scholarly journals Design, Preparation, and Characterization of Effective Dermal and Transdermal Lipid Nanoparticles: A Review

Cosmetics ◽  
2021 ◽  
Vol 8 (2) ◽  
pp. 39
Author(s):  
Dima Khater ◽  
Hamdi Nsairat ◽  
Fadwa Odeh ◽  
Mais Saleh ◽  
Areej Jaber ◽  
...  
Keyword(s):  
Stratum Corneum ◽  
Transdermal Delivery ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Recent Application ◽  
Active Compounds ◽  
Solid Lipid ◽  
Lipid Nanocarriers ◽  
Skin Care Products

Limited permeability through the stratum corneum (SC) is a major obstacle for numerous skin care products. One promising approach is to use lipid nanoparticles as they not only facilitate penetration across skin but also avoid the drawbacks of conventional skin formulations. This review focuses on solid lipid nanoparticles (SLNs), nanostructured lipid nanocarriers (NLCs), and nanoemulsions (NEs) developed for topical and transdermal delivery of active compounds. A special emphasis in this review is placed on composition, preparation, modifications, structure and characterization, mechanism of penetration, and recent application of these nanoparticles. The presented data demonstrate the potential of these nanoparticles for dermal and transdermal delivery.

Preparation and characterization of sumatriptan loaded solid lipid nanoparticles for transdermal delivery

2020 ◽  
Vol 57 ◽  
pp. 101719
Author(s):  
Soliman Mohammadi-Samani ◽  
Hasan Salehi ◽  
Elaheh Entezar-Almahdi ◽  
Moein Masjedi
Keyword(s):  
Transdermal Delivery ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Solid Lipid

scholarly journals Formulation and characterization of solid lipid nanoparticles, nanostructured lipid carriers and nanoemulsion of lornoxicam for transdermal delivery

2015 ◽  
Vol 65 (1) ◽  
pp. 1-13 ◽  
Author(s):  
Ümit Gönüllü ◽  
Melike Üner ◽  
Gülgün Yener ◽  
Ecem Fatma Karaman ◽  
Zeynep Aydoğmuş
Keyword(s):  
Transdermal Delivery ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Nanostructured Lipid Carriers ◽  
Drug Penetration ◽  
Rat Skin ◽  
Drug Diffusion ◽  
Solid Lipid ◽  
Inflammatory Conditions

Abstract Solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC) and nanoemulsion (NE) of lornoxicam (LRX) were prepared for the treatment of painful and inflammatory conditions of the skin. Compritol® 888 ATO, Lanette® O and oleic acid were used as solid and liquid lipids. SLN, NLC and NE were found physically stable at various temperatures for 6 months. Case I diffusional drug release was detected as the dominant mechanism indicating Fickian drug diffusion from nanoparticles and nanoemulsion. The highest rate of drug penetration through rat skin was obtained with NE followed by NLC, SLN and a gel formulation. Nanoformulations significantly increased drug penetration through rat skin compared to the gel (p < 0.05). Thus, SLN, NLC and NE of LRX can be suggested for relieving painful and inflammatory conditions of the skin

Nephrotoxicity of Albendazole and Albendazole-Loaded Solid Lipid Nanoparticles in Mice with Experimental Hydatidosis

2021 ◽  
Author(s):  
Kobra Kohansal ◽  
Abdollah Rafiei ◽  
Heibatullah Kalantari ◽  
Ali Jelowdar ◽  
Anayatollah Salimi ◽  
...  
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Physicochemical Characterization ◽  
Public Health Problem ◽  
New Product ◽  
Lipid Nanoparticles ◽  
Control Group ◽  
Histopathological Study ◽  
Normal Range ◽  
Solid Lipid

Purposes: Cystic echinococcosis (CE) is a serious contemporary public health problem. Different CE treatment methods are of considerable importance, with albendazole (ABZ) being one of the most preferred drugs for CE treatment and prophylaxis. In this study, we evaluated the nephrotoxicity caused by ABZ and ABZ-loaded solid lipid nanoparticles (SLNs) in mice with experimental hydatid cyst. Methods: ABZ-loaded SLNs were produced by micro-emulsification and a high shear homogenization technique. Thereafter, we evaluated the physicochemical characterization of the product. Live protoscolices were injected into mice to induce experimental hydatidosis. Mice were then treated with ABZ and ABZ-loaded SLNs. The nephrotoxicity effects were evaluated by biochemical and histopathological surveys. Results: Significantly different blood urea nitrogen (BUN) levels were observed between the two infected groups (ABZ treatment and ABZ-loaded SLN treatment) and the control group. The kidney malondialdehyde (MDA) and glutathione (GSH) levels of the infected groups were not significantly different from those of the control group. The histopathological study revealed nephropathic and pathologic changes in the ABZ and ABZ-loaded SLN groups. Conclusion: ABZ formulated for ABZ-loaded SLNs had a more prominent chemoprophylactic efficacy on CE and fewer side effects than ABZ alone. Neither ABZ nor ABZ-loaded SLNs caused significant biochemical and histopathological defects on the kidney, and all functional biochemical markers stayed within the normal range. Therefore, ABZ-loaded SLNs could be a potential new product for CE treatment.

Transdermal Delivery of Curcumin-Loaded Solid Lipid Nanoparticles as Microneedle Patch: an In Vitro and In Vivo Study

2022 ◽  
Vol 23 (1) ◽  
Author(s):  
Ankitha Prabhu ◽  
Jobin Jose ◽  
Lalit Kumar ◽  
S Salwa ◽  
M Vijay Kumar ◽  
...  
Keyword(s):  
Transdermal Delivery ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
In Vivo Study ◽  
Solid Lipid ◽  
Microneedle Patch
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