scholarly journals Genes and Weightlifting Performance

Genes ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 25
Author(s):  
Naoki Kikuchi ◽  
Ethan Moreland ◽  
Hiroki Homma ◽  
Ekaterina A. Semenova ◽  
Mika Saito ◽  
...  
Keyword(s):  
Genomic Dna ◽  
Case Control Study ◽  
Case Control ◽  
Dna Polymorphisms ◽  
Array Analysis ◽  
East European ◽  
Micro Array ◽  
Control Study ◽  
Independent Cohort ◽  
Polygenic Approach

A recent case-control study identified 28 DNA polymorphisms associated with strength athlete status. However, studies of genotype-phenotype design are required to support those findings. The aim of the present study was to investigate both individually and in combination the association of 28 genetic markers with weightlifting performance in Russian athletes and to replicate the most significant findings in an independent cohort of Japanese athletes. Genomic DNA was collected from 53 elite Russian (31 men and 22 women, 23.3 ± 4.1 years) and 100 sub-elite Japanese (53 men and 47 women, 21.4 ± 4.2 years) weightlifters, and then genotyped using PCR or micro-array analysis. Out of 28 DNA polymorphisms, LRPPRC rs10186876 A, MMS22L rs9320823 T, MTHFR rs1801131 C, and PHACTR1 rs6905419 C alleles positively correlated (p < 0.05) with weightlifting performance (i.e., total lifts in snatch and clean and jerk in official competitions adjusted for sex and body mass) in Russian athletes. Next, using a polygenic approach, we found that carriers of a high (6–8) number of strength-related alleles had better competition results than carriers of a low (0–5) number of strength-related alleles (264.2 (14.7) vs. 239.1 (21.9) points; p = 0.009). These findings were replicated in the study of Japanese athletes. More specifically, Japanese carriers of a high number of strength-related alleles were stronger than carriers of a low number of strength-related alleles (212.9 (22.6) vs. 199.1 (17.2) points; p = 0.0016). In conclusion, we identified four common gene polymorphisms individually or in combination associated with weightlifting performance in athletes from East European and East Asian geographic ancestries.

Analysis of glutathione S-transferase genes polymorphisms and the risk of schizophrenia in a sample of Iranian population

2011 ◽  
Vol 7 (2-4) ◽  
pp. 199-203 ◽  
Author(s):  
Farah Lotfi Kashani ◽  
Dor Mohammad Kordi-Tamandani ◽  
Roya Sahranavard ◽  
Mohammad Hashemi ◽  
Farzaneh Kordi-Tamandani ◽  
...  
Keyword(s):  
Genomic Dna ◽  
Case Control Study ◽  
Gene Interaction ◽  
Case Control ◽  
Glutathione S Transferase ◽  
Chain Reaction ◽  
Healthy Control ◽  
Glutathione S Transferases ◽  
Polymerase Chain ◽  
Control Study

Glutathione S-transferases (GSTs) are major intracellular antioxidants, which, impaired in their function, are involved in the progress of schizophrenia (SCZ). The aim of this case-control study was to investigate the association between the polymorphism of glutathione S-transferases M1 (GSTM1), T1 (GSTT1), the glutathione S-transferase P1 gene (GSTP1) and SCZ. We isolated genomic DNA from peripheral blood of 93 individuals with SCZ and 99 healthy control subjects' genotypes analyzing them for GSTM1, GSTT1 and GSTP1 using polymerase chain reaction. The analysis of the gene–gene interaction between GSTs indicated that the magnitude of the association was greater for the combined AG/GSTT1 & GSTM1 genotypes (OR = 2.51; 95% CI: 1.13–5.63, P = 0.02). The AG and combined AG + GG genotypes of GSTP1 increased the risk of SCZ (OR = 1.83; 95% CI: 0.94–3.75 and OR = 1.71; 95% CI: 0.92–3.19, respectively). The genotypes of GSTT/NULL, NULL/GSTM and NULL/NULL increased the risk of SCZ (OR = 2.05; 95% CI: 0.9–4.74; OR = 2.0; 95% CI: 1.68–2.31; and OR = 1.8; 95% CI: 0.57–2.46, respectively). The present study supports previous data that suggest that impairment in the function of GSTs genes may increase the risk of SCZ.

Folate status, genomic DNA hypomethylation, and risk of colorectal adenoma and cancer: a case control study

2003 ◽  
Vol 124 (5) ◽  
pp. 1240-1248 ◽  
Author(s):  
Maria Pufulete ◽  
Reyad Al-Ghnaniem ◽  
Andrew J.M Leather ◽  
Paul Appleby ◽  
Sally Gout ◽  
...  
Keyword(s):  
Colorectal Adenoma ◽  
Genomic Dna ◽  
Case Control Study ◽  
Case Control ◽  
Dna Hypomethylation ◽  
Folate Status ◽  
Control Study

scholarly journals Glutathione Peroxidase1 Gene Polymorphism (GPx1 Pro198Leu) in Association with Blighted Ovum

2016 ◽  
Author(s):  
Asiyeh Moshtaghi ◽  
Reyhaneh Sariri ◽  
Hamidreza Vaziri ◽  
Horiyeh Shayegan
Keyword(s):  
Statistical Analysis ◽  
Gene Polymorphism ◽  
Genomic Dna ◽  
Obstet Gynecol ◽  
Case Control Study ◽  
Case Control ◽  
Glutathione Peroxidase 1 ◽  
Control Study ◽  
Blighted Ovum

Objective: To evaluate salivary GPx-1 gene polymorphism in pregnant women suffering from blighted ovum. Method: In this case-control study, 34 blighted ovum patients and 34 healthy controls were studied. Genomic DNA was extracted from the saliva. The genotypes were determined by restriction fragment length polymorphism (RFLP-PCR) technique. Mad Calc (version 12.1) was used for statistical analysis. Result: The frequency of CC, CT, and TT genotypes of GPx-1 gene were 41%, 44% and 14%, respectively in blighted ovum patients and in healthy volunteers were 44%, 47%, and 8.82-9%, respectively. After statistical analysis, the study showed no significant association between this polymorphism and blighted ovum (with p = 0.63). Conclusion: These results indicated no significant association between GPx-1 (Pro198Leu) polymorphism and blighted ovum. However, further research is required to clarify the role of gene polymorphism in blighted ovum. [Indones J Obstet Gynecol 2016; 1: 15-18] Keywords: abortion, blighted ovum, glutathione peroxidase-1, GPx- 1, RFLP-PCR

HLA-A*24:07 as a potential biomarker for carbamazepine-induced Stevens–Johnson syndrome/toxic epidermal necrolysis in Filipino patients

2021 ◽  
Author(s):  
Francis Capule ◽  
Pramote Tragulpiankit ◽  
Surakameth Mahasirimongkol ◽  
Jiraphun Jittikoon ◽  
Nuanjun Wichukchinda ◽  
...  
Keyword(s):  
Toxic Epidermal Necrolysis ◽  
Medical Records ◽  
Odds Ratio ◽  
Genomic Dna ◽  
Case Control Study ◽  
Case Control ◽  
Stevens Johnson Syndrome ◽  
Johnson Syndrome ◽  
Potential Biomarker ◽  
Control Study

Aim: A case-control study was conducted in Filipino patients to determine the association between HLA alleles and carbamazepine-induced Stevens–Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN). Materials & methods: A retrospective review of medical records and data collection were performed. A total of 10 carbamazepine-induced SJS/TEN cases and 40 tolerant controls were recruited. Genomic DNA extracted from saliva samples was genotyped. Statistical analysis was done. Results: The HLA-B75 serotype (p = 0.003; odds ratio [OR] = 13.8; 95% CI = 2.5–76.8), HLA-B*15:21 (p = 0.041; OR = 4.7; 95% CI = 1.1–20.8) and HLA-A*24:07 (p = 0.032; OR = 6; 95% CI = 1.2–30.7) were significantly associated with carbamazepine-induced SJS/TEN. Conclusion: The HLA-B75 serotype, HLA-B*15:21 or HLA-A*24:07 may be used for pharmacogenetic screening prior to prescribing carbamazepine in Filipinos.

scholarly journals Does the Polymorphism in the Length of the Polyalanine Tract ofFOXE1Gene Influence the Risk of Thyroid Dysgenesis Occurrence?

2017 ◽  
Vol 2017 ◽  
pp. 1-6
Author(s):  
Clebson Pantoja Pimentel ◽  
Erik Artur Cortinhas-Alves ◽  
Edivaldo Herculano Correa de Oliveira ◽  
Luiz Carlos Santana-da-Silva
Keyword(s):  
Genomic Dna ◽  
Case Control Study ◽  
Case Control ◽  
Control Group ◽  
Thyroid Dysgenesis ◽  
Susceptibility Factor ◽  
History Of ◽  
And Control ◽  
Polyalanine Tract ◽  
Control Study

Background.Recent data have suggested that polymorphisms in the length of the polyalanine tract (polyA) ofFOXE1gene may act as a susceptibility factor for thyroid dysgenesis. The main purpose of this study was to investigate the influence of polyA ofFOXE1gene on the risk of thyroid dysgenesis.Method.A case-control study was conducted in a sample of 90 Brazilian patients with thyroid dysgenesis and 131 controls without family history of thyroid disease. Genomic DNA was isolated from peripheral blood samples and the genotype of each individual was determined by automated sequencing.Results.More than 90% of genotypes found in the group of patients with thyroid dysgenesis and in controls subjects were represented by sizes 14 and 16 polymorphisms in the following combinations: 14/14, 14/16, and 16/16. Genotypes 14/16 and 16/16 were more frequent in the control group, while genotype 14/14 was more frequent in the group of patients with thyroid dysgenesis. There was no difference between agenesis group and control group. Genotype 14/14 when compared to genotypes 14/16 and 16/16A showed an association with thyroid dysgenesis.Conclusion.PolyA ofFOXE1gene alters the risk of thyroid dysgenesis, which may explain in part the etiology of this disease.

scholarly journals Genomic DNA hypomethylation as a biomarker for bladder cancer susceptibility in the Spanish Bladder Cancer Study: a case–control study

2008 ◽  
Vol 9 (4) ◽  
pp. 359-366 ◽  
Author(s):  
Lee E Moore ◽  
Ruth M Pfeiffer ◽  
Cristina Poscablo ◽  
Francisco X Real ◽  
Manolis Kogevinas ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Genomic Dna ◽  
Case Control Study ◽  
Cancer Susceptibility ◽  
Case Control ◽  
Dna Hypomethylation ◽  
Cancer Study ◽  
Control Study

scholarly journals Genomic DNA Hypomethylation and Risk of Renal Cell Carcinoma: A Case–Control Study

2015 ◽  
Vol 22 (8) ◽  
pp. 2074-2082 ◽  
Author(s):  
Julia Mendoza- Pérez ◽  
Jian Gu ◽  
Luis A. Herrera ◽  
Nizar M. Tannir ◽  
Surena F. Matin ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Genomic Dna ◽  
Case Control Study ◽  
Case Control ◽  
Dna Hypomethylation ◽  
Control Study

scholarly journals The association of Q472H variant in the KDR gene with recurrent pregnancy loss in Southern Iran: A case-control study

2019 ◽  
Author(s):  
Leila Keshavarz ◽  
Majid Yavarian
Keyword(s):  
Genomic Dna ◽  
Case Control Study ◽  
Melting Curve ◽  
Case Control ◽  
Melting Curve Analysis ◽  
Term Infants ◽  
Southern Iran ◽  
High Resolution Melting Curve ◽  
Increased Risk ◽  
Control Study

Background: Recurrent spontaneous abortion (RSA) often remains unclear and can be burden for the patient and time consuming for clinician. RSA may initiates from a genetic or non-genetic factors. It is well known that the quality of placental circulation is critical for implantation and embryo development. Because of angiogenic effects of VEGF–KDR pathway on placenta, the genes involved in this pathway (the KDR or VEGFR genes) are thought to be linked with RSA. Objective: The aim of this study was to investigate the relationship between Gln472His (A/T) polymorphism of the KDR gene with RSAs in southern Iran. Materials and Methods: In this case-control study, 50 aborted embryonic tissue obtained from fetuses and 50 umbilical cord blood of newborn babies were studied. Fetal sample from mothers with history of at least two consecutive miscarriages and controls from mothers who had at least one full-term infants born were taken. Genomic DNA was extracted by using PureLink genomic DNA kit (Life Technologies, CA). The Rotor-Gene Q real-Time PCR machine and High-resolution melting curve analysis (HRM) technique were used for genotyping. Results: Based on the AA genotype as reference, it is shown that the T allele (OR = 2.447, 95% CI = 1.095–5.468, p = 0.029) as well as AT heterozygote genotype was significantly associated with an increased risk of miscarriage (OR = 2.824, 95% CI = 1.210-6.673, p = 0.016). Conclusion: A positive correlation between Q472H polymorphism of the KDR gene and RSA may be the cause in southern Iran.

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