Lipid-Associated Variants near ANGPTL3 and LPL Show Parent-of-Origin Specific Effects on Blood Lipid Levels and Obesity

Parent-of-origin effects (POE) and sex-specific parental effects have been reported for plasma lipid levels, and a strong relationship exists between dyslipidemia and obesity. We aim to explore whether genetic variants previously reported to have an association to lipid traits also show POE on blood lipid levels and obesity. Families from the Botnia cohort and the Hungarian Transdanubian Biobank (HTB) were genotyped for 12 SNPs, parental origin of alleles were inferred, and generalized estimating equations were modeled to assess parental-specific associations with lipid traits and obesity. POE were observed for the variants at the TMEM57, DOCK7/ANGPTL3, LPL, and APOA on lipid traits, the latter replicated in HTB. Sex-specific parental effects were also observed; variants at ANGPTL3/DOCK7 showed POE on lipid traits and obesity in daughters only, while those at LPL and TMEM57 showed POE on lipid traits in sons. Variants at LPL and DOCK7/ANGPTL3 showed POE on obesity-related traits in Botnia and HTB, and POE effects on obesity were seen to a higher degree in daughters. This highlights the need to include analysis of POEs in genetic studies of complex traits.

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Comparative Studies of Lipid Metabolism in Zebu and British Cattle in a Tropical Environment. II. Blood Lipid Levels of Cattle on Different Diets

Australian Journal of Biological Sciences ◽

10.1071/bi9681025 ◽

1968 ◽

Vol 21 (5) ◽

pp. 1025 ◽

Cited By ~ 12

Author(s):

JC O'kelly

Keyword(s):

Total Cholesterol ◽

Plasma Lipid ◽

Blood Lipid ◽

Lipid Levels ◽

Plasma Total Cholesterol ◽

Cholesterol Ratio ◽

Breed Differences ◽

Quality Diet ◽

Dietary Treatments ◽

Blood Lipid Levels

Breed differences in plasma lipid levels were previously reported for cattle grazing near Rockhampton, Qld. The present study investigated the blood lipids of British� and Zebu� type cattle subjected to the same dietary treatments. On high-quality diets only plasma non�esterified fatty acid concentrations were significantly affected (P < 0�01) by level of intake. Plasma total cholesterol, phospholipid, and triglyceride levels were depressed by a low-quality diet which elevated the free: total cholesterol ratio.

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Rare coding variants in 35 genes associate with circulating lipid levels – a multi-ancestry analysis of 170,000 exomes

10.1101/2020.12.22.423783 ◽

2020 ◽

Author(s):

George Hindy ◽

Peter Dornbos ◽

Mark D. Chaffin ◽

Dajiang J. Liu ◽

Minxian Wang ◽

...

Keyword(s):

Complex Traits ◽

Drug Target ◽

Large Scale ◽

Target Genes ◽

Genome Wide Association Study ◽

Sequence Data ◽

Blood Lipid ◽

Nucleotide Polymorphisms ◽

Lipid Levels ◽

Blood Lipid Levels

SummaryLarge-scale gene sequencing studies for complex traits have the potential to identify causal genes with therapeutic implications. We performed gene-based association testing of blood lipid levels with rare (minor allele frequency<1%) predicted damaging coding variation using sequence data from >170,000 individuals from multiple ancestries: 97,493 European, 30,025 South Asian, 16,507 African, 16,440 Hispanic/Latino, 10,420 East Asian, and 1,182 Samoan. We identified 35 genes associated with circulating lipid levels. Ten of these: ALB, SRSF2, JAK2, CREB3L3, TMEM136, VARS, NR1H3, PLA2G12A, PPARG and STAB1 have not been implicated for lipid levels using rare coding variation in population-based samples. We prioritize 32 genes identified in array-based genome-wide association study (GWAS) loci based on gene-based associations, of which three: EVI5, SH2B3, and PLIN1, had no prior evidence of rare coding variant associations. Most of the associated genes showed evidence of association in multiple ancestries. Also, we observed an enrichment of gene-based associations for low-density lipoprotein cholesterol drug target genes, and for genes closest to GWAS index single nucleotide polymorphisms (SNP). Our results demonstrate that gene-based associations can be beneficial for drug target development and provide evidence that the gene closest to the array-based GWAS index SNP is often the functional gene for blood lipid levels.

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Study in the Effect of Yavavati in the Management of Dyslipidemia

International Journal of Ayurvedic Medicine ◽

10.47552/ijam.v11i2.1475 ◽

2020 ◽

Vol 11 (2) ◽

pp. 265-270

Author(s):

Tejas Laxman Kakade ◽

Sadhana Misar Wajpeyi

Keyword(s):

Total Cholesterol ◽

Plasma Lipid ◽

Lipoprotein Metabolism ◽

Density Lipoprotein ◽

Blood Lipid ◽

Female Gender ◽

Lipid Levels ◽

Causative Factors ◽

Lukewarm Water ◽

Blood Lipid Levels

Dyslipidemia is considered as metabolic disorders related to lipoprotein metabolism, manifested as rise in plasma levels of total Cholesterol, Triglyceride (TGs), or both, or a decrease in high density lipoprotein level or all three together that contributes to the formation of atherosclerosis. It can be included under santarpanjanyavyadhi. Various conditions like Shonitabhishyandana, Rasagata SnehaVriddhi (raised plasma lipid levels), Rasaraktagata Snehavriddhi (raised plasma and blood lipid levels), Medovriddhi (elevation of generalized fat), Medoroga (obesity), Aam Medodhatu (abnormal form of adipose tissue) can be correlated with Dyslipidemia due to resemblance of their etiopathogenesis and clinical features. Total 30 patients of dyslipidemia fulfilling the diagnostic criteria were selected and treated with Yavavati 1.5 gm twice a day before meal with lukewarm water for 30 days. In this study it was observed that incidence of Dyslipidemia was more in advanced ages,female gender, middle socioeconomic group individuals having vatapittajaprakruti, madhyamagni and madhyamaakruti. In present study, sedentary lifestyle, day sleep, association of other diseases like hypertension, DM, hypothyroidism and hemiplegia are the main causative factors for Dyslipidemia. Yavavati showed significant improvement in BMI, total cholesterol, S.Triglicerides, S.VLDL and HDL level. This improvement may be due to its ruksha, lekhana, kaphamedahar, agnivadhaka and apatarpana properties of Yavavati. Hence from this study it can be concluded that, Yavavati is effective and can be safely used in the management of Dyslipidemia.

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The Effect of Knowledge, Behaviors, and Attitudes Towards Dietary Fatty Acids on Blood Lipid Levels

The Boller Review ◽

10.18776/tcu/br/4/110 ◽

2019 ◽

Vol 4 ◽

Author(s):

Amber Deckard

Keyword(s):

Fatty Acids ◽

Blood Lipid ◽

Strong Relationship ◽

Dietary Fatty Acids ◽

Blood Cholesterol ◽

Food Sources ◽

Lipid Levels ◽

Animal Fat ◽

Lipid Panel ◽

Blood Lipid Levels

Research has shown a strong relationship between dietary fatty acids (FAs) and their impact on blood cholesterol. Few studies have examined knowledge, behaviors and attitudes (KBA) towards dietary FAs impact blood lipid levels. The objective of this project was to determine: 1) KBA of FAs using the modified General Nutrition Knowledge Questionnaire (GNKQ); and 2) correlations between anthropometric data, GNKQ responses, and blood lipid levels. This study utilized across-sectional research design in which 104 women ages 18-40 consented and completed the modified GNKQ via Qualtrics®. The GNKQ consisted of 70 questions. Additionally, a subset of nine women also were instructed to fast for 12-15 hours prior to testing at the Obesity Prevention Laboratory at TCU. Height (cm), weight (kg), BMI (kg/m2), waist-to-hip ratio were recorded. Next, a fasting blood sample (5mL) was obtained. The blood samples were sent to AnyLabTestNow® (Fort Worth, Texas) for a lipid panel. Results were then analyzed via IBM SPSS® (Statistics Version 25.0. Armonk, NY). Significance was set at p<0.05.More than 80% of participants were aware of saturated, monounsaturated, and polyunsaturated FAs, but only 33.3% were able to identify their proper food sources. Of the 34 knowledge-based questions, approximately 1.9% demonstrated poor knowledge (answered 0-11 questions correctly), 54.3% moderate knowledge (12-23 questions correctly), and 43.8% strong knowledge (24-34 questions correctly). For the subset, there was a significant negative correlation between LDL and participants who self-reported consuming less or maintaining current consumption of animal fat (r= -0.725, p=0.027). There were no other significant correlations between KBA and lipid panel results. Despite self-reported awareness, participants lack knowledge of dietary FAs. The subset results showed strong correlation between LDL and consumption of animal fat representing the relationship between diet and lipid levels. Overall, more research should is needed with a larger sample.

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