine osteoporosis was 1.73 (95%CI; 0.60 to 4.94) when compared to post-menopausal women with normal lumbar spine bone mineral density. The presence of vulnerable plaque was greater in post-menopausal women with lumbar spine osteoporosis; however, the difference was not statistically significant after adjusting for other risk factors of cardiovascular disease (odds ratio 1.31; 95%CI; 0.39 to 4.43). There was no significant difference in carotid intima media thickness between the two groups. Multiple logistic regression analysis with backward elimination in assessment of potential risk factors for the presence of carotid plaque showed that the year since menopause, family history of cardiovascular disease and systolic blood pressure were nominally significant associated factors with a respective adjusted odds ratio of 1.06 (95%CI; 1.01 to 1.12), 6.23 (95%CI; 1.65 to 23.46) and 1.03 (95%CI; 1.01 to 1.06). Conclusions The current study indicates that lumbar spine osteoporosis is not associated with the presence of carotid plaque, whereas year since menopause, family history of cardiovascular disease and systolic blood pressure are associated factors.

Dose‐response effects of exercise on bone mineral density and content in post‐menopausal women

2019 ◽  
Vol 29 (8) ◽  
pp. 1121-1129 ◽  
Author(s):  
Paola Gonzalo‐Encabo ◽  
Jessica McNeil ◽  
Devon J. Boyne ◽  
Kerry S. Courneya ◽  
Christine M. Friedenreich
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Dose Response ◽  
Mineral Density ◽  
Menopausal Women ◽  
Post Menopausal
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