scholarly journals Design of Novel Photocatalytic Films for the Protection of Architectural Surfaces via the Incorporation of Green Photocatalysts

Coatings ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 934
Author(s):  
Dimitrios Stefanakis ◽  
Themis Krasoudaki ◽  
Anastasios-Ioannis Kaditis ◽  
Asterios Bakolas ◽  
Pagona-Noni Maravelaki
Keyword(s):  
Large Scale ◽  
Irradiation Time ◽  
Water Repellency ◽  
Cost Effective ◽  
Spectroscopic Techniques ◽  
Scale Production ◽  
Green Materials ◽  
Large Scale Production ◽  
Self Cleaning ◽  
Photocatalytic Films

In conservation science the demand of multifunctional green materials displaying water repellency, consolidation, resistance to organic pollutants and pigments is constantly increasing. This research developed a green nanocomposite exhibiting photocatalytic, hydrophobic, consolidation and self-cleaning properties. This was achieved by synthesizing a TiO2 photocatalyst enriched with carbon dots (C-dots) and successfully incorporated into a tetraethoxysilane nanocomposite modified with nano-calcium oxalate and polydimethylsiloxane. The TiO2/C-dots that were prepared with a simple, low temperature, cost-effective and large-scale procedure were assessed via analytical and spectroscopic techniques and were resulted in anatase structure ranging in size from 10 to 40 nm. Photooxidation measurements displayed that TiO2/C-dots nanoparticles could photodegrade completely Methyl Orange (MO) under UV and visible irradiation after 120 min. The photocatalytic performance of the nanocomposite with TiO2/C-dots resulted promising under UV after longer irradiation time. The degradation of MO was faster on bulk xerogels containing the TiO2/C-dots than the corresponding ones with TiO2. The treatment of concrete, limestone and lime mortars with the nanocomposite proved to be compatible with the substrates in terms of aesthetical aspects. This study demonstrates encouraging potential for large-scale production of a multifunctional protective composite that offers hydrophobicity, self-cleaning properties and consolidation to architectural surfaces.

scholarly journals Transgenic goats producing an improved version of cetuximab in milk

2020 ◽  
Author(s):  
Götz Laible ◽  
Sally Cole ◽  
Brigid Brophy ◽  
Paul Maclean ◽  
Li How Chen ◽  
...  
Keyword(s):  
Mammalian Cells ◽  
Large Scale ◽  
Growth Factor Receptor ◽  
Cost Effective ◽  
Scale Production ◽  
Cancer Treatments ◽  
Large Scale Production ◽  
Immunogenic Epitope ◽  
Dependent Cell ◽  
Transgenic Goats

ABSTRACTTherapeutic monoclonal antibodies (mAbs) represent one of the most important classes of pharmaceutical proteins to treat human diseases. Most are produced in cultured mammalian cells which is expensive, limiting their availability. Goats, striking a good balance between a relatively short generation time and copious milk yield, present an alternative platform for the cost-effective, flexible, large-scale production of therapeutic mAbs. Here, we focused on cetuximab, a mAb against epidermal growth factor receptor, that is commercially produced under the brand name Erbitux and approved for anti-cancer treatments. We generated several transgenic goat lines that produce cetuximab in their milk. Two lines were selected for detailed characterization. Both showed stable genotypes and cetuximab production levels of up to 10g/L. The mAb could be readily purified and showed improved characteristics compared to Erbitux. The goat-produced cetuximab (gCetuximab) lacked a highly immunogenic epitope that is part of Erbitux. Moreover, it showed enhanced binding to CD16 and increased antibody-dependent cell-dependent cytotoxicity compared to Erbitux. This indicates that these goats produce an improved cetuximab version with the potential for enhanced effectiveness and better safety profile compared to treatments with Erbitux. In addition, our study validates transgenic goats as an excellent platform for large-scale production of therapeutic mAbs.

ChipsetT: Embedded Die Substrate Applications

2013 ◽  
Vol 2013 (DPC) ◽  
pp. 000377-000397
Author(s):  
Jon G. Aday ◽  
Ted Tessier ◽  
Kazuhisa Itoi ◽  
Satoshi Okude
Keyword(s):  
Large Scale ◽  
Cost Effective ◽  
Scale Production ◽  
Robust Solution ◽  
Sintered Metal ◽  
Design Flexibility ◽  
Fine Pitch ◽  
Large Scale Production ◽  
Bottom Side ◽  
Board Level

Embedded die substrate technologies are being developed in an assortment of configurations and for different market segments. The technology being discussed in this paper will be focused on both a fan out technology – ChipsetT Fan-Out and a system in package approach (ChipsetT SiP) in which a multiple component bill of materials (BOM) is used. The Chipset process is based on the WABE (Wafer and Board Level Embedding) technology. WABE technology is based on co-lamination of multilayer polyimide flex wiring and conductive z-axis sintered metal interconnections. This ChipsetT Fan Out technology allows for large scale production of fan out type solutions which can allow for very thin packages in addition to unique pin out solutions such as pin compatibility for a competitor part. The ChipsetT SiP also allows embedding of single or multiple silicon die and/or components. Additional components can also be placed using conventional SMT on the top or bottom side of the package. There is a great deal of design flexibility with this technology which makes it a great solution for applications trying to reduce their x-y size or z-height. When utilizing RDL technology on the embedded die we are able to do the fine pitch routing in order to allow the substrate to route at larger pitches ensuring an overall cost effective solution. This paper will focus on the different classes of applications that have benefited from this technology and will discuss the benefits and tradeoffs of the different solutions that have been engineered. Assembly and reliability data will be presented on several of the applications showing a robust solution set.

Electro-reduction of hematite using water as the redox mediator

2019 ◽  
Vol 21 (2) ◽  
pp. 198-204 ◽  
Author(s):  
Kaiyu Xie ◽  
Ali Reza Kamali
Keyword(s):  
Molten Salt ◽  
Large Scale ◽  
Cost Effective ◽  
Redox Mediator ◽  
Electrolytic Reduction ◽  
Scale Production ◽  
Large Scale Production ◽  
Cost Effective Approach

Molten salt electrolytic reduction of Fe2O3 in the presence of water is proposed as a sustainable and cost-effective approach for large-scale production of iron.

Aluminium and Aluminium Alloy Powders for P/M Applications

2007 ◽  
Vol 534-536 ◽  
pp. 773-776
Author(s):  
R. Cook ◽  
I.T.H. Chang ◽  
C. Lucien Falticeanu
Keyword(s):  
Particle Size ◽  
Aluminium Alloy ◽  
Large Scale ◽  
Cost Effective ◽  
Powder Particle Size ◽  
Scale Production ◽  
Matrix Composites ◽  
Weight Saving ◽  
Large Scale Production ◽  
Particle Size And Structure

P/M aluminium components are attracting interest in an increasing variety of industries due to the possibilities for weight saving in engineering parts. There are many processes for manufacturing from powder feedstocks that are either in production, becoming commercialised or still undergoing development. The nature of these processes and the required properties of the end products mean that powders of different particle size, shape, composition and microstructure must be produced. The requirements of various processes requiring aluminium and aluminium alloy powders for metal matrix composites, laser sintering, powder forging and metal injection moulding are discussed in relation to powder particle size and structure. The key requirement of the powder manufacturer is to supply cost effective materials for these different processes. This may require compromises to be made by the supplier and consumer while the techniques evolve from development to large scale production.

scholarly journals An Overview of the Photocatalytic Water Splitting over Suspended Particles

Catalysts ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 60
Author(s):  
Muhammad Amtiaz Nadeem ◽  
Mohd Adnan Khan ◽  
Ahmed Abdeslam Ziani ◽  
Hicham Idriss
Keyword(s):  
Water Splitting ◽  
Large Scale ◽  
Cost Effective ◽  
Synthetic Methods ◽  
Scale Production ◽  
Practical Applications ◽  
Co Catalysts ◽  
Large Scale Production ◽  
Cost Effective Method ◽  
Order Of Magnitude

The conversion of solar to chemical energy is one of the central processes considered in the emerging renewable energy economy. Hydrogen production from water splitting over particulate semiconductor catalysts has often been proposed as a simple and a cost-effective method for large-scale production. In this review, we summarize the basic concepts of the overall water splitting (in the absence of sacrificial agents) using particulate photocatalysts, with a focus on their synthetic methods and the role of the so-called “co-catalysts”. Then, a focus is then given on improving light absorption in which the Z-scheme concept and the overall system efficiency are discussed. A section on reactor design and cost of the overall technology is given, where the possibility of the different technologies to be deployed at a commercial scale and the considerable challenges ahead are discussed. To date, the highest reported efficiency of any of these systems is at least one order of magnitude lower than that deserving consideration for practical applications.

scholarly journals Simplified Hatchery Protocols for Culture of Orange-Spotted Spinefoot Siganus guttatus (Bloch, 1787) in Palawan, Philippines

2021 ◽  
Vol 34 (3) ◽  
Author(s):  
ELMER G. VILLANUEVA ◽  
KYRA HOEVENAARS ◽  
JONAH VAN BEIJNEN ◽  
AL P. GONZALES ◽  
LOTA A. CREENCIA ◽  
...  
Keyword(s):  
Large Scale ◽  
Survival Rates ◽  
Cost Effective ◽  
Scale Production ◽  
Weekly Basis ◽  
Growth And Survival ◽  
Commercial Diet ◽  
Large Scale Production ◽  
Intensive Rearing ◽  
Commercial Feeds

Three hatchery experiments for orange-spotted spinefoot, Siganus guttatus (Bloch, 1787), were carried out in Puerto Princesa City, Palawan, Philippines using larvae and fingerlings produced through induced spawning. The first experiment (E1) involving larvae raised in six 5,000-L concrete tanks until 39 days post-hatch (dph) comparing two stocking densities (T1: 3; and T2: 5 larva.L-1), obtained survival rates (SR) of 6.00 and 7.85 %. The second experiment (E2) monitored the growth and survival of 47 dph juveniles for 3 weeks, raised in 25-L plastic basins, fed with a commercial diet at three stocking densities with five replications. The initial stocking densities (6, 12, 18 ind.L-1) were reduced during the second (4, 8, 12 ind.L-1) and third (2, 4, 6 ind.L-1) week, respectively. The weekly SR for all treatments ranged between 99.2 and 100 %. Weekly final total lengths (TL) were not significantly different except during the second week. The third experiment (E3) evaluated the effects of two types of commercial feeds (T1: grouper feed; T2: milkfish feed) on the growth and survival of 47 dph juveniles in plastic basins for 3 weeks, at similar densities reduced on a weekly basis. The SR (96.2 to 99.9 %) were not significantly different, but the TL of fish in T1 (4.39 cm) were significantly bigger than in T2 (3.52 cm). While there is a need to improve the low and irregular survival of S. guttatus larvae for cost-effective large-scale production, we recommend using small basins in the intensive rearing of juveniles.

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