scholarly journals Dataset on a Small-Scale Film-Coating Process Developed for Self-Expanding 4D Printed Drug Delivery Devices

Coatings ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 1252
Author(s):  
Marco Uboldi ◽  
Alice Melocchi ◽  
Saliha Moutaharrik ◽  
Matteo Cerea ◽  
Andrea Gazzaniga ◽  
...  
Keyword(s):  
Shape Memory ◽  
Smart Materials ◽  
Fused Deposition Modeling ◽  
Surface Characteristics ◽  
Film Coating ◽  
Poly Vinyl Alcohol ◽  
Small Scale ◽  
Prolonged Release ◽  
Coating Process ◽  
Fused Deposition

Film-coating is widely applied in pharmaceutics to enhance aspect/taste and mechanical properties of dosage forms, to protect them from the environment and to modify their release performance. In this respect, a film-coating process was recently involved in the development of 4D printed prolonged-release systems intended for organ retention. During coating processes, liquid formulations are sprayed onto moving cores, whose shape, weight and surface characteristics are essential to attain a homogeneous film. Devices of complex shapes, composed of smart materials and fabricated by hot-processing techniques, such as extrusion and fused deposition modeling 3D printing, might be poorly compatible with the requirements of traditional coating methods, e.g., need for spherical substrates with smooth surface and stable under process temperatures. This work was aimed at evaluating, at a small scale level, the feasibility of a versatile equipment for film-coating of rod-shaped extruded and printed prototypes with different section. Equipment design and set up of process parameters were performed starting from polymeric solutions and suspensions and selecting as cores 50 mm-long rod-shaped samples based on shape memory poly(vinyl alcohol). Integrity and thickness of the applied layer and its impact on shape memory and release performance of prototypes were investigated.

Extrusion-Based 3D Printing for Pharmaceuticals: Contemporary Research and Applications

2019 ◽  
Vol 24 (42) ◽  
pp. 4991-5008 ◽  
Author(s):  
Mohammed S. Algahtani ◽  
Abdul Aleem Mohammed ◽  
Javed Ahmad
Keyword(s):  
Cosmetic Surgery ◽  
Fused Deposition Modeling ◽  
Personalised Medicine ◽  
Organ Transplant ◽  
Three Dimensional ◽  
Dosage Forms ◽  
Release Profile ◽  
Small Scale ◽  
Drug Release Profile ◽  
Fused Deposition

Three-dimensional printing (3DP) has a significant impact on organ transplant, cosmetic surgery, surgical planning, prosthetics and other medical fields. Recently, 3 DP attracted the attention as a promising method for the production of small-scale drug production. The knowledge expansion about the population differences in metabolism and genetics grows the need for personalised medicine substantially. In personalised medicine, the patient receives a tailored dose and the release profile is based on his pharmacokinetics data. 3 DP is expected to be one of the leading solutions for the personalisation of the drug dispensing. This technology can fabricate a drug-device with complicated geometries and fillings to obtain the needed drug release profile. The extrusionbased 3 DP is the most explored method for investigating the feasibility of the technology to produce a novel dosage form with properties that are difficult to achieve using the conventional industrial methods. Extrusionbased 3 DP is divided into two techniques, the semi-solid extrusion (SSE) and the fused deposition modeling (FDM). This review aims to explain the extrusion principles behind the two techniques and discuss their capabilities to fabricate novel dosage forms. The advantages and limitations observed through the application of SSE and FDM for fabrication of drug dosage forms were discussed in this review. Further exploration and development are required to implement this technology in the healthcare frontline for more effective and personalised treatment.

scholarly journals 3D Printing of Mini Tablets for Pediatric Use

2021 ◽  
Vol 14 (2) ◽  
pp. 143
Author(s):  
Julius Krause ◽  
Laura Müller ◽  
Dorota Sarwinska ◽  
Anne Seidlitz ◽  
Malgorzata Sznitowska ◽  
...  
Keyword(s):  
3D Printing ◽  
Fused Deposition Modeling ◽  
Dosage Forms ◽  
Small Scale ◽  
Fused Deposition ◽  
On Demand ◽  
Pediatric Diseases ◽  
Deposition Modeling ◽  
Manufacturing Techniques ◽  
Pediatric Use

In the treatment of pediatric diseases, suitable dosages and dosage forms are often not available for an adequate therapy. The use of innovative additive manufacturing techniques offers the possibility of producing pediatric dosage forms. In this study, the production of mini tablets using fused deposition modeling (FDM)-based 3D printing was investigated. Two pediatric drugs, caffeine and propranolol hydrochloride, were successfully processed into filaments using hyprolose and hypromellose as polymers. Subsequently, mini tablets with diameters between 1.5 and 4.0 mm were printed and characterized using optical and thermal analysis methods. By varying the number of mini tablets applied and by varying the diameter, we were able to achieve different release behaviors. This work highlights the potential value of FDM 3D printing for the on-demand production of patient individualized, small-scale batches of pediatric dosage forms.

scholarly journals Pressure Orientation-Dependent Recovery of 3D-Printed PLA Objects with Varying Infill Degree

Polymers ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1275 ◽  
Author(s):  
Guido Ehrmann ◽  
Andrea Ehrmann
Keyword(s):  
Shape Memory ◽  
Fused Deposition Modeling ◽  
Static Load ◽  
Shape Memory Polymer ◽  
Applied Pressure ◽  
Poly Lactic Acid ◽  
Fused Deposition ◽  
Deposition Modeling ◽  
Load Tests ◽  
3D Printed

Poly(lactic acid) is not only one of the most often used materials for 3D printing via fused deposition modeling (FDM), but also a shape-memory polymer. This means that objects printed from PLA can, to a certain extent, be deformed and regenerate their original shape automatically when they are heated to a moderate temperature of about 60–100 °C. It is important to note that pure PLA cannot restore broken bonds, so that it is necessary to find structures which can take up large forces by deformation without full breaks. Here we report on the continuation of previous tests on 3D-printed cubes with different infill patterns and degrees, now investigating the influence of the orientation of the applied pressure on the recovery properties. We find that for the applied gyroid pattern, indentation on the front parallel to the layers gives the worst recovery due to nearly full layer separation, while indentation on the front perpendicular to the layers or diagonal gives significantly better results. Pressing from the top, either diagonal or parallel to an edge, interestingly leads to a different residual strain than pressing from front, with indentation on top always firstly leading to an expansion towards the indenter after the first few quasi-static load tests. To quantitatively evaluate these results, new measures are suggested which could be adopted by other groups working on shape-memory polymers.

Physical property of 3D-printed sinusoidal pattern using shape memory TPU filament

2020 ◽  
Vol 90 (21-22) ◽  
pp. 2399-2410 ◽  
Author(s):  
Shahbaj Kabir ◽  
Hyelim Kim ◽  
Sunhee Lee
Keyword(s):  
Mechanical Properties ◽  
Tensile Test ◽  
Shape Memory ◽  
Fused Deposition Modeling ◽  
Loss Modulus ◽  
Thermoplastic Polyurethane ◽  
Heating Process ◽  
Fused Deposition ◽  
3D Printed ◽  
Sinusoidal Pattern

This study has investigated the physical properties of 3D-printable shape memory thermoplastic polyurethane (SMTPU) filament and its 3D-printed sinusoidal pattern obtained by fused deposition modeling (FDM) technology. To investigate 3D filaments, thermoplastic polyurethane (TPU) and SMTPU filament were examined by conducting infrared spectroscopy, x-ray diffraction (XRD), dynamic mechanical thermal analysis (DMTA), differential scanning calorimetry (DSC) and a tensile test. Then, to examine the 3D-printed sinusoidal samples, a sinusoidal pattern was developed and 3D-printed. Those samples went through a three-step heating process: (a) untreated state; (b) 5 min heating at 70°C, cooling for 30 min at room temperature; and (c) a repeat of step 2. The results obtained by the three different heating processes of the 3D-printed sinusoidal samples were examined by XRD, DMTA, DSC and the tensile test to obtain the effect of heating or annealing on the structural and mechanical properties. The results show significant changes in structure, crystallinity and thermal and mechanical properties of SMTPU 3D-printed samples due to the heating steps. XRD showed the increase in crystallinity with heating. In DMTA, storage modulus, loss modulus and the tan σ peak position also changed for various heating steps. The DSC result showed that the Tg for different steps of the SMTPU 3D-printed sample remained almost the same at around 51°C. The tensile property of the TPU 3D-printed sinusoidal sample decreased in terms of both load and elongation with increased heating processes, while for the SMTPU 3D-printed sinusoidal sample, the load decreased but elongation increased about 2.5 times.

scholarly journals Experience of implementation in educational process modern technologies of FDM 3D printing

2021 ◽  
pp. 55-59
Author(s):  
Petr Andrienko ◽  
Vladimir Vasilevskij ◽  
Ivan Vittsivskyi
Keyword(s):  
Additive Manufacturing ◽  
3D Printing ◽  
Fused Deposition Modeling ◽  
Current Transformer ◽  
Educational Process ◽  
Small Scale ◽  
Thermoplastic Material ◽  
Fused Deposition ◽  
Deposition Modeling ◽  
Modern Technologies

Fused Deposition Modeling is an additive manufacturing technology where a temperature-controlled head extrudes a thermoplastic material onto a build platform in a predetermined path. Standard, advanced thermoplastics and composites are used for printing. Among the areas of application for FDM printing, the main ones are rapid prototyping, as well as small-scale and batch production. The purpose of the work is the implementation of FDM 3D printing technology in the educational process of students in specialty 141 "Electroenergy, electrotechnics and electromechanics". The features of the technology of additive manufacturing of electrical apparatuses parts by the method of FDM printing have been investigated. Parts of four standard sizes were printed using ABS + and PLA plastics, namely, current transformer carcasses in the amount of 110 pieces and sensor bodies in the amount of 100 pieces. For printing, an FDM 3D printer was used built on the XZ Head Y Bed kinematic scheme with an open working chamber. The analysis of defects in finished products was carried out, which showed that the main defects are deviations of the actual dimensions and geometric shape of the finished products. Ways to prevent the occurrence of these defects are considered, namely, correcting the size of the model at the stage of preparing the model for printing, minimizing the filling density of the model, using brims in models, setting the optimal temperature of the working platform and simultaneously printing several products. The results of the study o features of the technology of additive manufacturing of electrical apparatuses parts by the method of FDM printing made it possible to develop a set of laboratory works for students of the specialty 141 "Electroenergy, electrotechnics and electromechanics".

Additive manufacturing of shape memory polymers: effects of print orientation and infill percentage on shape memory recovery properties

2020 ◽  
Vol 26 (9) ◽  
pp. 1593-1602
Author(s):  
Jorge Villacres ◽  
David Nobes ◽  
Cagri Ayranci
Keyword(s):  
Additive Manufacturing ◽  
Shape Memory ◽  
Shape Recovery ◽  
Fused Deposition Modeling ◽  
Large Strain ◽  
Shape Memory Polymers ◽  
Polymeric Materials ◽  
Content Type ◽  
Fused Deposition ◽  
Memory Recovery

Purpose The purpose of this paper is to study the shape memory properties of SMP samples produced through a MEAM process. Fused deposition modeling or, as it will be referred to in this paper, material extrusion additive manufacturing (MEAM) is a technique in which polymeric materials are extruded though a nozzle creating parts via accumulation and joining of different layers. These layers are fused together to build three-dimensional objects. Shape memory polymers (SMP) are stimulus responsive materials, which have the ability to recover their pre-programmed form after being exposed to a large strain. To induce its shape memory recovery movement, an external stimulus such as heat needs to be applied. Design/methodology/approach This project investigates and characterizes the influence of print orientation and infill percentage on shape recovery properties. The analyzed shape recovery properties are shape recovery force, shape recovery speed and time elapsed before activation. To determine whether the analyzed factors produce a significant variation on shape recovery properties, t-tests were performed with a 95% confidence factor between each analyzed level. Findings Results proved that print angle and infill percentage do have a significant impact on recovery properties of the manufactured specimens. Originality/value The manufacturing of SMP objects through a MEAM process has a vast potential for different applications; however, the shape recovery properties of these objects need to be analyzed before any practical use can be developed. These have not been studied as a function of print parameters, which is the focus of this study.

Sign in / Sign up

Export Citation Format

Share Document