Comparison of Polydrug Use Prevalences and Typologies between Men Who Have Sex with Men and General Population Men, in Madrid and Barcelona

This study compares the prevalence of drug use and the typologies of polydrug use (PDU) in men who have sex with men (MSM) and general population men (GPM). Participants were men aged 16–64, living in the provinces of Madrid and Barcelona: 1720 were recruited in a GPM survey, and 2658 were HIV-negative MSM from HIV/STIs diagnosis services. Lifetime and last-year prevalence of drug use and prevalence ratios (PRs) of MSM to GPM for the different drugs were calculated using Poisson regression. Latent class analysis (LCA) was performed to identify typologies of PDU. Lifetime use of the drugs considered was higher in MSM, and even higher for drug use in the last-year: PRs for cannabis, hallucinogens and cocaine ranged from 2–5; for amphetamine, ecstasy and methamphetamine 12–16; and above 60 for ketamine, GHB/GBL, inhalants and mephedrone. In the LCA for lifetime PDU four classes arose from the GPM (No-PDU (79.6%); Conventional PDU (13.8%); Intensive conventional PDU (4.9%); Heavy PDU (1.8%)) and four among MSM (No-PDU (57.7%); Conventional PDU plus poppers (18.8%); PDU preferring chemsex drugs (6.4%); Heavy PDU (17.2%)). For PDU during the last-year, three classes arose in the GPM: No-PDU (94.7%); Conventional PDU (4.3%); Heavy PDU (0.9%). For MSM, we identified four classes: No-PDU (64.7%); Conventional PDU plus poppers (15.6%); PDU preferring chemsex drugs (6.2%); Heavy PDU (13.5%). MSM should be considered a priority group for the prevention of the use of all drugs but the heterogeneity of PDU typologies regarding users’ preference towards conventional and/or sexualised drugs needs to be taken into account.

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Perceived barriers to pre-exposure prophylaxis use among HIV-negative men who have sex with men in Tijuana, Mexico: A latent class analysis

PLoS ONE ◽

10.1371/journal.pone.0221558 ◽

2019 ◽

Vol 14 (8) ◽

pp. e0221558

Author(s):

Rudy Patrick ◽

Jennifer Jain ◽

Alicia Harvey-Vera ◽

Shirley J. Semple ◽

Gudelia Rangel ◽

...

Keyword(s):

Latent Class Analysis ◽

Latent Class ◽

Perceived Barriers ◽

Class Analysis ◽

Sex With Men ◽

Exposure Prophylaxis ◽

Hiv Negative

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Changes in recreational drug use, drug use associated with chemsex, and HIV-related behaviours, among HIV-negative men who have sex with men in London and Brighton, 2013–2016

Sexually Transmitted Infections ◽

10.1136/sextrans-2017-053439 ◽

2018 ◽

Vol 94 (7) ◽

pp. 494-501 ◽

Cited By ~ 27

Author(s):

Janey Sewell ◽

Valentina Cambiano ◽

Ada Miltz ◽

Andrew Speakman ◽

Fiona C Lampe ◽

...

Keyword(s):

Drug Use ◽

Sexual Health ◽

Sociodemographic Factors ◽

Post Exposure Prophylaxis ◽

Specific Drug ◽

Cross Sectional ◽

Polydrug Use ◽

Sex With Men ◽

Exposure Prophylaxis ◽

Hiv Negative

ObjectivesThe objective of this study was to compare the prevalence of polydrug use, use of drugs associated with chemsex, specific drug use, and HIV-related behaviours, between two time periods, using two groups of HIV-negative men who have sex with men (MSM) attending the same sexual health clinics in London and Brighton, in two consecutive periods of time from 2013 to 2016.MethodsData from MSM in the cross-sectional Attitudes to and Understanding Risk of Acquisition of HIV (AURAH) study (June 2013 to September 2014) were compared with baseline data from different MSM in the prospective cohort study Attitudes to and Understanding Risk of Acquisition of HIV over Time (AURAH2) (November 2014 to April 2016). Prevalence of polydrug use, drug use associated with chemsex and specific drug use, and 10 measures of HIV-related behaviours including condomless sex, post-exposure prophylaxis (PEP) use, pre-exposure prophylaxis (PrEP) use, and HIV testing, were compared. Prevalence ratios (PRs) for the association of the study (time period) with drug use and HIV-related behaviour measures were estimated using modified Poisson regression analysis, unadjusted and adjusted for sociodemographic factors.ResultsIn total, 991 MSM were included from AURAH and 1031 MSM from AURAH2. After adjustment for sociodemographic factors, use of drugs associated with chemsex had increased (adjusted PR (aPR) 1.30, 95% CI 1.11 to 1.53) and there were prominent increases in specific drug use; in particular, mephedrone (aPR 1.32, 95% CI 1.10 to 1.57), γ-hydroxybutyric/γ-butryolactone (aPR 1.47, 95% CI 1.15 to 1.87) and methamphetamine (aPR 1.42, 95% CI 1.01 to 2.01). Use of ketamine had decreased (aPR 0.54, 95% CI 0.38 to 0.78). Certain measures of HIV-related behaviours had also increased, most notably PEP use (aPR 1.50, 95% CI 1.21 to 1.88) and number of self-reported bacterial STI diagnoses (aPR 1.24, 95% CI 1.08 to 1.43).ConclusionsThere have been significant increases in drug use associated with chemsex and some measures of HIV-related behaviours among HIV-negative MSM in the last few years. Changing patterns of drug use and associated behaviours should be monitored to enable sexual health services to plan for the increasingly complex needs of some clients.

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The association between non-injection drug use and hepatitis C infection among HIV-negative men who have sex with men

10.21203/rs.3.rs-946966/v1 ◽

2021 ◽

Author(s):

Jing Zhao ◽

Charles Green ◽

Christine Markham ◽

Kayo Fujimoto ◽

Alan G. Nyitray ◽

...

Keyword(s):

Hepatitis C ◽

Drug Use ◽

Injection Drug Use ◽

Latent Class ◽

Crack Cocaine ◽

Hcv Infection ◽

Injection Drug ◽

Latent Classes ◽

Sex With Men ◽

Hiv Negative

Abstract Background: This study investigated the association between drug use and Hepatitis C Virus (HCV) infection in HIV-negative men who have sex with men (MSM) who reported drug use but not injection drug use. Methods: This cross-sectional study analyzed the data of 118 HIV-negative MSM who reported drug use but not injection drug use recruited from two inner-city communities between 2004 and 2007. Latent class analysis (LCA) was used to identify drug use latent classes. Multinomial logistic regression analysis was used to evaluate the association between drug use latent class and HCV infection. Results: Four distinct latent classes of drug use were identified: (1) persons >=42 years old who used only crack cocaine, (2) persons about 42 years old who used >2 drugs, (3) persons <42 years old who used >5 drugs, and (4) persons >=42 years old who used >6 drugs. Class 4, persons >= 42 years old who used >6 drugs were significantly associated with HCV infection. Compared with persons about 42 years old who used >2 drugs, persons >=42 years old who used >6 drugs had more than 16 times the odds of having HCV infection (adjusted OR = 16.9, 95%CI: 1.4-205.4), and compared with persons <42 years old who used >5 drugs, persons >=42 years old who used >6 drugs were about 22 times as likely to have HCV infection (adjusted OR=21.8, 95%CI: 1.5-322.8). Conclusions: The subgroup of MSM >=42 years old with non-injection but multiple use of heroin, speedball, and methamphetamine, in addition to crack cocaine and marijuana, had high probability of HCV infection. Public health and education programs, as well as drug treatment and rehabilitation programs, should be developed for this high-risk subgroup to prevent HCV acquisition and transmission.

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A latent class analysis of sexual and romantic relationships among HIV-positive and HIV-negative gay and bisexual men in Vancouver

The Canadian Journal of Human Sexuality ◽

10.3138/cjhs.262.a1 ◽

2017 ◽

Vol 26 (2) ◽

pp. 78-96 ◽

Cited By ~ 2

Author(s):

Allison Carter ◽

Nathan Lachowsky ◽

Jamie I. Forrest ◽

Zishan Cui ◽

Paul Sereda ◽

...

Keyword(s):

Romantic Relationships ◽

Latent Class Analysis ◽

Latent Class ◽

Gay And Bisexual Men ◽

Hiv Positive ◽

Class Analysis ◽

Bisexual Men ◽

And Bisexual ◽

Hiv Negative

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Faculty Opinions recommendation of Patterns of drug use and abuse among aging adults with and without HIV: a latent class analysis of a US Veteran cohort.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.4823957.4739056 ◽

2010 ◽

Author(s):

Gerald Friedland ◽

R Douglas Bruce

Keyword(s):

Drug Use ◽

Latent Class Analysis ◽

Latent Class ◽

Class Analysis ◽

Aging Adults

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A latent class analysis of cannabis use products in a general population sample of adolescents and their association with paranoia, hallucinations, cognitive disorganisation and grandiosity

Addictive Behaviors ◽

10.1016/j.addbeh.2021.106837 ◽

2021 ◽

Vol 117 ◽

pp. 106837

Author(s):

Clare J. Mackie ◽

Jack Wilson ◽

Tom P. Freeman ◽

Sam Craft ◽

Thalia Escamilla De La Torre ◽

...

Keyword(s):

General Population ◽

Latent Class Analysis ◽

Latent Class ◽

Population Sample ◽

Cannabis Use ◽

Class Analysis ◽

General Population Sample

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Food Insecurity Partially Mediates the Association Between Drug Use and Depressive Symptoms among Men who have Sex with Men in Los Angeles, California

Public Health Nutrition ◽

10.1017/s1368980021002494 ◽

2021 ◽

pp. 1-26

Author(s):

David A. Wiss ◽

Marjan Javanbakht ◽

Michael J. Li ◽

Michael Prelip ◽

Robert Bolan ◽

...

Keyword(s):

Food Security ◽

Depressive Symptoms ◽

High Risk ◽

Los Angeles ◽

Drug Use ◽

Food Insecurity ◽

Hiv Positive ◽

Sex With Men ◽

The Relationship ◽

Hiv Negative

Abstract Objective: To understand the relationship between drug use, food insecurity (FI), and mental health among men who have sex with men (MSM). Design: Cohort study (2014-2019) with at least one follow-up. Setting: Visits at 6-month intervals included self-assessment for FI and depressive symptoms. Urine testing results confirmed drug use. Factors associated with FI were assessed using multiple logistic regression with random effects for repeated measures. General structural equation modeling tested whether FI mediates the relationship between drug use and depressive symptoms. Participants: Data were from HIV-positive and high-risk HIV negative MSM in Los Angeles, CA (n=431; 1,192 visits). Results: At baseline, FI was reported by 50.8% of participants, depressive symptoms in 36.7%, and 52.7% of urine screening tests were positive for drugs (i.e., marijuana, opioids, methamphetamine, cocaine, ecstasy). A positive drug test was associated with a 96% increase in the odds of being food insecure (95% CI: 1.26-3.07). Compared to those with high food security, individuals with very low food security have a nearly 7-fold increase in the odds of reporting depressive symptoms (95% CI: 3.71-11.92). Findings showed 14.9% of the association between drug use (exposure) and depressive symptoms (outcome) can be explained by FI (mediator). Conclusion: The prevalence of FI among this cohort of HIV-positive and high-risk HIV-negative MSM was high; the association between drug use and depressive symptoms was partially mediated by FI. Findings suggest that enhancing access to food and nutrition may improve mood in the context of drug use, especially among MSM at risk for HIV-transmission.

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