scholarly journals A Meta-Analysis of the Efficacy of Hyaluronic Acid Eye Drops for the Treatment of Dry Eye Syndrome

2021 ◽  
Vol 18 (5) ◽  
pp. 2383
Author(s):  
Yun-Jung Yang ◽  
Won-Young Lee ◽  
Young-jin Kim ◽  
Yeon-pyo Hong
Keyword(s):  
Hyaluronic Acid ◽  
Confidence Interval ◽  
Dry Eye ◽  
Test Scores ◽  
Meta Analysis ◽  
Mean Difference ◽  
Dry Eye Syndrome ◽  
Eye Drops ◽  
Cochrane Central Register ◽  
Standard Mean Difference

Hyaluronic acid (HA) is commonly used for treating dry eye syndrome (DES). This meta-analysis was performed to compare the efficacies of HA- and non-HA-based eye drops, including saline and conventional artificial tears (ATs), for the treatment of dry eye disease. Eight databases (PubMed, EMBASE, Cochrane Central Register of Controlled Trials, DBpia, KoreaMed, KMBASE, RISS, KISS) were searched for studies comparing the efficacies of HA- and non-HA-based ATs in patients with DES published up to September 2020. Two independent reviewers assessed the quality and extracted the relevant data. The mean differences of Schirmer’s (SH) test scores, tear breakup times (TBUT), corneal fluorescein staining scores (Oxford scale, 0–4), and ocular surface disease indexes were calculated. The standard mean difference and 95% confidence interval were calculated using a random effect model. Nineteen studies, including 2078 cases, were included. HA eye drops significantly improved tear production compared with non-HA-based eye drops (standard mean difference (SMD) 0.18; 95% confidence interval (CI) 0.03, 0.33). In a subgroup analysis, the SH test scores and TBUT values after using HA significantly increased compared to those measured after using saline (SMD 0.27; 95% CI 0.05, 0.49 and SMD 0.28; 95% CI 0.03, 0.52, respectively). Based on these results, HA eye drops may be superior to non-HA eye drops including normal saline and ATs. Further research is needed to assess the efficacies stratified by age, treatment duration, the severity of dry eye, and optimal dosages.

Associations between paraoxonase-1 and systemic lupus erythematosus

Lupus ◽  
2019 ◽  
Vol 28 (13) ◽  
pp. 1571-1576
Author(s):  
S -C Bae ◽  
Y H Lee
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Confidence Interval ◽  
Lupus Erythematosus ◽  
Meta Analysis ◽  
Small Sample ◽  
Mean Difference ◽  
Paraoxonase 1 ◽  
Systemic Lupus ◽  
Standard Mean Difference ◽  
Meta Analyses

Objective The objective of this analysis was to explore associations between paraoxonase-1 levels, gene polymorphisms and systemic lupus erythematosus. Methods Meta-analyses of paraoxonase-1 levels and Q192R and L55M and polymorphisms in systemic lupus erythematosus were conducted. Results Nine articles were incorporated in our meta-analysis, which uncovered that the paraoxonase-1 level was decreased in systemic lupus erythematosus compared to control (standard mean difference = −1.626, 95% confidence interval = −2.829–−0.424, p = 0.008). Ethnicity-specific meta-analysis demonstrated a relation tendency between decreased paraoxonase-1 activity and lupus in Europeans (standard mean difference = −1.236, 95% confidence interval = −2.634–0.163, p = 0.083). Paraoxonase-1 activity was reduced in systemic lupus erythematosus in a single Arab and African population. Decreased paraoxonase-1 activity was found in a small sample of systemic lupus erythematosus patients (standard mean difference = −1.642, 95% confidence interval = −3.076–−0.247, p = 0.021). Ethnicity-specific analysis indicated a relationship between the paraoxonase-1 55 M allele in the Arab systemic lupus erythematosus population. However, a lack of association with systemic lupus erythematosus and the paraoxonase-1 192 R allele was observed. Conclusions Meta-analyses revealed reduced paraoxonase-1 activity in patients with systemic lupus erythematosus and found possible associations between systemic lupus erythematosus and paraoxonase-1 L55M polymorphism in a specific ethnic group.

scholarly journals Effect of surface treatment on the mechanical stability of orthodontic miniscrews:

2021 ◽  
Author(s):  
Yousef Al-Thomali ◽  
Sakeenabi Basha ◽  
Roshan Noor Mohamed
Keyword(s):  
Confidence Interval ◽  
Surface Treatment ◽  
Mechanical Stability ◽  
Meta Analysis ◽  
Risk Of Bias ◽  
Mean Difference ◽  
Forest Plot ◽  
Total N ◽  
Standard Mean Difference ◽  
Effect Of Surface

ABSTRACT Objectives To provide collective quantitative evidence about the effect of surface treatments on the mechanical stability of orthodontic miniscrews (MSs). Materials and Methods The study was registered in PROSPERO (No. CRD42020209652). The research question was defined according to the PICO (population, intervention, control, and outcomes) format. Various research databases were searched for animal and human studies on effects of surface treatment on the mechanical stability of MSs. Both prospective and retrospective in vivo clinical studies published in English were included. The risk of bias was assessed using SYRCLE's risk of bias tool for animal studies. The meta-analysis was conducted using RevMan 5.4. Results A total of 109 articles were identified; 14 were included in the systematic review, and seven studies with sandblasting, acid etching (SLA) methods of surface treatment were included for meta-analysis. The number of study participants ranged from 6 to 24 (total n = 185), with a mean of 13.2. A total of 949 MSs were used with a mean of 67.8. The overall success rate for surface-treated MSs ranged from 47.9% to 100%. Forest plot of removal torque values showed significantly higher values for SLA surface-treated MSs compared with controls with a standard mean difference of 2.61 (95% confidence interval = 1.49–3.72, I2 = 85%). Forest plot of insertion torque showed a standard mean difference of –6.19 (95% confidence interval = –13.63–1.25, I2 = 98%, P = .10). Conclusions Surface treatment of MSs improved primary and secondary stability with good osseointegration at the bone-implant surface. However, significant heterogeneity across the studies included in the meta-analysis made it difficult to draw conclusions.

Effects of the FIFA 11 training program on injury prevention and performance in football players: a systematic review and meta-analysis

2016 ◽  
Vol 31 (5) ◽  
pp. 651-659 ◽  
Author(s):  
Mansueto Gomes Neto ◽  
Cristiano Sena Conceição ◽  
Alécio Jorge Alves de Lima Brasileiro ◽  
Camila Santana de Sousa ◽  
Vitor Oliveira Carvalho ◽  
...  
Keyword(s):  
Confidence Interval ◽  
Injury Prevention ◽  
Dynamic Balance ◽  
Meta Analysis ◽  
Mean Difference ◽  
Football Players ◽  
Weighted Mean ◽  
Standard Mean Difference ◽  
And Performance ◽  
Mean Differences

Objective: To investigate the effects of FIFA 11 training on injury prevention and performance in football players. Design and methods: Systematic review and meta-analysis. We conducted a systematic search using four databases (CINAHL, Cochrane Library, EMBASE, and PubMed) to find controlled trials evaluating the effects of FIFA 11 on injury prevention and performance among football players. Weighted mean differences, standard mean differences, risk ratios, and 95% confidence intervals were calculated, and heterogeneity was assessed using the I2 test. Results: We analyzed 11 trials, including 4700 participants. FIFA 11 resulted in a significant reduction in injury risk (risk ratio = 0.69; 95% confidence interval, 0.49–0.98; P = 0.02) and improvements in dynamic balance (weighted mean difference = 2.68; 95% confidence interval, 0.44–4.92; P = 0.02) and agility (standard mean difference = −0.36; 95% confidence interval, 0.70–0.02; P = 0.04). The meta-analysis indicated a non-significant improvement in jump height (standard mean difference = 0.25; 95% confidence interval, 0.08–0.59; P = 0.14) and running sprint (standard mean difference = −0.24; 95% confidence interval, 0.58–0.10; P = 0.17) in the FIFA 11 group. Conclusions: FIFA 11 can be considered as a tool to reduce the risk of injury. It may improve dynamic balance and agility and can be considered for inclusion in the training of football players.

scholarly journals Foetal responses to dexmedetomidine in parturients undergoing caesarean section: a systematic review and meta-analysis

2017 ◽  
Vol 45 (5) ◽  
pp. 1613-1625 ◽  
Author(s):  
Jian Zhang ◽  
Haibin Zhou ◽  
Kaihua Sheng ◽  
Tian Tian ◽  
Anshi Wu
Keyword(s):  
Caesarean Section ◽  
Meta Analysis ◽  
Blood Gases ◽  
Sensory Block ◽  
Mean Difference ◽  
Controlled Trials ◽  
Cochrane Central Register ◽  
Apgar Scores ◽  
Umbilical Blood ◽  
Standard Mean Difference

Objective This current meta-analysis was conducted to evaluate effects of dexmedetomidine on neonatal maternal factors. Methods The electronic databases of PubMed, Embase, and Cochrane Central Register of Controlled Trials were searched. The primary outcomes were neonatal parameters, including umbilical blood gases and Apgar scores. The secondary outcomes were maternal parameters. Results We identified six randomized controlled trials (RCTs). No differences in neonatal umbilical blood gases, and Apgar scores at 1 min (WMD: −0.09; 95% CI: −0.21 to 0.04; I2 = 0%) and 5 min (weighted mean difference (WMD): 0.03; 95% CI: −0.05 to 0.11; I2 = 37%) were observed with dexmedetomidine. For maternal parameters, characteristics of motor and sensory block and postoperative analgesia (standard mean difference (SMD): 3.99; 95% CI: 2.85 to 5.12; I2 = 78%) were significantly improved after dexmedetomidine treatment. Adverse events, including nausea/vomiting and shivering (risk ratio (RR): 0.26; 95% CI: 0.11 to 0.60; I2 = 0%), were lower after dexmedetomidine treatment. Conclusion This meta-analysis shows that dexmedetomidine is safe for neonates who are delivered by caesarean section. Moreover, dexmedetomidine used in neuraxial anaesthesia can improve the characteristics of motor and sensory block and prolong the maternal pain-free period. Dexmedetomidine can also reduce the maternal incidence of postoperative adverse effects.

scholarly journals Gelatin–epigallocatechin gallate nanoparticles with hyaluronic acid decoration as eye drops can treat rabbit dry-eye syndrome effectively via inflammatory relief

2018 ◽  
Vol Volume 13 ◽  
pp. 7251-7273 ◽  
Author(s):  
Hsin-Yi Huang ◽  
Ming-Chen Wang ◽  
Zhi-Yu Chen ◽  
Wen-Ying Chiu ◽  
Ko-Hua Chen ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Dry Eye ◽  
Epigallocatechin Gallate ◽  
Dry Eye Syndrome ◽  
Eye Drops

Speech and language therapy treatment on hypokinetic dysarthria in Parkinson disease: Systematic review and meta-analysis

2020 ◽  
pp. 026921552097626
Author(s):  
Natalia Muñoz-Vigueras ◽  
Esther Prados-Román ◽  
Marie Carmen Valenza ◽  
Maria Granados-Santiago ◽  
Irene Cabrera-Martos ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Standard Deviation ◽  
Confidence Interval ◽  
Sound Pressure Level ◽  
Sound Pressure ◽  
Meta Analysis ◽  
Pressure Level ◽  
Mean Difference ◽  
Hypokinetic Dysarthria ◽  
Standard Mean Difference

Objective: To assess the effect of speech and language therapy (SLT) on Hypokinetic dysarthria (HD) in Parkinson’s disease. Design: Systematic review and meta-analysis of randomized controlled trials. Methods: We performed a literature search of randomized controlled trials using PubMed, Web of Science, Science Direct and Cochrane database (last search October 2020). Quality assessment and risk of bias were assessed using the Downs and Black scale and the Cochrane tool. The data were pooled and a meta-analysis was completed for sound pressure levels, perceptual intelligibility and inflection of voice fundamental frequency. Results: We selected 15 high to moderate quality studies, which included 619 patients with Parkinson’s disease. After pooling the data, 7 studies, which compared different speech language therapies to no treatment, control groups and 3 of their variables, (sound pressure level, semitone standard deviation and perceptual intelligibility) were included in the analysis. Results showed significant differences in favor of SLT for sound pressure level sustained phonation tasks (standard mean difference = 1.79; 95% confidence interval = 0.86, 2.72; p ⩽ 0.0001). Significant results were also observed for sound pressure level and semitone standard deviation in reading tasks (standard mean difference = 1.32; 95% confidence interval = 1.03, 1.61; p ⩽ 0.0001). Additionally, sound pressure levels in monologue tasks showed similar results when SLT was compared to other treatments (standard mean difference = 0.87; 95% confidence interval = 0.46, 1.28; p ⩽ 0.0001). Conclusion: This meta-analysis suggests a beneficial effect of SLT for reducing Hypokinetic Dysarthria in Parkinson’s disease, improving perceptual intelligibility, sound pressure level and semitone standard deviation.

scholarly journals TREATMENT OF DEGENERATIVE CHANGES IN THE EPITHELIUM OF THE OCULAR SURFACE WITH "DRY EYE" SYNDROME

2020 ◽  
Vol 20 (2) ◽  
pp. 19-22
Author(s):  
L.K. Voskresenskaya ◽  
V.V. Ryadnova ◽  
O.Yu. Maksimuk ◽  
I.S. Steblovska ◽  
A.V. Voskresenskaya
Keyword(s):  
Hyaluronic Acid ◽  
Dry Eye ◽  
Dry Eye Syndrome ◽  
Bulbar Conjunctiva ◽  
Eye Drops ◽  
Costal Margin ◽  
Department Of Ophthalmology ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

According to recent studies, the prevalence of dry eye syndrome makes up 14% of cases in patients under the age of 50 years and 65-75% in patients over 50 years of age. Risk factors for the development of dry eye syndrome include aging, stress, side effect of frequent instillations of eye preparations, exposure to radiant energy, and diabetes mellitus. Therefore, the purpose of this study is to investigate the possibility of using “Delargin”, an antioxidant medicine, in the treatment of dry eye syndrome. 50 patients (100 eyes) aged 30-70 years were examined at the Department of Ophthalmology and then divided into three groups depending on the treatment used. Group 1 included 10 patients (20 eyes), who were prescribed to instil Oksial eye drops. Group 2 included 10 patients (20 eyes), who received basic therapy by instilling a solution of sodium salt of hyaluronic acid 0.0015 g / ml. Group 3 involved 20 patients (40 eyes), who instilled Delargin and hyaluronic acid. Monitoring the effectiveness of the treatment was carried out using the following methods: to assess basal tear production, a Schirmer 1 test was performed using the Ophthalic Test diagnostic bands (India); a Norn test was performed to control the stability of the tear membrane. Fluorescence test (staining of the cornea with 1% sodium fluorescein solution) was applied to detect corneal defects; Lipcof test was used to assess the degree of lid-parallel fold formation of the bulbar conjunctiva relative to the costal margin of the lower eyelid. As a result of the treatment, the patients of the Group 1 demonstrated that the Norn test scores increased to some extent from 6.8 ± 0.1 s up to 7.5 ± 0.1 s; in the patients of the Group 2 following the treatment, it was 8.5 ± 0.2 s and in the Group 3, the Norn test values were 11.2 ± 0.2 s (P<0.05). The frequency of blinking movements decreased significantly and approached the normal. It has been found out that the therapy of dry eye syndrome that includes the antioxidant Delargin, can significantly promotes normalizing of parameters typical for this process.

scholarly journals Oxygen therapy versus conservative therapy in suspected uncomplicated myocardial infarction without hypoxemia: A meta-analysis of randomized controlled studies

2019 ◽  
pp. 102490791989441
Author(s):  
Rui Zhang ◽  
Youfeng Zhu ◽  
Min Zhang ◽  
Haiyan Yin ◽  
Jianrui Wei
Keyword(s):  
Myocardial Infarction ◽  
Confidence Interval ◽  
Risk Ratio ◽  
Oxygen Therapy ◽  
Conservative Therapy ◽  
Meta Analysis ◽  
Mean Difference ◽  
Randomized Controlled ◽  
Standard Mean Difference

Background: The effect of oxygen therapy in patients with suspected uncomplicated myocardial infarction and without hypoxemia at baseline was uncertain. Objectives: We aimed to perform a rigorous and comprehensive meta-analysis to robustly quantify the efficacy of oxygen therapy in patients with suspected uncomplicated myocardial infarction and without hypoxemia at baseline. Methods: We searched EMBASE, MEDLINE, Web of Science, and the Cochrane Library from inception to August 2018. Two researchers screened studies and collected the data independently. Randomized controlled trials were included. The main outcome was mortality at the longest duration of follow-up. Results: Seven studies involving 7732 patients (median = 157 patients; range = 72–6629 patients; interquartile range = 136–441 patients; oxygen therapy group = 3856 patients; conservative group = 3876 patients) were included. Compared with conservative therapy, oxygen therapy did not significantly reduce mortality at the longest follow-up (risk ratio = 0.97; 95% confidence interval = 0.68 to 1.40; z = 0.15; p = 0.88), at discharge (risk ratio = 1.04; 95% confidence interval = 0.48 to 2.26; z = 0.11; p = 0.91), 30 days (risk ratio = 1.08; 95% confidence interval = 0.78 to 1.49; z = 0.44; p = 0.66), and 6 months (risk ratio = 0.93; 95% confidence interval = 0.73 to 1.17; z = 0.66; p = 0.51) in patients with suspected uncomplicated myocardial infarction and without hypoxemia at baseline. Furthermore, there was no significant difference between two groups with regard to infarct size (standard mean difference = 0.15, confidence interval = –0.13 to 0.44; z = 1.07, p = 0.28), cardiac troponin levels (standard mean difference = 0.30, confidence interval = –0.09 to 0.69; z = 1.51, p = 0.13), in hospital reinfarction (risk ratio = 1.49, confidence interval = 0.80 to 2.78; z = 1.25, p = 0.21), and new-onset atrial fibrillation (risk ratio = 0.91, confidence interval = 0.69 to 1.18; z = 0.72, p = 0.47). Multiple subgroup analysis, sensitivity analysis, and trial sequential analysis were consistent with overall findings. Conclusion: Compared with conservative therapy, oxygen therapy did not decrease the mortality at the longest duration of follow-up, discharge, 30 days, and 6 months in patients with suspected uncomplicated myocardial infarction and without hypoxemia at baseline. Furthermore, large-scale, multicenter studies are needed to confirm our results. Registration: PROSPERO, number CRD42017078807.

Home-Based Phototherapy Versus Hospital-Based Phototherapy for Treatment of Neonatal Hyperbilirubinemia: A Systematic Review and Meta-Analysis

2020 ◽  
Vol 59 (6) ◽  
pp. 588-595 ◽  
Author(s):  
Liangliang Chu ◽  
Jianhong Qiao ◽  
Cuiping Xu
Keyword(s):  
Confidence Interval ◽  
Meta Analysis ◽  
Mean Difference ◽  
Neonatal Hyperbilirubinemia ◽  
Cochrane Library ◽  
Total Serum ◽  
Standard Mean Difference ◽  
Home Based ◽  
Significant Difference ◽  
The Comparative Study

Objective. Phototherapy devices have been found to be an effective method for treating neonatal hyperbilirubinemia. We reviewed the current literature to determine whether home-based phototherapy is more effective than hospital-based phototherapy for the treatment of neonatal hyperbilirubinemia. Method. PubMed, Scopus, Embase, Cochrane library, CBM, CNKI, and Wanfang Data were searched to collect the comparative study of home-based phototherapy versus hospital-based phototherapy for the treatment of neonatal hyperbilirubinemia. All studies were found to be of low risk based on Cochrane Collaborative Risk of Bias Tool. Data were statistically extracted and evaluated by RevMan 5.3 software. Result. A total of 259 neonates were included in the meta-analysis. Compared with hospital-based phototherapy, home-based phototherapy appeared more effective for the treatment of neonatal hyperbilirubinemia in reducing the rate of total serum bilirubin (standard mean difference = 0.32, 95% confidence interval = −0.22 to 0.86, P = .04); however, there was no significant difference in duration of phototherapy (standard mean difference = 0.59, 95% confidence interval = 0.28 to 0.90, P = .06) in the 2 groups. Conclusion. Home-based phototherapy was more effective than hospital-based phototherapy in treatment for neonatal hyperbilirubinemia; home-based phototherapy is an effective, feasible, safe, and alternative to hospital-based phototherapy for neonatal hyperbilirubinemia.

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