scholarly journals Genetic Variants in Smoking-Related Genes in Two Smoking Cessation Programs: A Cross-Sectional Study

2021 ◽  
Vol 18 (12) ◽  
pp. 6597
Author(s):  
Gloria Pérez-Rubio ◽  
Luis Alberto López-Flores ◽  
Ana Paula Cupertino ◽  
Francisco Cartujano-Barrera ◽  
Luz Myriam Reynales-Shigematsu ◽  
...  
Keyword(s):  
Smoking Cessation ◽  
Cross Sectional Study ◽  
Nucleotide Polymorphisms ◽  
Sectional Study ◽  
Cross Sectional ◽  
Single Nucleotide ◽  
Genotype Frequencies ◽  
Quitting Smoking ◽  
Genes Encoding ◽  
Genomic Regions

Previous studies have identified variants in genes encoding proteins associated with the degree of addiction, smoking onset, and cessation. We aimed to describe thirty-one single nucleotide polymorphisms (SNPs) in seven candidate genomic regions spanning six genes associated with tobacco-smoking in a cross-sectional study from two different interventions for quitting smoking: (1) thirty-eight smokers were recruited via multimedia to participate in e-Decídete! program (e-Dec) and (2) ninety-four attended an institutional smoking cessation program on-site. SNPs genotyping was done by real-time PCR using TaqMan probes. The analysis of alleles and genotypes was carried out using the EpiInfo v7. on-site subjects had more years smoking and tobacco index than e-Dec smokers (p < 0.05, both); in CYP2A6 we found differences in the rs28399433 (p < 0.01), the e-Dec group had a higher frequency of TT genotype (0.78 vs. 0.35), and TG genotype frequency was higher in the on-site group (0.63 vs. 0.18), same as GG genotype (0.03 vs. 0.02). Moreover, three SNPs in NRXN1, two in CHRNA3, and two in CHRNA5 had differences in genotype frequencies (p < 0.01). Cigarettes per day were different (p < 0.05) in the metabolizer classification by CYP2A6 alleles. In conclusion, subjects attending a mobile smoking cessation intervention smoked fewer cigarettes per day, by fewer years, and by fewer cumulative pack-years. There were differences in the genotype frequencies of SNPs in genes related to nicotine metabolism and nicotine dependence. Slow metabolizers smoked more cigarettes per day than intermediate and normal metabolizers.

scholarly journals APPLICATION OF THE REAL – TIME PCR FOR THE DETECTION OF CYP2C19*2 SINGLE NUCLEOTIDE POLYMORPHISM IN PATIENS WITH GASTRITIS AT TRA VINH GENERAL HOSPITAL

2018 ◽  
Vol 1 (32) ◽  
pp. 39-43
Author(s):  
Duy Anh Ngo ◽  
Trung Thien Tran ◽  
Anh Tuan Nguyen ◽  
Thanh Tien Nguyen
Keyword(s):  
New York ◽  
General Hospital ◽  
Cross Sectional Study ◽  
Nucleotide Polymorphisms ◽  
Sectional Study ◽  
Nucleotide Polymorphism ◽  
Cross Sectional ◽  
Single Nucleotide ◽  
Taqman Probes ◽  
Pcr Method

The aim of this study is to identify CYP2C19*2 single nucleotide polymorphisms in patients with gastritis at TraVinh General Hospital. A cross-sectional study was conducted in 280 endoscopic gastric biopsy samples of patients with gastritis at TraVinh General Hospital. CYP2C19*2 genotypes were determined by realtime PCR method using TaqMan probes. Data were stored and analyzed by IBM SPSS Statistic (version 20.0; Armonk, New York, USA) and Excel 2010. The prevallelece of GG, AG and AA genotypes were 51.8, 39.6 and 8.6% correspondingly. The ratio of allele G and A were 0.716 and 0.284 respectively. The correlation of CYP2C19*2 polymorphisms with age (p=0.891), gender (p=0.652) was not significantly distinguished

scholarly journals A Cross-Sectional Study of Happiness and Smoking Cessation Among Parents

2015 ◽  
Vol 12 (1) ◽  
pp. 6-14 ◽  
Author(s):  
Jeremy E. Drehmer ◽  
Bethany Hipple ◽  
Deborah J. Ossip ◽  
Emara Nabi-Burza ◽  
Jonathan P. Winickoff
Keyword(s):  
Smoking Cessation ◽  
Secondhand Smoke ◽  
Cross Sectional Study ◽  
Evidence Based ◽  
Sectional Study ◽  
Cross Sectional ◽  
Factors Associated ◽  
Quit Smoking ◽  
Quitting Smoking

Introduction:Smoking cessation among adults is associated with increased happiness. This association has not been measured in parents, a subset of adults who face uniquely stressful and challenging circumstances that can affect happiness.Aims:The aim of this study was to determine if parental smoking cessation is associated with increased happiness and to identify characteristics of parental quitters who experience increased happiness.Methods:A total of 1,355 parents completed a 12-month follow-up interview from a U.S. national trial, Clinical Effort Against Secondhand Smoke Exposure (CEASE). Multivariable logistic regression examined if level of happiness was independently associated with quitting smoking and identified characteristics associated with feeling happier after quitting smoking.Results/Findings:Parents’ level of happiness was independently associated with quitting smoking (aOR = 1.60, 95% CI = 1.42–1.79). Factors associated with increased happiness among quitters include engaging in evidence-based cessation assistance (aOR = 2.69, 95% CI = 1.16–6.26), and adopting strictly enforced smoke-free home (aOR = 2.55, 95% CI = 1.19–5.48) and car (aOR = 3.85, 95% CI = 1.94–7.63) policies. Additionally, parents who believed that being a smoker got in the way of being a parent (aOR = 5.37, 95% CI = 2.61–11.07) and who believed that thirdhand smoke is harmful to children (aOR = 3.28, 95% CI = 1.16–9.28) were more likely to report feeling happier after quitting.Conclusions:Parents who quit smoking reported being happier than parents who did not quit. Though prospective studies can clarify what factors cause an increase in happiness, letting paediatricians know that most parents who smoke report being happier when quitting may facilitate communication with parents around cessation.

scholarly journals Willingness to Stop Smoking: A Cross-Sectional Study of a Primary Healthcare Center Visitors’ in an Urban Area of Alexandria in Egypt

2020 ◽  
Author(s):  
Rehab A. Rayan
Keyword(s):  
Smoking Cessation ◽  
Urban Area ◽  
Primary Healthcare ◽  
Health Hazard ◽  
Single Point ◽  
Cross Sectional Study ◽  
P Value ◽  
Sectional Study ◽  
Cross Sectional ◽  
Stop Smoking

For improving accomplished attempts to stop smoking, it is necessary to learn about the qualities of individuals who can willingly stop smoking. This study seeks to discover the willingness degree and associated determinants to stop smoking between adult visitors of a primary healthcare centre in an urban area of Alexandria in Egypt. In this single point and descriptive cross-sectional study, a semi-structured questionnaire was distributed to a sample of 53 adults aged ≥18 years in May 2019. Descriptive statistical analyses were conducted to evaluate the determinants influencing the willingness to stop smoking. Of the 53 respondents (with a mean age of 38.7 years old), 41.5% of them were males. Almost 18.9% of the respondents were ongoing smokers (36.4% of males and 6.5% of females), though 83.7% of those smokers were willing to stop smoking. The number of male smokers was significantly greater than female smokers (Pearson Chi-Square = 7.52, p-value = 0.006). Determinants, which can favourably influence the willingness to stop smoking, were believing that smoking is a health risk to them (100%) and the others around (94.3%). A bulk of participants (56.6%) doubted the need for nicotine supplements to help in smoking cessation. Smoker respondents were willing to stop smoking. Understanding that smoking is a health hazard for both smokers and the others around can motivate smoking cessation. Relying on nicotine supplements alone might not add favourably to a strong smoking cessation decision. Tailoring campaigns to raise awareness about smoking health hazards’ would support and sustain smoking cessation.

Smoking Cessation Counseling: Attitude in the Background of Poor Practice Compliance among Palestinian Primary Health Care Physicians: A cross sectional study

2020 ◽  
Author(s):  
Beesan Maraqa ◽  
Zaher Nazzal ◽  
Jurouh Jabareen
Keyword(s):  
Health Care ◽  
Smoking Cessation ◽  
Primary Health Care ◽  
General Practitioners ◽  
Positive Attitude ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Smoking Cessation Counseling ◽  
Cross Sectional ◽  
Primary Health

Abstract Background: Health-care systems have primary responsibility for treating tobacco dependence. Despite its proven effectiveness, international studies have shown that provision of smoking cessation advice to patients in primary health care is suboptimal. This study aimed at assessing Palestinian PHC physicians' compliance and attitude towards smoking cessation counseling and their determinants.Methods: the study utilized a cross-sectional study design using a self-reported questionnaire targeted general practitioners, family medicine doctors, obstetrics & gynecologists and dentists working at PHC Centers in Palestine in the period between April to September,2019. Proportionate stratified random sampling method was used. Sociodemograpic, medical experience, if received any training in smoking cessation counseling, smoking history, practice compliance, knowledge, confidence and attitude were assessed. Results: 294 PHC physicians' participated in the study with high response rate. More than a half (53%) were between 31-45 years of age. Most of them (76.5%) were general practitioners seeing more than 30 patients per day (66%) and only 15% (n=40) get training about smoking cessation counseling. Practice compliance was low; only 39 (13.3%) reported compliance to smoking cessation practice. Attitude level among the participant physicians was good as the overall attitude score mean was 75.1 ± 9.6. Positive attitude, assigned as any score ≥65, was observed in 87.7% (n=258) of physicians. Job title, experience and knowledge are predictors of positive attitude towards smoking cessation counseling.Conclusion: Building supportive environment, improving physicians’ capabilities will reflect on their self-efficacy and their con­fidence level and will improve their practice in smoking cessation counseling.

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