scholarly journals Sudden Death from Primary Cerebral Melanoma: Clinical Signs and Pathological Observations

Healthcare ◽  
2021 ◽  
Vol 9 (3) ◽  
pp. 341
Author(s):  
Alfonso Maiellaro ◽  
Antonio Perna ◽  
Pasquale Giugliano ◽  
Massimiliano Esposito ◽  
Giuseppe Vacchiano
Keyword(s):  
Sudden Death ◽  
Parietal Lobe ◽  
Clinical Symptoms ◽  
Clinical Signs ◽  
Forensic Pathologist ◽  
Unexpected Death ◽  
Autopsy Series ◽  
Medicolegal Autopsy ◽  
The Right ◽  
Uncommon Neoplasm

Primary cerebral tumors rarely provoke sudden death. The incidence is often underestimated with reported frequencies in the range of 0.02 to 2.1% in medicolegal autopsy series. Furthermore, primary cerebral melanoma is an uncommon neoplasm. It represents approximately 1% of all melanoma cases and 0.07% of all brain tumors. This neoplasm is very aggressive, and its annual incidence is about 1 in 10 million people. In the present study, a 20-year-old male was admitted to hospital with vomiting, headache, paresthesia and aggressive behavior. A computed tomography (CT) scan of the head was performed showing a hyperdense nodule in the right parietal lobe with inflammation of the Silvian fissure. A complete autopsy was performed 48 h after death. A blackish material was displayed on the skull base, and posterior fossa. Microscopic examination diagnosed primary brain melanoma. A systematic review of the literature was also performed where no previous analogous cases were found. The forensic pathologist rarely encounters primary cerebral melanoma, and for these reasons, it seemed appropriate to describe this case as presenting aspecific clinical symptoms and leading to sudden unexpected death. Histopathological observations are reported and discussed to explain this surprising sudden death caused by a primary cerebral melanoma.

scholarly journals Pathological, Bacteriological and Virological Findings in Sudden and Unexpected Deaths in Young Dogs

Animals ◽  
2020 ◽  
Vol 10 (7) ◽  
pp. 1134
Author(s):  
Giuseppe Piegari ◽  
Lorena Cardillo ◽  
Flora Alfano ◽  
Lucia Vangone ◽  
Valentina Iovane ◽  
...  
Keyword(s):  
Sudden Death ◽  
Clinical Symptoms ◽  
World Health ◽  
Unexpected Death ◽  
Proportional Mortality ◽  
Mortality Ratio ◽  
Health Organization ◽  
Specific Symptoms ◽  
Canine Parvovirus Type 2

In human medicine, “sudden death” has been defined by the World Health Organization (WHO) as a non-violent, unexpected death occurring less than 24 h from the onset of symptoms. The aims of this study were: (1) to estimate the proportional mortality ratio for “sudden and unexpected death” (SUD) in young dogs; (2) to investigate the pathological and microbiological findings in SUD cases in young dogs. For these purposes, a retrospective study of a total of 145 cases of young dead dogs was performed. For each case, we collected information about the age, medical history and the gross and microbiological findings of the animals. The results of this study found 21 cases of SUD. The most frequently observed clinical symptoms in the cases of sudden death were acute respiratory symptoms, followed by acute gastroenteric symptoms, non-specific symptoms and neurological symptoms. The evaluation of necropsy reports allowed us to observe enteritis in 18 out of 21 cases and pneumonia in seven out of 21 cases. Viral infection with Canine parvovirus type 2 was the most common cause of SUD observed. These results could provide a valuable tool for the investigation of sudden death in young dogs.

2. Sudden Death in a Child Due to Rare Endocranial Neoformation

1998 ◽  
Vol 38 (2) ◽  
pp. 176-178 ◽  
Author(s):  
S Buzzi ◽  
C Verdura ◽  
S Arlati ◽  
M Colecchia
Keyword(s):  
Sudden Death ◽  
Cause Of Death ◽  
Pilocytic Astrocytoma ◽  
Clinical Signs ◽  
Unexpected Death ◽  
Specific Symptoms

A case of unexpected death in a six-year-old child, who died after a period of non-specific symptoms and clinical signs, is described. The cause of death was a pilocytic astrocytoma of the pontocerebellar angle, rare with regard to location and histology. The authors have reviewed the literature, which was scanty.

scholarly journals Achilles Tendon Structure Differs Between Runners And Non-Runners Despite No Clinical Signs Or Symptoms Of Mid-Substance Tendinopathy

2018 ◽  
Author(s):  
Todd J. Hullfish ◽  
Kenton L. Hagan ◽  
Ellen Casey ◽  
Josh R. Baxter
Keyword(s):  
Young Adults ◽  
Achilles Tendon ◽  
Clinical Symptoms ◽  
Clinical Signs ◽  
Achilles Tendinopathy ◽  
Ultrasound Images ◽  
Distance Running ◽  
Distance Runners ◽  
Structural Differences ◽  
The Right

AbstractAchilles tendinopathy affects many running athletes and often leads to chronic pain and functional deficits. While changes in tendon structure have been linked with tendinopathy, the effects of distance running on tendon structure is not well understood. Therefore, the purpose of this study was to characterize structural differences in the Achilles tendons in healthy young adults and competitive distance runners using quantitative ultrasound analyses. We hypothesized that competitive distance runners with no clinical signs or symptoms of tendinopathy would have quantitative signs of tendon damage, characterized by decreased collagen alignment and echogenicity, in addition to previous reports of thicker tendons. Longitudinal ultrasound images of the right Achilles tendon mid-substance were acquired in competitive distance runners and recreationally-active adults. Collagen organization, mean echogenicity, and tendon thickness were quantified using image processing techniques. Clinical assessments confirmed that runners had no signs or symptoms of tendinopathy and controls were only included if they had no history of Achilles tendon pain or injuries. Runner tendons were 40% less organized, 48% thicker, and 41% less echogenic compared to the control tendons (p < 0.001). Young adults engaged in competitive distance-running have structurally different tendons than recreationally-active young adults. While these structural differences have been associated with tendon damage, the lack of clinical symptoms of tendinopathy may suggest that these detected differences may either be precursors of tendinopathy development or protective adaptations to cyclic tendon loading experienced during running.

scholarly journals HASIL AUTOPSI SEBAB KEMATIAN MENDADAK TAK TERDUGA DI BAGIAN FORENSIK BLU RSUP. PROF. DR. R. D. KANDOU MANADO TAHUN 2010-2012

e-CliniC ◽  
2014 ◽  
Vol 2 (1) ◽  
Author(s):  
Dione S. M. Bhaskara
Keyword(s):  
Sudden Death ◽  
Cardiovascular System ◽  
Incomplete Data ◽  
Sampling Method ◽  
Unexpected Death ◽  
Unknown Reason ◽  
Medicolegal Autopsy ◽  
Research Population ◽  
Death Cases ◽  
Descriptive Method

Abstract: According to WHO, sudden death is the death that occurred 24 hours after the symptom arise, but in some forensic cases, most of the death cases occurred in matter of minutes or might be seconds as the first symptom arise. Sudden deaths increase along the aging. Sudden deaths that caused by disease are often bring suspicion thus they need to be proven by doing the medicolegal autopsy, to which the result will be revealed. This research aims to determine the results of the autopsy cause of sudden unexpected death on forensic BLU department of RSUP. Prof. Dr. R. D. Kandou Manado in 2010-2012. This research is using retrospective descriptive method. Research population is all the alleged victims of sudden deaths in BLU. RSUP. Prof. Dr. R. D. Kandou Manado in 2010-2012. Sample is taken by total sampling method. There are 12 cases of sudden deaths, 4 of them are not qualified to be taken as sample because of incomplete data. The total of sudden deaths based on gender are 7 cases of Males (87.5%), and 1 case of Female (12.5%). Sudden death occurs more frequently in adult with 3 cases (37.5%) on 41-59 years old range. 3 cases on heart disease (37.5%), 2 cases on lung disease (25%), 1 case on lung cancer (12.5%), and the other 2 are unknown reason (25%). From this study, it is concluded that sudden deaths are more common to male in 41-59 years old range, and the most common cause of sudden death is cardiovascular system Keywords: Sudden deaths, autopsy, cardiovascular system.     Abstrak: Kematian mendadak menurut WHO adalah kematian yang terjadi pada 24 jam sejak gejala-gejala timbul, namun pada kasus-kasus forensik, sebagian besar kematian terjadi dalam hitungan menit atau bahkan detik sejala gejala pertama timbul. Kejadian kematian mendadak meningkat seiring dengan bertambahnya usia. Kematian mendadak yang disebabkan oleh penyakit, sering mendatangkan kecurigaan sehingga perlu dibuktikan dengan dilakukannya autopsi medikolegal, yang hasilnya dapat menunjukkan sebab kematian tersebut. Penelitian ini bertujuan untuk mengetahui hasil autopsi sebab kematian mendadak tak terduga di Bagian Ilmu Kedokteran Forensik BLU. RSUP. Prof. Dr. R. D. Kandou Manado tahun 2010-2012. Penelitian ini merupakan penelitian deskriptif retrospektif. Populasi penelitian adalah seluruh korban dugaan mati mendadak di BLU. RSUP. Prof. Dr. R. D. Kandou Manado tahun 2010-2012. Pengambilan sampel menggunakan teknik total sampling. Terdapat sebanyak 12 kasus kematian mendadak, 4 diantaranya tidak memenuhi syarat untuk dijadikan sampel karena datanya yang tidak lengkap. Jumlah kematian mendadak berdasarkan jenis kelamin yaitu laki-laki sebanyak 7 kasus (87.5%) dan perempuan 1 kasus (12.5%). Kematian mendadak lebih banyak terjadi pada kelompok dewasa yaitu dengan usia 41-59 tahun sebanyak 3 kasus (37.5%). Kematian mendadak akibat penyakit jantung sebanyak 3 kasus (37.5%), penyakit paru sebanyak 2 kasus (25%), penyakit lainnya (tidak diketahui sebabnya) 2 kasus (25%), dan kanker paru hanya terdapat 1 kasus (12.5%). Dari penelitian ini disimpulkan bahwa kematian mendadak terjadi lebih sering pada laki-laki, serta paling banyak dialami pada usia 41-59 tahun. Penyebab tersering kematian mendadak diakibatkan oleh sistem kardiovaskular. Kata Kunci: Kematian mendadak, autopsi, sistem kardiovaskular.

Cardiac Dysrhythmias and Sports

PEDIATRICS ◽  
1995 ◽  
Vol 95 (5) ◽  
pp. 786-788
Author(s):  
Keyword(s):  
Sudden Death ◽  
Medical History ◽  
Cardiac Death ◽  
Arrhythmogenic Right Ventricular Dysplasia ◽  
Sudden Onset ◽  
Sudden Unexpected Death ◽  
Qtc Interval ◽  
Unexpected Death ◽  
Ventricular Dysrhythmias ◽  
The Right

Sudden unexpected death during athletic participation is the overriding consideration in advising individuals with dysrhythmias about participation in sports. The incidence of sudden death is 1 to 2 per 200 000 athletes per year and approximately 12 per year in US high school athletes.1 Between 5 and 22% of these deaths occur during sports or physical activities that include basketball, racquetball, jogging, football, soccer, and golf.2 The remainder occur during sedentary activities.2 Another potential risk for the athlete with a dysrhythmia is injury to self or others from syncope or near syncope while playing sports. The leading cause of sudden unexpected cardiac death is hypertrophic cardiomyopathy.1 A dysrhythmia of ventricular or supraventricular origin may be a significant factor in the sudden unexpected death of these individuals.1 Myocarditis is also a cause of sudden cardiac death. Severe dysrhythmia may be a prominent feature of myocarditis even in the absence of significant cardiac dysfunction.1 This diagnosis should be considered in an individual who has a recent sudden onset of a symptomatic dysrhythmia.3 Ventricular dysrhythmias with exercise are a potential cause of death in individuals with arrhythmogenic right ventricular dysplasia (a rare muscle disorder of the right ventricle).1 Sudden death resulting from dysrhythmia can occur with exertion or excitement in individuals who have hereditary syndromes that include prolongation of the QTc interval.3 Sudden death has also been associated with mitral valve prolapse (rarely) and with Wolff-Parkinson-White syndrome.3 MEDICAL HISTORY The patient's medical history is of critical importance. Dysrhythmias may be episodic and not apparent at the time of physical examination.

Evaluation of Temporomandibular Disorders in Children Using Limited Cone-beam Computed Tomography: a case report

2007 ◽  
Vol 31 (1) ◽  
pp. 14-16 ◽  
Author(s):  
Ruka Sakabe ◽  
Jun Sakabe ◽  
Yosuke Kuroki ◽  
Ichiro Nakajima ◽  
Naoto Kijima ◽  
...  
Keyword(s):  
Clinical Symptoms ◽  
Temporomandibular Disorder ◽  
Cone Beam Ct ◽  
Three Dimensional ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Diagnostic Procedures ◽  
Cone Beam ◽  
Dimensional Image ◽  
The Right

Considerable advances have been made in dental and orthodontic diagnosis resulting from the development of a device known as a limited cone beam dental compact-CT (3DX). This report documents the diagnostic procedures and treatment performed on an eight year old female patient who presented with clinical signs and symptoms of a temporomandibular disorder (TMD). Evaluation of a bony abnormality of the temporomandibular joint (TMJ) using the limited cone-beam CT (3DX) proved to be of considerable value. A three-dimensional image of the right TMJ showed erosion and flattening of the condyle. Following treatment, there was marked alleviation of the clinical symptoms while considerable improvement of the bony abnormalities was clearly evident on a three-dimensional image.

Acute abdomen in pregnancy: a retrospective study of pregnant patients hospitalised for abdominal pain

2020 ◽  
Vol 99 (3) ◽  
pp. 131-135
Keyword(s):  
Abdominal Pain ◽  
Clinical Signs ◽  
University Hospital ◽  
Diagnostic Process ◽  
Abdominal Emergency ◽  
Lower Abdominal Quadrant ◽  
Abdominal Emergencies ◽  
The Right ◽  
Abdominal Quadrant ◽  
In Pregnancy

Introduction: Abdominal emergencies occur in pregnant women with the rate of 1:500−635 pregnancies. Such conditions usually develop from full health and worsen rapidly. Symptoms are often similar to those in physiological pregnancy (abdominal pain, vomiting, constipation). The diagnostic process is thus difficult and both the mother and her child are at risk. Our aim was to evaluate the frequency of abdominal emergencies in the Department of Surgery, University Hospital in Pilsen and to consider their impact on pregnancy and on the newborn. Methods: We acquired a set of patients by retrograde collection of data. We searched for pregnant patients suspected of developing an abdominal emergency admitted to the Department of Surgery, Faculty of Medicine, Pilsen between 2004 and 2015. We evaluated a number of clinical signs to statistically describe the set. Results: The set included 121 patients; 42 of the patients underwent a surgical procedure and 79 received conservative treatment. 38 patients underwent appendectomy; 6 appendixes were with no pathologies. McBurney’s incision was an approach of choice in most cases. The most frequent symptom was pain in the right lower abdominal quadrant. The foetus has been lost in none of the cases. Conclusion: Acute appendicitis was the most frequent abdominal emergency in our set and also the most frequent reason for surgical intervention. The most specific sign was pain in the right lower abdominal quadrant. No impact of appendicitis or appendectomy on the health of the newborn has been observed. Even though abdominal emergencies in pregnancy are relatively rare, the results of the department are very good.

Off-Pump Supraarterial Decompression Myotomy for Myocardial Bridging

2005 ◽  
Vol 8 (1) ◽  
pp. 49 ◽  
Author(s):  
Mersa M. Baryalei ◽  
Theodorus Tirilomis ◽  
Wolfgang Buhre ◽  
Stephan Kazmaier ◽  
Friedrich A. Schoendube ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Exercise Testing ◽  
Clinical Symptoms ◽  
Therapeutic Option ◽  
Median Sternotomy ◽  
Myocardial Bridging ◽  
Off Pump ◽  
Hemodynamic Compromise ◽  
Artery Disease ◽  
The Right

Background: Myocardial bridging of the left anterior descending (LAD) artery may result in clinical symptoms. Surgery with cardiopulmonary bypass (CPB) is a therapeutic option with considerable risk. We hypothesized that off-pump supraarterial myotomy could be an effective treatment modality. Methods: Between October 1998 and May 2000, 13 patients were referred for surgery. All were symptomatic despite medical therapy. Anteroseptal ischemia had been proven by thallium scintigraphy in all 13 patients, exercise testing was positive in 11. All patients were operated on with an off-pump approach after median sternotomy. Results: Mean patient age was 61 8 years (range, 43-71 years). Coronary artery disease mandating additional bypasses was present in 3 patients. The bypasses were done off pump in 2 patients. Conversion to on-pump surgery was necessary in 3 of 13 patients (23%) because of hemodynamic compromise (1 patient), opening of the right ventricle (1 patient), and injury to the LAD (1 patient). Supraarterial myotomy was performed in all patients. One patient who underwent surgery with CPB developed postoperative anteroseptal myocardial infarction. Postoperative exercise testing was performed in all patients and did not reveal any persistent ischemia. Mortality was 0%. All patients were free from symptoms and had not undergone repeat interventions after an average of 51 7 months of follow-up. Conclusions: Off-pump supraarterial myotomy effectively relieves coronary obstruction but has a certain periprocedural risk as evidenced by 1 myocardial infarction, 1 right ventricular injury, and 1 LAD injury. Long-term freedom from symptoms and from reintervention favor further investigation of this surgical therapy.

Prevalence and Characteristics of Liver Cancer Patients in Immanuel Hospital Bandung within January 2013 until December 2014 Period

2016 ◽  
Vol 1 (4) ◽  
Author(s):  
Achmad R. Permadi ◽  
Hana Ratnawati ◽  
Teresa L. Wargasetia
Keyword(s):  
Liver Cancer ◽  
Cancer Patients ◽  
Medical Records ◽  
Clinical Symptoms ◽  
Data Retrieval ◽  
Common Cancer ◽  
Key Words Liver Cancer ◽  
Liver Cancer Patient ◽  
Right Lobe ◽  
The Right

Liver cancer is the fifth most common cancer in Indonesia. This research is to find out the prevalence and characteristics of liver cancer patients in Immanuel Hospital Bandung within the January 2013 until December 2014 period based on age, gender, clinical symptoms and predilections. This study was a descriptive verificative research with data retrieval of patients medical records that have been diagnosed with liver cancer that were hospitalized in Immanuel Hospital Bandung within January 2013 until December 2014 period. The study showed that the liver cancer patient prevalence in Immanuel Hospital Bandung within the period of January 2013 until December 2014 was 46 people. Characteristics of liver cancer patients in Immanuel Hospital Bandung within January 2013 until December 2014 period showed that the most liver cancer patients were male, compare with female with ratio 4:1, the most common age group of 56-65 years old, the most common clinical symptoms were abdominal pain with or without reffered pain to the right scapular bone and the most common predilection was right lobe of the liver. Key words: liver cancer, patients' characteristics, prevalence 

Neural Underpinnings of Numerical and Spatial Cognition: An fMRI Meta-Analysis of Brain Regions Associated with Symbolic Number, Arithmetic, and Mental Rotation

2019 ◽  
Author(s):  
Zachary Hawes ◽  
H Moriah Sokolowski ◽  
Chuka Bosah Ononye ◽  
Daniel Ansari
Keyword(s):  
Mental Rotation ◽  
Parietal Lobe ◽  
Meta Analysis ◽  
Likelihood Estimation ◽  
Brain Regions ◽  
Angular Gyrus ◽  
Number Representation ◽  
Neural Underpinnings ◽  
The Right ◽  
Symbolic Number

Where and under what conditions do spatial and numerical skills converge and diverge in the brain? To address this question, we conducted a meta-analysis of brain regions associated with basic symbolic number processing, arithmetic, and mental rotation. We used Activation Likelihood Estimation (ALE) to construct quantitative meta-analytic maps synthesizing results from 86 neuroimaging papers (~ 30 studies/cognitive process). All three cognitive processes were found to activate bilateral parietal regions in and around the intraparietal sulcus (IPS); a finding consistent with shared processing accounts. Numerical and arithmetic processing were associated with overlap in the left angular gyrus, whereas mental rotation and arithmetic both showed activity in the middle frontal gyri. These patterns suggest regions of cortex potentially more specialized for symbolic number representation and domain-general mental manipulation, respectively. Additionally, arithmetic was associated with unique activity throughout the fronto-parietal network and mental rotation was associated with unique activity in the right superior parietal lobe. Overall, these results provide new insights into the intersection of numerical and spatial thought in the human brain.

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