scholarly journals Changes in the Concentration of Markers Participating in the Regulation of the Apoptosis Receptor Pathway Involving Soluble Tumour Necrosis Factor Ligand Inducing Apoptosis (sTRAIL) and Osteoprotegerin (OPG) in the Serum of Women with Ovarian Cancer—Participation in Pathogenesis or a Possible Clinical Use?

Cells ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. 612
Author(s):  
Aleksandra Mielczarek-Palacz ◽  
Zdzisława Kondera-Anasz ◽  
Marta Smycz-Kubańska
Keyword(s):  
Ovarian Cancer ◽  
Tumour Necrosis Factor ◽  
Tumour Necrosis ◽  
Statistical Significance ◽  
Control Group ◽  
Histological Differentiation ◽  
Mucinous Cancer ◽  
Soluble Trail ◽  
Apoptosis Process ◽  
Necrosis Factor

Due to the ability to selectively induce apoptosis in cancer cells, the most interesting target for clinical research is the tumour necrosis factor ligand inducing apoptosis (TRAIL), which binds specific receptors, including osteoprotegerin (OPG). The aim of the study was to analyse the concentration of soluble TRAIL (sTRAIL) and OPG in the serum of women with serous or mucinous ovarian cancer, taking into account different levels of cancer histological differentiation. The group included 97 women with the diagnosed Cystadenocarcinoma papillare serosum IIIc and Cystadenocarcinoma mucinosum IIIc. Concentrations of parameters were measured by ELISA. Analysis of the obtained results showed a statistically significantly higher concentration of sTRAIL and OPG in the serum of women with ovarian serous and mucinous cancer compared to the control group (p < 0.0001). Statistical significance was found between sTRAIL and OPG concentration in G1 and G3 serous cancer (p < 0.01) and in OPG mucinous cancer between G1 and G3 (p < 0.01) and G2 and G3 (p < 0.01). An important role in the pathogenesis of ovarian cancer is played by disorders of the apoptosis process involving the sTRAIL/OPG system, which are associated with the histological type and the degree of histological differentiation of the tumour. Determining the concentration of tested parameters in combination with other markers may be useful in the future in the diagnosis of ovarian cancer, but that requires further research.

scholarly journals Assessment Of Tumour Necrosis Factor-Alpha (Tnf- Α) And Creatinine Levels In Echis Ocellatus Bite Victims In Jos Metropolis, Nigeria

2016 ◽  
Vol 12 (21) ◽  
pp. 70
Author(s):  
Manafa P.O. ◽  
Osmond E.O. ◽  
Onyenekwe C.C. ◽  
Okeke C.O. ◽  
Chukwuma G.O. ◽  
...  
Keyword(s):  
Serum Level ◽  
Tumour Necrosis Factor ◽  
Tumour Necrosis ◽  
Tumour Necrosis Factor Alpha ◽  
Control Group ◽  
Necrosis Factor Alpha ◽  
Significant Difference ◽  
Factor Alpha ◽  
The Mean ◽  
Necrosis Factor

This study was designed to assess tumour necrosis factor-alpha and creatinine levels in Echis ocellatus bite victims. A total of 50 subjects were recruited. Out of this number, 40 were victims of E. ocellatus bite and the remaining 10 were non-victims of snake bite who served as the control group. Blood samples were collected from the victims within 24 hours of the snake bite and EchiTAb-G antivenom administered within the same period. Another batch of blood sample was collected 48 hours post-administration of the anti-venom. Tumour necrosis factor-alpha (TNF-alpha) levels were estimated by the Enzyme Linked Immunosorbent Assay technique while creatinine levels were determined using kinetic-spectrophotometric procedure. The mean serum levels of tumour necrosis factor-alpha and creatinine were significantly increased in E. ocellatus bite victims compared with the control group (P<0.05). Furthermore, the mean serum level of TNFalpha was significantly lower in E. ocellatus bite victims, post-administration of anti-venom, compared with the pre-administration of anti-venom (P<0.05). In contrast, no significant difference was observed in the mean serum level of creatinine in E. ocellatus bite victims, post-administration of anti-venom, compared with the pre-administration of anti-venom (P>0.05). Moreover, the mean serum level of creatinine was found to be significantly increased in E. ocellatus bite victims, post-administration of anti-venom, compared with the control group (P<0.05), while no significant difference was observed in the mean serum level of tumour necrosis factor-alpha in E. ocellatus bite victims, post-administration of anti-venom, compared with the control group(P>0.05). A positive correlation existed between tumour necrosis factor-alpha and creatinine levels in E. ocellatus bite subjects (r= 0.782). Echis ocellatus bite is a risk factor for renal damage indicated by an elevated serum creatinine, thus health authorities should make EchiTAb-G anti-venom freely available in health facilities and administered as quickly as possible to reduce the risk of renal damage in Echis ocellatus bite-prone areas.

Paradoxical effects of tumour necrosis factor in experimental ovarian cancer

1989 ◽  
Vol 44 (5) ◽  
pp. 918-925 ◽  
Author(s):  
S. T. A. Malik ◽  
D. B. Griffin ◽  
W. Fiers ◽  
F. R. Balkwill
Keyword(s):  
Ovarian Cancer ◽  
Tumour Necrosis Factor ◽  
Tumour Necrosis ◽  
Paradoxical Effects ◽  
Necrosis Factor

scholarly journals Early Lyme Borreliosis in Patients Treated with Tumour Necrosis Factor-Alfa Inhibitors

2019 ◽  
Vol 8 (11) ◽  
pp. 1857
Author(s):  
Vera Maraspin ◽  
Petra Bogovič ◽  
Tereza Rojko ◽  
Katarina Ogrinc ◽  
Eva Ružić-Sabljić ◽  
...  
Keyword(s):  
Tumour Necrosis Factor ◽  
Lyme Borreliosis ◽  
Tumour Necrosis ◽  
Erythema Migrans ◽  
Control Group ◽  
Tnf Inhibitor ◽  
Necrosis Factor Alpha ◽  
Tnf Α ◽  
Necrosis Factor ◽  
Immunocompetent Patients

The study evaluated the course and outcome of erythema migrans in patients receiving tumour necrosis factor-alpha (TNF-α) inhibitors. Among 4157 adults diagnosed with erythema migrans in the period 2009–2018, 16 (2.6%) patients were receiving TNF-α inhibitors (adalimumab, infliximab, etarnecept, golimumab), often in combination with other immunosuppressants, for rheumatic (13 patients) or inflammatory bowel (three patients) disease. Findings in this group were compared with those in 32 sex- and age-matched immunocompetent patients diagnosed with erythema migrans in the same years. In comparison with the control group, the immunocompromised patients had a shorter incubation period (7 vs. 14 days; p = 0.0153), smaller diameter of erythema migrans (10.5 vs. 15.5 cm; p = 0.0014), and more frequent comorbidities other than immune-mediated diseases (62.5% vs. 25%, p = 0.0269), symptoms/signs of disseminated Lyme borreliosis (18.8% vs. 0%, p = 0.0324), and treatment failure (25% vs. 0%, p = 0.0094). After retreatment with an antibiotic, the clinical course of Lyme borreliosis resolved. Continuing TNF inhibitor treatment during concomitant borrelial infection while using identical approaches for antibiotic treatment as in immunocompetent patients resulted in more frequent failure of erythema migrans treatment in patients receiving TNF inhibitors. However, the majority of treatment failures were mild, and the course and outcome of Lyme borreliosis after retreatment with antibiotics was favourable.

Treatment of advanced ovarian cancer with intraperitoneal tumour necrosis factor

1990 ◽  
Vol 26 (6) ◽  
pp. 771 ◽  
Author(s):  
J. Hardy ◽  
A. Jones ◽  
M.E. Gore ◽  
C. Viner ◽  
P. Selby ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Tumour Necrosis Factor ◽  
Tumour Necrosis ◽  
Advanced Ovarian Cancer ◽  
Necrosis Factor

In situ detection of tumour necrosis factor in human ovarian cancer specimens

1990 ◽  
Vol 26 (10) ◽  
pp. 1027-1030 ◽  
Author(s):  
M. Stuart Naylor ◽  
Saleem T.A. Malik ◽  
Gordon W.H. Stamp ◽  
Tom Jobling ◽  
Frances R. Balkwill
Keyword(s):  
Ovarian Cancer ◽  
Tumour Necrosis Factor ◽  
Tumour Necrosis ◽  
Human Ovarian Cancer ◽  
In Situ Detection ◽  
Necrosis Factor

scholarly journals Roles of the ovarian surface epithelium in ovulation and carcinogenesis

Reproduction ◽  
2002 ◽  
pp. 743-750 ◽  
Author(s):  
WJ Murdoch ◽  
AC McDonnel
Keyword(s):  
Ovarian Cancer ◽  
Tumour Necrosis Factor ◽  
Tumour Necrosis ◽  
Ovarian Surface Epithelium ◽  
Tumour Necrosis Factor Alpha ◽  
Surface Epithelium ◽  
Necrosis Factor Alpha ◽  
Ovarian Surface ◽  
Factor Alpha ◽  
Necrosis Factor

Although ovarian mechanisms of ovulation have been a subject of investigation for more than a century, essential regulatory pathways remain uncertain. A role for the ovarian surface epithelium in ovulation has recently been demonstrated. Ovarian surface epithelial cells in close contact with the apical wall of preovulatory ovine follicles secrete a urokinase-type plasminogen activator in response to surge concentrations of (locally delivered) gonadotrophins. Urokinase activates latent collagenases and stimulates release of tumour necrosis factor alpha from thecal endothelium. Tumour necrosis factor alpha progressively induces matrix metalloproteinase gene expression, apoptosis and inflammatory necrosis. Collagenolysis and cellular death are a prelude to stigma formation and ovarian rupture. Epithelium exfoliated from the dome of ovulatory follicles is replenished by generative stem cell replication and migration from the wound edges. Common epithelial ovarian cancer has been related to successive bouts of ovulation and mitosis. The integrity of the DNA of surface cells circumjacent to the ovarian rupture site is compromised during the ovulatory process. Clonal expansion of an epithelial cell with damaged (unrepaired) DNA is a putative factor in carcinogenesis. Ovarian cancer is a deadly insidious disease because typically it is asymptomatic until the malignancy has reached beyond the ovaries.

Effectiveness of corticosteroids in otitis media with effusion: an experimental study

2007 ◽  
Vol 122 (1) ◽  
pp. 25-30 ◽  
Author(s):  
H Yaman ◽  
K Ozturk ◽  
Y Uyar ◽  
M Gurbilek
Keyword(s):  
Tumour Necrosis Factor ◽  
Otitis Media ◽  
Tumour Necrosis ◽  
Otitis Media With Effusion ◽  
Interleukin 1Β ◽  
Control Group ◽  
Tumour Necrosis Factor Α ◽  
Significant Difference ◽  
Factor Α ◽  
Necrosis Factor

AbstractObjective:The aim of the present study was to investigate the dose-related effectiveness of corticosteroids in the management of otitis media with effusion, by using the objective assessment techniques of tympanometry and cytokine measurement.Materials and methods:The eustachian tubes of 42 male rats were obstructed. Thirty-six subjects with effusion were randomly divided into three equal groups: controls; 0.5 mg/kg/day corticosteroid; and 1 mg/kg/day corticosteroid. Concentrations of interleukin-1β and tumour necrosis factor α in the middle-ear effusions were analysed using enzyme-linked immunosorbent assay.Results:An effusion occurred on the 14th post-operative day and was present on the 30th post-operative day in the control group. Otomicroscopic examination and tympanometric measurement showed an improvement in the intervention groups. There was a significant difference between both intervention groups and the control group for both interleukin-1β and tumour necrosis factor α concentrations (p < 0.01). However, there was no significant difference between the 0.5 mg/kg and the 1 mg/kg corticosteroid groups (p > 0.05).Conclusion:The study confirmed a short term beneficial effect of systemic steroids on resolution of otitis media with effusion in a rat model. Our results support the theory that corticosteroids significantly decrease concentrations of both interleukin-1β and tumour necrosis factor α. In our model, the 0.5 mg/kg corticosteroid dose was as effective as the 1 mg/kg corticosteroid dose. Further studies should be carried out to determine the optimal dose and duration of corticosteroids in the treatment of otitis media with effusion.

Tumour Necrosis Factor: A Role in Ovarian Cancer?

2015 ◽  
pp. 199-202 ◽  
Author(s):  
S. Naylor ◽  
G. W. Stamp ◽  
W. Foulkes ◽  
D. Eccles ◽  
F. R. Balkwill
Keyword(s):  
Ovarian Cancer ◽  
Tumour Necrosis Factor ◽  
Tumour Necrosis ◽  
Necrosis Factor
Sign in / Sign up

Export Citation Format

Share Document