Prevalence and Characteristics of Liver Cancer Patients in Immanuel Hospital Bandung within January 2013 until December 2014 Period

2016 ◽  
Vol 1 (4) ◽  
Author(s):  
Achmad R. Permadi ◽  
Hana Ratnawati ◽  
Teresa L. Wargasetia

Liver cancer is the fifth most common cancer in Indonesia. This research is to find out the prevalence and characteristics of liver cancer patients in Immanuel Hospital Bandung within the January 2013 until December 2014 period based on age, gender, clinical symptoms and predilections. This study was a descriptive verificative research with data retrieval of patients medical records that have been diagnosed with liver cancer that were hospitalized in Immanuel Hospital Bandung within January 2013 until December 2014 period. The study showed that the liver cancer patient prevalence in Immanuel Hospital Bandung within the period of January 2013 until December 2014 was 46 people. Characteristics of liver cancer patients in Immanuel Hospital Bandung within January 2013 until December 2014 period showed that the most liver cancer patients were male, compare with female with ratio 4:1, the most common age group of 56-65 years old, the most common clinical symptoms were abdominal pain with or without reffered pain to the right scapular bone and the most common predilection was right lobe of the liver. Key words: liver cancer, patients' characteristics, prevalence 

2020 ◽  
Vol 42 (1) ◽  
pp. 78
Author(s):  
Anshu K Thakur ◽  
Anish Shah ◽  
Barun K Ray

Introduction The incidence of cancer is rising in Nepal. It is estimated to reach 38.5 per 100,000 for males and 41.5 per 100,000 for females by 2020. The studies to determine the cancer burden in Nepal at provincial level have been insufficient and those that have been done are more inclined to Province 3. With establishment of a dedicated cancer facility in this area, we present an overview of clinical scenario of cancer patients in Province 2. MethodsWe performed a single centered, retrospective review of 118 patients who were registered in Oncology Clinics between May 2019 and February 2020. Demographics, diagnoses and the treatment strategies were obtained from the medical records. ResultsMedian age of presentation for cancer was 55 years (range, 6 to 83 years) with maximum number of patients falling within range of 50-60 years (31.4%). 71 patients (60.2%) were female and 47 patients (39.8%) were male. The common presenting cancers were gastrointestinal (27.1%), breast (16.9%), head and neck (15.3), gynecological (13.6%), hematological (11.9%) and others (15.2%). Among the gastrointestinal cancers, carcinoma of gallbladder with 15 cases (46.9%) was the most frequently occurring, followed by colorectal cancer with 6 cases (18.8%) and esophageal cancer with 4 cases (12.5%). Among all, 78 patients (66.1%) received palliative care only, 25 patients (21.2%) received chemotherapy only, 8 patients (6.8%) underwent surgery only, 3 patients (2.5%) underwent surgery and received chemotherapy as well, 2 patients (1.7%) received both chemotherapy and palliative care and 2 patients (1.7%) were reassured and observed. ConclusionThe most common age of presentation for cancer of any type was 50-60 years, with most common cancer being gastrointestinal in origin. Most of the patients received palliative care owing to their advanced stage at presentation.


Author(s):  
Ngọc Phú Đặng

CHARACTERISTICS AND TREATMENT OF HEPATOBLASTOMA IN CHILDREN AT PEDIATRIC HOSPITAL 2 Objective: To determine the epidemiological, clinical, paraclinical characteristics and evaluate the result in treatment of hepatoblastoma (HB) at Department of Hematology-Oncology, Children’s Hospital 2 from January 2011 to end of May 2019. Method: Cases series study in combination of retrospective and prospective. Results: From January 2011 to end of May 2019, there were 67 patients diagnosed with HB. The mean age at diagnosis was 22.7 ± 22.9 months with the most prevalent age group ranging from 6 months to 3 years. The male to female ratio was 1.8/1. The most common clinical symptoms were abdominal distention and hepatomegaly, approximately 7.5% HB cases were detected accidentally by ultrasound. Nearly 60% and 80% patients presented with anemia and thrombocytosis at admission, respectively.Almost tumors were unifocal locating in the right lobe of the liver and 58.2% cases belonged to standard risk group. Assessing treatment protocol in 54 HB patients demonstrate that number of patients undergoing hepatectomy after preoperative chemotherapy accounted for 82%. The most frequent acuteside effects after chemotherapy were myelotoxicity and infection. The proportion of fatal and relapsed cases was 31.5% and 12.9% respectively. Overall and event-free survival rate of the study after 3 years was 65.7% and 68.1% individually. Conclusion: Hepatoblastoma is a rare malignant childhood disease, pretty good response to chemotherapy followed by surgery. However mortality rate is rather high compared to worldwide reasearchs. Thus development of liver transplant is necessary to improve survival rate. Keywords: Hepatoblastoma, chemothearapy, surgery, liver transplant.


Author(s):  
Dar Abdul Waheed ◽  
Saba Sumaira ◽  
Lone Mushtaq Ahmad ◽  
Qurat Ul Ain ◽  
Sanaullah Kuchay ◽  
...  

Abstract Background Cancer can have profound social and economic consequences for the people in India, often leading to family impoverishment and societal inequity. Reported age-adjusted incidence rates for cancer are still quite low in the demographically young country. Slightly more than 1 million new cases of cancer are diagnosed every year in a population of 1.2 billion. It accounts for about 23 and 7% deaths in United States and India, respectively. The world's population is expected to be 7.5 billion by 2020 and approximations predict that about 15.0 million new cancer cases will be diagnosed, with deaths of about 12.0 million cancer patients. Early detection of cancers is a challenging task because clinical symptoms develop slowly. Objective The aim of the present study was to analyze the cancer scenario in the Kashmir valley. Materials and Methods This was a retrospective study. So, all patients were included who had histopathologically confirmed neoplasm registered at Regional Cancer Centre of Government Medical College Srinagar, Kashmir between 2015 and 2018. All the patient characteristics including age, sex, and anatomical site of the disease were studied in detail. Results The number of cancer patients in 2015, 2016, 2017, and 2018 were 230, 239, 391, and 511, respectively, with a combined total of 1,371. Thus, it is clear from these figures that the number of cancer cases has increased gradually with time. Stomach cancer is the most common cancer in the Kashmir territory. In males the most common cancer is stomach cancer with 175 (12.8%) reported cases and in females the most common cancer is breast cancer with 151 (11%) reported cases. The male to female ratio was 1.4:1. Conclusion A careful reading the reported cancer cases indicates an increased number of cancer patients every year in Indian-occupied Kashmir. Kashmir is a growing state in India playing a crucial role in the development of India and, hence, it needs special attention on this issue. A multidisciplinary approach to cancer treatment is essential and this has to be made available at all regional cancer centers. Cancer control is an area in which we need participation from all sectors of the society.


2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Shuai Lu ◽  
Maoqi Gong ◽  
Yejun Zha ◽  
Aimin Cui ◽  
Wei Tian ◽  
...  

Abstract Background Multiple pathological manifestations are rarely present in patients with primary hyperparathyroidism (PHPT). Here we described a case of a young woman who presented with multiple skeletal destructions and received an unclear diagnosis at several hospitals. Case presentation A 30-year-old woman was admitted to our hospital due to pain in both knees and walking difficulty that lasted for 6 and 2 years, respectively. Her laboratory test results revealed a high parathyroid hormone level (822 pg/ml) and hypercalcemia (2.52 mmol/L) in the blood. Parathyroid imaging revealed a lumpy concentration of radioactive uptake detected at the lower pole in the right lobe of the thyroid, and was nearly 2.2 cm * 2.4 cm in size. Next, the patient was treated with parathyroidectomy that resulted in a significant improvement in physiological and clinical symptoms. Moreover, the skeletal destruction and bone mineral density were significantly improved after a 5-years follow-up period. Conclusions Multiple skeletal destructions can be caused by PHPT that should be taken into consideration in young patients with complex bone lesions.


Author(s):  
Duy Hien Pham

Background: Hepatoblastoma is the most common malignant liver tumor in children. Aims: Study on clinical and subclinical features of pediatric patients with hepatoblastoma at National Children Hospital from 1/2016 to 8/2019. Materials and Methods: A total patients with operated Hepatoblastoma diagnosed by pathologists, at the Viet Nam National Children’s Hospital from January 2016 to August 2019. The study design is retrospective. Resullts: Study subject’s mean of age was 36,8 months (range 4 – 149 months), the common group of age was under 5 years old (76,7%), male’s more than female (56,7% and 43,3%). The most common clinical symptoms were hepatomegaly (50%), a palpable abdominal mass (30%), abdominal pain (13,3%), secondary anemia (13,3%), weight loss (6,7%), jaundice (3,3%). About laboratory test: 83,3% patients with anemia, 36,7% patients with thrombocytosis, 90% patients with hight GOT levels, 53,3% patients with hight GPT levels, 96,7% patients with hight serum AFP levels and the average value of AFP was 217160,7 ng/ml (range 575 – 1686328,6 ng/ml). Mean size of the tumor on computerized tomography was 5,48cm (range 2 – 15cm), 60% size of tumor  ≤ 5cm, 96,7% had only one tumor,  70% primary tumor located to the right lobe of the liver, 76,7% were staged PRETEXT II, the most common hepatoblastoma histopathological subtypes was as follows: epithelial (80%). Conclusion: Clinical symptoms of hepatoblastoma are usually nonspecific. A routine check – up strategy for early detection of hepatoblastoma and the role of subclinical aids in diagnosis is very important.  


2012 ◽  
pp. 57-65
Author(s):  
Dinh Binh Tran ◽  
Ngoc Hai Phan ◽  
Phuong Phung ◽  
Van Hoa Tran ◽  
Van Trung Ngo ◽  
...  

Objective: To examine the clinical characteristics, paraclinical signs of patients with liver cancer and evaluate the results of treatment of liver cancer by gamma knife. Material and Methods: 95 patients were diagnosed liver cancer that treated with Gamma Knife in Hue University Hospital from January 2011 to May 2012. Daily monitoring of patients in treatment process and after treatment for 1 month, 3 months, 6 months...The data on clinical monitoring, images are recorded. Results and discussion: (i) Most patients with a history of hepatitis B, C (66.3%), what has not been previously treated (78.9%). Common clinical symptoms are right lower ribs pain (62.1%), poor diet (47.4%), enlarged liver (41.1%), weight loss (36.8%), fatigue (30,5%). The majority of liver tumors located in the right liver (74.8%) and usually have two or more tumors (91.6%). Large tumor size mostly bigger than 6 cm (48.4%), 43.2% of patients with tumor size 3-6cm. Hepatic enzyme increased 15.9%, 22.1% Billirubin increase, accounting for 26.3% of AFP increase. (ii) Gamma treatment with focus of more than 20 at a rate 47.4%, primarily radiation time longer than 15 minutes (58.9%). Most patients reported no abnormalities in the proces of treatment (57.9%), only a few patients have a feeling of fullness, indigestion (26.3%), pain (28.4%), dizziness (3.2%). The main clinical symptoms improved after treatment. (iii) The paraclinical biochemics, after 1-6 months of treatment patients with paraclinical signs improved. Tumor size after 1-6 months of treatment accounted for 66.3% reduction, not reduced to 22.1%, increase in size accounted for only 11.6%. Conclusion: after Gamma Knife treatment from 1 to 6 months, most patients respond well and are quite good. After one month, this rate is 84.2%. After 3-6 months, this rate is 73.1%. Keywords: liver cancer, treatment, Gamma Knife Key words: liver cancer, treatment, Gamma Knife


2015 ◽  
Vol 33 (3_suppl) ◽  
pp. 209-209
Author(s):  
Daisuke Izumi ◽  
Naoya Yoshida ◽  
Masayuki Watanabe ◽  
Takatsugu Ishimoto ◽  
Keisuke Kosumi ◽  
...  

209 Background: It is sometimes difficult to exactly measure maximum diameters of tumor after chemotherapy in esophageal cancer. Richard et al. proposed PET Response Criteria in Solid Tumor (PERCIST) for assessing response of tumor after chemotherapy by PET in 2009. The first purpose is to investigate the utility of PERCIST after neoadjvant chemotherapy in esophageal cancer. The second purpose is to clarify the utility of modified PERCIST of which we use the SUV of normal (non-cancerous) esophagus as a reference of comparison for diagnosing complete response (CR) instead of the right lobe liver SUV. Methods: The clinicopathological data of the 71 esophageal cancer patients who received neoadjuvant chemotherapy (DCF) and underwent curative resection from November 2008 to May 2012 were collected. Among them, we compared pathological grade with PERCIST of the 26 esophageal cancer patients who were examined by PET before and after chemotherapy. Furthermore we investigated which reference of comparison is appropriate for diagnosing complete response between the right lobe of liver (L group) and normal esophagus (E group). Results: We could measure the tumor size of all cases after chemotherapy by PERCIST although 6 cases could not be assessed by RECIST. All of the 6 cases which were diagnosed as stable disease or progressive disease by PERCIST were pathological grade1a. The cases of complete response are 7 cases in L group and 3 cases in esophageal cases. Among the complete response cases in L group, 1 case were pathological grade1 a and 2 cases were grade 2 although all the complete response cases in E group were pathological grade 3. One case of L group relapsed after curative resection although there was no recurrent case in E group. Conclusions: The esophageal cancer patients often have history of massive alcohol intake or liver damage caused by viral hepatitis or fatty liver. Although PERCIST is useful for evaluating the effect of neoadjuvant chemotherapy of esophageal cancer, it is better to use normal esophagus as a comparison standard for diagnosing complete response.


Author(s):  
Lodiana Nitti ◽  
Friandry Windisany Thoomaszen

ABSTRACT Parental perception will affect the fulfillment of children’s participation rights. Fullfilment of children’s participation rights will be fulfilled optimally if parents pay anttention to opinions while providing opportunities for children to make and make decisions about the child’s goals and self-interest. The subjects studied consisted of 5 subjects consisting of father and mother who had children aged 9- 12 years. This study uses qualitative research methods, with data retrieval tools in teh form of interviews, observation and documentation. From the research found data were the subjects do not fulfill the right of participation of children up to the maximum ladder where children’s participation rights range from the first ladder to the third ladder. The first ladder to the third ladder is actually a non- participating ladder. This means that children is manipulated, dominated by parents, there is direct communation and the severity of the parent. The children felt disappointed, sad, and angry with the parents but they still tried to hear and obey the parent’s decision. Children from third and fourth subjects experienced excessive fear to speak to their parent (father). Suggestions for parents to be more caring and fulfill the rights of children’s participation so as not to affect the growth and development of children. Keywords: participation rights, children, parents


2005 ◽  
Vol 8 (1) ◽  
pp. 49 ◽  
Author(s):  
Mersa M. Baryalei ◽  
Theodorus Tirilomis ◽  
Wolfgang Buhre ◽  
Stephan Kazmaier ◽  
Friedrich A. Schoendube ◽  
...  

Background: Myocardial bridging of the left anterior descending (LAD) artery may result in clinical symptoms. Surgery with cardiopulmonary bypass (CPB) is a therapeutic option with considerable risk. We hypothesized that off-pump supraarterial myotomy could be an effective treatment modality. Methods: Between October 1998 and May 2000, 13 patients were referred for surgery. All were symptomatic despite medical therapy. Anteroseptal ischemia had been proven by thallium scintigraphy in all 13 patients, exercise testing was positive in 11. All patients were operated on with an off-pump approach after median sternotomy. Results: Mean patient age was 61 8 years (range, 43-71 years). Coronary artery disease mandating additional bypasses was present in 3 patients. The bypasses were done off pump in 2 patients. Conversion to on-pump surgery was necessary in 3 of 13 patients (23%) because of hemodynamic compromise (1 patient), opening of the right ventricle (1 patient), and injury to the LAD (1 patient). Supraarterial myotomy was performed in all patients. One patient who underwent surgery with CPB developed postoperative anteroseptal myocardial infarction. Postoperative exercise testing was performed in all patients and did not reveal any persistent ischemia. Mortality was 0%. All patients were free from symptoms and had not undergone repeat interventions after an average of 51 7 months of follow-up. Conclusions: Off-pump supraarterial myotomy effectively relieves coronary obstruction but has a certain periprocedural risk as evidenced by 1 myocardial infarction, 1 right ventricular injury, and 1 LAD injury. Long-term freedom from symptoms and from reintervention favor further investigation of this surgical therapy.


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