scholarly journals Late Effects and Survivorship Issues in Patients with Neuroblastoma

Children ◽  
2018 ◽  
Vol 5 (8) ◽  
pp. 107 ◽  
Author(s):  
Danielle Friedman ◽  
Tara Henderson
Keyword(s):  
Late Effects ◽  
Survival Rates ◽  
Premature Mortality ◽  
The Past ◽  
Excess Morbidity ◽  
Related Risk ◽  
Impaired Quality ◽  
Made In

Over the past two decades, marked progress has been made in understanding the biology of neuroblastoma; this has led to refined risk stratification and treatment modifications with resultant increasing 5-year survival rates for children with neuroblastoma. Survivors, however, remain at risk for a wide variety of potential treatment-related complications, or “late effects”, which may lead to excess morbidity and premature mortality in this cohort. This review summarizes the existing survivorship literature on long-term health outcomes for survivors of neuroblastoma, focusing specifically on potential injury to the endocrine, sensory, cardiovascular, pulmonary, and renal systems, as well as survivors’ treatment-related risk for subsequent neoplasms and impaired quality of life. Additional work is needed to assess the potential late effects of newer multimodality therapies with the aim of optimizing long-term medical and psychosocial outcomes for all survivors of neuroblastoma.

Pediatric Cancer Survivorship: Research and Clinical Care

2006 ◽  
Vol 24 (32) ◽  
pp. 5160-5165 ◽  
Author(s):  
Anna T. Meadows
Keyword(s):  
Pediatric Cancer ◽  
Late Effects ◽  
Clinical Care ◽  
Survival Rates ◽  
The United States ◽  
Term Survival ◽  
Pediatric Cancer Survivors ◽  
Effects Of Aging

Regardless of how one defines survivorship, more than 10 million individuals in the United States have been treated for a malignant disease; about 250,000 were younger than 21 years of age at diagnosis. Thirty years ago, pediatric oncologists recognized that children with cancer might be cured by adding chemotherapy to surgery and radiation. Studies were then begun of complications that could reduce survival or the quality of survival, and that might be associated with previous therapy. The complications were termed late effects, and studies focused on patients who were likely to be cured, or less likely to succumb to the original cancer than they were to experience disabilities. Clinical trials tested whether changes in therapy to reduce complications could maintain the same excellent survival rates. During the last 20 years, articles detailing late effects and the relationship between therapy and outcome have been published. This article reviews the progress made in understanding the outcomes reported and the efforts made to improve the quality of long-term survival for children and adolescents. Several questions remain regarding the long-term complications of therapy. Clinicians need more data regarding the effects of aging to guide them in managing former patients. Caregivers and pediatric cancer survivors who are now adults seek the optimal venue in which to receive care as independent adults. In addition, medical oncologists need to determine whether the models for research and clinical care of survivors created in pediatric oncology can be applied to survivors of adult-onset cancer.

scholarly journals Experience of long-term clinical observation of a patient with a rare type of stomach cancer – lymphoepithelioma-like carcinoma

2020 ◽  
pp. 277-282
Author(s):  
L. M. Kogoniya ◽  
L. E. Gurevich ◽  
V. S. Mazurin ◽  
E. V. Markarova
Keyword(s):  
Stomach Cancer ◽  
Survival Rates ◽  
Palliative Therapy ◽  
Diagnostic Methods ◽  
Rare Type ◽  
The Past ◽  
Methods Of Treatment ◽  
Improved Methods

Stomach cancer is one of the most frequently diagnosed cancers. The success of special methods of treatment are still disappointing in this disease, and stomach cancer has historically been considered a tumor refractory to treatment. Therefore, this category of patients, especially in the stage of dissemination, in most cases, palliative therapy is recommended. In recent years, the use of systemic chemotherapy and targeted therapy has led to a significant improvement in the quality of life and survival rates for stomach cancer compared to palliative therapy. However, significant progress in diagnostic methods over the past two decades has made it possible and possible to review approaches to the treatment of many cancer diseases that are refractory to chemotherapy. The last 2 decades, due to improved methods of diagnosis have allowed to revise approaches to the treatment of many refractory to chemotherapy of neoplastic diseases. In particular, the literature describes cases of revision and changes due to pre-existing diagnosis of IHC Research (carcinoid, NEO, stomach cancer, pancreatic cancer). This communication allows to share their own long experience of observation and treatment of a patient with a rare form of stomach cancer – lymphoepithelioma-like carcinoma.

Quality of life in long-term childhood cancer survivors and the relation of late effects and subjective well-being

2004 ◽  
Vol 13 (1) ◽  
pp. 49-56 ◽  
Author(s):  
Sigrid Pemberger ◽  
Reinhold Jagsch ◽  
Eva Frey ◽  
Rosemarie Felder-Puig ◽  
Helmut Gadner ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cancer Survivors ◽  
Childhood Cancer ◽  
Late Effects ◽  
Well Being ◽  
Childhood Cancer Survivors ◽  
Subjective Well Being

scholarly journals Trends and Developments in Bioinformatics in 2010: Prospects and Perspectives

2011 ◽  
Vol 20 (01) ◽  
pp. 146-155
Author(s):  
A. V. Alekseyenko ◽  
Y. Aphinyanaphongs ◽  
S. Brown ◽  
D. Fenyo ◽  
L. Fu ◽  
...  
Keyword(s):  
Best Practices ◽  
Open Problems ◽  
The Past ◽  
New Methods ◽  
Methods Development ◽  
Long Term Trends ◽  
To Come ◽  
Generation Sequencing

SummaryTo survey major developments and trends in the field of Bioinformatics in 2010 and their relationships to those of previous years, with emphasis on long-term trends, on best practices, on quality of the science of informatics, and on quality of science as a function of informatics.A critical review of articles in the literature of Bioinformatics over the past year.Our main results suggest that Bioinformatics continues to be a major catalyst for progress in Biology and Translational Medicine, as a consequence of new assaying technologies, most predominantly Next Generation Sequencing, which are changing the landscape of modern biological and medical research. These assays critically depend on bioinformatics and have led to quick growth of corresponding informatics methods development. Clinical-grade molecular signatures are proliferating at a rapid rate. However, a highly publicized incident at a prominent university showed that deficiencies in informatics methods can lead to catastrophic consequences for important scientific projects. Developing evidence-driven protocols and best practices is greatly needed given how serious are the implications for the quality of translational and basic science.Several exciting new methods have appeared over the past 18 months, that open new roads for progress in bioinformatics methods and their impact in biomedicine. At the same time, the range of open problems of great significance is extensive, ensuring the vitality of the field for many years to come.

scholarly journals Advances in the management of craniopharyngioma in children and adults

2019 ◽  
Vol 53 (4) ◽  
pp. 388-396 ◽  
Author(s):  
Mojca Jensterle ◽  
Soncka Jazbinsek ◽  
Roman Bosnjak ◽  
Mara Popovic ◽  
Lorna Zadravec Zaletel ◽  
...  
Keyword(s):  
Survival Rates ◽  
Tumor Location ◽  
Subtotal Resection ◽  
Metabolic Complications ◽  
Optimal Outcomes ◽  
Parasellar Region ◽  
Long Term Follow Up ◽  
Considerable Controversy

Abstract Background Childhood and adult-onset craniopharyngioma is a rare embryogenic tumor of the sellar, suprasellar, and parasellar region. Survival rates are high; however, tumor location and treatment sequalae including endocrine deficits, visual impairment, metabolic complications, cognitive and psychosocial deficits can significantly impair patient’s quality of life. There is considerable controversy regarding the optimal management of craniopharyngiomas. Subtotal resection of the tumor followed by targeted irradiation to avoid further hypothalamic damage is currently indicated. Novel insights in the tumor’s molecular pathology present the possibility for targeted therapy possibly decreasing the rate and severity of treatment-associated morbidity. Conclusions Craniopharyngioma should be seen as a chronic disease. To achieve optimal outcomes a multidisciplinary team of specialized neurosurgeons, neuro-radiologists, neuro-oncologists, pathologists and endocrinologists should be involved in the diagnosis, planning of the surgery, irradiation and long-term follow-up.

Oncofertility

2021 ◽  
pp. 136-150
Author(s):  
Bruno Ramalho de Carvalho ◽  
Jhenifer Kliemchen Rodrigues ◽  
Teresa K. Woodruff
Keyword(s):  
Ethical Issues ◽  
Survival Rates ◽  
Ethical Considerations ◽  
Death Rates ◽  
Functional Failure ◽  
Personal Level ◽  
After Cancer ◽  
Reproductive Consequences

Advances in cancer treatment, particularly chemotherapeutics, are expected to lead to significant improvements in survival rates. While cancer incidence and death rates are decreasing, quality of life after cancer may be reduced due to early functional failure of the gonads and, consequently, infertility, resulting from either the disease itself or its treatment. This chapter introduces clinicians to the new field of oncofertility and the ethical issues it raises. It will consider the situation of young cancer patients facing reproductive consequences globally, the retrieval of gametes or gonadal tissue from minors, and the use of these tissues long term. The field of oncofertility is new, but ethical considerations regarding reproductive interventions are old. Understanding how we approach these issues on a personal level and from the public’s perspective will be assessed in this chapter.

Quality of life following surgery for congenital cardiac malformations in neonates and infants

2005 ◽  
Vol 15 (S1) ◽  
pp. 174-178 ◽  
Author(s):  
Kathleen Mussatto ◽  
James Tweddell
Keyword(s):  
Quality Of Life ◽  
Future Research ◽  
Cardiac Malformations ◽  
The Past ◽  
Congenital Cardiac Disease ◽  
Major Shift ◽  
Neonates And Infants ◽  
The Impact

The past two decades have witnessed a major shift towards repair of most congenital cardiac malformations during the neonatal or infant periods of life.1 Early anatomic correction or palliation, dramatic improvements in survival, and reduced morbidity due to improvements in perioperative and long-term medical management, have resulted in new populations of children that have reaped the benefits of the best care currently available for treatment of congenital cardiac disease. The impact of the congenital cardiac malformations, however, extends far beyond the walls of the hospital or clinic where we diagnose, treat, and follow our patients. The breakthrough of achieving predictable results with repair or palliation of most lesions during the neonatal and infant periods mandates us to look beyond survival, and to examine the lives our patients lead when they are outside of our care. Our purpose in this review is to discuss the measures of psychosocial outcome that are appropriate for exploration in those neonates and infants who survive cardiac surgery, to explore what is known about the psychosocial outcomes and quality of life for these patients, and what needs exist for future research.

Remembering socialist entertainment: Romanian television, gestures and intimacy

2017 ◽  
Vol 20 (3) ◽  
pp. 341-358 ◽  
Author(s):  
Alice Bardan
Keyword(s):  
Eastern Europe ◽  
Television Series ◽  
Intimate Connection ◽  
The Past ◽  
New Year’S Eve ◽  
Television Characters ◽  
State Socialist ◽  
Made In ◽  
Do So

This essay tackles the question of why people enjoy the re-broadcasting of state socialist programmes, asking whether their desires are driven by nostalgia, manipulated by neocapitalist schemes that commodify the past as an audience-raising strategy or simply linked to a compulsive desire to revisit a ‘traumatic’ past. To do so, I first draw on existing literature on mediated nostalgia to examine some of the possible explanations for the continued popularity of socialist-era television in post-socialist Eastern Europe. Focusing on the Romanian context, I discuss audience memories of socialist TV and then zoom in on some of the most prevalent memories of socialist entertainment in this country: the New Year’s Eve comedy sketches and Pistruiatul, one of very few television series made in Romania during socialism. I argue that in order to understand the popularity of socialist-era reruns, we need to look both into how audiences remember these programmes and into how these programmes construct long-term affinities with the audience. To do so, I discuss two kinds of pleasures: first, the pleasure of recalling one’s ability to resist ideological messages and, second, the pleasure of re-watching familiar content and, through that, reliving the sense of intimate connection with television characters.

Impaired quality of life in patients with treated acromegaly despite long-term biochemically stable disease: Results from a 5-years prospective study

2017 ◽  
Vol 86 (6) ◽  
pp. 806-815 ◽  
Author(s):  
Nikolaos Kyriakakis ◽  
Julie Lynch ◽  
Stephen G. Gilbey ◽  
Susan M. Webb ◽  
Robert D. Murray
Keyword(s):  
Quality Of Life ◽  
Prospective Study ◽  
Stable Disease ◽  
Impaired Quality

Gamete quality in fish: evaluation parameters and determining factors

Zygote ◽  
2013 ◽  
Vol 23 (2) ◽  
pp. 177-197 ◽  
Author(s):  
Iván I. Valdebenito ◽  
Patricia C. Gallegos ◽  
Brian R. Effer
Keyword(s):  
Water Quality ◽  
Survival Rates ◽  
Physical Factors ◽  
Male And Female ◽  
Feeding Management ◽  
Determining Factors ◽  
Water Conditions ◽  
Evaluation Parameters

SummaryThe quality of fish gametes, both male and female, are determined by several factors (age, management, feeding, chemical and physical factors, water quality, etc.) that have an impact on the survivability of embryos, larvae and/or fry in the short or long term. One of the most important factors is gamete ageing, especially for those species that are unable to spawn naturally in hatcheries. The chemical and physical factors in hatcheries and the nutrition that they provide can significantly alter harvest quality, especially from females; as a rule, males are more tolerant of stress conditions produced by inadequate feeding, management and/or poor water conditions. The stress produced on broodstock by inadequate conditions in hatcheries can produce adverse effects on gamete quality, survival rates, and the embryonic eggs after hatching.

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