scholarly journals Associations among Bone Mineral Density, Physical Activity and Nutritional Intake in Middle-Aged Women with High Levels of Arterial Stiffness: A Pilot Study

Author(s):  
Kanako Hamaguchi ◽  
Toshiyuki Kurihara ◽  
Masahiro Fujimoto ◽  
Koji Sato ◽  
Motoyuki Iemitsu ◽  
...  

There is little consensus regarding the impacts of physical activity and nutrient intake on bone mineral density (BMD) in subjects with high or low levels of arterial stiffness. This study was performed to investigate whether physical activity and nutrient intake are associated with BMD in middle-aged women with high levels of arterial stiffness. The study population consisted of middle-aged women aged 40–64 years (n = 22). BMD was assessed by dual-energy X-ray absorptiometry. Carotid-femoral pulse wave velocity (cf-PWV) was used as an indicator of arterial stiffness. Subjects were divided into two groups by median cf-PWV. Physical activity in free-living conditions was evaluated using a triaxial accelerometer. Nutrient intake was also measured using the brief-type self-administered diet history questionnaire. In the High-PWV group, BMD showed a significant negative correlation with age. Using a partial correlation model, BMD was associated with the number of steps and unsaturated fatty acid intake in the High-PWV group. These results suggest that BMD in middle-aged women with high levels of arterial stiffness may be associated with both the number of steps and nutritional intake. Recommendations of physical activity and nutritional intake for the prevention of osteopenia should include consideration of arterial stiffness.

2005 ◽  
Vol 8 (3-4) ◽  
pp. 162-165 ◽  
Author(s):  
M. Mędraś ◽  
M. Słowińska-Lisowska ◽  
P. Jóźków

2012 ◽  
Vol 26 (6) ◽  
pp. 341-347 ◽  
Author(s):  
Neil R. Nokes ◽  
Larry A. Tucker

Purpose. This study was conducted to determine if physical activity volume (PAv) and intensity (PAi) at baseline influence the likelihood of gaining hip bone mineral density (BMD) over 6 years. Design and Sample. In a prospective study, the sample was limited to 244 female nonsmokers, ages 35 to 45 years, and was approximately 90% white. Setting and Measures. PAv and PAi were measured in daily living conditions using accelerometers at baseline. BMD, measured by dual energy x-ray absorptiometry, and several confounding factors were measured in the lab. Analysis. On the basis of BMD change scores, participants were divided into three categories: BMD loss, minimal change, and BMD gain. Risk ratios were used to show the likelihood of BMD gains over time across different levels of PAv and PAi at baseline. Results. Women with higher PAv were more likely to show improvements in hip BMD from baseline to follow-up than their counterparts, as indicated by the Mantel-Haenszel chi-square (χ2mh = 6.1, p = .01). Women with high PAv were 2.50 times (95% CI, 1.19–5.24) more likely to experience hip BMD gains than women with low PAv, and women with moderate PAv were 2.20 times (95% CI, 1.08–4.45) more likely. PAi was not predictive of gains in hip BMD. Adjusting for potential confounders had little influence on the results. Conclusions. Middle-aged women with moderate or high levels of PAv are more likely to experience BMD gains at the hip over time compared with those who have low levels of PAv. However, PAi does not appear to influence the likelihood of gaining BMD at the hip over 6 years.


2021 ◽  
Author(s):  
Zhang-Xin Wen ◽  
Yong-Fang Li ◽  
Lu-Lu Xu ◽  
Chun Yue ◽  
Qin-Yi Wang ◽  
...  

Abstract Purpose: This study aimed to investigate the relationship of triglyceride glucose-body mass index (TyG-BMI) with bone mineral density, femoral neck geometry, and risk of fracture in middle-aged and elderly Chinese individuals. Methods: A total of 832 nondiabetic individuals (474 men aged ≥50 years and 358 postmenopausal women) were selected from the prospective population-based HOPE cohort. All individuals underwent dual-energy X-ray absorptiometry for assessment of bone mineral density (BMD) at the lumbar spine, femoral neck, and total hip, as well as femoral neck geometry. The 10-year probabilities of major osteoporotic fractures (MOFs) and hip fractures (HFs) were calculated. Correlations of TyG-BMI with BMD at different sites, femoral neck geometry, and risk of fractures were examined in men and women. Results: Cortical thickness (CT), compression strength index (CSI), cross-sectional moment of inertia (CSMI), cross-sectional area (CSA), section modulus (SM), and 25(OH)D levels were significantly lower in women (all P < 0.001). The presence of osteoporosis was related to age, BMI, BMD and femoral neck geometry, TyG-BMI index and TyG index, MOF and HF in both sex. TyG-BMI was positively correlated with BMD at femoral neck, lumber spine, and total hip and with femoral neck geometry parameters in men, Similar significant association was also present in women. In men, TyG-BMI showed significant negative correlation with HF but not with MOF. In women, TyG-BMI showed significant negative correlation with both factors only after adjusting for other variable. The various geometric indices of the femoral neck were 3 significantly impaired in individuals with low TyG-BMI. the TyG-BMI index was found to be significantly associated with osteoporosis after adjusting for confounders. Conclusion: TyG-BMI is positively associated with BMD and femoral neck geometry, and negatively associated with risk of fracture in nondiabetic middle-aged and elderly Chinese men and women.


BMJ Open ◽  
2019 ◽  
Vol 9 (8) ◽  
pp. e029946 ◽  
Author(s):  
Meng Zhang ◽  
Lijuan Bai ◽  
Jing Kang ◽  
Jing Ge ◽  
Wen Peng

ObjectivesTo explore whether bone mineral density (BMD) is associated with arterial stiffness in middle-aged and elderly people with an advanced arterial stiffness index as indicated by the cardio-ankle vascular index (CAVI).DesignA cross-sectional study.SettingThis study was conducted from September 2015 to May 2017 at the geriatrics department of a provincial medical centre in China.ParticipantsA total of 580 patients aged 50 and over were enrolled in the study. The mean age of the group was 64.82±11.4 years, and 63.1% were male.Primary outcome measuresAssociations of age with CAVI values and BMD. Associations between BMD and CAVI values.ResultsWith increasing age, CAVI values gradually increased (p<0.001) and the femoral neck (FN) and total hip (TH) BMD gradually decreased (p<0.001, all). In the bivariate correlation analyses between the covariates and CAVI values, age and CAVI values showed the greatest positive correlation (r=0.631, p<0.001), and CAVI values were negatively correlated with FN BMD (r=−0.229, p<0.001) and TH BMD (r=−0.218, p<0.001). In the linear regression analyses, TH BMD (B=−1.812 (95% CI −2.475 to −1.149), p<0.001) and FN BMD (B=−1.968 (95% CI −2.651 to −1.284), p<0.001) were negatively correlated with CAVI values. After adjusting for age, gender, body mass index, smoking, history of cardiovascular or cerebrovascular disease, history of diabetes mellitus, systolic blood pressure, high-density lipoprotein cholesterol, blood uric acid, fibrinogen and estimated glomerular filtration rate, only TH BMD was still negatively correlated with CAVI values (B=−0.843 (95%CI −1.454 to −0.232), p=0.007). However, there was no consistent and significant correlation between lumbar spine BMD and CAVI values.ConclusionIn this cross-sectional study, a significant correlation between TH BMD and CAVI values was observed in middle-aged and elderly Chinese inpatients. However, our cohort was a small sample of inpatients, and prospective studies from more centres are expected.


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