scholarly journals Restless Legs Syndrome across the Lifespan: Symptoms, Pathophysiology, Management and Daily Life Impact of the Different Patterns of Disease Presentation

2020 ◽  
Vol 17 (10) ◽  
pp. 3658
Author(s):  
Giuseppe Didato ◽  
Roberta Di Giacomo ◽  
Giuseppa Jolanda Rosa ◽  
Ambra Dominese ◽  
Marco de Curtis ◽  
...  
Keyword(s):  
Effective Treatment ◽  
Restless Legs Syndrome ◽  
Genetic Factors ◽  
Correct Diagnosis ◽  
Daily Functioning ◽  
Sleep Disruption ◽  
Neurologic Disorder ◽  
Restless Legs ◽  
Dopaminergic Agents ◽  
Life Impact

Restless legs syndrome is a common but still underdiagnosed neurologic disorder, characterized by peculiar symptoms typically occurring in the evening and at night, and resulting in sleep disruption and daily functioning impairment. This disease can affect subjects of all age ranges and of both sexes, manifesting itself with a broad spectrum of severity and deserving special attention in certain patient categories, in order to achieve a correct diagnosis and an effective treatment. The diagnosis of restless legs syndrome can be challenging in some patients, especially children and elderly people, and an effective treatment might be far from being easy to achieve after some years of drug therapy, notably when dopaminergic agents are used. Moreover, the pathophysiology of this disorder offers an interesting example of interaction between genetics and the environment, considering strong iron metabolism involvement and its interaction with recognized individual genetic factors. Therefore, this syndrome allows clinicians to verify how lifespan and time can modify diagnosis and treatment of a neurological disorder.

Restless legs syndrome

2019 ◽  
Vol 12 (12) ◽  
pp. 714-719
Author(s):  
Robert West
Keyword(s):  
Effective Treatment ◽  
Restless Legs Syndrome ◽  
Daily Functioning ◽  
Dopaminergic Receptors ◽  
Quality Of Sleep ◽  
Iron Depletion ◽  
Restless Legs ◽  
The Brain

Restless legs syndrome is a common, often debilitating disorder, which is under-recognised and under-diagnosed. Patients typically describe an uncomfortable urge to move their legs, this occurs mainly at night. It often has a significant impact on the quality of sleep, and hence, daily functioning. The pathophysiology of the disorder is well known, it relates to iron depletion and dopaminergic receptors in the brain, and this has aided the development of effective treatment. This article will cover the recognition, pathophysiology and management of the condition.

Effective treatment of restless legs syndrome by safinamide in Parkinson's disease patients

2018 ◽  
Vol 41 ◽  
pp. 113-114 ◽  
Author(s):  
Claudio Liguori ◽  
Nicola Biagio Mercuri ◽  
Alessandro Stefani ◽  
Mariangela Pierantozzi
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Effective Treatment ◽  
Restless Legs Syndrome ◽  
Restless Legs

scholarly journals Why Are Women Prone to Restless Legs Syndrome?

2020 ◽  
Vol 17 (1) ◽  
pp. 368 ◽  
Author(s):  
Mary V. Seeman
Keyword(s):  
Restless Legs Syndrome ◽  
Reproductive Hormones ◽  
Comorbid Condition ◽  
Depression And Anxiety ◽  
Predisposing Factor ◽  
Neurologic Disorder ◽  
Periodic Leg Movements ◽  
Restless Legs ◽  
Glutamate Transmission ◽  
The Central Nervous System

Restless legs syndrome is a relatively common neurologic disorder considerably more prevalent in women than in men. It is characterized by an inactivity-induced, mostly nocturnal, uncomfortable sensation in the legs and an urge to move them to make the disagreeable sensation disappear. Some known genes contribute to this disorder and the same genes contribute to an overlapping condition—periodic leg movements that occur during sleep and result in insomnia. Dopamine and glutamate transmission in the central nervous system are involved in the pathophysiology, and an iron deficiency has been shown in region-specific areas of the brain. A review of the literature shows that pregnant women are at particular risk and that increased parity is a predisposing factor. Paradoxically, menopause increases the prevalence and severity of symptoms. This implies a complex role for reproductive hormones. It suggests that changes rather than absolute levels of estrogen may be responsible for the initiation of symptoms. Both iron (at relatively low levels in women) and estrogen (at relatively high oscillating levels in women) influence dopamine and glutamate transmission, which may help to explain women’s vulnerability to this condition. The syndrome is comorbid with several disorders (such as migraine, depression, and anxiety) to which women are particularly prone. This implies that the comorbid condition or its treatment, or both, contribute to the much higher prevalence in women than in men of restless legs syndrome.

The Impact of Restless Legs Syndrome/ Willis–Ekbom Disorder on Quality of Life

2013 ◽  
Vol 8 (2) ◽  
pp. 97 ◽  
Author(s):  
Aadi Kalloo ◽  
Charlene E Gamaldo ◽  
Anthony B Kwan ◽  
Rachel E Salas ◽  
◽  
...  
Keyword(s):  
Quality Of Life ◽  
Restless Legs Syndrome ◽  
Sleep Disruption ◽  
Iron Supplements ◽  
Prevalence Studies ◽  
Adverse Side Effects ◽  
Restless Legs ◽  
The Us ◽  
The Impact

Restless legs syndrome (RLS), also known as Willis–Ekbom Disorder (WED), is a condition associated with nocturnal sensorimotor symptoms that can result in significant sleep disruption. RLS is a prevalent condition, affecting an estimated 3.9–14.3 % of the US population. Despite the most recently reported prevalence studies, many experts in the field still believe RLS is a generally underdiagnosed condition. RLS can negatively affect a patient’s quality of life (QoL) across several domains, such as daytime sleepiness, decreased general health, decreased immune function, stress and mood. Of those patients with moderate-to-severe symptoms that require treatment, the currently available therapeutic options (e.g. iron supplements, dopamine agonists, benzodiazepines, opioids and anticonvulsants) can also come with adverse side effects that can further impact QoL. The purpose of this article is to examine the QoL deficits experienced by RLS patients.

Restless legs syndrome: the most prevalent “unknown” disorder

2011 ◽  
Vol 152 (7) ◽  
pp. 259-266 ◽  
Author(s):  
Anett Lindner ◽  
Márta Novák ◽  
Miklós Zsolt Molnár
Keyword(s):  
Restless Legs Syndrome ◽  
Health Care Professionals ◽  
Clinical Presentation ◽  
Social Consequences ◽  
Sleep Disruption ◽  
Daytime Functioning ◽  
Restless Legs ◽  
High Prevalence ◽  
Consequences Of Disease

Sleep disorders are also considered as significant chronic disorders, as their physiological and psycho-social consequences are well documented. Restless legs syndrome has high prevalence, as it occurs in 5–10 % of the general population. Since clinical presentation is not well appreciated by many of the health care professionals, only a small proportion of the patients with restless legs syndrome is diagnosed and treated. The consequences of disease, however, are not negligible. The majority of the patients suffer from insomnia, impaired daytime functioning and quality of life. Although, restless legs syndrome is frequently characterized as a sleep disorder, it does not only influence sleep but also the daytime functioning of the patients. Additionally, restless legs syndrome causes not only subjective complaints and sleep disruption, but it is also associated with cardiovascular disorders. Orv. Hetil., 2011, 152, 259–266.

scholarly journals Clonazepam: effective treatment for restless legs syndrome in uraemia.

BMJ ◽  
1981 ◽  
Vol 283 (6296) ◽  
pp. 885-886 ◽  
Author(s):  
D J Read ◽  
T G Feest ◽  
M A Nassim
Keyword(s):  
Effective Treatment ◽  
Restless Legs Syndrome ◽  
Restless Legs

scholarly journals The Prevalence of Restless Legs Syndrome in Patients with Migraine: A Systematic Review and Meta-Analysis

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Hooman Ghasemi ◽  
Behnam Khaledi-Paveh ◽  
Alireza Abdi ◽  
Rostam Jalali ◽  
Nader Salari ◽  
...  
Keyword(s):  
Systematic Review ◽  
Sample Size ◽  
Restless Legs Syndrome ◽  
Meta Analysis ◽  
Total Sample ◽  
Knowledge Network ◽  
Cross Sectional ◽  
Neurologic Disorder ◽  
Restless Legs ◽  
Persian Language

Background. Migraine is a severe and debilitating neurologic disorder and is claimed to be the sixth disabling illness in the world. This study aimed to determine the overall prevalence of restless legs syndrome (RLS) in patients with migraine through a systematic review and meta-analysis. Methods. To identify and select related studies, the Scopus, ScienceDirect, Embase, SID, IranDoc, Web of Science, Knowledge Network System Medline (PubMed), and Google Scholar databases were searched. All related cross-sectional studies, published in English or Persian language between January 2000 and December 2019 and using the keywords such as migraine, restless leg syndrome, sleep disorder, RLS, and migraine disorder, were collected. The heterogeneity of the studies was assessed using the I2 index, and the data analysis was performed using the Comprehensive Meta-Analysis software. Results. Analysis was conducted on the reported results of the final 12 articles with the total sample size of 15196. The overall prevalence of RLS in patients with migraine was 16.3% (95% CI: 12.6–20.8%). The prevalence of RLS migraine patients decreased with increasing the sample size, and the prevalence of RLS migraine patients increased with increasing the research year, which was statistically significant (P<0.05). Conclusion. This study highlights that RLS is high in patients with migraine, and therefore, the clinicians should be aware of its incidence and take preventive measures.

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